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  1. Article ; Online: Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation.

    Yamaguchi, Takuya / Uchida, Kunitoshi / Yamazaki, Jun

    The Journal of veterinary medical science

    2023  Volume 85, Issue 12, Page(s) 1301–1309

    Abstract: Transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel that is activated by a variety of stimuli and acts as a nociceptor. Mouse and human TRPA1 exhibit different reactivity to some stimuli, including chemicals such as menthol as ...

    Abstract Transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel that is activated by a variety of stimuli and acts as a nociceptor. Mouse and human TRPA1 exhibit different reactivity to some stimuli, including chemicals such as menthol as well as cold stimuli. The cold sensitivity of TRPA1 in mammalian species is controversial. Here, we analyzed the reactivity of heterologously expressed canine TRPA1 as well as the mouse and human orthologs to menthol or cold stimulation in Ca
    MeSH term(s) Animals ; Dogs ; Humans ; Mice ; Cold Temperature ; Mammals ; Menthol/pharmacology ; Transient Receptor Potential Channels ; TRPA1 Cation Channel/metabolism ; TRPM Cation Channels
    Chemical Substances Menthol (1490-04-6) ; Transient Receptor Potential Channels ; TRPA1 Cation Channel ; TRPA1 protein, human ; TRPM Cation Channels
    Language English
    Publishing date 2023-10-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1071753-5
    ISSN 1347-7439 ; 0916-7250
    ISSN (online) 1347-7439
    ISSN 0916-7250
    DOI 10.1292/jvms.23-0327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes.

    Kenmochi, Manato / Kawarasaki, Satoko / Takizawa, Satsuki / Okamura, Kazuhiko / Goto, Tsuyoshi / Uchida, Kunitoshi

    The journal of physiological sciences : JPS

    2022  Volume 72, Issue 1, Page(s) 13

    Abstract: Brown adipocytes expend energy via heat production and are a potential target for the prevention of obesity and related metabolic disorders. Piezo1 is a ... ...

    Abstract Brown adipocytes expend energy via heat production and are a potential target for the prevention of obesity and related metabolic disorders. Piezo1 is a Ca
    MeSH term(s) Adipocytes, Brown/metabolism ; Adipose Tissue, Brown/metabolism ; Animals ; Cell Differentiation ; Ion Channels/metabolism ; Mice ; Thermogenesis
    Chemical Substances Ion Channels ; Piezo1 protein, mouse
    Language English
    Publishing date 2022-06-20
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2234472-X
    ISSN 1880-6562 ; 1880-6546
    ISSN (online) 1880-6562
    ISSN 1880-6546
    DOI 10.1186/s12576-022-00837-1
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  3. Article ; Online: Publisher Correction: Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity.

    Zhou, Yiming / Suzuki, Yoshiro / Uchida, Kunitoshi / Tominaga, Makoto

    Nature communications

    2018  Volume 9, Page(s) 16205

    Abstract: This corrects the article DOI: 10.1038/ncomms3399. ...

    Abstract This corrects the article DOI: 10.1038/ncomms3399.
    Language English
    Publishing date 2018-03-29
    Publishing country England
    Document type Journal Article ; Published Erratum
    ISSN 2041-1723
    ISSN (online) 2041-1723
    DOI 10.1038/ncomms16205
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  4. Article ; Online: Allyl Isothiocyanate Maintains DHA-Containing Glycerophospholipids and Ameliorates the Cognitive Function Decline in OVX Mice

    Akika Nagata / Shiori Oishi / Nanako Kirishita / Keita Onoda / Takuma Kobayashi / Yuko Terada / Akira Minami / Nanami Senoo / Yasukiyo Yoshioka / Kunitoshi Uchida / Keisuke Ito / Shinji Miura / Noriyuki Miyoshi

    ACS Omega, Vol 8, Iss 45, Pp 43118-

    2023  Volume 43129

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Identification and classification of a new TRPM3 variant (γ subtype).

    Uchida, Kunitoshi / Fukuta, Naomi / Yamazaki, Jun / Tominaga, Makoto

    The journal of physiological sciences : JPS

    2019  Volume 69, Issue 4, Page(s) 623–634

    Abstract: TRPM3 is a non-selective cation channel that is activated by neural steroids such as pregnenolone sulfate, nifedipine, and clotrimazole. Despite the number of TRPM3 variants, few reports have described functional analyses of these different TRPM3 types. ... ...

