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  1. Book: Lymphangiogenesis in cancer metastasis

    Stacker, Steven A.

    (Cancer metastasis - biology and treatment ; 13)

    2009  

    Author's details ed. by Steven A. Stacker
    Series title Cancer metastasis - biology and treatment ; 13
    Collection
    Language English
    Size IX, 249 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Dordrecht
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016079171
    ISBN 978-90-481-2246-2 ; 9789048122479 ; 90-481-2246-5 ; 9048122473
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 4557 order for loan Magazin

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  2. Article ; Online: Soothing a Broken Heart: Can Therapeutic Cross-Talk Between Lymphatics and the Immune Response Improve Recovery From Myocardial Infarction?

    Farnsworth, Rae H / Stacker, Steven A

    Arteriosclerosis, thrombosis, and vascular biology

    2020  Volume 40, Issue 7, Page(s) 1611–1613

    MeSH term(s) Heart ; Humans ; Lymphatic Vessels ; Myocardial Infarction
    Language English
    Publishing date 2020-06-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.120.314666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The cellular and molecular mediators of metastasis to the lung.

    Cucanic, Oliver / Farnsworth, Rae H / Stacker, Steven A

    Growth factors (Chur, Switzerland)

    2022  Volume 40, Issue 3-4, Page(s) 119–152

    Abstract: Organ-specific metastasis to secondary organs is dependent on the formation of a supportive pre-metastatic niche. This tissue-specific microenvironmental response is thought to be mediated by mutational and epigenetic changes to primary tumour cells ... ...

    Abstract Organ-specific metastasis to secondary organs is dependent on the formation of a supportive pre-metastatic niche. This tissue-specific microenvironmental response is thought to be mediated by mutational and epigenetic changes to primary tumour cells resulting in altered cross-talk between cell types. This response is augmented through the release of tumour and stromal signalling mediators including cytokines, chemokines, exosomes and growth factors. Although researchers have elucidated some of the cancer-promoting features that are bespoke to organotropic metastasis to the lungs, it remains unclear if these are organ-specific or generic between organs. Understanding the mechanisms that mediate the metastasis-promoting synergy between the host microenvironment, immunity, and pulmonary structures may elucidate predictive, prognostic and therapeutic markers that could be targeted to reduce the metastatic burden of disease. Herein, we give an updated summary of the known cellular and molecular mechanisms that contribute to the formation of the lung pre-metastatic niche and tissue-specific metastasis.
    MeSH term(s) Exosomes/metabolism ; Exosomes/pathology ; Humans ; Lung ; Neoplasm Metastasis/pathology ; Neoplasms/metabolism ; Signal Transduction ; Tumor Microenvironment
    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1035755-5
    ISSN 1029-2292 ; 0897-7194
    ISSN (online) 1029-2292
    ISSN 0897-7194
    DOI 10.1080/08977194.2022.2087520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2612: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Growth factors: the journey continues.

    Stacker, Steven A

    Growth factors (Chur, Switzerland)

    2016  Volume 34, Issue 1-2, Page(s) 1–4

    Language English
    Publishing date 2016-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1035755-5
    ISSN 1029-2292 ; 0897-7194
    ISSN (online) 1029-2292
    ISSN 0897-7194
    DOI 10.1080/08977194.2016.1200842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2612: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Brain Vascular Microenvironments in Cancer Metastasis.

    Tobar, Lucas E / Farnsworth, Rae H / Stacker, Steven A

    Biomolecules

    2022  Volume 12, Issue 3

    Abstract: Primary tumours, particularly from major solid organs, are able to disseminate into the blood and lymphatic system and spread to distant sites. These secondary metastases to other major organs are the most lethal aspect of cancer, accounting for the ... ...

    Abstract Primary tumours, particularly from major solid organs, are able to disseminate into the blood and lymphatic system and spread to distant sites. These secondary metastases to other major organs are the most lethal aspect of cancer, accounting for the majority of cancer deaths. The brain is a frequent site of metastasis, and brain metastases are often fatal due to the critical role of the nervous system and the limited options for treatment, including surgery. This creates a need to further understand the complex cell and molecular biology associated with the establishment of brain metastasis, including the changes to the environment of the brain to enable the arrival and growth of tumour cells. Local changes in the vascular network, immune system and stromal components all have the potential to recruit and foster metastatic tumour cells. This review summarises our current understanding of brain vascular microenvironments, fluid circulation and drainage in the context of brain metastases, as well as commenting on current cutting-edge experimental approaches used to investigate changes in vascular environments and alterations in specialised subsets of blood and lymphatic vessel cells during cancer spread to the brain.
    MeSH term(s) Brain/pathology ; Brain Neoplasms/pathology ; Humans ; Lymphatic System/physiology ; Lymphatic Vessels ; Neoplasm Metastasis/pathology ; Tumor Microenvironment
    Language English
    Publishing date 2022-03-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom12030401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Control of Gene Expression by Exosome-Derived Non-Coding RNAs in Cancer Angiogenesis and Lymphangiogenesis.

    Arcucci, Valeria / Stacker, Steven A / Achen, Marc G

    Biomolecules

    2021  Volume 11, Issue 2

    Abstract: ... ...

