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  1. Article ; Online: Providing assessable information on effectiveness of maintenance treatments for bipolar disorder to psychiatrists and patients.

    Bowden, Charles L

    Evidence-based mental health

    2015  Volume 18, Issue 2, Page(s) 58

    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2009065-1
    ISSN 1468-960X ; 1362-0347
    ISSN (online) 1468-960X
    ISSN 1362-0347
    DOI 10.1136/eb-2014-102014
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  2. Article: Expand the applicability and acceptability of CBT approaches in mood disorders.

    Bowden, Charles L

    World psychiatry : official journal of the World Psychiatric Association (WPA)

    2014  Volume 13, Issue 3, Page(s) 261–262

    Language English
    Publishing date 2014-10-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2236130-3
    ISSN 2051-5545 ; 1723-8617
    ISSN (online) 2051-5545
    ISSN 1723-8617
    DOI 10.1002/wps.20165
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  3. Article ; Online: Advancing randomized controlled trial methodologies: The place of innovative trial design in eating disorders research.

    Ryan, Elizabeth G / Gao, Caroline X / Grantham, Kelsey L / Thao, Le Thi Phuong / Charles-Nelson, Anaïs / Bowden, Rhys / Herschtal, Alan / Lee, Katherine J / Forbes, Andrew B / Heritier, Stephane / Phillipou, Andrea / Wolfe, Rory

    The International journal of eating disorders

    2024  

    Abstract: Randomized controlled trials can be used to generate evidence on the efficacy and safety of new treatments in eating disorders research. Many of the trials previously conducted in this area have been deemed to be of low quality, in part due to a number ... ...

    Abstract Randomized controlled trials can be used to generate evidence on the efficacy and safety of new treatments in eating disorders research. Many of the trials previously conducted in this area have been deemed to be of low quality, in part due to a number of practical constraints. This article provides an overview of established and more innovative clinical trial designs, accompanied by pertinent examples, to highlight how design choices can enhance flexibility and improve efficiency of both resource allocation and participant involvement. Trial designs include individually randomized, cluster randomized, and designs with randomizations at multiple time points and/or addressing several research questions (master protocol studies). Design features include the use of adaptations and considerations for pragmatic or registry-based trials. The appropriate choice of trial design, together with rigorous trial conduct, reporting and analysis, can establish high-quality evidence to advance knowledge in the field. It is anticipated that this article will provide a broad and contemporary introduction to trial designs and will help researchers make informed trial design choices for improved testing of new interventions in eating disorders. PUBLIC SIGNIFICANCE: There is a paucity of high quality randomized controlled trials that have been conducted in eating disorders, highlighting the need to identify where efficiency gains in trial design may be possible to advance the eating disorder research field. We provide an overview of some key trial designs and features which may offer solutions to practical constraints and increase trial efficiency.
    Language English
    Publishing date 2024-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603170-5
    ISSN 1098-108X ; 0276-3478
    ISSN (online) 1098-108X
    ISSN 0276-3478
    DOI 10.1002/eat.24187
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  4. Article ; Online: KIOS: A smartphone app for self-monitoring for patients with bipolar disorder.

    Pahwa, Mehak / McElroy, Susan L / Priesmeyer, Richard / Siegel, Gregg / Siegel, Phyllis / Nuss, Sharon / Bowden, Charles L / El-Mallakh, Rif S

    Bipolar disorders

    2023  Volume 26, Issue 1, Page(s) 84–92

    Abstract: Objectives: This study examined the use of a self-monitoring/self-management smartphone application (app) for patients with bipolar disorder. The app was specifically designed with patient-centered computational software system based on concepts from ... ...

    Abstract Objectives: This study examined the use of a self-monitoring/self-management smartphone application (app) for patients with bipolar disorder. The app was specifically designed with patient-centered computational software system based on concepts from nonlinear systems (chaos) theory.
    Methods: This was a randomized, active comparator study of use of the KIOS app compared to an existing free app that has high utilization rates known as eMoods, over 52 weeks, and performed in three academic centers. Patients were evaluated monthly utilizing the Bipolar Inventory of Symptoms Schedule (BISS). The primary outcome measure was the persistence of using the app over the year of the study.
    Results: Patients assigned to KIOS persisted in the study longer than those assigned to eMoods; 57 patients (87.70%) in the KIOS group versus 42 (73.69%) in the eMoods group completed the study (p = 0.03). By 52 weeks, significantly more of KIOS group (84.4%) versus eMoods group (54%) entered data into their programs (χ
    Conclusions: This is the first randomized comparison study comparing two apps for the self-monitoring/self-management of bipolar disorder. The study revealed greater patient satisfaction and greater adherence to a patient-centered software program (KIOS) than a monitoring program that does not provide feedback (eMoods).
    MeSH term(s) Humans ; Mobile Applications ; Bipolar Disorder ; Self-Management ; Smartphone
    Language English
    Publishing date 2023-06-20
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13362
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  5. Article: Pharmacological treatments for bipolar disorder: present recommendations and future prospects.