    Abstract TRPM3 is a non-selective cation channel that is activated by neural steroids such as pregnenolone sulfate, nifedipine, and clotrimazole. Despite the number of TRPM3 variants, few reports have described functional analyses of these different TRPM3 types. Here we identified a new TRPM variant from mouse dorsal root ganglion, termed TRPM3γ3. We classified TRPM3γ3 and another known variant (variant 6) into the γ subtype, and analyzed the TRPM3γ variants. mRNA expression of TRPM3γ was higher than that of TRPM3α variants in the mouse dorsal root ganglion. In Ca
    MeSH term(s) Animals ; Calcium/metabolism ; Cell Line ; Ganglia, Spinal/metabolism ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Oocytes/metabolism ; RNA, Messenger/metabolism ; TRPM Cation Channels/metabolism ; Xenopus/metabolism
    Chemical Substances RNA, Messenger ; TRPM Cation Channels ; TRPM3 protein, mouse ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2019-04-22
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2234472-X
    ISSN 1880-6562 ; 1880-6546
    ISSN (online) 1880-6562
    ISSN 1880-6546
    DOI 10.1007/s12576-019-00677-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction to: Hypotonicity-induced cell swelling activates TRPA1.

    Fujita, Fumitaka / Uchida, Kunitoshi / Takayama, Yasunori / Suzuki, Yoshiro / Takaishi, Masayuki / Tominaga, Makoto

    The journal of physiological sciences : JPS

    2019  Volume 69, Issue 3, Page(s) 553

    Abstract: ... Kunitoshi Uchida, Yasunori Takayama, Yoshiro Suzuki, Masayuki Takaishi and Makoto Tominaga, was originally ...

    Abstract The article Hypotonicity-induced cell swelling activates TRPA1, written by Fumitaka Fujita, Kunitoshi Uchida, Yasunori Takayama, Yoshiro Suzuki, Masayuki Takaishi and Makoto Tominaga, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 16 June 2017 without open access.
    Language English
    Publishing date 2019-02-08
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 2234472-X
    ISSN 1880-6562 ; 1880-6546
    ISSN (online) 1880-6562
    ISSN 1880-6546
    DOI 10.1007/s12576-019-00662-z
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  7. Article: Involvement of pore helix in voltage-dependent inactivation of TRPM5 channel.

    Uchida, Kunitoshi / Kita, Tomo / Hatta, Mitsutoki / Itoh, Satoru G / Okumura, Hisashi / Tominaga, Makoto / Yamazaki, Jun

    Heliyon

    2021  Volume 7, Issue 1, Page(s) e06102

    Abstract: The transient receptor potential melastatin 5 (TRPM5) channel is a monovalent-permeable cation channel that is activated by intracellular ... ...

    Abstract The transient receptor potential melastatin 5 (TRPM5) channel is a monovalent-permeable cation channel that is activated by intracellular Ca
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e06102
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  8. Article ; Online: Intragastric administration of AMG517, a TRPV1 antagonist, enhanced activity-dependent energy metabolism

    Hai, Jun / Kawabata, Fuminori / Uchida, Kunitoshi / Nishimura, Shotaro / Tabata, Shoji

    Bioscience, biotechnology, and biochemistry

    2020  Volume 84, Issue 10, Page(s) 2121–2127

    Abstract: Transient receptor potential vanilloid 1 (TRPV1), a nociceptive cation channel, is known to play roles in regulating the energy metabolism (EM) of the whole body. We previously reported that TRPV1 antagonists such as AMG517 enhanced EM in mice, however, ... ...

    Abstract Transient receptor potential vanilloid 1 (TRPV1), a nociceptive cation channel, is known to play roles in regulating the energy metabolism (EM) of the whole body. We previously reported that TRPV1 antagonists such as AMG517 enhanced EM in mice, however, these mechanisms remain unclear. The aim of this study was to explore the mechanisms underlying the enhancement of EM by AMG517, a selective TRPV1 antagonist, in mice. Respiratory gas analysis indicated that intragastric administration of AMG517 enhanced EM along with increasing locomotor activity in mice. Next, to clarify the possible involvement with afferent sensory nerves, including the vagus, we desensitized the capsaicin-sensitive sensory nerves of mice by systemic capsaicin treatment. In the desensitized mice, intragastric administration of AMG517 did not change EM and locomotor activity. Therefore, this study indicated that intragastric administration of AMG517 enhanced EM and increased locomotor activity
    MeSH term(s) Animals ; Benzothiazoles/administration & dosage ; Benzothiazoles/pharmacology ; Capsaicin/pharmacology ; Energy Metabolism/drug effects ; HEK293 Cells ; Humans ; Locomotion/drug effects ; Mice ; Pyrimidines/administration & dosage ; Pyrimidines/pharmacology ; Sensory Receptor Cells/drug effects ; Sensory Receptor Cells/metabolism ; TRPV Cation Channels/antagonists & inhibitors
    Chemical Substances Benzothiazoles ; N-(4-(6-(4-trifluoromethylphenyl)pyrimidin-4-yloxy)benzothiazol-2-yl)acetamide ; Pyrimidines ; TRPV Cation Channels ; TRPV1 receptor ; Capsaicin (S07O44R1ZM)
    Keywords covid19
    Language English
    Publishing date 2020-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1080/09168451.2020.1789836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Role of Thermo-Sensitive Transient Receptor Potential Channels in Brown Adipose Tissue.

