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Article ; Online: Michael R. Greenberg-Talking to the media requires clear, concise, relatable messages.

Burger, Joanna / Lowrie, Karen / Greenberg, Michael R

Risk analysis : an official publication of the Society for Risk Analysis

2023 Volume 42, Issue 11, Page(s) 2504–2509

MeSH term(s)	Mass Media
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Editorial ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	778660-8
ISSN	1539-6924 ; 0272-4332
ISSN (online)	1539-6924
ISSN	0272-4332
DOI	10.1111/risa.14057
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Article ; Online: Restore and Rebuild (R&R) - a feasibility pilot study of a co-designed intervention for moral injury-related mental health difficulties.

Williamson, Victoria / Murphy, Dominic / Bonson, Amanda / Aldridge, Vicky / Serfioti, Danai / Greenberg, Neil

European journal of psychotraumatology

2023 Volume 14, Issue 2, Page(s) 2256204

Abstract: ... aimed to examine whether the Restore and Rebuild (R&R) treatment was feasible to deliver, acceptable and ... The R&R treatment was delivered to 20 patients who reported distress related to exposure to a morally ... injurious event(s) during military service. R&R is a 20-session psychotherapy with key themes of processing ...

Abstract	Background: Moral injury can significantly negatively impact mental health, but currently no validated treatment for moral injury-related mental health difficulties exists in a UK context. This study aimed to examine whether the Restore and Rebuild (R&R) treatment was feasible to deliver, acceptable and well tolerated by UK military veterans with moral injury related mental health difficulties. Method: The R&R treatment was delivered to 20 patients who reported distress related to exposure to a morally injurious event(s) during military service. R&R is a 20-session psychotherapy with key themes of processing the event, self compassion, connecting with others and core values. Treatment was delivered online, weekly, one-to-one by a single therapist. Qualitative interviews with patients and the therapist who delivered R&R were conducted to explore acceptability and analysed using thematic analysis. Results: Following treatment, patients experienced a significant reduction in symptoms of post-traumatic stress disorder, depression, alcohol misuse and moral injury related distress. R&R was found to be well tolerated by patients and improved their perceived wellbeing. Conclusions: These results provide preliminary evidence that veterans struggling with moral injury related mental ill health can benefit from R&R treatment.
MeSH term(s)	Humans ; Feasibility Studies ; Mental Health ; Pilot Projects ; Stress Disorders, Post-Traumatic/therapy ; Psychotherapy
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2586642-4
ISSN	2000-8066 ; 2000-8066
ISSN (online)	2000-8066
ISSN	2000-8066
DOI	10.1080/20008066.2023.2256204
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Article ; Online: The challenge of connecting the dots in the B.R.A.I.N.

Devor, Anna / Bandettini, Peter A / Boas, David A / Bower, James M / Buxton, Richard B / Cohen, Lawrence B / Dale, Anders M / Einevoll, Gaute T / Fox, Peter T / Franceschini, Maria Angela / Friston, Karl J / Fujimoto, James G / Geyer, Mark A / Greenberg, Joel H / Halgren, Eric / Hämäläinen, Matti S / Helmchen, Fritjof / Hyman, Bradley T / Jasanoff, Alan /

Jernigan, Terry L / Judd, Lewis L / Kim, Seong-Gi / Kleinfeld, David / Kopell, Nancy J / Kutas, Marta / Kwong, Kenneth K / Larkum, Matthew E / Lo, Eng H / Magistretti, Pierre J / Mandeville, Joseph B / Masliah, Eliezer / Mitra, Partha P / Mobley, William C / Moskowitz, Michael A / Nimmerjahn, Axel / Reynolds, John H / Rosen, Bruce R / Salzberg, Brian M / Schaffer, Chris B / Silva, Gabriel A / So, Peter T C / Spitzer, Nicholas C / Tootell, Roger B / Van Essen, David C / Vanduffel, Wim / Vinogradov, Sergei A / Wald, Lawrence L / Wang, Lihong V / Weber, Bruno / Yodh, Arjun G

Neuron

2013 Volume 80, Issue 2, Page(s) 270–274

Abstract: The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative has focused scientific attention on the necessary tools to understand the human brain and mind. Here, we outline our collective vision for what we can achieve within a ... ...

