LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article: The role of zinc in cerebral ischemia.

    Galasso, Sherri L / Dyck, Richard H

    Molecular medicine (Cambridge, Mass.)

    2006  Volume 13, Issue 7-8, Page(s) 380–387

    Abstract: Ischemic stroke is one of the most pervasive life-threatening neurological conditions for which there currently exists limited therapeutic intervention beyond prevention. As calcium-focused neuroprotective strategies have met with limited clinical ... ...

    Abstract Ischemic stroke is one of the most pervasive life-threatening neurological conditions for which there currently exists limited therapeutic intervention beyond prevention. As calcium-focused neuroprotective strategies have met with limited clinical success, it is imperative that alternative therapeutic targets be considered in the attempt to antagonize ischemic-mediated injury. As such, zinc, which is able to function both as a signaling mediator and neurotoxin, has been implicated in cerebral ischemia. While zinc was first purported to have a role in cerebral ischemia nearly twenty years ago, our understanding of how zinc mediates ischemic injury is still in its relative infancy. Within this review, we examine some of the studies by which zinc has exerted either neuroprotective or neurotoxic effects during global and focal cerebral ischemia.
    MeSH term(s) Animals ; Brain Ischemia/metabolism ; Brain Ischemia/prevention & control ; Cytoprotection ; Humans ; Neuroprotective Agents/metabolism ; Neuroprotective Agents/therapeutic use ; Zinc/analysis ; Zinc/metabolism ; Zinc/therapeutic use
    Chemical Substances Neuroprotective Agents ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2006-09-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1283676-x
    ISSN 1076-1551
    ISSN 1076-1551
    DOI 10.2119/2007–00044.Galasso
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Slow progressive degeneration of nigral dopaminergic neurons in postnatal Engrailed mutant mice.

    Sgadò, Paola / Albéri, Lavinia / Gherbassi, Daniel / Galasso, Sherri L / Ramakers, Geert M J / Alavian, Kambiz N / Smidt, Marten P / Dyck, Richard H / Simon, Horst H

    Proceedings of the National Academy of Sciences of the United States of America

    2006  Volume 103, Issue 41, Page(s) 15242–15247

    Abstract: The homeobox transcription factors Engrailed-1 and Engrailed-2 are required for the survival of mesencephalic dopaminergic neurons in a cell-autonomous and gene-dose-dependent manner. Because of this requirement, the cells die by apoptosis when all four ... ...

    Abstract The homeobox transcription factors Engrailed-1 and Engrailed-2 are required for the survival of mesencephalic dopaminergic neurons in a cell-autonomous and gene-dose-dependent manner. Because of this requirement, the cells die by apoptosis when all four alleles of the Engrailed genes are genetically ablated (En1-/-;En2-/-). In the present study, we show that viable and fertile mice, heterozygous null for Engrailed-1 and homozygous null for Engrailed-2 (En1+/-;En2-/-), have an adult phenotype that resembles key pathological features of Parkinson's disease. Specifically, postnatal mutant mice exhibit a progressive degeneration of dopaminergic neurons in the substantia nigra during the first 3 mo of their lives, leading to diminished storage and release of dopamine in the caudate putamen, motor deficits similar to akinesia and bradykinesia, and a lower body weight. This genetic model may provide access to the molecular etiology for Parkinson's disease and could assist in the development of novel treatments for this neurodegenerative disorder.
    MeSH term(s) Animals ; Animals, Newborn ; Disease Models, Animal ; Dopamine/physiology ; Homeodomain Proteins/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Tissue Proteins/genetics ; Neurons/pathology ; Neurons/physiology ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Substantia Nigra/pathology ; Substantia Nigra/physiology
    Chemical Substances En1 protein, mouse ; Homeodomain Proteins ; Nerve Tissue Proteins ; engrailed 2 protein ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2006-10-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.0602116103
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top