    Bowden, Charles L

    Current topics in behavioral neurosciences

    2014  Volume 5, Page(s) 263–283

    Abstract: In selecting and adapting medications to treat the specific clinical features of a patient with bipolar disorder (BPD) over time, a foundation strategy is to have good working knowledge of up-to-date practice guidelines. The World Federation of Societies ...

    Abstract In selecting and adapting medications to treat the specific clinical features of a patient with bipolar disorder (BPD) over time, a foundation strategy is to have good working knowledge of up-to-date practice guidelines. The World Federation of Societies of Biological Psychiatry Guidelines has the reasoned advantage of weighing safety/tolerability as high as efficacy. Most successful treatments for BPD start to separate from placebo within 1 week; most differences between regimens occur within the first 4 weeks. This observation extrapolates to a strategy of discontinuing or adding a second drug for symptoms unimproved within 1 month of treatment initiation. The weight of evidence argues against starting treatment with combination regimens, despite evidence that over time most patients do receive combination drug regimens and appear to tolerate them well. The current design paradigm for adjunctive trials generally strongly weights trials in favor of the sponsor drug.Well managed, BPD is often compatible with fully good health, both symptomatically and functionally. Consequently, for whatever regimens are found to accomplish excellent symptom control, it is important to achieve regimens that are well tolerated by all bodily systems. This chapter emphasizes the tactics needed to accomplish this specific to individual medications. The chapter also addresses the serious, broad failure of pharmaceutical companies to develop new drugs with novel mechanisms for BPD therapy and proposes a series of steps that might reenergize drug development to the benefit of psychiatrists and patients alike.
    MeSH term(s) Bipolar Disorder/drug therapy ; Humans ; Placebo Effect
    Language English
    Publishing date 2014-09-18
    Publishing country Germany
    Document type Journal Article
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2010_73
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  6. Article ; Online: Urinary cortisol responses of longtailed macaques to five cage sizes, tethering, sedation, and room change.

    Crockett, Carolyn M / Bowers, Charles L / Sackett, Gene P / Bowden, Douglas M

    American journal of primatology

    2020  Volume 30, Issue 1, Page(s) 55–74

    Abstract: Urinary free cortisol responses to five cage sizes, cage level, room change, tethering adaptation, chronic catheterization, and ketamine sedation were measured in 14 female and 14 male wild-born adult Macaca fascicularis. Urinary free cortisol, a ... ...

    Abstract Urinary free cortisol responses to five cage sizes, cage level, room change, tethering adaptation, chronic catheterization, and ketamine sedation were measured in 14 female and 14 male wild-born adult Macaca fascicularis. Urinary free cortisol, a physiological measure of psychological well-being that can be collected unobtrusively, provided a measure of the animals' general adrenocortical response to various conditions over a time course of hours. Urinary free cortisol values in response to stimulation with adrenocorticotropic hormone (ACTH) validated the measure as a reflection of blood values. Cortisol values were expressed as a ratio to creatinine, which normalized for differences in urinary output and body weight (muscle mass). Cage size (20-140% of regulation floor area) and housing level (upper vs. lower cage) had no effect on stress, as measured by cortisol excretion. Room change elicited a slight increase in cortisol excretion for the first day, but not to a level suggesting stress. Sedation, surgery, some aspects of tethering adaptation, and chronic catheterization produced urinary cortisol evidence of stress. Even so, animals varied in their responses and all showed adaptation. Males and females did not differ in normal mean values but females tended to have higher cortisol levels in response to potential stressors investigated in this study. Cortisol levels continued to decline gradually throughout the study. © 1993 Wiley-Liss, Inc.
    Language English
    Publishing date 2020-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1495834-X
    ISSN 1098-2345 ; 0275-2565
    ISSN (online) 1098-2345
    ISSN 0275-2565
    DOI 10.1002/ajp.1350300105
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  7. Article ; Online: Sex differences in compatibility of pair-housed adult longtailed macaques.