Abstract	The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative has focused scientific attention on the necessary tools to understand the human brain and mind. Here, we outline our collective vision for what we can achieve within a decade with properly targeted efforts and discuss likely technological deliverables and neuroscience progress.
MeSH term(s)	Animals ; Biomedical Research/methods ; Biomedical Research/trends ; Brain Mapping/methods ; Brain Mapping/trends ; Humans ; Neurosciences/methods ; Neurosciences/trends
Language	English
Publishing date	2013-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2013.09.008
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Zs.A 2496: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Antisense miR-132 blockade via the AChE-R splice variant mitigates cortical inflammation.

Mishra, Nibha / Friedson, Lyndon / Hanin, Geula / Bekenstein, Uriya / Volovich, Meshi / Bennett, Estelle R / Greenberg, David S / Soreq, Hermona

Scientific reports

2017 Volume 7, Page(s) 42755

Abstract: ... AChE-R over synaptic-bound AChE-S, potentiating miR-132-mediated brain and body cholinergic suppression ... targets, suppressed AChE-S more than AChE-R and elevated inflammatory hallmarks. Furthermore, blockade ... of peripheral miR-132 by chemically protected AM132 antisense oligonucleotide elevated muscle AChE-R 10-fold ...

Abstract	MicroRNA (miR)-132 brain-to-body messages suppress inflammation by targeting acetylcholinesterase (AChE), but the target specificity of 3'-AChE splice variants and the signaling pathways involved remain unknown. Using surface plasmon resonance (SPR), we identified preferential miR-132 targeting of soluble AChE-R over synaptic-bound AChE-S, potentiating miR-132-mediated brain and body cholinergic suppression of pro-inflammatory cytokines. Inversely, bacterial lipopolysaccharide (LPS) reduced multiple miR-132 targets, suppressed AChE-S more than AChE-R and elevated inflammatory hallmarks. Furthermore, blockade of peripheral miR-132 by chemically protected AM132 antisense oligonucleotide elevated muscle AChE-R 10-fold over AChE-S, and cortical miRNA-sequencing demonstrated inverse brain changes by AM132 and LPS in immune-related miRs and neurotransmission and cholinergic signaling pathways. In neuromuscular junctions, AM132 co-elevated the nicotinic acetylcholine receptor and AChE, re-balancing neurotransmission and reaching mild muscle incoordination. Our findings demonstrate preferential miR-132-induced modulation of AChE-R which ignites bidirectional brain and body anti-inflammatory regulation, underscoring splice-variant miR-132 specificity as a new complexity level in inflammatory surveillance.
MeSH term(s)	Acetylcholinesterase/genetics ; Acetylcholinesterase/metabolism ; Animals ; Cerebral Cortex/drug effects ; Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Cytokines/genetics ; Cytokines/metabolism ; Inflammation ; Isoenzymes ; Lipopolysaccharides/toxicity ; Male ; Mice ; Mice, Inbred BALB C ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Receptors, Nicotinic/metabolism
Chemical Substances	Cytokines ; Isoenzymes ; Lipopolysaccharides ; MIRN132 microRNA, mouse ; MicroRNAs ; Receptors, Nicotinic ; Acetylcholinesterase (EC 3.1.1.7)
Language	English
Publishing date	2017-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep42755
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Article ; Online: ReRouting biomedical innovation: observations from a mapping of the alternative research and development (R&D) landscape.

Greenberg, Alexandra / Kiddell-Monroe, Rachel

Globalization and health

2016 Volume 12, Issue 1, Page(s) 54

Abstract: ... of the current biomedical research and development (R&D) system in responding to patient needs globally ... To mitigate this lack of responsiveness, over 100 self-identified "alternative" R&D initiatives, have emerged ... of the alternative biomedical R&D landscape. We developed a two phase approach: (1) an investigation, via the RE ...

