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Article: Feasibility of Quality of Life Assessment in Patients with Lymphoma Aged ≥80 Years Receiving Reduced-Intensity Chemotherapy: A Single-Institute Study.

Yamasaki, Satoshi

2023 Volume 16, Issue 1, Page(s) 1–10

Abstract: Quality of life (QOL) must be carefully monitored in older patients with lymphoma who are suitable for chemotherapy, but few reports have assessed QOL in older patients who received reduced-intensity chemotherapy. This study investigated QOL in patients ... ...

Abstract	Quality of life (QOL) must be carefully monitored in older patients with lymphoma who are suitable for chemotherapy, but few reports have assessed QOL in older patients who received reduced-intensity chemotherapy. This study investigated QOL in patients with lymphoma aged ≥80 years to clarify the feasibility of such assessments following reduced-intensity chemotherapy. QOL was prospectively analyzed (using the QOL Questionnaire for Cancer Patients Treated with Anticancer Drugs (QOL-ACD)] and the SF-36
Language	English
Publishing date	2023-12-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2586645-X
ISSN	2038-8330 ; 2038-8322
ISSN (online)	2038-8330
ISSN	2038-8322
DOI	10.3390/hematolrep16010001
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Article ; Online: Bisphosphonate use for glucocorticoid-induced osteoporosis in older patients with immune thrombocytopenia: a clinical perspective.

Yamasaki, Satoshi

Annals of hematology

2023 Volume 102, Issue 7, Page(s) 1645–1656

Abstract: Prednisolone, used as a standard initial treatment for immune thrombocytopenia (ITP), is an important risk factor for osteoporosis. Recently, we found that prescription of bisphosphonate during initial loading of prednisolone may prevent reduction in ... ...

Abstract	Prednisolone, used as a standard initial treatment for immune thrombocytopenia (ITP), is an important risk factor for osteoporosis. Recently, we found that prescription of bisphosphonate during initial loading of prednisolone may prevent reduction in bone mineral density and development of glucocorticoid-induced osteoporosis (GIO) in older patients with ITP receiving prolonged steroid therapy. In this review, I describe the treatment options for older patients with ITP, and present the best practices for screening, evaluating, and diagnosing ITP. I also summarize the literature from 2017 to 2022 on the treatment options for ITP, including discussions on the contraindications and side effects, with an emphasis on GIO, and the relative merits of bisphosphonates as a co-treatment for prevention of GIO. Finally, I present a perspective and an expert recommendation on how older patients with ITP would best be served in the future.
MeSH term(s)	Humans ; Aged ; Diphosphonates/adverse effects ; Glucocorticoids/therapeutic use ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Osteoporosis/drug therapy ; Bone Density Conservation Agents/adverse effects ; Bone Density ; Prednisolone/adverse effects
Chemical Substances	Diphosphonates ; Glucocorticoids ; Bone Density Conservation Agents ; Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	2023-05-12
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-023-05266-7
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Article: Hypoxia-Inducible Factor-Prolyl-Hydroxylase and Sodium-Glucose Cotransporter 2 Inhibitors for Low-Risk Myelodysplastic Syndrome-Related Anemia in Patients with Chronic Kidney Disease: A Report of Three Cases.

Yamasaki, Satoshi / Horiuchi, Takahiko

Hematology reports

2023 Volume 15, Issue 1, Page(s) 180–187

Abstract: Although daprodustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, and dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, have been approved for the treatment of renal anemia in Japan, their efficacy and safety for patients aged 80 ... ...

Abstract	Although daprodustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, and dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, have been approved for the treatment of renal anemia in Japan, their efficacy and safety for patients aged 80 years or older with low-risk myelodysplastic syndrome (MDS)-related anemia have not been demonstrated. Our case series comprised two men and one woman aged >80 years with low-risk MDS-related anemia and diabetic mellitus (DM)-related chronic kidney disease who were dependent on red blood cell transfusions and in whom erythropoiesis-stimulating agents had been insufficient. All three patients received daprodustat and additional dapagliflozin achieved red blood cell transfusion independence and were followed up for >6 months. Daily oral daprodustat was well tolerated. There were no fatalities or progression to acute myeloid leukemia during the >6-month follow-up after daprodustat initiation. On the basis of these outcomes, we consider 24 mg of daprodustat combined with 10 mg of dapagliflozin daily an effective form of treatment for low-risk MDS-related anemia. Further studies are required to clarify the synergistic effects of daprodustat and dapagliflozin, which correct chronic kidney disease-related anemia by promoting endogenous erythropoietin production and normalizing iron metabolism to manage low-risk MDS in the long term.
Language	English
Publishing date	2023-03-06
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2586645-X
ISSN	2038-8330 ; 2038-8322
ISSN (online)	2038-8330
ISSN	2038-8322
DOI	10.3390/hematolrep15010019
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Article ; Online: [Analysis of factors leading to brain MRI lesions in Wernicke's encephalopathy].

