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Article ; Online: Effects of Lombok Island's local moringa (

Cahyaningrum, Aladhiana / Rahayu, Masruroh / Rudijanto, Achmad / Handayani, Dian

2023 Volume 13, Issue 5, Page(s) 532–540

Abstract: Background: Consumed fructose enters enterocytes of the intestinal epithelial apical membrane mediated by glucose transporter 5 (GLUT5).: Aim: To determine the effects of Lombok Island's local Moringa leaf powder on reducing liver fructose levels and ...

Abstract	Background: Consumed fructose enters enterocytes of the intestinal epithelial apical membrane mediated by glucose transporter 5 (GLUT5). Aim: To determine the effects of Lombok Island's local Moringa leaf powder on reducing liver fructose levels and GLUT5 expression in the small intestine of albino rats ( Methods: Moringa leaf ( Results: The ANOVA test proved that there are significant differences ( Conclusion: The administration of local moringa (
MeSH term(s)	Male ; Animals ; Rats ; Moringa oleifera ; Moringa ; Powders ; Quercetin ; Liver ; Diet/veterinary ; Fructose/pharmacology ; Plant Leaves
Chemical Substances	Powders ; Quercetin (9IKM0I5T1E) ; Fructose (30237-26-4)
Language	English
Publishing date	2023-05-06
Publishing country	Libya
Document type	Journal Article
ZDB-ID	2651664-0
ISSN	2218-6050 ; 2218-6050
ISSN (online)	2218-6050
ISSN	2218-6050
DOI	10.5455/OVJ.2023.v13.i5.5
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Article ; Online: Effects of Lombok Island's local moringa (Moringa oleifera) leaf powder on the decrease of liver fructose levels and GLUT5 expression in albino rats (Rattus novergicus) fed a high fructose diet

Aladhiana Cahyaningrum / Masruroh Rahayu / Achmad Rudijanto / Dian Handayani

Open Veterinary Journal, Vol 13, Iss 5, Pp 532-

2023 Volume 540

Abstract: Background: Consumed fructose enters enterocytes of the intestinal epithelial apical membrane mediated by glucose transporter 5 (GLUT5). Aim: To determine the effects of Lombok Island's local Moringa leaf powder on reducing liver fructose levels and ... ...

Abstract	Background: Consumed fructose enters enterocytes of the intestinal epithelial apical membrane mediated by glucose transporter 5 (GLUT5). Aim: To determine the effects of Lombok Island's local Moringa leaf powder on reducing liver fructose levels and GLUT5 expression in the small intestine of albino rats (Rattus novergicus) fed a high-fructose diet. Methods: Moringa leaf (Moringa oleifera) was obtained from Lombok Island, Indonesia. Subsequently, 30 male albino rats (Rattus novergicus) were used, divided into the normal group (NG), treatment group 1 (T1G), treatment group 2 (T2G), Quercetin group (QG), Moringa group (MG). Quercetin and moringa leaf powder (Moringa oleifera) was administered at 50 mg/kgbw and 500 mg/kgbw for 28 days. Enzyme-linked immunosorbent assay (Elisa) method used to examine liver fructose levels. The observation of GLUT5 expression in the small intestine was performed by the Immunofluorescence method. Results: The Anova test prove that there are significant differences (p < 0.005) in liver fructose levels in all groups. Further post hoc tests show no significant difference (p>0.005) in liver fructose levels in rats fed a high fructose diet in T1G and T2G with QG and MG rats. However, Moringa leaf powder freduces liver fructose levels by 32.1% and 17.2% in T1G and T2G rats. The Anova test showed a significant difference (p < 0.005) in the expression of GLUT5 in all groups. Further post hoc tests showed a significant difference (p < 0.005) in the expression of GLUT5 in the duodenum, jejunum, and ileum between the normal group and the T1G rats. Meanwhile, in T2G rats, significant differences were only found in the jejunum. Moringa leaf powder reduces GLUT5 expression in T1G rats by 44.5%, 59.5%, and 57.2% in the duodenum, jejunum, and ileum, whereas in T2G rats is by 33.5%, 50.2%, and 48.1%, respectively. Conclusion: The administration of local moringa (Moringa oleifera) leaf powder in Lombok Island had an effect on reducing GLUT5 expression in the small intestine, however, did not ...
Keywords	fructose levels ; glut5 expression ; high fructose diet ; local moringa leaf powder ; quercetin ; Zoology ; QL1-991
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Tripoli University
Document type	Article ; Online
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Article: DLBS3233 enhances nephrin and podocin expression also reduces oxidative stress marker and insulin receptor serine diabetic rats' podocytes.

