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  1. Article ; Online: Promising therapeutic targets for the treatment of urine storage dysfunction: what's the status?

    Andersson, Karl-Erik

    Expert opinion on therapeutic targets

    2024  , Page(s) 1–8

    Abstract: Introduction: Opinions differ on what drugs have both a rationale and a development potential for the treatment of bladder storage dysfunction.: Areas covered: In the present review, the focus is given to small molecule blockers of TRP channels ( ... ...

    Abstract Introduction: Opinions differ on what drugs have both a rationale and a development potential for the treatment of bladder storage dysfunction.
    Areas covered: In the present review, the focus is given to small molecule blockers of TRP channels (TRPV1, TRPV4, TRPA1, and TRPM8), P2 × 3receptor antagonists, drugs against oxidative stress, antifibrosis agents, cyclic nucleotide - dependent pathways, and MaxiK±channel - gene therapy.
    Expert opinion: TRPV1 channel blockers produce hypothermia which seems to be a problem even with the most efficacious second-generation TRPV1 antagonists. This has so far precluded their application to urine storage disorders. Other TRP channel blockers with promising rationale have yet to be tested on the human lower urinary tract. The P2 × 3receptor antagonist, eliapixant, was tested in a randomized controlled clinical trial, was well tolerated but did not meet clinical efficacy endpoints. Antifibrosis agent still await application to the human lower urinary tract. New drug principles for oxidative stress, purine nucleoside phosphorylase inhibition, and NOX inhibition are still at an experimental stage, and so are soluble guanylate cyclase stimulators. Gene therapy with MaxiK±channels is still an interesting approach but no new trials seem to be in pipeline.
    Language English
    Publishing date 2024-04-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2024.2344698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Urinary tract

    Andersson, Karl-Erik

    (Handbook of Experimental Pharmacology ; 202)

    2011  

    Author's details Karl-Erik Andersson ... eds
    Series title Handbook of Experimental Pharmacology ; 202
    Handbook of experimental pharmacology
    Collection Handbook of experimental pharmacology
    Keywords Harnwegskrankheit
    Subject Harnwege
    Language English
    Size XII, 577 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT016755944
    ISBN 978-3-642-16498-9 ; 9783642164996 ; 3-642-16498-6 ; 3642164994
    Database Catalogue ZB MED Medicine, Health

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    2011 A 1197 order for loan Magazin
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  3. Article ; Online: Emerging drugs for the treatment of bladder storage dysfunction.

    Andersson, Karl-Erik

    Expert opinion on emerging drugs

    2022  Volume 27, Issue 3, Page(s) 277–287

    Abstract: Introduction: Current drug treatment of lower urinary tract disorders, for example, overactive bladder syndrome and lower urinary tract symptoms associated with benign prostatic hyperplasia, is moderately effective, has a low treatment persistence and ... ...

    Abstract Introduction: Current drug treatment of lower urinary tract disorders, for example, overactive bladder syndrome and lower urinary tract symptoms associated with benign prostatic hyperplasia, is moderately effective, has a low treatment persistence and some short- and long-term adverse events. Even if combination therapy with approved drugs may offer advantages in some patients, there is still a need for new agents.
    Areas covered: New b
    Expert opinion: New potential alternatives to currently used drugs/drug principles are emerging, but further clinical testing is required before they can be evaluated as therapeutic alternatives. It seems that for the near future individualized treatment with approved drugs and their combinations will be the prevailing therapeutic approach.
    MeSH term(s) Male ; Humans ; Urinary Bladder, Overactive/drug therapy ; Urinary Bladder ; Lower Urinary Tract Symptoms/drug therapy ; Muscarinic Antagonists/pharmacology ; Prostatic Hyperplasia/drug therapy
    Chemical Substances Muscarinic Antagonists
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2061369-6
    ISSN 1744-7623 ; 1472-8214
    ISSN (online) 1744-7623
    ISSN 1472-8214
    DOI 10.1080/14728214.2022.2113057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Conference proceedings: Managing LUTS: new treatment options

    Andersson, Karl-Erik

    papers presented at the Frontiers in Urology Meeting ; May 10 - 11, 2006, Fukushima, Japan

    (Neurology and urodynamics ; 26,6, Suppl.)

