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Article ; Online: The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality.

Ilie, Petre Cristian / Stefanescu, Simina / Smith, Lee

Aging clinical and experimental research

2020 Volume 32, Issue 7, Page(s) 1195–1198

Abstract: WHO declared SARS-CoV-2 a global pandemic. The present aim was to propose an hypothesis that there is a potential association between mean levels of vitamin D in various countries with cases and mortality caused by COVID-19. The mean levels of vitamin D ... ...

Abstract	WHO declared SARS-CoV-2 a global pandemic. The present aim was to propose an hypothesis that there is a potential association between mean levels of vitamin D in various countries with cases and mortality caused by COVID-19. The mean levels of vitamin D for 20 European countries and morbidity and mortality caused by COVID-19 were acquired. Negative correlations between mean levels of vitamin D (average 56 mmol/L, STDEV 10.61) in each country and the number of COVID-19 cases/1 M (mean 295.95, STDEV 298.7, and mortality/1 M (mean 5.96, STDEV 15.13) were observed. Vitamin D levels are severely low in the aging population especially in Spain, Italy and Switzerland. This is also the most vulnerable group of the population in relation to COVID-19. It should be advisable to perform dedicated studies about vitamin D levels in COVID-19 patients with different degrees of disease severity.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/etiology ; Coronavirus Infections/mortality ; Coronavirus Infections/prevention & control ; Humans ; Italy/epidemiology ; Pandemics/prevention & control ; Pneumonia, Viral/etiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Spain/epidemiology ; Vitamin D/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology
Chemical Substances	Vitamin D (1406-16-2)
Keywords	covid19
Language	English
Publishing date	2020-05-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-020-01570-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Emerging molecular mechanisms and genetic targets for developing novel therapeutic strategies for treating bladder diseases.

Zoqlam, Randa / Lazauskaite, Sandra / Glickman, Scott / Zaitseva, Lyubov / Ilie, Petre-Cristian / Qi, Sheng

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

2022 Volume 173, Page(s) 106167

Abstract: Bladder diseases affect millions of patients worldwide and compromise their quality of life with a substantial economic impact. The not fully understood aetiologies of bladder diseases limit the current diagnosis and therapeutic options to primarily ... ...

Abstract	Bladder diseases affect millions of patients worldwide and compromise their quality of life with a substantial economic impact. The not fully understood aetiologies of bladder diseases limit the current diagnosis and therapeutic options to primarily symptomatic treatment. In addition, bladder targeted drug delivery is challenging due to its unique anatomical features and its natural physiological function of urine storage and frequent voiding. Therefore, current treatment options often fail to provide a highly effective, precisely targeted and long-lasting treatment. With the growing maturity of gene therapy, comprehensive studies are needed to provide a better understanding of the molecular mechanisms underpinning bladder diseases and help to identify novel gene therapeutic targets and biomarkers for treating bladder diseases. In this review, molecular mechanisms involved in pathology of bladder cancer, interstitial cystitis and overactive bladder syndrome are reviewed, with focus on establishing potential novel treatment options. Proposed novel therapies, including gene therapy combined with nanotechnology, localised drug delivery by nanoparticles, and probiotics, are discussed in regard to their safety profiles, efficacy, treatment lenght, precise targeting, and in comparison to conventional treatment methods.
MeSH term(s)	Biomarkers ; Cystitis, Interstitial ; Female ; Humans ; Male ; Nanoparticles ; Quality of Life ; Urinary Bladder
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-03-15
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1154366-8
ISSN	1879-0720 ; 0928-0987
ISSN (online)	1879-0720
ISSN	0928-0987
DOI	10.1016/j.ejps.2022.106167
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Article: Changes in frequency of urology clinic visits and diagnosis of erectile dysfunction in Germany before and during COVID-19.