    Crockett, Carolyn M / Bowers, Charles L / Bowden, Douglas M / Sackett, Gene P

    American journal of primatology

    2020  Volume 32, Issue 2, Page(s) 73–94

    Abstract: This research was designed to evaluate the effects of same-sex pair housing on the psychological well-being of adult wild-born longtailed macaques (Macaca fascicularis). We studied behavioral compatibility and stress as measured by urinary cortisol ... ...

    Abstract This research was designed to evaluate the effects of same-sex pair housing on the psychological well-being of adult wild-born longtailed macaques (Macaca fascicularis). We studied behavioral compatibility and stress as measured by urinary cortisol excretion in 15 pairs of each sex. Before they were housed together, the pairs were categorized by noncontact pairedpreference testing as preferred, nonpreferred, or randomly assigned partners. Every aspect of data analysis indicated that the success of pairing was strongly related to gender. Whereas 100% of female pairs were compatible, only eight of the 15 male pairs were still together after two weeks, and only five (33%) showed a degree of compatibility resembling that of females. The psychological well-being of virtually all females seemed to be improved during the physical contact paired-housing conditions; they spent more than one-third of the day engaged in social grooming. Paired adult males had much lower interaction rates than adult females. On average, males were initially somewhat stressed by the introduction to a cagemate as indicated by increased urinary cortisol excretion. The noncontact preference testing procedure was no more predictive of pair success than random assignment. For males, the presence of fighting combined with the absence of grooming during the first 90 min opportunity for physical contact ("introduction") was associated with pair incompatibility, but not to a statistically significant extent. For research protocols permitting social grouping of this species, the social contact requirement of the USDA Animal Welfare Rules usually can be met for adult females by pair housing. For males, pairing with other adult males often is unsuccessful; by our estimates, at least 20% of males cannot be pair-housed with other males. These sex differences in response to same-sex adults are consistent with the known socioecology of macaques. Further research is necessary to determine whether adult males have a lower need for social contact than females, or whether their needs are better met by other types of social contact. © 1994 Wiley-Liss, Inc.
    Language English
    Publishing date 2020-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1495834-X
    ISSN 1098-2345 ; 0275-2565
    ISSN (online) 1098-2345
    ISSN 0275-2565
    DOI 10.1002/ajp.1350320202
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  8. Article ; Online: Accumulation mechanisms for contaminants on weak-base hybrid ion exchange resins.

    Saslow, Sarah A / Cordova, Elsa A / Escobedo, Nancy M / Qafoku, Odeta / Bowden, Mark E / Resch, Charles T / Lahiri, Nabajit / Nienhuis, Emily T / Boglaienko, Daria / Levitskaia, Tatiana G / Meyers, Peter / Hager, Jacqueline R / Emerson, Hilary P / Pearce, Carolyn I / Freedman, Vicky L

    Journal of hazardous materials

    2023  Volume 459, Page(s) 132165

    Abstract: Mechanism of hexavalent chromium removal (Cr(VI) as ... ...

    Abstract Mechanism of hexavalent chromium removal (Cr(VI) as CrO
    Language English
    Publishing date 2023-07-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2023.132165
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  9. Article ; Online: Cognitive Dysfunction in Bipolar Disorder: A Guide for Cliniciansedited by Goldberg Joseph F. and Burdick Katherine E. . Foreword by Goodwin Frederick K. . Washington, D.C. American Psychiatric Publishing, Inc. , 2008 , 316 pp., $45.00.

    Bowden, Charles L

    The American journal of psychiatry

    2010  Volume 167, Issue 2, Page(s) 222

    Language English
    Publishing date 2010-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2009.09060774
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  10. Article: Comorbidities with bipolar disorders: significance, recognition, and management.

    Bowden, Charles L

    CNS spectrums

    2010  Volume 15, Issue 2 Suppl 3, Page(s) 8–9; discussion 17

    MeSH term(s) Antisocial Personality Disorder/complications ; Anxiety Disorders/complications ; Bipolar Disorder/complications ; Bipolar Disorder/therapy ; Comorbidity ; Humans ; Male ; Middle Aged ; Substance-Related Disorders/complications ; United States
    Language English
    Publishing date 2010-04-22
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/s1092852900027760
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