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  1. Article ; Online: Enantioselective Construction of Consecutive Tetrasubstituted Stereogenic Centers by Reaction of α-Substituted β-Nitroacrylates with Oxazol-5-(4

    Fujita, Kazuki / Hattori, Momona / Takehara, Tsunayoshi / Suzuki, Takeyuki / Nakamura, Shuichi

    Organic letters

    2023  Volume 25, Issue 16, Page(s) 2835–2839

    Abstract: The enantioselective reaction of α-substituted β-nitroacrylates with oxazol-5-( ... ...

    Abstract The enantioselective reaction of α-substituted β-nitroacrylates with oxazol-5-(4
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c00783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Three-dimensional sonographic images of fetal hirsutism: prenatal characteristic features in cornelia de lange syndrome.

    Yamazaki, Yu / Isohata, Hitoshi / Goto, Hiroyuki / Yoshimura, Yoshihiro / Hattori, Kyoko / Shimaoka, Takao / Sekiguchi, Kazuki / Onishi, Yoko / Ochiai, Daigo

    Journal of medical ultrasonics (2001)

    2024  

    Language English
    Publishing date 2024-02-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-024-01410-6
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  3. Article ; Online: Clinical Utility of Precision Medicine in Early Breast Cancer: What Is the Optimal Framework to Develop Precision Medicine?

    Nozawa, Kazuki / Hattori, Masaya / Yoshimura, Akiyo / Iwata, Hiroji

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2022  Volume 40, Issue 17, Page(s) 1962–1963

    MeSH term(s) Breast Neoplasms/genetics ; Breast Neoplasms/therapy ; Female ; Humans ; Precision Medicine
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.00153
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    Zs.A 1847: Show issues Location:
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  4. Article ; Online: A novel endoscopic ultrasound guided re-pancreaticogastrostomy using forward-viewing echoendoscope.

    Maehara, Kosuke / Tamura, Tetsuo / Hirano, Kazuki / Hattori, Daisuke / Sato, Yoshiki / Koyama, Rikako / Imamura, Tsunao

    Endoscopy

    2023  Volume 55, Issue S 01, Page(s) E1059–E1061

    MeSH term(s) Humans ; Endosonography ; Pancreas ; Ultrasonography, Interventional
    Language English
    Publishing date 2023-09-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2156-0444
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  5. Article ; Online: Slightly Hydrogen-Ordered State of Ice IV Evidenced by

    Kobayashi, Hiroki / Komatsu, Kazuki / Ito, Hayate / Machida, Shinichi / Hattori, Takanori / Kagi, Hiroyuki

    The journal of physical chemistry letters

    2023  Volume 14, Issue 47, Page(s) 10664–10669

    Abstract: Ice IV is a metastable high-pressure phase of ice in which the water molecules exhibit orientational disorder. Although orientational ordering is commonly observed for other ice phases, it has not been reported for ice IV. We ... ...

    Abstract Ice IV is a metastable high-pressure phase of ice in which the water molecules exhibit orientational disorder. Although orientational ordering is commonly observed for other ice phases, it has not been reported for ice IV. We conducted
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c02563
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  6. Article: Nocturnal melatonin increases glucose uptake via insulin-independent action in the goldfish brain.

    Watanabe, Kazuki / Nakano, Masaki / Maruyama, Yusuke / Hirayama, Jun / Suzuki, Nobuo / Hattori, Atsuhiko

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1173113

    Abstract: Melatonin, a neurohormone nocturnally produced by the pineal gland, is known to regulate the circadian rhythm. It has been recently reported that variants of melatonin receptors are associated with an increased risk of hyperglycemia and type 2 diabetes, ... ...

    Abstract Melatonin, a neurohormone nocturnally produced by the pineal gland, is known to regulate the circadian rhythm. It has been recently reported that variants of melatonin receptors are associated with an increased risk of hyperglycemia and type 2 diabetes, suggesting that melatonin may be involved in the regulation of glucose homeostasis. Insulin is a key hormone that regulates circulating glucose levels and cellular metabolism after food intake in many tissues, including the brain. Although cells actively uptake glucose even during sleep and without food, little is known regarding the physiological effects of nocturnal melatonin on glucose homeostasis. Therefore, we presume the involvement of melatonin in the diurnal rhythm of glucose metabolism, independent of insulin action after food intake. In the present study, goldfish (
    MeSH term(s) Animals ; Melatonin/metabolism ; Goldfish/physiology ; Diabetes Mellitus, Type 2 ; Glucose/metabolism ; Brain/metabolism
    Chemical Substances Melatonin (JL5DK93RCL) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-05-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1173113
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  7. Article ; Online: High-Throughput 3D Imaging Flow Cytometry of Suspended Adherent 3D Cell Cultures.

    Yamashita, Minato / Tamamitsu, Miu / Kirisako, Hiromi / Goda, Yuki / Chen, Xiaoyao / Hattori, Kazuki / Ota, Sadao

    Small methods

    2023  , Page(s) e2301318

    Abstract: 3D cell cultures are indispensable in recapitulating in vivo environments. Among the many 3D culture methods, culturing adherent cells on hydrogel beads to form spheroid-like structures is a powerful strategy for maintaining high cell viability and ... ...