Mohani, Chandra I / Rudijanto, Achmad / Aulanni'am, Aulanni'am / Soeharto, Setyawati

Annals of medicine and surgery (2012)

2023 Volume 85, Issue 8, Page(s) 3894–3900

Abstract: Numerous oxidative stresses are detected in patients with diabetic kidney disease, resulting in insulin resistance that damages the pancreas and kidney. Renal podocytes insensitive to insulin lead to decreased nephrin and podocin and increased insulin ... ...

Abstract	Numerous oxidative stresses are detected in patients with diabetic kidney disease, resulting in insulin resistance that damages the pancreas and kidney. Renal podocytes insensitive to insulin lead to decreased nephrin and podocin and increased insulin receptor serine. The authors did an experiment on diabetic rats to examine the effect of DLBS3233 on repairing insulin resistance. Materials and methods: Thirty adult male Wistar rats were randomly divided into six groups ( Result: In the DBLS3233 group, immunohistochemistry showed enhanced expression of renal nephrin and podocin, as well as diminished expression of anti-MDA antibody, along with decreased insulin receptor serine. From statistical analysis, anti-MDA antibodies and insulin receptor serine showed lower expression, whereas the expression of nephrin and podocin were enhanced compared to untreated groups ( Conclusion: DLBS3233 reduces oxidative stress by decreasing MDA and improves insulin resistance by increasing the expression of renal nephrin and podocin as well as decreasing insulin receptor serine.
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000000308
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Article ; Online: A high-fat and high-fructose diet lowers the cecal digesta's weight and short-chain fatty acid level of a Sprague-Dawley rat model.

Sulistyowati, Etik / Handayani, Dian / Soeharto, Setyawati / Rudijanto, Achmad

Turkish journal of medical sciences

2022 Volume 52, Issue 1, Page(s) 268–275

Abstract: Background: This study aimed to analyze the effect of a high-fat and high-fructose diet (HFFD) on the digesta weight and shortchain fatty acid (SCFA) levels of cecal digesta in rats.: Methods: This study was an experimental study with a posttest-only ...

Abstract	Background: This study aimed to analyze the effect of a high-fat and high-fructose diet (HFFD) on the digesta weight and shortchain fatty acid (SCFA) levels of cecal digesta in rats. Methods: This study was an experimental study with a posttest-only control group design with male Sprague-Dawley strain rats as the samples. A total of 36 rats were divided into two groups with normal diet (N) and modified HFFD. The data of energy intake, nutrients and fiber, body weight, Lee index, abdominal circumference, digesta weight, and SCFA levels of cecal digesta were collected. Results: The results showed an 11.94% increase in body weights of rats with HFFD. The total energy intake of the HFFD group was significantly higher than that of N (p = 0.000). The fiber intake and cecal digesta weight in group N were higher than that in the HFFD group (p = 0.00 and p = 0.02, respectively). The concentrations of acetate, butyrate, propionate, and total SCFA in the N group were significantly higher than in the HFFD (p = 0.041,,p = 0.004, p = 0.040, p = 0.013, respectively). A significant negative relationship was observed between the abdominal circumference and cecal digesta concentration (p = 0.029; r = -0.529) and between the Lee index and the SCFA concentration of cecal digesta (p = 0.036, r = -0.206).
MeSH term(s)	Acetates ; Animals ; Butyrates ; Diet ; Diet, High-Fat ; Fatty Acids ; Fatty Acids, Volatile ; Fructose ; Male ; Propionates ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Acetates ; Butyrates ; Fatty Acids ; Fatty Acids, Volatile ; Propionates ; Fructose (30237-26-4)
Language	English
Publishing date	2022-02-22
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-1911-14
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Article ; Online: Cognitive status and low sun exposure as frailty major risk factor among older people in a rural area of East Java, Indonesia: A cross-sectional study.