Abstract	In recent years, the world has witnessed the tragic outcomes of multiple global health crises. From Ebola to high prices to antibiotic resistance, these events highlight the fundamental constraints of the current biomedical research and development (R&D) system in responding to patient needs globally.To mitigate this lack of responsiveness, over 100 self-identified "alternative" R&D initiatives, have emerged in the past 15 years. To begin to make sense of this panoply of initiatives working to overcome the constraints of the current system, UAEM began an extensive, though not comprehensive, mapping of the alternative biomedical R&D landscape. We developed a two phase approach: (1) an investigation, via the RE:Route Mapping, of both existing and proposed initiatives that claim to offer an alternative approach to R&D, and (2) evaluation of those initiatives to determine which are in fact achieving increased access to and innovation in medicines. Through phase 1, the RE:Route Mapping, we examined 81 initiatives that claim to redress the inequity perpetuated by the current system via one of five commonly recognized mechanisms necessary for truly alternative R&D.Preliminary analysis of phase 1 provides the following conclusions: 1. No initiative presents a completely alternative model of biomedical R&D. 2. The majority of initiatives focus on developing incentives for drug discovery. 3. The majority of initiatives focus on rare diseases or diseases of the poor and marginalized. 4. There is an increasing emphasis on the use of push, pull, pool, collaboration and open mechanisms alongside the concept of delinkage in alternative R&D. 5. There is a trend towards public funding and launching of initiatives by the Global South. Given the RE:Route Mapping's inevitable limitations and the assumptions made in its methodology, it is not intended to be the final word on a constantly evolving and complex field; however, its findings are significant. The Mapping's value lies in its timely and unique insight into the importance of ongoing efforts to develop a new global framework for biomedical R&D. As we progress to phase 2, an evaluation tool for initiatives focused on identifying which approaches have truly achieved increased innovation and access for patients, we aim to demonstrate that there are a handful of initiatives which represent some, but not all, of the building blocks for a new approach to R&D.Through this mapping and our forthcoming evaluation, UAEM aims to initiate an evidence-based conversation around a truly alternative biomedical R&D model that serves people rather than profits.
MeSH term(s)	Biomedical Research/economics ; Biomedical Research/trends ; Cooperative Behavior ; Drug Discovery/ethics ; Drug Discovery/methods ; Drug Industry/economics ; Drug Industry/ethics ; Humans ; Inventions/trends
Language	English
Publishing date	2016-09-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2185774-X
ISSN	1744-8603 ; 1744-8603
ISSN (online)	1744-8603
ISSN	1744-8603
DOI	10.1186/s12992-016-0190-8
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Article ; Online: Quantifying murine placental extracellular vesicles across gestation and in preterm birth data with tidyNano: A computational framework for analyzing and visualizing nanoparticle data in R.

Nguyen, Sean L / Greenberg, Jacob W / Wang, Hao / Collaer, Benjamin W / Wang, Jianrong / Petroff, Margaret G

PloS one

2019 Volume 14, Issue 6, Page(s) e0218270

Abstract: ... a novel software package, tidyNano, an R package that provides functions to import, clean, and quickly ...

