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Article: Ten-years outcome analysis in patients with clinically localized prostate cancer treated by radical prostatectomy or external beam radiation therapy.

Li, Shu-Wen / Chiu, Allen W / Huang, Andy C / Lai, Yu-Wei / Leu, Jyh-Der / Hsiao, Yi-Chun / Chen, Shiou-Sheng / Hsueh, Thomas Y

Frontiers in surgery

2022 Volume 9, Page(s) 966025

Abstract: Purpose: Since there was no consensus on treatment options for localized prostate cancer, we performed a retrospective study to compare the long-term survival benefit of radiotherapy (RT) versus laparoscopic radical prostatectomy (LRP) in Taiwan.: ... ...

Abstract	Purpose: Since there was no consensus on treatment options for localized prostate cancer, we performed a retrospective study to compare the long-term survival benefit of radiotherapy (RT) versus laparoscopic radical prostatectomy (LRP) in Taiwan. Methods: 218 patients with clinically localized prostate cancer treated between 2008 and 2017 (64 with LRP and 154 with RT) were enrolled in this study. The outcomes of RT and LRP were assessed after patients were stratified according to Gleason score, stage, and risk group. Crude survival, prostate cancer-specific survival, and metastasis-free survival were evaluated using the log-rank test. Results: The 5-year crude survival rate was 93.3% in the LRP group and 59.3% in the RT group. A significant survival benefit was found in the LRP group compared with the RT group ( Conclusions: Men with localized prostate cancer treated initially with LRP had a lower risk of prostate cancer-specific death and metastases compared with those treated with RT.
Language	English
Publishing date	2022-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2022.966025
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Article: A 15-Year-Old with Aphasia and Right Hemiparesis.

Wadowski, Benjamin / Chadha, Tanya / Wen, Andy Y

Journal of pediatric intensive care

2017 Volume 6, Issue 3, Page(s) 221–224

Abstract: Takayasu arteritis (TA) is the third most common vasculitis in childhood, peaking in the second to third decades of life but affecting patients as young as 6 months of age. It often presents with nonspecific systemic symptoms, although at late stages, it ...

Abstract	Takayasu arteritis (TA) is the third most common vasculitis in childhood, peaking in the second to third decades of life but affecting patients as young as 6 months of age. It often presents with nonspecific systemic symptoms, although at late stages, it may present with cardiac, renal, or focal neurologic sequelae of vascular compromise. In this case, we describe a 15-year-old patient who presented acutely with stroke. In the absence of more classic rheumatological symptoms and significant laboratory abnormalities on initial testing, the diagnosis of TA was only reached through extensive vascular imaging following consultation with multiple subspecialty teams. This case demonstrates the need to maintain a high index of suspicion for vasculitis in pediatric patients presenting with new onset stroke in the absence of known predisposing factors. Doing so may reduce the time to diagnosis, hasten treatment, and optimize outcomes.
Language	English
Publishing date	2017-02-17
Publishing country	Germany
Document type	Case Reports
ISSN	2146-4618
ISSN	2146-4618
DOI	10.1055/s-0037-1598205
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Article ; Online: Injuries associated with electric-powered bikes and scooters: analysis of US consumer product data.

DiMaggio, Charles J / Bukur, Marko / Wall, Stephen P / Frangos, Spiros G / Wen, Andy Y

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention

2019 Volume 26, Issue 6, Page(s) 524–528

Abstract: Background: Powered, two-wheeled transportation devices like electric bicycles (E-bikes) and scooters are increasingly popular, but little is known about their relative injury risk compared to pedal operated bicycles.: Methods: Descriptive and ... ...