Soenarti, Sri / Mahendra, Aditya Indra / Rudijanto, Achmad / Soeharto, Setyawati / Ratnawati, Retty / Maryunani / Marintan, Silmy

Geriatrics & gerontology international

2023 Volume 24 Suppl 1, Page(s) 170–175

Abstract: Aim: To reveal the prevalence of frailty and factors that strongly affected the frailty condition among older adults in East Java, Indonesia.: Method: We conducted a cross-sectional study carried out among 400 older adults aged ≥60 years without any ... ...

Abstract	Aim: To reveal the prevalence of frailty and factors that strongly affected the frailty condition among older adults in East Java, Indonesia. Method: We conducted a cross-sectional study carried out among 400 older adults aged ≥60 years without any acute illness. Data were collected from rural area in two locations in Malang and Pasuruan, East Java, Indonesia, in 2019-2020. For data collection, we used the sociodemographic profile assessment, Fried frailty phenotype, Geriatric Depression Scale, Mini Mental State assessment, sun exposure, handgrip strength, International Physical Activity Questionnaire, walk score, and body mass index. We used logistic regression statistics for data analysis. Results: The result showed that 2.5% were robust, 83% were prefrail, and 14.5% were frail. A higher proportion of subjects were aged 60-74 years (83.3%), women (70.3%), with lower educational status (84.5%). Multivariate analysis showed that the intrinsic factors low cognitive status (odds ratio [OR], 3.052 [95% confidence interval (CI), 1.691-5.508]) and older age (OR, 3.073 [95% CI, 1.637-5.767]) were associated with frailty among the older adults in a rural area. Depression was also associated with frailty (OR, 2.458 [95% CI, 0.465-12.985]). From extrinsic factors, we also found that low sun exposure (OR, 2.931 [95% CI, 1.650-5.204]) and unemployment (OR, 1.997 [95% CI, 1.112-3.588]) were associated with frailty. Conclusion: For the Indonesian elderly in this study, low cognitive status, older age, depression, low sun exposure, and unemployment were associated with frailty. Understanding the modifiable risk factors of frailty can provide a valuable reference for future prevention and intervention. Geriatr Gerontol Int 2024; 24: 170-175.
MeSH term(s)	Aged ; Humans ; Female ; Frailty/psychology ; Frail Elderly ; Indonesia/epidemiology ; Cross-Sectional Studies ; Hand Strength ; Independent Living/psychology ; Geriatric Assessment ; Risk Factors ; Cognition ; Sunlight
Language	English
Publishing date	2023-11-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2113849-7
ISSN	1447-0594 ; 1444-1586
ISSN (online)	1447-0594
ISSN	1444-1586
DOI	10.1111/ggi.14738
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Article: Effects of mobile phone electromagnetic radiation on thyroid glands and hormones in

Zufry, Hendra / Rudijanto, Achmad / Soeatmadji, Djoko Wahono / Sakti, Setyawan Purnomo / Munadi, Khairul / Sujuti, Hidayat / Mintaroem, Karyono

Journal of advanced pharmaceutical technology & research

2023 Volume 14, Issue 2, Page(s) 63–68

Abstract: The aim of this study was to investigate the effects of mobile phone electromagnetic radiation (MP-EMR) on the thyroid glands and hormones ... ...

Abstract	The aim of this study was to investigate the effects of mobile phone electromagnetic radiation (MP-EMR) on the thyroid glands and hormones in
Language	English
Publishing date	2023-04-13
Publishing country	India
Document type	Journal Article
ISSN	2231-4040
ISSN	2231-4040
DOI	10.4103/japtr.japtr_680_22
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Article ; Online: Areas of Work Life as Burnout Predictors in Dentists of Denpasar, Indonesia

Sylvia Jessy Kurniawan / Kuswantoro Rusca Putra / Achmad Rudijanto / Wayan Agus Wirya Pratama

International Journal of Occupational Safety and Health, Vol 13, Iss

2023 Volume 3

Abstract: Introduction: Burnout is most common among healthcare workers and is characterized by emotional fatigue, depersonalization and low personal accomplishment impacting behaviors also the work environment. This study aimed to analyze areas of work-life and ... ...