    Abstract A
    MeSH term(s) Exosomes/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Lymphangiogenesis/genetics ; Neoplasms/blood supply ; Neoplasms/pathology ; Neovascularization, Pathologic/genetics ; RNA, Untranslated/metabolism
    Chemical Substances RNA, Untranslated
    Language English
    Publishing date 2021-02-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11020249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exit Stage Left: A Tumor Cell's Journey from Lymph Node to Beyond.

    Achen, Marc G / Stacker, Steven A

    Trends in cancer

    2018  Volume 4, Issue 8, Page(s) 519–522

    Abstract: Even though we have known for over 250 years that cancers spread to regional lymph nodes (LNs) and distant organs, the fundamental question of which anatomical routes are taken by tumor cells has remained a mystery. Two recently published papers in ... ...

    Abstract Even though we have known for over 250 years that cancers spread to regional lymph nodes (LNs) and distant organs, the fundamental question of which anatomical routes are taken by tumor cells has remained a mystery. Two recently published papers in Science, by Pereira et al. and Brown et al., directly address this important issue in tumor biology by assessing the capacity of tumor cells in LNs to spread to distant sites.
    MeSH term(s) Animals ; Humans ; Lymph Nodes ; Lymphatic Metastasis ; Mice
    Language English
    Publishing date 2018-06-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2018.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  8. Article ; Online: Emerging Roles for VEGF-D in Human Disease.

    Stacker, Steven A / Achen, Marc G

    Biomolecules

    2018  Volume 8, Issue 1

    Abstract: Blood vessels and lymphatic vessels are located in many tissues and organs throughout the body, and play important roles in a wide variety of prevalent diseases in humans. Vascular endothelial growth factor-D (VEGF-D) is a secreted protein that can ... ...

    Abstract Blood vessels and lymphatic vessels are located in many tissues and organs throughout the body, and play important roles in a wide variety of prevalent diseases in humans. Vascular endothelial growth factor-D (VEGF-D) is a secreted protein that can promote the remodeling of blood vessels and lymphatics in development and disease. Recent fundamental and translational studies have provided insight into the molecular mechanisms by which VEGF-D exerts its effects in human disease. Hence this protein is now of interest as a therapeutic and/or diagnostic target, or as a potential therapeutic agent, in a diversity of indications in cardiovascular medicine, cancer and the devastating pulmonary condition lymphangioleiomyomatosis. This has led to clinical trial programs to assess the effect of targeting VEGF-D signaling pathways, or delivering VEGF-D, in angina, cancer and ocular indications. This review summarizes our understanding of VEGF-D signaling in human disease, which is largely based on animal disease models and clinicopathological studies, and provides information about the outcomes of recent clinical trials testing agonists or antagonists of VEGF-D signaling.
    MeSH term(s) Animals ; Cardiovascular Diseases/metabolism ; Humans ; Lung Diseases/metabolism ; Lymphatic Diseases/metabolism ; Neoplasms/metabolism ; Neovascularization, Physiologic ; Receptors, Vascular Endothelial Growth Factor/genetics ; Receptors, Vascular Endothelial Growth Factor/metabolism ; Signal Transduction ; Vascular Endothelial Growth Factor D/genetics ; Vascular Endothelial Growth Factor D/metabolism
    Chemical Substances Vascular Endothelial Growth Factor D ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
    Language English
    Publishing date 2018-01-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom8010001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling.

    Pillay, Vinochani / Shukla, Lipi / Herle, Prad / Maciburko, Simon / Bandara, Nadeeka / Reid, Isabella / Morgan, Steven / Yuan, Yinan / Luu, Jennii / Cowley, Karla J / Ramm, Susanne / Simpson, Kaylene J / Achen, Marc G / Stacker, Steven A / Shayan, Ramin / Karnezis, Tara

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1152314

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1152314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The biochemistry, signalling and disease relevance of RYK and other WNT-binding receptor tyrosine kinases.

    Roy, James P / Halford, Michael M / Stacker, Steven A

    Growth factors (Chur, Switzerland)

    2018  Volume 36, Issue 1-2, Page(s) 15–40

    Abstract: The receptor tyrosine kinases (RTKs) are a well-characterized family of growth factor receptors that have central roles in human disease and are frequently therapeutically targeted. The RYK, ROR, PTK7 and MuSK subfamilies make up an understudied subset ... ...

    Abstract The receptor tyrosine kinases (RTKs) are a well-characterized family of growth factor receptors that have central roles in human disease and are frequently therapeutically targeted. The RYK, ROR, PTK7 and MuSK subfamilies make up an understudied subset of WNT-binding RTKs. Numerous developmental, stem cell and pathological roles of WNTs, in particular WNT5A, involve signalling via these WNT receptors. The WNT-binding RTKs have highly context-dependent signalling outputs and stimulate the β-catenin-dependent, planar cell polarity and/or WNT/Ca
    MeSH term(s) Animals ; Humans ; Ligands ; Neoplasms/metabolism ; Protein Domains ; Receptor Protein-Tyrosine Kinases/chemistry ; Receptor Protein-Tyrosine Kinases/metabolism ; Wnt Signaling Pathway
    Chemical Substances Ligands ; RYK protein, human (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2018-05-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035755-5
    ISSN 1029-2292 ; 0897-7194
    ISSN (online) 1029-2292
    ISSN 0897-7194
    DOI 10.1080/08977194.2018.1472089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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