    Uchida, Kunitoshi / Sun, Wuping / Yamazaki, Jun / Tominaga, Makoto

    Biological & pharmaceutical bulletin

    2018  Volume 41, Issue 8, Page(s) 1135–1144

    Abstract: Brown and beige adipocytes are a major site of mammalian non-shivering thermogenesis and energy dissipation. Obesity is caused by an imbalance between energy intake and expenditure and has become a worldwide health problem. Therefore modulation of ... ...

    Abstract Brown and beige adipocytes are a major site of mammalian non-shivering thermogenesis and energy dissipation. Obesity is caused by an imbalance between energy intake and expenditure and has become a worldwide health problem. Therefore modulation of thermogenesis in brown and beige adipocytes could be an important application for body weight control and obesity prevention. Over the last few decades, the involvement of thermo-sensitive transient receptor potential (TRP) channels (including TRPV1, TRPV2, TRPV3, TRPV4, TRPM4, TRPM8, TRPC5, and TRPA1) in energy metabolism and adipogenesis in adipocytes has been extensively explored. In this review, we summarize the expression, function, and pathological/physiological contributions of these TRP channels and discuss their potential as future therapeutic targets for preventing and combating human obesity and obesity-related metabolic disorders.
    MeSH term(s) Adipose Tissue, Brown/metabolism ; Adipose Tissue, Brown/physiology ; Animals ; Energy Metabolism ; Humans ; Temperature ; Thermogenesis ; Transient Receptor Potential Channels/metabolism ; Transient Receptor Potential Channels/physiology
    Chemical Substances Transient Receptor Potential Channels
    Language English
    Publishing date 2018-08-02
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1150271-x
    ISSN 1347-5215 ; 0918-6158
    ISSN (online) 1347-5215
    ISSN 0918-6158
    DOI 10.1248/bpb.b18-00063
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  10. Article ; Online: Allyl Isothiocyanate Maintains DHA-Containing Glycerophospholipids and Ameliorates the Cognitive Function Decline in OVX Mice.

    Nagata, Akika / Oishi, Shiori / Kirishita, Nanako / Onoda, Keita / Kobayashi, Takuma / Terada, Yuko / Minami, Akira / Senoo, Nanami / Yoshioka, Yasukiyo / Uchida, Kunitoshi / Ito, Keisuke / Miura, Shinji / Miyoshi, Noriyuki

    ACS omega

    2023  Volume 8, Issue 45, Page(s) 43118–43129

    Abstract: Low-temperature-induced fatty acid desaturation is highly conserved in animals, plants, and bacteria. Allyl isothiocyanate (AITC) is an agonist of the transient receptor potential ankyrin 1 (TRPA1), which is activated by various chemophysiological ... ...

    Abstract Low-temperature-induced fatty acid desaturation is highly conserved in animals, plants, and bacteria. Allyl isothiocyanate (AITC) is an agonist of the transient receptor potential ankyrin 1 (TRPA1), which is activated by various chemophysiological stimuli, including low temperature. However, whether AITC induces fatty acid desaturation remains unknown. We showed here that AITC increased levels of glycerophospholipids (GP) esterified with unsaturated fatty acids, especially docosahexaenoic acid (DHA) in TRPA1-expressing HEK cells. Additionally, GP-DHA including phosphatidylcholine (18:0/22:6) and phosphatidylethanolamine (18:0/22:6) was increased in the brain and liver of AITC-administered mice. Moreover, intragastrical injection of AITC in ovariectomized (OVX) female C57BL/6J mice dose-dependently shortened the Δlatency time determined by the Morris water maze test, indicating AITC ameliorated the cognitive function decline in these mice. Thus, the oral administration of AITC maintains GP-DHA in the liver and brain, proving to be a potential strategy for preventing cognitive decline.
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c06622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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