Abstract	Background: Powered, two-wheeled transportation devices like electric bicycles (E-bikes) and scooters are increasingly popular, but little is known about their relative injury risk compared to pedal operated bicycles. Methods: Descriptive and comparative analysis of injury patterns and trends associated with E-bikes, powered scooters and pedal bicycles from 2000 to 2017 using the US National Electronic Injury Surveillance System. Results: While persons injured using E-bikes were more likely to suffer internal injuries (17.1%; 95% CI 5.6 to 28.6) and require hospital admission (OR=2.8, 95% CI 1.3 to 6.1), powered scooter injuries were nearly three times more likely to result in a diagnosis of concussion (3% of scooter injuries vs 0.5% of E-bike injuries). E-bike-related injuries were also more than three times more likely to involve a collision with a pedestrian than either pedal bicycles (OR=3.3, 95% CI 0.5 to 23.6) or powered scooters (OR=3.3, 95% CI 0.3 to 32.9), but there was no evidence that powered scooters were more likely than bicycles to be involved in a collision with a pedestrian (OR=1.0, 95% CI 0.3 to 3.1). While population-based rates of pedal bicycle-related injuries have been decreasing, particularly among children, reported E-bike injuries have been increasing dramatically particularly among older persons. Conclusions: E-bike and powered scooter use and injury patterns differ from more traditional pedal operated bicycles. Efforts to address injury prevention and control are warranted, and further studies examining demographics and hospital resource utilisation are necessary.
MeSH term(s)	Accidents, Traffic ; Aged ; Aged, 80 and over ; Bicycling ; Brain Concussion ; Child ; Hospitalization ; Humans ; Pedestrians
Language	English
Publishing date	2019-11-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1433667-4
ISSN	1475-5785 ; 1353-8047
ISSN (online)	1475-5785
ISSN	1353-8047
DOI	10.1136/injuryprev-2019-043418
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Article ; Online: Anterior Segment Biometry Changes with Cycloplegia in Myopic Adults.

Chang, Shu-Wen / Lo, Andy Y / Su, Po-Fang

Optometry and vision science : official publication of the American Academy of Optometry

2016 Volume 93, Issue 1, Page(s) 12–18

Abstract: Purpose: To determine the effect of cycloplegia on corneal thickness, corneal curvature, anterior chamber depth (ACD), angle-to-angle (ATA) and white-to-white (WTW) distances, and axial length (AL).: Methods: Changes in corneal thickness, corneal ... ...

Abstract	Purpose: To determine the effect of cycloplegia on corneal thickness, corneal curvature, anterior chamber depth (ACD), angle-to-angle (ATA) and white-to-white (WTW) distances, and axial length (AL). Methods: Changes in corneal thickness, corneal curvature, ACD, ATA and WTW distances, and AL with and without cycloplegia were analyzed in 31 eyes of 31 young myopic adults, aged 26.4 ± 3.0 years. Pentacam was used to measure the corneal thickness, corneal volume, and corneal curvatures. Visante optical coherent tomography (OCT) measured corneal thickness, ATA distance, ACD, and pupil size. The AL and WTW distance were measured using IOLMaster. Results: Cycloplegia induced significant flattening of corneal curvatures (p = 0.019, 0.001, and 0.003 for anterior sagittal, posterior tangential, and posterior sagittal curvatures, respectively). The difference in the posterior corneal curvature was greater in corneas with steeper posterior curvatures. Cycloplegia also induced significant deepening of ACD (0.08 ± 0.06, p < 0.001) and widening of both WTW (0.42 ± 0.43, p < 0.001) and ATA (0.08 ± 0.17, p = 0.015) distances. The cycloplegia-related increase in the ATA distance correlated negatively with AL (r = -0.361, p = 0.046), whereas the cycloplegia-related increase in WTW distance correlated weakly with the increase in ACD (r = 0.347, p = 0.056) but not with AL. The AL did not change with cycloplegia. Pentacam measured a slightly thicker cornea than OCT (p = 0.002). Both Pentacam and OCT detected a significant increase in corneal thickness of 4 μm, which could be attributed to reflex tearing, after cycloplegia. Conclusions: Cycloplegia resulted in deeper ACD, greater ATA distance, and flatter corneal curvatures. Surgeons should be aware of these cycloplegia-related alterations for more accurate phakic/functional intraocular lens selection and better refraction results.
MeSH term(s)	Adult ; Anterior Eye Segment/drug effects ; Anterior Eye Segment/physiology ; Biometry/methods ; Ciliary Body/drug effects ; Ciliary Body/physiology ; Cornea/physiopathology ; Corneal Topography ; Female ; Humans ; Male ; Muscle, Smooth/physiology ; Mydriatics/administration & dosage ; Myopia/physiopathology ; Pupil/drug effects ; Pupil/physiology ; Tomography, Optical Coherence ; Tropicamide/administration & dosage ; Young Adult
Chemical Substances	Mydriatics ; Tropicamide (N0A3Z5XTC6)
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1001706-9
ISSN	1538-9235 ; 1040-5488
ISSN (online)	1538-9235
ISSN	1040-5488
DOI	10.1097/OPX.0000000000000748
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Article: A 15-Year-Old with Aphasia and Right Hemiparesis