    Abstract 3D cell cultures are indispensable in recapitulating in vivo environments. Among the many 3D culture methods, culturing adherent cells on hydrogel beads to form spheroid-like structures is a powerful strategy for maintaining high cell viability and functions in the adherent states. However, high-throughput, scalable technologies for 3D imaging of individual cells cultured on the hydrogel scaffolds are lacking. This study reports the development of a high throughput, scalable 3D imaging flow cytometry platform for analyzing spheroid models. This platform is realized by integrating a single objective fluorescence light-sheet microscopy with a microfluidic device that combines hydrodynamic and acoustofluidic focusing techniques. This integration enabled unprecedentedly high-throughput and scalable optofluidic 3D imaging, processing 1310 spheroids consisting of 28 117 cells min
    Language English
    Publishing date 2023-12-22
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202301318
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  8. Article ; Online: A materials informatics driven fine-tuning of triazine-based electron-transport layer for organic light-emitting devices.

    Sato, Kosuke / Hattori, Kazuki / Uehara, Fuminari / Kitaguni, Tomoko / Nishiura, Toshiki / Yamagata, Takuya / Nomura, Keisuke / Matsumoto, Naoki / Tanaka, Tsuyoshi / Aihara, Hidenori

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4336

    Abstract: Materials informatics in the development of organic light-emitting diode (OLED) related materials have been performed and exhibited the effectiveness for finding promising compounds with a desired property. However, the molecular structure optimization ... ...

    Abstract Materials informatics in the development of organic light-emitting diode (OLED) related materials have been performed and exhibited the effectiveness for finding promising compounds with a desired property. However, the molecular structure optimization of the promising compounds through the conventional approach, namely the fine-tuning of molecules, still involves a significant amount of trial and error. This is because it is challenging to endow a single molecule with all the properties required for practical applications. The present work focused on fine-tuning triazine-based electron-transport materials using machine learning (ML) techniques. The prediction models based on localized datasets containing only triazine derivatives showed high prediction accuracy. The descriptors from density functional theory calculations enhanced the prediction of the glass transition temperature. The proposed multistep virtual screening approach extracted the promising triazine derivatives with the coexistence of higher electron mobility and glass transition temperature. Nine selected triazine compounds from 3,670,000 of the initial search space were synthesized and used as the electron transport layer for practical OLED devices. Their observed properties matched the predicted properties, and they enhanced the current efficiency and lifetime of the device. This paper provides a successful model for the ML assisted fine-tuning that effectively accelerates the development of practical materials.
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54473-3
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  9. Article ; Online: Transcriptome analysis of an AKT inhibitor-resistant endometrial cancer cell line.

    Onishi, Takafumi / Takashima, Tsuyoshi / Shibahara, Kazuki / Takagi, Shoji / Tanaka, Shinichi / Mori, Michihiro / Odashima, Hirokazu / Osawa, Yukihiko / Hattori, Manabu

    Pharmacological reports : PR

    2024  Volume 76, Issue 2, Page(s) 379–389

    Abstract: Background: Drug resistance in endometrial cancer (EC) is a serious problem and a barrier to improving prognosis. The PI3K/AKT/mTOR pathway is highly activated in EC and can serve as a potential therapeutic target. Inhibitors against AKT have been ... ...

    Abstract Background: Drug resistance in endometrial cancer (EC) is a serious problem and a barrier to improving prognosis. The PI3K/AKT/mTOR pathway is highly activated in EC and can serve as a potential therapeutic target. Inhibitors against AKT have been developed, but resistance to these inhibitors is a concern. This study aimed to establish AKT inhibitor resistant cell lines and identify differentially expressed genes (DEGs) between parental and AKT inhibitor resistant cell lines to understand the mechanism of drug resistance to AKT inhibitors in EC.
    Methods: The sensitivity of eight EC cell lines to AKT inhibitor was analyzed. One of them was used to establish a drug-resistant cell line. DEGs were examined using RNA sequencing (RNA-seq). Furthermore, DEGs were comprehensively analyzed to identify hub genes. Hub genes were evaluated using quantitative real-time polymerase chain reaction.
    Results: RNA-seq identified 617 DEGs. Hub genes were selected using bioinformatics analysis. The top 10 hub genes were TNF, CDH1, CCND1, COL1A1, CDH2, ICAM1, CAV1, THBS1, NCAM1, and CDKN2A. Relative mRNA expression was significantly upregulated for TNF, CDH1, CCND1, THBS1, p16
    Conclusions: Drug resistance to AKT inhibitors may depend on genes related to cell adhesion-mediated resistance and transforming growth factor β signaling.
    MeSH term(s) Female ; Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Gene Expression Profiling ; Protein Kinase Inhibitors/pharmacology ; Endometrial Neoplasms/drug therapy ; Endometrial Neoplasms/genetics ; Cell Line, Tumor ; Transcriptome
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2186248-5
    ISSN 2299-5684 ; 1734-1140
    ISSN (online) 2299-5684
    ISSN 1734-1140
    DOI 10.1007/s43440-024-00581-w
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  10. Article: A novel endoscopic ultrasound guided re-pancreaticogastrostomy using forward-viewing echoendoscope

    Maehara, Kosuke / Tamura, Tetsuo / Hirano, Kazuki / Hattori, Daisuke / Sato, Yoshiki / Koyama, Rikako / Imamura, Tsunao

    Endoscopy

    2023  Volume 55, Issue S 01, Page(s) E1059–E1061

    Language English
    Publishing date 2023-09-21
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2156-0444
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