Abstract	Extracellular vesicles (EVs) are increasingly recognized as important mediators of intercellular communication that carry protein, lipids, and nucleic acids via the circulation to target cells whereupon they mediate physiological changes. In pregnancy, EVs are released in high quantities from the placenta and have been postulated to target multiple cell types, including those of the vascular and immune systems. However, most studies of pregnancy-associated EVs have used clinical samples and in vitro models; to date, few studies have taken advantage of murine models in which pregnancy can be precisely timed and manipulated. In this study, we used a murine model to determine whether the quantity of EVs is altered during healthy pregnancy and during inflammation-associated preterm birth. To facilitate data analysis, we developed a novel software package, tidyNano, an R package that provides functions to import, clean, and quickly summarize raw data generated by the nanoparticle tracking device, NanoSight (Malvern Panalytical). We also developed shinySIGHT, a Shiny web application that allows for interactive exploration and visualization of EV data. In mice, EV concentration in blood increased linearly across pregnancy, with significant rises at GD14.5 and 17.5 relative to EV concentrations in nonpregnant females. Additionally, lipopolysaccharide treatment resulted in a significant reduction in circulating EV concentrations relative to vehicle-treated controls at GD16.5 within 4 hours. Use of tidyNano facilitated rapid analysis of EV data; importantly, this package provides a straightforward framework by which diverse types of large datasets can be simply and efficiently analyzed, is freely available under the MIT license, and is hosted on GitHub (https://nguyens7.github.io/tidyNano/). Our data highlight the utility of the mouse as a model of EV biology in pregnancy, and suggest that placental dysfunction is associated with reduced circulating EVs.
MeSH term(s)	Animals ; Cell Communication/drug effects ; Cell Communication/genetics ; Data Visualization ; Disease Models, Animal ; Exosomes/metabolism ; Exosomes/pathology ; Extracellular Vesicles/drug effects ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/pathology ; Female ; Humans ; Immune System/drug effects ; Lipopolysaccharides/pharmacology ; Mice ; Nanoparticles/chemistry ; Nanotechnology ; Placenta/metabolism ; Placenta/pathology ; Pregnancy ; Premature Birth/epidemiology ; Premature Birth/pathology ; Trophoblasts/metabolism ; Trophoblasts/pathology
Chemical Substances	Lipopolysaccharides
Language	English
Publishing date	2019-06-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0218270
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reply to M.J. Brenner et al and I.R. Vogelius et al.

Pollack, Alan / Walker, Gail / Horwitz, Eric M / Price, Robert / Feigenberg, Steven / Konski, Andre A / Stoyanova, Radka / Movsas, Benjamin / Greenberg, Richard E / Uzzo, Robert G / Ma, Charlie / Buyyounouski, Mark K

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2014 Volume 32, Issue 17, Page(s) 1853–1854

MeSH term(s)	Humans ; Male ; Prostatic Neoplasms/radiotherapy ; Radiotherapy, Intensity-Modulated/methods
Language	English
Publishing date	2014-06-10
Publishing country	United States
Document type	Comment ; Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2013.54.7729
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Controlled Ovarian Hyperstimulation with Intrauterine Insemination Is More Successful After r-hCG Administration Than Spontaneous LH Surge.

Taerk, Evan / Hughes, Edward / Greenberg, Cassandra / Neal, Michael / Amin, Shilpa / Faghih, Mehrnoosh / Karnis, Megan

Journal of reproduction & infertility

2017 Volume 18, Issue 3, Page(s) 316–322

Abstract: ... by timing intrauterine insemination (IUI) according to serum LH surge, r-hCG trigger, or a combination of LH ... surge and r-hCG trigger in controlled ovarian hyperstimulation (COH) cycles for patients with a variety ... Administration of r-hCG prior to IUI resulted in a higher clinical pregnancy rate compared with spontaneous serum ...