Wadowski, Benjamin / Chadha, Tanya / Wen, Andy Y.

Journal of Pediatric Intensive Care

2017 Volume 06, Issue 03, Page(s) 221–224

Abstract	Takayasu arteritis (TA) is the third most common vasculitis in childhood, peaking in the second to third decades of life but affecting patients as young as 6 months of age. It often presents with nonspecific systemic symptoms, although at late stages, it may present with cardiac, renal, or focal neurologic sequelae of vascular compromise. In this case, we describe a 15-year-old patient who presented acutely with stroke. In the absence of more classic rheumatological symptoms and significant laboratory abnormalities on initial testing, the diagnosis of TA was only reached through extensive vascular imaging following consultation with multiple subspecialty teams. This case demonstrates the need to maintain a high index of suspicion for vasculitis in pediatric patients presenting with new onset stroke in the absence of known predisposing factors. Doing so may reduce the time to diagnosis, hasten treatment, and optimize outcomes.
Keywords	aphasia ; arteritis ; stroke ; Takayasu ; vasculitis
Language	English
Publishing date	2017-02-17
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2146-4626 ; 2146-4618
ISSN (online)	2146-4626
ISSN	2146-4618
DOI	10.1055/s-0037-1598205
Database	Thieme publisher's database

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Article: Porosity estimation of Phyllostachys edulis (Moso bamboo) by computed tomography and backscattered electron imaging

Huang, Puxi / Wen-Shao Chang / Martin P. Ansell / Chew Y. M. John / Andy Shea

Wood science and technology. 2017 Jan., v. 51, no. 1

2017

Abstract: This study aims to investigate and quantify the porosity in the cross section of Phyllostachys edulis (Moso bamboo) culm wall. The porosity results are expected to be utilised in numerical study of heat and moisture transfer. Computed tomography (CT) and ...

Abstract	This study aims to investigate and quantify the porosity in the cross section of Phyllostachys edulis (Moso bamboo) culm wall. The porosity results are expected to be utilised in numerical study of heat and moisture transfer. Computed tomography (CT) and backscattered electron (BSE) imaging methods are utilised in this study because these two methods allow measurements of the anisotropic features of bamboo specimens. The results of these two methods can be represented as the function of the real dimension rather than the pore size distribution of the specimen. The specimens are obtained from eight different locations along the Moso bamboo culms. Both internodes and nodes specimens are measured in this study. The average porosity, standard deviation (SD) and coefficient of variation (COV) are calculated for BSE and CT results. Pearson product-moment correlation coefficient (PPMCC) is also calculated in this study to analyse the correlation between the BSE results and CT results. Typical porosity results from 400 sampling points and 10 portions average porosity are analysed in this study. The CT scanning results show similar trend with BSE results. The correlation relationship between BSE and CT results approaches moderate correlation level to strong correlation level. The average porosity of internode specimens is from 43.9 to 58.8Â % by BSE measurement and from 44.9 to 63.4Â % by CT measurement. The average porosity of node specimens is from 37.4 to 56.6Â % by BSE measurement and from 32.1 to 62.2Â % by CT measurement.
Keywords	Phyllostachys edulis ; bamboos ; computed tomography ; correlation ; culms ; heat ; image analysis ; internodes ; porosity
Language	English
Dates of publication	2017-01
Size	p. 11-27.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	241313-9
ISSN	0043-7719
ISSN	0043-7719
DOI	10.1007/s00226-016-0865-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Predictors of extubation outcomes among extremely and very preterm infants: a retrospective cohort study.