Abstract	Introduction: Burnout is most common among healthcare workers and is characterized by emotional fatigue, depersonalization and low personal accomplishment impacting behaviors also the work environment. This study aimed to analyze areas of work-life and burnout among dentists in dental hospitals. Methods: A cross-sectional survey study was conducted on 72 dentists in a dental hospital in Denpasar. An online questionnaire containing the Maslach Burnout Inventory and the Areas of Work Life Survey by Michael Leiter and Christina Maslach to estimate burnout and work life was used for data collection from April-May 2022. Multiple linear regression was used to evaluate the association. Results: The work-life area category had a score of 3.45, while the dentist’s average score for burnout had a mean value of 4.15. Workload, control, rewards, community, fairness, and values were associated with burnout. The control dimension showed the strongest correlation to burnout. The reward dimension had the most significant role in burnout. All dimensions of the work-life area are predictors of dentist burnout. Conclusion: Based on the finding of this study, all of the dimensions of work life can potentially cause burnout in dentists. A reward is the most dominant variable in the emergence of burnout. Management needs to set policies to reduce burnout for dentists at work.
Keywords	burnout ; dentists ; work-life ; Public aspects of medicine ; RA1-1270
Subject code	300
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Occupational Health and Safety Society of Nepal
Document type	Article ; Online
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Article: Effect of Uric Acid on Blood Glucose Levels.

Wardhana, Wardhana / Rudijanto, Achmad

Acta medica Indonesiana

2018 Volume 50, Issue 3, Page(s) 253–256

Abstract: Uric acid as the final result of purine bases metabolism. In high level condition, uric acid enters the cell and act as oxidant, and acts as independent risk factor and predicts the incident of type 2 diabetes mellitus (T2DM). It may directly inactivate ... ...

Abstract	Uric acid as the final result of purine bases metabolism. In high level condition, uric acid enters the cell and act as oxidant, and acts as independent risk factor and predicts the incident of type 2 diabetes mellitus (T2DM). It may directly inactivate or through oxidative reaction that lower the nitric oxide (NO) level. Lower NO level will reduce insulin uptake in tissues and reduce in GLUT4 translocation in cell that will effect the blood glucose level. The High level of uric acid or hyperuricemia makes oxidative stress by inducing the production of reactive oxygen species (ROS) which interferes the insulin signalling pathway,creates inflammatory state that reduced the insulin sensitivity,blood glucose uptake and metabolism, also reducing the insulin production from pancreatic islet cells.
MeSH term(s)	Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Humans ; Hyperuricemia/blood ; Hyperuricemia/complications ; Insulin Resistance ; Nitric Oxide/blood ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Uric Acid/blood
Chemical Substances	Blood Glucose ; Reactive Oxygen Species ; Uric Acid (268B43MJ25) ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2018-10-16
Publishing country	Indonesia
Document type	Journal Article ; Review
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
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Article ; Online: Knowledge and behavior changes in clinician after training of partnership for Diabetes Control in Indonesia.

Yunir, Em / Soewondo, Pradana / Soelistijo, Soebagijo Adi / Rudijanto, Achmad

Diabetes & metabolic syndrome

2021 Volume 15, Issue 3, Page(s) 719–724

Abstract: Background and aims: One of the main determinants of successful diabetes management is the quality of healthcare provider including general practitioner and internist which can be increased through medical training. This study aimed to describe the ... ...

