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  1. Article ; Online: Identifying and repurposing antiviral drugs against severe acute respiratory syndrome coronavirus 2 with in silico and in vitro approaches.

    Watashi, Koichi

    Biochemical and biophysical research communications

    2020  Volume 538, Page(s) 137–144

    Abstract: Coronavirus infectious diseases 2019 (COVID-19), a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a serious public health threat worldwide. So far, there are no drugs and vaccines whose efficacy has been ... ...

    Abstract Coronavirus infectious diseases 2019 (COVID-19), a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a serious public health threat worldwide. So far, there are no drugs and vaccines whose efficacy has been well-proven. After the outbreak, there has been a massive search for anti-SARS-CoV-2 medications, focusing on approved drugs because repurposing approved drugs will take less time to reach clinical usage than new drugs. This article summarizes the studies using in silico and in vitro approaches to identify therapeutic candidates among approved drugs that target the SARS-CoV-2 life cycle.
    MeSH term(s) Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Caco-2 Cells ; Chlorocebus aethiops ; Computer Simulation ; Drug Repositioning/methods ; Humans ; Mice ; SARS-CoV-2/drug effects ; Vero Cells
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2020-11-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.10.094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identifying and repurposing antiviral drugs against severe acute respiratory syndrome coronavirus 2 with in silico and in vitro approaches

    Watashi, Koichi

    Abstract: Coronavirus infectious diseases 2019 (COVID-19), a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a serious public health threat worldwide. So far, there are no drugs and vaccines whose efficacy has been ... ...

    Abstract Coronavirus infectious diseases 2019 (COVID-19), a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a serious public health threat worldwide. So far, there are no drugs and vaccines whose efficacy has been well-proven. After the outbreak, there has been a massive search for anti-SARS-CoV-2 medications, focusing on approved drugs because repurposing approved drugs will take less time to reach clinical usage than new drugs. This article summarizes the studies using in silico and in vitro approaches to identify therapeutic candidates among approved drugs that target the SARS-CoV-2 life cycle.
    Keywords covid19
    Publisher Elsevier
    Document type Article ; Online
    DOI 10.1016/j.bbrc.2020.10.094
    Database COVID19

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  3. Article ; Online: HBV Slow Maturation Process Leads to Infection.

    Watashi, Koichi

    Trends in microbiology

    2016  Volume 24, Issue 8, Page(s) 597–599

    Abstract: Initial hepatitis B virus (HBV) attachment occurs via heparan sulfate proteoglycans (HSPGs), which then trigger receptor-mediated internalization. Although HSPGs express in many tissues, HBV is destined for hepatotropic infection. A recent paper by Seitz ...

    Abstract Initial hepatitis B virus (HBV) attachment occurs via heparan sulfate proteoglycans (HSPGs), which then trigger receptor-mediated internalization. Although HSPGs express in many tissues, HBV is destined for hepatotropic infection. A recent paper by Seitz et al. proposed that the slow viral maturation process plays a critical role in liver-specific distribution.
    Language English
    Publishing date 2016-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2016.06.007
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3738: Show issues Location:
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  4. Article: [HBV entry and its application to the drug development].

    Watashi, Koichi

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73 Suppl 9, Page(s) 372–376

    MeSH term(s) Biological Products/chemistry ; Hepatitis B/virology ; Hepatitis B virus/physiology ; Humans ; Organic Anion Transporters, Sodium-Dependent/chemistry ; Organic Anion Transporters, Sodium-Dependent/metabolism ; Symporters/chemistry ; Symporters/metabolism ; Viral Envelope Proteins/chemistry ; Viral Envelope Proteins/metabolism ; Virus Internalization
    Chemical Substances Biological Products ; Organic Anion Transporters, Sodium-Dependent ; Symporters ; Viral Envelope Proteins ; viron ; sodium-bile acid cotransporter (145420-23-1)
    Language Japanese
    Publishing date 2015-12
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 429: Show issues Location:
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  5. Article ; Online: Hepatitis B virus biology and life cycle.