Kuzume, Daisuke / Morimoto, Yuko / Tsutsumi, Satoshi / Yamasaki, Masahiro / Hosomi, Naohisa

Rinsho shinkeigaku = Clinical neurology

2024

Abstract: Objective] To investigate association between Wernicke encephalopathy (WE) and brain MRI. [Subjects] 26 patients (7 females, mean age 63.9 ± 12.7 years) with WE admitted to our department between May 2008 and September 2022. [Methods] Wernicke's ... ...

Abstract	[Objective] To investigate association between Wernicke encephalopathy (WE) and brain MRI. [Subjects] 26 patients (7 females, mean age 63.9 ± 12.7 years) with WE admitted to our department between May 2008 and September 2022. [Methods] Wernicke's encephalopathy in patients with MRI lesions was defined as "MRI-positive group" (MPG), and those without MRI lesions as "MRI-negative group" (MNG). The following parameters were assessed between the two groups: age, sex, alcoholism, neurological symptoms, vitamin B
Language	Japanese
Publishing date	2024-04-20
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001919
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Article ; Online: [A case of bilateral middle cerebellar peduncle infarction with hot cross bun sign].

Kuzume, Daisuke / Morimoto, Yuko / Tsutsumi, Satoshi / Yamasaki, Masahiro / Hosomi, Naohisa

Rinsho shinkeigaku = Clinical neurology

2024 Volume 64, Issue 3, Page(s) 190–193

Abstract: A 71-year-old man with hypertension and diabetes mellitus presented to our hospital because he felt lightheaded. Diffusion-weighted images (DWI) on brain MRI showed high signal lesions in the left cerebellar hemisphere and the right pons. The diagnosis ... ...

Abstract	A 71-year-old man with hypertension and diabetes mellitus presented to our hospital because he felt lightheaded. Diffusion-weighted images (DWI) on brain MRI showed high signal lesions in the left cerebellar hemisphere and the right pons. The diagnosis of cerebellar infarction was made, but he refused treatment. One month later, he came to our hospital because his body leaned to the left. Neurological examination revealed dysarthria and cerebellar truncal ataxia. An electrocardiogram showed atrial fibrillation. DWI on brain MRI showed high signal lesions in the bilateral cerebellar hemispheres and middle cerebellar peduncles (MCP). Dabigatran 300 ‍mg/day was administered for cardiogenic cerebral embolism. On the 12th day of onset, he was transferred to a rehabilitation hospital. At 72 years old, T
MeSH term(s)	Male ; Humans ; Aged ; Middle Cerebellar Peduncle ; Pons/diagnostic imaging ; Cerebellum/diagnostic imaging ; Cerebellum/pathology ; Magnetic Resonance Imaging ; Brain Stem Infarctions
Language	Japanese
Publishing date	2024-02-17
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001897
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Article ; Online: Recent advances in the role of RNA-binding protein, tristetraprolin, in arthritis.

Yamasaki, Satoshi

Immunological medicine

2018 Volume 41, Issue 3, Page(s) 98–102

Abstract: The expression levels of cytokines and chemokines are strictly regulated at transcriptional and post-transcriptional levels. These small proteins are closely related to inflammatory diseases such as rheumatoid arthritis (RA). The purpose of this review ... ...