He, Fang / Wu, Dehua / Sun, Yi / Lin, Yan / Wen, Xiulan / Cheng, Andy S K

Jornal de pediatria

2022 Volume 98, Issue 6, Page(s) 648–654

Abstract: Objective: To explore the clinical or sociodemographic predictors for both successful and failed extubation among Chinese extremely and very preterm infants METHODS: A retrospective cohort study was carried out among extremely and very preterm infants ... ...

Abstract	Objective: To explore the clinical or sociodemographic predictors for both successful and failed extubation among Chinese extremely and very preterm infants METHODS: A retrospective cohort study was carried out among extremely and very preterm infants born at less than 32 weeks of gestational age (GA). Results: Compared with the infants who experienced extubation failure, the successful infants had higher birth weight (OR 0.997; CI 0.996-0.998), higher GA (OR 0.582; 95% CI 0.499-0.678), a caesarean section delivery (OR 0.598; 95% CI 0.380-0.939), a higher five-minute Apgar score (OR 0.501; 95% CI 0.257-0.977), and a higher pH prior to extubation (OR 0.008; 95% CI 0.001-0.058). Failed extubation was associated with older mothers (OR 1.055; 95% CI 1.013-1.099), infants intubated in the delivery room (OR 2.820; 95% CI 1.742-4.563), a higher fraction of inspired oxygen (FiO Conclusions: Higher GA, higher pre-extubation pH, lower pre-extubation FiO
MeSH term(s)	Pregnancy ; Infant ; Infant, Newborn ; Humans ; Female ; Airway Extubation ; Retrospective Studies ; Cesarean Section ; Infant, Premature ; Infant, Very Low Birth Weight ; Infant, Premature, Diseases ; Fetal Growth Retardation ; Infant, Extremely Premature
Language	English
Publishing date	2022-05-28
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	731324-x
ISSN	1678-4782 ; 0021-7557
ISSN (online)	1678-4782
ISSN	0021-7557
DOI	10.1016/j.jped.2022.04.001
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Article: Thermal diffusivity measurement of Phyllostachys edulis (Moso bamboo) by the flash method

Huang, Puxi / Simon G. Pickering / Wen-shao Chang / Martin P. Ansell / John Y.M. Chew / Andy Shea

Holzforschung. 2017 Apr. 1, v. 71, no. 4

2017

Abstract: Thermal diffusivity (ThD) of Phyllostachys edulis (Moso bamboo) has been determined in three directions of the cylindrical coordinate system of the culm. A flash tube and an infrared camera system was utilised for this purpose. The results, calculated by ...

Abstract	Thermal diffusivity (ThD) of Phyllostachys edulis (Moso bamboo) has been determined in three directions of the cylindrical coordinate system of the culm. A flash tube and an infrared camera system was utilised for this purpose. The results, calculated by the MATLAB programme, serve as a database for numerical simulation studies concerning the heat and moisture transfer behaviour of Moso bamboo. The porosity and complexity of cellular structure and interconnectivity are the essential parametres influencing the ThD of Moso bamboo.
Keywords	Phyllostachys edulis ; cameras ; cell structures ; culms ; databases ; heat ; mathematical models ; porosity ; thermal diffusivity
Language	English
Dates of publication	2017-0401
Size	p. 349-354.
Publishing place	De Gruyter
Document type	Article
ZDB-ID	1466072-6
ISSN	1437-434X ; 0018-3830
ISSN (online)	1437-434X
ISSN	0018-3830
DOI	10.1515/hf-2016-0135
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The role of the transcription factor CREB in immune function.