Abstract	Background: The purpose of this study was to evaluate whether clinical pregnancy rate is affected by timing intrauterine insemination (IUI) according to serum LH surge, r-hCG trigger, or a combination of LH surge and r-hCG trigger in controlled ovarian hyperstimulation (COH) cycles for patients with a variety of infertility etiologies. Methods: The last 365 consecutive COH-IUI cycles performed at ONE Fertility Burlington in 2014 were reviewed and categorized according to method of IUI timing. Associations between categorical variables were analyzed using a combination of Chi-square and Fisher's Exact tests, and between continuous variables using independent sample t-tests and logistic regression to a level of significance of p<0.05. Results: The overall clinical pregnancy rate in this sample was 18.1% (66/365). Administration of r-hCG prior to IUI resulted in a higher clinical pregnancy rate compared with spontaneous serum LH surge: 18.2% Conclusion: In subfertile couples undergoing COH-IUI, r-hCG administration was associated with an increased clinical pregnancy rate compared with spontaneous serum LH surge. When r-hCG was administered concomitantly with a serum LH surge, this benefit was amplified. The effect appears to be of particular importance in r-FSH-medicated cycles.
Language	English
Publishing date	2017-10-18
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2548922-7
ISSN	2251-676X ; 1735-8507 ; 2228-5482 ; 1726-7536
ISSN (online)	2251-676X ; 1735-8507
ISSN	2228-5482 ; 1726-7536
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Article: Inappropriate subcutaneous implantable cardioverter-defibrillator therapy due to R-wave amplitude variation: Another challenge in device management.

Batul, Syeda A / Yang, Felix / Wats, Karan / Shrestha, Suvash / Greenberg, Yisachar J

HeartRhythm case reports

2016 Volume 3, Issue 1, Page(s) 78–82

Language	English
Publishing date	2016-09-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834871-0
ISSN	2214-0271
ISSN	2214-0271
DOI	10.1016/j.hrcr.2016.09.010
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Article ; Online: Utility of the R.E.N.A.L. nephrometry scoring system in objectifying treatment decision-making of the enhancing renal mass.

Canter, Daniel / Kutikov, Alexander / Manley, Brandon / Egleston, Brian / Simhan, Jay / Smaldone, Marc / Teper, Ervin / Viterbo, Rosalia / Chen, David Y T / Greenberg, Richard E / Uzzo, Robert G

Urology

2011 Volume 78, Issue 5, Page(s) 1089–1094

Abstract: ... subjective. The R.E.N.A.L. (radius, exophytic/endophytic properties, nearness of tumor to the collecting ... a significantly greater size (R), central proximity (N), and location (L) component scores (P < .001). Furthermore ... < .001) and nonpolar location (P = .016).: Conclusion: The R.E.N.A.L nephrometry score standardizes ...

Abstract	Objective: To evaluate the treatment patterns of solid renal masses according to the quantifiable anatomic features using nephrometry. The treatment of localized renal cell carcinoma remains overly subjective. The R.E.N.A.L. (radius, exophytic/endophytic properties, nearness of tumor to the collecting system or sinus in millimeters, anterior/posterior, location relative to polar lines) nephrometry score quantifies the salient characteristics of renal mass anatomy in an objective and reproducible manner. Methods: Nephrometry scores were available in 615 patients in our prospective kidney tumor database (2000-2010). The nephrometry score sum and its individual component scores were analyzed to determine their relationship to treatment approach. Results: The median age, age-adjusted Charlson co-morbidity index, and estimated glomerular filtration rate was 60 years (range 25-89), 2 (range 0-10), and 80.5 mL/min (range 5.1-120.0), respectively. Increasing tumor complexity, as measured by a greater overall nephrometry score was associated with both radical nephrectomy and open partial nephrectomy (P < .0001). Compared with patients who underwent partial nephrectomy, the patients treated with radical nephrectomy had a significantly greater size (R), central proximity (N), and location (L) component scores (P < .001). Furthermore, tumors treated with radical nephrectomy were more often hilar (P < .001). Similarly, compared with minimally invasive partial nephrectomy (laparoscopic or robotic), open partial nephrectomy was associated with an increasing individual component score for size, endophytic, and central proximity to the collecting system (P < .001) and nonpolar location (P = .016). Conclusion: The R.E.N.A.L nephrometry score standardizes the reporting of solid renal masses and appears to effectively stratify by treatment type. Although only 1 part of the treatment decision-making process, nephrometry aids in objectifying previously subjective measures.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Middle Aged ; Nephrectomy ; Organ Size ; Prospective Studies
Language	English
Publishing date	2011-11-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2011.04.035
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Zs.MO 275: Show issues

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