    Tsukuda, Senko / Watashi, Koichi

    Antiviral research

    2020  Volume 182, Page(s) 104925

    Abstract: Hepatitis B virus (HBV) specifically infects hepatocytes and causes severe liver diseases. The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double-stranded DNA: rcDNA) is converted to a molecular template DNA (covalently ... ...

    Abstract Hepatitis B virus (HBV) specifically infects hepatocytes and causes severe liver diseases. The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double-stranded DNA: rcDNA) is converted to a molecular template DNA (covalently closed circular DNA: cccDNA) to amplify a viral RNA intermediate, which is then reverse-transcribed back to viral DNA. The highly stable characteristics of cccDNA result in chronic infection and a poor rate of cure. This complex life cycle of HBV offers a variety of targets to develop antiviral agents. We provide here an update on the current knowledge of HBV biology and its life cycle, which may help to identify new antiviral targets.
    Language English
    Publishing date 2020-08-28
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2020.104925
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    Zs.A 1627: Show issues Location:
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  6. Article ; Online: Anti-SARS-CoV-2 Agents in

    Maehara, Shoji / Nakajima, Shogo / Watashi, Koichi / Agusta, Andria / Kikuchi, Misato / Hata, Toshiyuki / Takayama, Kento

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 9

    Abstract: Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therapeutic agents for the disease are being developed. Endophytes are diverse and produce various secondary metabolites and bioactive substances. We ... ...

    Abstract Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therapeutic agents for the disease are being developed. Endophytes are diverse and produce various secondary metabolites and bioactive substances. We isolated 13 endophytes from the leaves and stems of
    Language English
    Publishing date 2023-09-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9090905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Synthesis of the full-length hepatitis B virus core protein and its capsid formation.

    Aoki, Keisuke / Tsuda, Shugo / Ogata, Naoko / Kataoka, Michiyo / Sasaki, Jumpei / Inuki, Shinsuke / Ohno, Hiroaki / Watashi, Koichi / Yoshiya, Taku / Oishi, Shinya

    Organic & biomolecular chemistry

    2024  Volume 22, Issue 11, Page(s) 2218–2225

    Abstract: Chronic infection with hepatitis B virus (HBV) is a major cause of cirrhosis and liver cancer. Capsid assembly modulators can induce error-prone assembly of HBV core proteins to prevent the formation of infectious virions, representing promising ... ...

    Abstract Chronic infection with hepatitis B virus (HBV) is a major cause of cirrhosis and liver cancer. Capsid assembly modulators can induce error-prone assembly of HBV core proteins to prevent the formation of infectious virions, representing promising candidates for treating chronic HBV infections. To explore novel capsid assembly modulators from unexplored mirror-image libraries of natural products, we have investigated the synthetic process of the HBV core protein for preparing the mirror-image target protein. In this report, the chemical synthesis of full-length HBV core protein (Cp183) containing an arginine-rich nucleic acid-binding domain at the C-terminus is presented. Sequential ligations using four peptide segments enabled the synthesis of Cp183
    MeSH term(s) Humans ; Capsid/chemistry ; Capsid Proteins/metabolism ; Hepatitis B virus ; Hepatitis B/metabolism ; Viral Core Proteins/analysis ; Viral Core Proteins/chemistry ; Viral Core Proteins/metabolism ; Nucleic Acids ; Virus Replication ; Antiviral Agents/metabolism
    Chemical Substances Capsid Proteins ; Viral Core Proteins ; Nucleic Acids ; Antiviral Agents
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob02099a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Antiviral Activity of Micafungin and Its Derivatives against SARS-CoV-2 RNA Replication.