Stefanac, Sinisa / Smith, Lee / Grabovac, Igor / Jacob, Louis / López Sánchez, Guillermo F / Ilie, Petre Cristian / Koyanagi, Ai / Schiffler, Tobias / Kostev, Karel

Revue d'epidemiologie et de sante publique

2023 Volume 71, Issue 6, Page(s) 102181

Abstract: Objectives: To explore and analyze [1] the differences in the total number of patients visiting urology practices in Germany, [2] explore and analyze any differences in the number of newly diagnosed erectile dysfunction (ED) patients as well as [3] the ... ...

Abstract	Objectives: To explore and analyze [1] the differences in the total number of patients visiting urology practices in Germany, [2] explore and analyze any differences in the number of newly diagnosed erectile dysfunction (ED) patients as well as [3] the number of new drug prescription, before and during the COVID-19 pandemic in Germany (April 2019-March 2020 and April 2020-March 2021). Methods: This retrospective cross-sectional study used data from the Disease Analyzer database (IQVIA) and included all patients aged ≥18 years with at least one visit to one of 85 urology practices across Germany. Outcomes were the mean number of patients with [1] new diagnosis of ED and [2] new prescription of drugs for erectile dysfunction per practice, in pandemic (April 2020-March 2021) versus non-pandemic (April 2019-March 2020) time periods. Differences between the periods were assessed using Wilcoxon tests. Results: In the non-pandemic period, there were 195,895 men, and in the pandemic period, 192,659 men visiting urology practices in Germany. A total of 10,977 men were initially diagnosed with ED in non-pandemic and 12,213 (+11.26%) men in pandemic time periods. Although the differences of new ED diagnoses were not statistically significant, a non-significant increase of new ED diagnoses was observed across all age groups. Also, a non-significant increase in new ED prescription drugs was detected across all age groups. Conclusions: Even though less urology practice-visits of men with ED were recorded during the COVID-19 pandemic, an increase of new ED diagnosis was observed across all age groups between April 2020 and March 2021.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Male ; Ambulatory Care ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Cross-Sectional Studies ; Erectile Dysfunction/diagnosis ; Erectile Dysfunction/epidemiology ; Pandemics ; Retrospective Studies ; Urology ; Quarantine
Language	English
Publishing date	2023-11-01
Publishing country	France
Document type	Journal Article
ZDB-ID	199128-0
ISSN	0398-7620
ISSN	0398-7620
DOI	10.1016/j.respe.2023.102181
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Article ; Online: The role of Vitamin D in the prevention of Coronavirus Disease 2019 infection and mortality

Petre Cristian, Ilie / Stefanescu, Simina / Smith, Lee

2020

Abstract	WHO declared SARS-CoV-2 a global pandemic. The present aim was to propose an hypothesis that there is a potential association between mean levels of vitamin D in various countries with cases and mortality caused by COVID-19. The mean levels of vitamin D for 20 European countries and morbidity and mortality caused by COVID-19 were acquired. Negative correlations between mean levels of vitamin D (average 56 mmol/L, STDEV 10.61) in each country and the number of COVID-19 cases/1 M (mean 295.95, STDEV 298.7, and mortality/1 M (mean 5.96, STDEV 15.13) were observed. Vitamin D levels are severely low in the aging population especially in Spain, Italy and Switzerland. This is also the most vulnerable group of the population in relation to COVID-19. It should be advisable to perform dedicated studies about vitamin D levels in COVID-19 patients with different degrees of disease severity.
Keywords	covid19
Language	English
Publisher	Springer
Publishing country	uk
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Prevalence and Indications of Intravenous Rehydration Therapy in Hospital Settings: A Systematic Review.

Gawronska, Julia / Koyanagi, Ai / López Sánchez, Guillermo F / Veronese, Nicola / Ilie, Petre Cristian / Carrie, Anne / Smith, Lee / Soysal, Pinar

Epidemiologia (Basel, Switzerland)

2022 Volume 4, Issue 1, Page(s) 18–32

Abstract: 1) Objective: We performed a systematic review to explore the prevalence of intravenous (IV) rehydration therapy in hospital settings, and we assessed it by patient groups and populations. (2) Methods: A systematic review of major databases and grey ... ...