Wen, Andy Y / Sakamoto, Kathleen M / Miller, Lloyd S

Journal of immunology (Baltimore, Md. : 1950)

2010 Volume 185, Issue 11, Page(s) 6413–6419

Abstract: CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes ...

Abstract	CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element. Several immune-related genes possess this cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-α. In addition, phosphorylated CREB has been proposed to directly inhibit NF-κB activation by blocking the binding of CREB binding protein to the NF-κB complex, thereby limiting proinflammatory responses. CREB also induces an antiapoptotic survival signal in monocytes and macrophages. In T and B cells, CREB activation promotes proliferation and survival and differentially regulates Th1, Th2, and Th17 responses. Finally, CREB activation is required for the generation and maintenance of regulatory T cells. This review summarizes current advances involving CREB in immune function--a role that is continually being defined.
MeSH term(s)	Animals ; Cell Differentiation/immunology ; Cell Proliferation ; Cell Survival/immunology ; Cyclic AMP Response Element-Binding Protein/physiology ; Humans ; Immunity, Cellular
Chemical Substances	CREB1 protein, human ; Creb1 protein, mouse ; Cyclic AMP Response Element-Binding Protein
Language	English
Publishing date	2010-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1001829
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Model Generalizability Investigation for GFCE-MRI Synthesis in NPC Radiotherapy Using Multi-Institutional Patient-Based Data Normalization.

Li, Wen / Lam, Saikit / Wang, Yinghui / Liu, Chenyang / Li, Tian / Kleesiek, Jens / Cheung, Andy Lai-Yin / Sun, Ying / Lee, Francis Kar-Ho / Au, Kwok-Hung / Lee, Victor Ho-Fun / Cai, Jing

IEEE journal of biomedical and health informatics

2024 Volume 28, Issue 1, Page(s) 100–109

Abstract: Recently, deep learning has been demonstrated to be feasible in eliminating the use of gadoliniumbased contrast agents (GBCAs) through synthesizing gadolinium-free contrast-enhanced MRI (GFCE-MRI) from contrast-free MRI sequences, providing the community ...

Abstract	Recently, deep learning has been demonstrated to be feasible in eliminating the use of gadoliniumbased contrast agents (GBCAs) through synthesizing gadolinium-free contrast-enhanced MRI (GFCE-MRI) from contrast-free MRI sequences, providing the community with an alternative to get rid of GBCAs-associated safety issues in patients. Nevertheless, generalizability assessment of the GFCE-MRI model has been largely challenged by the high inter-institutional heterogeneity of MRI data, on top of the scarcity of multi-institutional data itself. Although various data normalization methods have been adopted to address the heterogeneity issue, it has been limited to single-institutional investigation and there is no standard normalization approach presently. In this study, we aimed at investigating generalizability of GFCE-MRI model using data from seven institutions by manipulating heterogeneity of MRI data under five popular normalization approaches. Three state-of-the-art neural networks were applied to map from T1-weighted and T2-weighted MRI to contrast-enhanced MRI (CE-MRI) for GFCE-MRI synthesis in patients with nasopharyngeal carcinoma. MRI data from three institutions were used separately to generate three uni-institution models and jointly for a tri-institution model. The five normalization methods were applied to normalize the data of each model. MRI data from the remaining four institutions served as external cohorts for model generalizability assessment. Quality of GFCE-MRI was quantitatively evaluated against ground-truth CE-MRI using mean absolute error (MAE) and peak signal-to-noise ratio(PSNR). Results showed that performance of all uni-institution models remarkably dropped on the external cohorts. By contrast, model trained using multi-institutional data with Z-Score normalization yielded the best model generalizability improvement.
MeSH term(s)	Humans ; Gadolinium ; Magnetic Resonance Imaging/methods ; Neural Networks, Computer ; Signal-To-Noise Ratio
Chemical Substances	Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2024-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2695320-1
ISSN	2168-2208 ; 2168-2194
ISSN (online)	2168-2208
ISSN	2168-2194
DOI	10.1109/JBHI.2023.3308529
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