    Nakajima, Shogo / Ohashi, Hirofumi / Akazawa, Daisuke / Torii, Shiho / Suzuki, Rigel / Fukuhara, Takasuke / Watashi, Koichi

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Echinocandin antifungal drugs, including micafungin, anidulafungin, and caspofungin, have been recently reported to exhibit antiviral effects against various viruses such as flavivirus, alphavirus, and coronavirus. In this study, we focused on micafungin ...

    Abstract Echinocandin antifungal drugs, including micafungin, anidulafungin, and caspofungin, have been recently reported to exhibit antiviral effects against various viruses such as flavivirus, alphavirus, and coronavirus. In this study, we focused on micafungin and its derivatives and analyzed their antiviral activities against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The micafungin derivatives Mi-2 and Mi-5 showed higher antiviral activity than micafungin, with 50% maximal inhibitory concentration (IC
    MeSH term(s) Humans ; Antiviral Agents/pharmacology ; COVID-19 ; Micafungin/pharmacology ; RNA Replication ; RNA, Viral ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Micafungin (R10H71BSWG) ; RNA, Viral
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Antiviral agents for analyzing virus life cycle: chemical genetics for virology.

    Watashi, Koichi

    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

    2013  Volume 133, Issue 11, Page(s) 1169–1175

    Abstract: Hepatitis C virus, which affects approximately 170 million people worldwide, is a major causative agent of hepatocellular carcinoma. Anti-HCV treatment is available with the combination of pegylated interferon and ribavirin, and newly approved protease ... ...

    Abstract Hepatitis C virus, which affects approximately 170 million people worldwide, is a major causative agent of hepatocellular carcinoma. Anti-HCV treatment is available with the combination of pegylated interferon and ribavirin, and newly approved protease inhibitors. However, because of the diverse anti-HCV efficacy among HCV genotypes and significant side effects, alternative anti-HCV agents are in great demand. Using cell-based systems supporting a part of or the whole HCV life cycle, we identified cyclosporin A, tamoxifen, and benzamide derivatives that inhibited the replication of HCV RNA or the production of infectious HCV particles. In this article, we summarize the mechanistic analyses of the HCV life cycle using these small molecules. Thus, chemical genetics is a powerful approach for revealing molecular mechanisms of the viral life cycle as well as for developing new antiviral agents.
    MeSH term(s) Antiviral Agents/pharmacology ; Hepacivirus/drug effects ; Hepacivirus/physiology ; Hepatitis C/drug therapy ; Humans ; RNA, Viral/biosynthesis ; Virion/drug effects ; Virus Replication/drug effects
    Chemical Substances Antiviral Agents ; RNA, Viral
    Language Japanese
    Publishing date 2013-10-24
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 200514-1
    ISSN 1347-5231 ; 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    ISSN (online) 1347-5231
    ISSN 0031-6903 ; 0372-7750 ; 0919-2085 ; 0919-2131
    DOI 10.1248/yakushi.13-00212-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 643: Show issues Location:
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  10. Article: HBV Slow Maturation Process Leads to Infection

    Watashi, Koichi

    Trends in microbiology. 2016 Aug., v. 24, no. 8

    2016  

    Abstract: Initial hepatitis B virus (HBV) attachment occurs via heparan sulfate proteoglycans (HSPGs), which then trigger receptor-mediated internalization. Although HSPGs express in many tissues, HBV is destined for hepatotropic infection. A recent paper by Seitz ...

    Abstract Initial hepatitis B virus (HBV) attachment occurs via heparan sulfate proteoglycans (HSPGs), which then trigger receptor-mediated internalization. Although HSPGs express in many tissues, HBV is destined for hepatotropic infection. A recent paper by Seitz et al. proposed that the slow viral maturation process plays a critical role in liver-specific distribution.
    Keywords heparan sulfate ; Hepatitis B virus ; proteoglycans ; tissues
    Language English
    Dates of publication 2016-08
    Size p. 597-599.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2016.06.007
    Database NAL-Catalogue (AGRICOLA)

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