    2007  

    Event/congress Frontiers in Urology Meeting (2006, Fukushima)
    Author's details co-ed.: Karl-Erik Andersson
    Series title Neurology and urodynamics ; 26,6, Suppl.
    Neurourology and urodynamics
    Collection Neurourology and urodynamics
    Language English
    Size S. 897 - 954 : Ill., graph. Darst.
    Publisher Wiley
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT015351487
    Database Catalogue ZB MED Medicine, Health

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  5. Book: Regenerative pharmacology

    Christ, George J. / Andersson, Karl-Erik

    2013  

    Abstract: Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues, and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental, and molecular biology; chemical and ... ...

    Author's details ed. by George J. Christ ; Karl-Erik Andersson
    Abstract "Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues, and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental, and molecular biology; chemical and material sciences (i.e., nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. The goal of this book is to draw attention to the critical role that the pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. This is the first state-of-the-art book in this rapidly evolving field of research"--Provided by publisher
    Keywords Regenerative Medicine / methods ; Tissue Engineering ; Drug Therapy ; Pharmacology, Clinical / methods
    Language English
    Size XXI, 338, [12] S. : Ill., graph. Darst.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index ; Machine generated contents note: Part I. Basic Principles of Regenerative Pharmacology: 1. Introduction to regenerative pharmacology George J. Christ and Karl-Erik Andersson; 2. Regenerative pharmacology of the bladder David Burmeister, Karl-Erik Andersson and George J. Christ; 3. Mechanical control of adult mesenchymal stem cells in cardiac applications Peter Galie and Jan P. Stegmann; 4. Kidney and bladder regeneration: pharmacological methods Timothy A. Bertram, Belinda J. Wagner and Bert Spilker; Part II. Enabling Technologies for Regenerative Pharmacology: 5. Stem and progenitor cells in regenerative pharmacology Mark E. Furth, Martin K. Childers and Lola M. Reid; 6. Micro- and nano-scale delivery of therapeutic agents for regenerative therapy Justin M. Saul and Benjamin S. Harrison; 7. Bioreactor technologies for tissue engineering a replacement heart valve Stefanie Biechler, Michael J. Yost, Richard L. Goodwin and Jay D. Potts; 8. Incorporation of active factors (pharmacological substances) in biomaterials for tissue engineering Roche de Guzman and Mark Van Dyke; 9. Enabling drug discovery technologies for regenerative pharmacology G. Sitta Sittampalam; 10. Animal models of regenerative medicine J. Koudy Williams, James Yoo and Anthony Atala; Part III. Future Applications of Regenerative Pharmacology: 11. Gap junction mediated therapies to eliminate cardiac arrhythmias Peter R. Brink and Ira S. Cohen; 12. Regenerative cardiac pharmacology: translating stem cell biology into therapeutic solutions Atta Behfar and Andre Terzic; 13. Wound healing and cell therapy for muscle repair J. B. Vella and J. Huard; 14. Regenerative pharmacology of implanted materials and tissue engineered constructs Emily Ongstad, Michael J. Yost, Richard L. Goodwin, Harold I. Friedman, Stephen A. Fann, Gautam S. Chatnekar and Robert G. Gourdie; 15. The past, present, and future of tissue regeneration M. Natalia Vergara and Panagiotis A. Tsonis
    HBZ-ID HT018461771
    ISBN 978-0-521-89949-9 ; 0-521-89949-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 4354 available for loan (reading room) Lesesaal EG

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  6. Article: Incontinence in Patients With Underactive Bladder.

    Andersson, Karl-Erik

    International neurourology journal

    2020  Volume 24, Issue 3, Page(s) 293–294

    Language English
    Publishing date 2020-09-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2584447-7
    ISSN 2093-6931 ; 2093-4777
    ISSN (online) 2093-6931
    ISSN 2093-4777
    DOI 10.5213/inj.2040258.129
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  7. Article ; Online: Re: Systemic Therapy for Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC): Systematic Review of Published Trials in the Last 5 Years.

    Andersson, Karl-Erik

    European urology

    2020  Volume 79, Issue 3, Page(s) 431–432

    MeSH term(s) Cystitis, Interstitial/diagnosis ; Cystitis, Interstitial/drug therapy ; Humans
    Language English
    Publishing date 2020-11-27
    Publishing country Switzerland
    Document type Journal Article ; Systematic Review
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2020.11.037
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  8. Article ; Online: Oxidative stress and lower urinary tract symptoms: cause or consequence?

    Andersson, Karl-Erik

    BJU international

    2019  Volume 123, Issue 5, Page(s) 749–750

    MeSH term(s) Humans ; Lower Urinary Tract Symptoms/etiology ; Lower Urinary Tract Symptoms/physiopathology ; Oxidative Stress/physiology
    Language English
    Publishing date 2019-05-03
    Publishing country England
    Document type Editorial
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.14633
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  9. Article ; Online: Early history of skin preservation and transplantation; the role of Carl August Ljunggren.