Abstract	Background and aims: One of the main determinants of successful diabetes management is the quality of healthcare provider including general practitioner and internist which can be increased through medical training. This study aimed to describe the changes of clinician's knowledge and behavior of comprehensive diabetes management training program around Indonesia. Method: We conducted a three-day training program for general practitioners and internists for 3.5 years, 2013 to 2016. All clinicians invited as voluntary participant to send their patient data from medical record. Each participant was expected to submit a minimum of 25 type 2 diabetes (T2DM) set patient data before and 6 months after training program to analyze the impact of program in physician knowledge and behavior related to diabetes management. Result: 120 of 489 voluntary participants submitted completed baseline data with 4676 patient data. Meanwhile, only 32 participants that submitted completed data of 6 months before after training with 886 patient data. Most of parameters were improve before and after program. The greatest and lowest improvement were on A1c measurement (21%) and smoking assessment (2%). Conclusion: Intensive seminar and training was not enough to empower diabetes management. This research might push the creation of clinical practice program that were tailored to each care facilities and integrated within routine care aimed at continual improvement of its healthcare worker.
MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; Blood Glucose/analysis ; Clinical Competence/standards ; Diabetes Mellitus, Type 2/prevention & control ; Education, Medical, Graduate/methods ; Female ; Follow-Up Studies ; Glycated Hemoglobin A/analysis ; Health Knowledge, Attitudes, Practice ; Health Personnel/education ; Health Personnel/psychology ; Humans ; Hypoglycemic Agents/therapeutic use ; Internal Medicine/education ; Male ; Middle Aged ; Partnership Practice/statistics & numerical data ; Prognosis ; Retrospective Studies ; Young Adult
Chemical Substances	Biomarkers ; Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; hemoglobin A1c protein, human
Language	English
Publishing date	2021-03-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2021.03.012
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Article: Indonesia DIA-RAMADAN Study: A Real-life, Prospective and Observational of Gliclazide MR in Type-2 Diabetes Patients During Ramadan Fasting.

Soelistijo, Soebagijo Adi / Aman, Andi Makbul / Zufry, Hendra / Pranoto, Agung / Rudijanto, Achmad / Hassanien, Mohamed

Acta medica Indonesiana

2022 Volume 54, Issue 1, Page(s) 3–9

Abstract: Background: Sulfonylureas (SUs) have been widely used in many countries for T2DM treatment. Gliclazide is one of the SUs with the lowest risk of hypoglycemia; however, the safety and effectiveness of gliclazide MR during Ramadan has not yet been ... ...

Abstract	Background: Sulfonylureas (SUs) have been widely used in many countries for T2DM treatment. Gliclazide is one of the SUs with the lowest risk of hypoglycemia; however, the safety and effectiveness of gliclazide MR during Ramadan has not yet been reported in Indonesia. This study aimed to assess safety, efficacy, and tolerability of gliclazide modified release (MR) during Ramadan fasting. Methods: The study was a part of DIA-RAMADAN study, a prospective observational study with subjects of T2DM patients aged >18 years, who had either controlled or sub-optimally controlled blood glucose level, performed Ramadan fasting. Subjects had been treated with gliclazide MR for at least 90 days prior the study, and were examined for their body mass index (BMI), fasting plasma glucose (FPG) and HbA1c levels 6 to 8 weeks before Ramadan (V0) and 4 to 6 weeks after the end of Ramadan (V1). Results: Out of 198 subjects participating in the study, there were only two subjects (1.0%) who reported symptomatic HEs (either confirmed or not confirmed) and no severe HEs had been reported. There were no significant changes in HbA1c and FPG levels (p>0.05). Interestingly, there was a reduction of bodyweight (-0.4kg) from pre- to post-Ramadan (p < 0.001). Almost no subjects reported discontinuation of gliclazide MR throughout the entire study; however, there was one subject who reported a change of diabetic treatment into diet only. Conclusion: gliclazide MR is safe, well tolerated and can maintain glycemic control effectively for Indonesian patients with T2DM who perform Ramadan fasting.
MeSH term(s)	Blood Glucose ; Diabetes Mellitus, Type 2 ; Fasting ; Gliclazide/adverse effects ; Gliclazide/therapeutic use ; Glycated Hemoglobin A ; Humans ; Hypoglycemic Agents/therapeutic use ; Indonesia ; Islam ; Prospective Studies
Chemical Substances	Blood Glucose ; Glycated Hemoglobin A ; Hypoglycemic Agents ; Gliclazide (G4PX8C4HKV)
Language	English
Publishing date	2022-04-10
Publishing country	Indonesia
Document type	Journal Article ; Observational Study
ZDB-ID	2474707-5
ISSN	2338-2732 ; 0125-9326
ISSN (online)	2338-2732
ISSN	0125-9326
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