Abstract	(1) Objective: We performed a systematic review to explore the prevalence of intravenous (IV) rehydration therapy in hospital settings, and we assessed it by patient groups and populations. (2) Methods: A systematic review of major databases and grey literature was undertaken from inception to 28 March 2022. Studies reporting prevalence of IV rehydration therapy in a hospital setting were identified. The data were synthesised in a narrative approach. (3) Results: Overall, 29 papers met the inclusion criteria. The prevalence of IV rehydration therapy in paediatric patients ranged from 4.5% (hospitalised with diarrhoea and dehydration) to 100% (admitted to the emergency department with mild to moderate dehydration caused by viral gastroenteritis), and in adults this ranged from 1.5% (had single substance ingestion of modafinil) to 100% (hospitalised with hypercalcemia). The most common indication for IV rehydration therapy in paediatric patients was dehydration due to fluid loss from the gastrointestinal tract. Other causes included malnutrition, neuromuscular disease, bronchiolitis, and influenza. In adults, indications for IV rehydration therapy were much more diverse: fever, diarrhoea, drug intoxication, hypercalcemia, cancer, and postural tachycardia syndrome; (4) Conclusions: This systematic review showed that IV rehydration therapy in paediatric patients is often used to treat dehydration and diarrhoea, while in adults it has a broader spectrum of use. While IV rehydration therapy is important in correcting fluid problems and electrolyte status, the maintenance fluid prescribing practices vary considerably, and guidelines are scarce.
Language	English
Publishing date	2022-12-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2673-3986
ISSN (online)	2673-3986
DOI	10.3390/epidemiologia4010002
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Article ; Online: Urinary incontinence and quality of life: A longitudinal analysis from the English Longitudinal Study of Ageing.

Veronese, Nicola / Smith, Lee / Pizzol, Damiano / Soysal, Pinar / Maggi, Stefania / Ilie, Petre-Cristian / Dominguez, Ligia J / Barbagallo, Mario

Maturitas

2022 Volume 160, Page(s) 11–15

Abstract: Objectives: To explore the longitudinal association between urinary incontinence (UI) and quality of life (QoL) in the English Longitudinal Study on Ageing, a large study of older UK adults with ten years of follow-up.: Study design: Cohort study.: ...

Abstract	Objectives: To explore the longitudinal association between urinary incontinence (UI) and quality of life (QoL) in the English Longitudinal Study on Ageing, a large study of older UK adults with ten years of follow-up. Study design: Cohort study. Main outcomes interest: To determine the presence of UI, participants reported whether they had lost urine beyond their control in the last 12 months. Participants also reported whether UI lasted more than one month, indicating a more chronic problem. QoL was measured using the CASP (control, autonomy, self-realisation and pleasure)-19, with higher values indicating a higher QoL. Results: Of the 8028 participants (mean age: 65.2 years; 56.7% females) included, 1172 reported UI at baseline. No significant differences in CASP-19 score were found at baseline (p = 0.24). In people with UI, a significant decline in CASP-19 score (from 34.3 ± 14.0 at baseline to 30.9 ± 16.1 in wave 7) (p = 0.016) was observed. The results were stronger in men than in women and with a longer duration of UI. Conclusion: UI was associated with poor QoL over ten years of follow-up in a large cohort of UK participants. Our findings further suggest the importance of UI as a potential risk factor for poor QoL.
MeSH term(s)	Aged ; Aging ; Cohort Studies ; Female ; Humans ; Longitudinal Studies ; Male ; Quality of Life ; Surveys and Questionnaires ; Urinary Incontinence
Language	English
Publishing date	2022-01-29
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2022.01.010
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Zs.MO 575: Show issues

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Article ; Online: The Prevalence and Indications of Intravenous Rehydration Therapy in Hospital Settings

Julia Gawronska / Ai Koyanagi / Guillermo F. López Sánchez / Nicola Veronese / Petre Cristian Ilie / Anne Carrie / Lee Smith / Pinar Soysal