    Uvelius, Bengt / Andersson, Karl-Erik

    Journal of medical biography

    2022  Volume 32, Issue 1, Page(s) 82–89

    Abstract: During the late 19th and the early 20th century there was an unprecedented development in medical research. Tissue and cell culture rapidly developed into areas with many contributing scientists. The same is true for tissue transplantation. When these ... ...

    Abstract During the late 19th and the early 20th century there was an unprecedented development in medical research. Tissue and cell culture rapidly developed into areas with many contributing scientists. The same is true for tissue transplantation. When these achievements are described afterwards in a historical context and a mainline development is constructed, there are researchers whose pioneering work is forgotten. The present paper attempts to correct this and to present a correct description of the start of tissue preservation and transplantation. We have traced relevant original publications in international journals between 1870 and 1920. The traditional view is that Alexis Carrel was the first He received a Nobel Prize 1912 for his work on vascular suture and the transplantation of blood vessels and organs. The same year he published an article on human skin storage and transplantation. This was more than a decade later than Carl August Ljunggren (1860-1934) who 1898 published his pioneering but long forgotten work on human skin preservation and transplantation, and with a vision of tissue banks. Our article contains a brief biography of Ljunggren, and further reconstructs the processes that resulted in the lack of awareness today of his achievements.
    MeSH term(s) Humans ; Vascular Surgical Procedures/history ; Nobel Prize
    Language English
    Publishing date 2022-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1159267-9
    ISSN 1758-1087 ; 0967-7720
    ISSN (online) 1758-1087
    ISSN 0967-7720
    DOI 10.1177/09677720221099007
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  10. Article ; Online: Molecular and Morphological Characteristics of the De-Obstructed Rat Urinary Bladder-An Update.

    Uvelius, Bengt / Andersson, Karl-Erik

    International journal of molecular sciences

    2022  Volume 23, Issue 19

    Abstract: Many patients with outlet obstruction secondary to prostatic enlargement have lower urinary tract symptoms (LUTSs) and an increased frequency of micturition. The standard treatment is transurethral resection of the prostate (TURP), which alleviates ... ...

    Abstract Many patients with outlet obstruction secondary to prostatic enlargement have lower urinary tract symptoms (LUTSs) and an increased frequency of micturition. The standard treatment is transurethral resection of the prostate (TURP), which alleviates obstruction and symptoms. However, after TURP, 20-40 percent of patients continue to experience LUTSs. The aim of the present study in rats was to identify the mechanisms that do not normalize after the removal of the obstruction and that could explain the persisting symptoms. We had microarray data from control, obstructed, and de-obstructed female rat bladders, which made it possible to study 14,553 mRNA expressions. We also had a bank of electron micrographs from similar detrusors. Microarrays: There were significant differences between the control and obstructed bladders for 1111 mRNAs. The obstructed and de-obstructed bladders differed significantly for 1059 mRNAs. The controls and the de-obstructed bladders differed significantly for 798 mRNAs. We observed many mRNAs that were increased in the obstructed bladder and then decreased to control levels after de-obstruction, and many mRNAs that were decreased in the obstructed bladder and then increased following de-obstruction. mRNAs that were significantly higher or lower in the de-obstructed bladder than in the control bladder were also found. Ultrastructure: The detrusor cells in the obstructed bladders had cross-sectional areas that were much larger than those in the controls. The control cells had smooth outlines and similar cross-sectional areas. The de-obstructed detrusor cells had larger cross-sectional areas than the controls, as well as corrugated surfaces. The cell areas varied, suggesting that the shrinkage of the de-obstructed cells was not even. We did not find any points of contact of the gap junction plaque type between the detrusor cells. There were abundant finger-like processes between the detrusor cells in the obstructed and in de-obstructed bladders, which were only occasionally found in the control detrusors. They are the only possible localization for gap junction channels. The de-obstructed rat bladder is not an organ with properties intermediate between those of the control and obstructed bladders. Instead, de-obstructed bladders have gene expressions, morphologies, and functional properties of the individual cells and their organization, which make them distinctly different from both control and obstructed bladders.
    MeSH term(s) Animals ; Female ; Male ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats ; Transurethral Resection of Prostate ; Urinary Bladder/metabolism ; Urinary Bladder Neck Obstruction/genetics ; Urinary Bladder Neck Obstruction/metabolism ; Urination
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2022-09-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231911330
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