Abstract	The expression levels of cytokines and chemokines are strictly regulated at transcriptional and post-transcriptional levels. These small proteins are closely related to inflammatory diseases such as rheumatoid arthritis (RA). The purpose of this review is to highlight the potential utilization of tristetraprolin (TTP) as a therapeutic target in treating RA. TTP is the most notable and well-characterized RNA-binding protein that destabilizes mRNA of pro-inflammatory cytokines. TTP is thought to play an important role in RA because its target mRNA includes a lot of inflammatory cytokines such as TNFα. Post-translational modifications, especially phosphorylation, seem to be critical for the anti-inflammatory effects of TTP. Importantly, various mouse models, many of which are consistent with in vitro studies, are now available to elicit a more detailed understanding of the pathogenic role of TTP. The results of these multidisciplinary studies indicate that it is possible to improve inflammation by controlling TTP activity. Through this review, I propose that the use of recently developed mouse models and establishment of clever designs to target TTP will greatly contribute to future drug development to treat RA.
Language	English
Publishing date	2018-11-04
Publishing country	England
Document type	Journal Article
ISSN	2578-5826
ISSN (online)	2578-5826
DOI	10.1080/25785826.2018.1531187
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Article: [Clinical features of acyclovir encephalopathy without acute kidney injury].

Kuzume, Daisuke / Morimoto, Yuko / Tsutsumi, Satoshi / Yamasaki, Masahiro / Hosomi, Naohisa

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics

2024 Volume 61, Issue 1, Page(s) 61–67

Abstract: Introduction: Few reports have described acyclovir (ACV) encephalopathy without acute kidney injury (AKI).: Objective: This study clarified the clinical features of ACV encephalopathy without AKI compared to that with AKI.: Methods: Creatinine ( ... ...

Abstract	Introduction: Few reports have described acyclovir (ACV) encephalopathy without acute kidney injury (AKI). Objective: This study clarified the clinical features of ACV encephalopathy without AKI compared to that with AKI. Methods: Creatinine (Cre) levels were measured on admission. After admission, Cre was measured in a timely manner for the first seven hospital days. The minimum Cre level in these measurements was then determined. ACV encephalopathy was defined when two criteria were met: 1) neurological symptoms appeared after valacyclovir (VACV) administration, and 2) neurological symptoms improved after VACV discontinuation. AKI was defined when the Cre level on admission was >1.5 times higher than the minimum Cre level. The subjects were divided into AKI and non-AKI groups based on these findings. Results: Eighteen patients had ACV encephalopathy (5 males, mean age 81.3±5.5 years old). All patients were prescribed VACV 3,000 mg/day. The minimum Cre was 1.93±1.76 mg/dL. AKI occurred in 10 (56.6%) patients. VACV was discontinued in all patients, and emergency hemodialysis treatment was administered in 10 (55.6%) patients. All patients recovered. Compared to the AKI group, the non-AKI group had a lower history of taking a Ca-blocker (33.3% vs 80.0%, p=0.092), a lower rate of emergency dialysis (16.9% vs 70.0%, p=0.059) and a longer time to clinical improvement (3.67±1.86 vs 2.20±0.63 days, p=0.073). Conclusion: ACV encephalopathy without AKI is characterized by a low rate of emergency dialysis, which may be linked to a prolonged duration of symptoms.
MeSH term(s)	Male ; Humans ; Aged ; Aged, 80 and over ; Acyclovir/adverse effects ; Valacyclovir ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/drug therapy ; Renal Dialysis ; Brain Diseases/chemically induced ; Brain Diseases/drug therapy ; Retrospective Studies
Chemical Substances	Acyclovir (X4HES1O11F) ; Valacyclovir (MZ1IW7Q79D)
Language	Japanese
Publishing date	2024-01-23
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604107-3
ISSN	0300-9173
ISSN	0300-9173
DOI	10.3143/geriatrics.61.61
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Book ; Online: Crowd-Powered Photo Enhancement Featuring an Active Learning Based Local Filter

Kosugi, Satoshi / Yamasaki, Toshihiko

2023

Abstract: ... by the existing enhancement methods. Our source code and results are available at https://github.com/satoshi ...