Epidemiologia, Vol 4, Iss 2, Pp 18-

A Systematic Review

2022 Volume 32

Abstract	(1) Objective: We performed a systematic review to explore the prevalence of intravenous (IV) rehydration therapy in hospital settings, and we assessed it by patient groups and populations. (2) Methods: A systematic review of major databases and grey literature was undertaken from inception to 28 March 2022. Studies reporting prevalence of IV rehydration therapy in a hospital setting were identified. The data were synthesised in a narrative approach. (3) Results: Overall, 29 papers met the inclusion criteria. The prevalence of IV rehydration therapy in paediatric patients ranged from 4.5% (hospitalised with diarrhoea and dehydration) to 100% (admitted to the emergency department with mild to moderate dehydration caused by viral gastroenteritis), and in adults this ranged from 1.5% (had single substance ingestion of modafinil) to 100% (hospitalised with hypercalcemia). The most common indication for IV rehydration therapy in paediatric patients was dehydration due to fluid loss from the gastrointestinal tract. Other causes included malnutrition, neuromuscular disease, bronchiolitis, and influenza. In adults, indications for IV rehydration therapy were much more diverse: fever, diarrhoea, drug intoxication, hypercalcemia, cancer, and postural tachycardia syndrome; (4) Conclusions: This systematic review showed that IV rehydration therapy in paediatric patients is often used to treat dehydration and diarrhoea, while in adults it has a broader spectrum of use. While IV rehydration therapy is important in correcting fluid problems and electrolyte status, the maintenance fluid prescribing practices vary considerably, and guidelines are scarce.
Keywords	intravenous fluids therapy ; IV rehydration ; paediatric patients ; adult patients ; Internal medicine ; RC31-1245
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality

Ilie, Petre Cristian / Stefanescu, Simina / Smith, Lee

Aging Clin Exp Res

Abstract	WHO declared SARS-CoV-2 a global pandemic. The present aim was to propose an hypothesis that there is a potential association between mean levels of vitamin D in various countries with cases and mortality caused by COVID-19. The mean levels of vitamin D for 20 European countries and morbidity and mortality caused by COVID-19 were acquired. Negative correlations between mean levels of vitamin D (average 56 mmol/L, STDEV 10.61) in each country and the number of COVID-19 cases/1 M (mean 295.95, STDEV 298.7, and mortality/1 M (mean 5.96, STDEV 15.13) were observed. Vitamin D levels are severely low in the aging population especially in Spain, Italy and Switzerland. This is also the most vulnerable group of the population in relation to COVID-19. It should be advisable to perform dedicated studies about vitamin D levels in COVID-19 patients with different degrees of disease severity.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #186346
Database	COVID19

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Article: Editorial comment on: endoluminal isoproterenol irrigation decreases renal pelvic pressure during flexible ureterorenoscopy: a clinical randomized, controlled study.

Ilie, Cristian Petre

European urology

2008 Volume 54, Issue 6, Page(s) 1412–1413

MeSH term(s)	Adrenergic beta-Agonists/pharmacology ; Humans ; Isoproterenol/pharmacology ; Kidney Calculi/surgery ; Kidney Pelvis/drug effects ; Pressure ; Randomized Controlled Trials as Topic ; Therapeutic Irrigation ; Ureteroscopy
Chemical Substances	Adrenergic beta-Agonists ; Isoproterenol (L628TT009W)
Language	English
Publishing date	2008-12
Publishing country	Switzerland
Document type	Comment ; Editorial
ZDB-ID	193790-x
ISSN	1421-993X ; 0302-2838
ISSN (online)	1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2008.03.095
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Zs.MO 294: Show issues

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Article ; Online: Editorial comment on: Ureteral obstruction: is the full metallic double-pigtail stent the way to go?

Ilie, Cristian Petre / Mischianu, Dan

European urology

2010 Volume 57, Issue 3, Page(s) 486–487

MeSH term(s)	Humans ; Prosthesis Design ; Stents ; Ureteral Obstruction/surgery
Language	English
Publishing date	2010-03
Publishing country	Switzerland
Document type	Comment ; Editorial
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2009.02.005
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Zs.MO 294: Show issues

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