Abstract	In this study, we address local photo enhancement to improve the aesthetic quality of an input image by applying different effects to different regions. Existing photo enhancement methods are either not content-aware or not local; therefore, we propose a crowd-powered local enhancement method for content-aware local enhancement, which is achieved by asking crowd workers to locally optimize parameters for image editing functions. To make it easier to locally optimize the parameters, we propose an active learning based local filter. The parameters need to be determined at only a few key pixels selected by an active learning method, and the parameters at the other pixels are automatically predicted using a regression model. The parameters at the selected key pixels are independently optimized, breaking down the optimization problem into a sequence of single-slider adjustments. Our experiments show that the proposed filter outperforms existing filters, and our enhanced results are more visually pleasing than the results by the existing enhancement methods. Our source code and results are available at https://github.com/satoshi-kosugi/crowd-powered. Comment: Accepted to IEEE Transactions on Circuits and Systems for Video Technology (TCSVT)
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	004
Publishing date	2023-06-15
Publishing country	us
Document type	Book ; Online
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Book ; Online: Personalized Image Enhancement Featuring Masked Style Modeling

Kosugi, Satoshi / Yamasaki, Toshihiko

2023

Abstract: ... other previous methods in this field. Our source code is available at https://github.com/satoshi-kosugi/masked ...

Abstract	We address personalized image enhancement in this study, where we enhance input images for each user based on the user's preferred images. Previous methods apply the same preferred style to all input images (i.e., only one style for each user); in contrast to these methods, we aim to achieve content-aware personalization by applying different styles to each image considering the contents. For content-aware personalization, we make two contributions. First, we propose a method named masked style modeling, which can predict a style for an input image considering the contents by using the framework of masked language modeling. Second, to allow this model to consider the contents of images, we propose a novel training scheme where we download images from Flickr and create pseudo input and retouched image pairs using a degrading model. We conduct quantitative evaluations and a user study, and our method trained using our training scheme successfully achieves content-aware personalization; moreover, our method outperforms other previous methods in this field. Our source code is available at https://github.com/satoshi-kosugi/masked-style-modeling. Comment: Accepted to IEEE Transactions on Circuits and Systems for Video Technology (TCSVT)
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	004
Publishing date	2023-06-15
Publishing country	us
Document type	Book ; Online
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Article ; Online: Impact evaluation of typhoons and remediation works on spatiotemporal evolution of air dose rate in two riverside parks in Fukushima, Japan after the Dai-ichi nuclear power plant accident.

Yamasaki, Takuhei / Suzuki, Satoshi / Nishikiori, Tatsuhiro

Journal of environmental management

2023 Volume 332, Page(s) 117311

Abstract: This study elucidated the impacts of typhoon events and remediation works on the spatiotemporal evolution of the air dose rate in riverside areas frequented by residents. Spatial distribution of the air dose rate and radiocesium concentration in the ... ...

Abstract	This study elucidated the impacts of typhoon events and remediation works on the spatiotemporal evolution of the air dose rate in riverside areas frequented by residents. Spatial distribution of the air dose rate and radiocesium concentration in the sediments were measured in two riverside parks located near each other in Fukushima Prefecture, Japan, for 2015-2020. The air dose rates measured by walk surveys were interpolated using ordinary kriging to generate air dose rate maps, to facilitate a comparison between the results at different points in time during the measurement campaigns. After the typhoons that occurred during 2015-2018, the air dose rate near the riverside in one park decreased, but not in the other, because the erosion and sediment deposition patterns differed between them. This could be due to the presence of a dam upstream, which serves a flood mitigation function. However, the extreme event of typhoon Hagibis in 2019 dropped the air dose rates near the riversides in both parks. In contrast to the typhoon events which affected the riverside areas, remediation works such as decontamination undertaken during 2015-2019 reduced the air dose rates around the garden and lawn areas which are frequently used as recreational sites. Modeling the temporal evolutions in the air dose rates for the entire area of the riverside parks revealed that 35% of the reduction was caused by physical decay of radiocesium on average, 14% by vertical migration of radiocesium in the soil through precipitation, and 51% by the three typhoons and remediation works during 2015-2019. The contribution of 20% from the strongest typhoon Hagibis highlights the fact that floods resulting from large typhoons are effective in causing natural attenuation of air dose rates in riverside parks.
MeSH term(s)	Cesium Radioisotopes/analysis ; Cyclonic Storms ; Japan ; Fukushima Nuclear Accident ; Nuclear Power Plants ; Radiation Monitoring ; Soil Pollutants, Radioactive/analysis
Chemical Substances	Cesium Radioisotopes ; Soil Pollutants, Radioactive
Language	English
Publishing date	2023-01-30
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.117311
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