LIVIVO - Search results -

Search results

Result 1 - 10 of total 88

Search options

Article ; Online: Tuberculosis in biologic users for rheumatic diseases: results from the South African Biologics Registry (SABIO).

Pettipher, Clive / Benitha, Romela

2019 Volume 79, Issue 2, Page(s) 292–299

Abstract: Objectives: To evaluate the rate of tuberculosis (TB) in biologic users for rheumatic diseases in South Africa, the effectiveness of our latent TB infection (LTBI) programme, risk factors and outcome.: Methods: TB cases were collected from the South ... ...

Abstract	Objectives: To evaluate the rate of tuberculosis (TB) in biologic users for rheumatic diseases in South Africa, the effectiveness of our latent TB infection (LTBI) programme, risk factors and outcome. Methods: TB cases were collected from the South African Biologics Registry (SABIO), rheumatologists and pharmaceutical companies. Demographics, LTBI screening and treatment, biological and disease modifying antirheumatic drug (DMARD) therapies, TB diagnosis and outcomes were recorded. Results: 96 TB cases were collected from 1999 to June 2017: rheumatoid arthritis 55, ankylosing spondylitis 27, psoriatic arthritis 4, and juvenile inflammatory arthritis 10. The TB rate was 1240/100 000 person years for biologic users (n=96) versus the biologic naive cohort of 0/100 000 years with an incidence rate difference of 0.0124 (p<0.0001). 60/96 had pulmonary and 36/96 had extra-pulmonary TB. Reactivation TB occurred in 45/96 cases. TB occurred in all biologics licenced in South Africa, the majority in monoclonal inhibitors (1683/100 000 person years) compared with etanercept (861/100 000 person years) and non-tumour necrosis factor (TNF) inhibitors (681/100 000 person years). The incidence rate ratio for monoclonal inhibitors compared with etanercept was 1.96 (p=0.005) and 2.47 (p=0.002) compared with non-TNF inhibitors with no significant difference between non-TNF inhibitors and etanercept (p=0.336). From those (12.9%) who screened LTBI positive, 14 developed TB, while the majority (77) screened LTBI negative. Black race, male sex, younger age and residence in the Western Cape were statistical risk factors. Two drug resistant TB cases and six deaths occurred. Conclusion: Reactivation and new onset TB is a significant risk for all biologics users in SA. Screening for LTBI is an imperative preventative strategy.
MeSH term(s)	Adult ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/immunology ; Biological Products/adverse effects ; Biological Products/immunology ; Female ; Humans ; Incidence ; Latent Tuberculosis/chemically induced ; Latent Tuberculosis/epidemiology ; Latent Tuberculosis/immunology ; Male ; Middle Aged ; Prospective Studies ; Registries ; Rheumatic Diseases/drug therapy ; Rheumatic Diseases/immunology ; South Africa/epidemiology ; Tuberculosis, Pulmonary/chemically induced ; Tuberculosis, Pulmonary/epidemiology ; Tuberculosis, Pulmonary/immunology
Chemical Substances	Antirheumatic Agents ; Biological Products
Language	English
Publishing date	2019-12-02
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2019-216128
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 167: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses.

Pettipher, R

British journal of pharmacology

2007 Volume 153 Suppl 1, Page(s) S191–9

Abstract: Prostaglandin D(2) (PGD(2)) is produced by mast cells, Th2 lymphocytes and dendritic cells and has been detected in high concentrations at sites of allergic inflammation. PGD(2) exerts its inflammatory effects through high affinity interactions with the ... ...

Abstract	Prostaglandin D(2) (PGD(2)) is produced by mast cells, Th2 lymphocytes and dendritic cells and has been detected in high concentrations at sites of allergic inflammation. PGD(2) exerts its inflammatory effects through high affinity interactions with the G protein coupled receptors DP(1) and chemoattractant-homologous receptor expressed on Th2 cells (CRTH2, also known as DP(2)). DP(1) and CRTH2 act in concert to promote a number of biological effects associated with the development and maintenance of the allergic response. During the process of allergen sensitization, DP(1) activation may enhance polarization of Th0 cells to Th2 cells by inhibiting production of interleukin 12 by dendritic cells. Upon exposure to allergen in sensitized individuals, activation of DP(1) may contribute to the long lasting blood flow changes in the target organ. CRTH2 is expressed by Th2 lymphocytes, eosinophils and basophils and may mediate the recruitment of these cell types during the late phase allergic response. The role played by CRTH2 in promoting the production of Th2 cytokines and IgE make antagonism of this receptor a particularly attractive approach to the treatment of chronic allergic disease.
MeSH term(s)	Animals ; Humans ; Hypersensitivity/genetics ; Hypersensitivity/metabolism ; Hypersensitivity/physiopathology ; Inflammation/metabolism ; Receptors, Immunologic/drug effects ; Receptors, Immunologic/genetics ; Receptors, Immunologic/physiology ; Receptors, Prostaglandin/drug effects ; Receptors, Prostaglandin/genetics ; Receptors, Prostaglandin/physiology ; Th2 Cells/physiology
Chemical Substances	Receptors, Immunologic ; Receptors, Prostaglandin ; prostaglandin D2 receptor (XZF106QU24)
Language	English
Publishing date	2007-10-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1038/sj.bjp.0707488
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uf I Zs.146: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: The psychiatric inpatient physical health assessment sheet (PIPHAS): a useful tool to improve the speed, efficiency, and documentation of physical examination in new psychiatric inpatients.

Pettipher, Alexander / Ovens, Richard

BMJ quality improvement reports

2015 Volume 4, Issue 1

Abstract: There is increased morbidity and mortality among patients suffering from mental illness. This is believed to be multi-factorial. Poor access to healthcare, the stigma of mental illness, reduced clinic attendance, lifestyle factors, and side effects of ... ...

Abstract	There is increased morbidity and mortality among patients suffering from mental illness. This is believed to be multi-factorial. Poor access to healthcare, the stigma of mental illness, reduced clinic attendance, lifestyle factors, and side effects of medications are cited as possible contributing factors. It is therefore vital to perform a physical examination to identify previously undiagnosed conditions during the admission of a psychiatric inpatient. The Royal College of Psychiatrists recommends that all patients admitted to a psychiatric hospital should receive a full physical examination on admission, or within twenty-four hours of admission. A snapshot audit was carried out at Prospect Park Hospital in Reading, which highlighted that The Royal College of Psychiatrist's recommendation, along with Trust guidelines regarding physical examination were not being met, with only 78 out of 111 patients (70.3%) undergoing an examination during their admission. In addition to this, examinations were often poorly documented and not covering all examination domains. A psychiatric inpatient physical health assessment sheet (PIPHAS) was designed and introduced, providing a quick and standardised approach to the documentation of a physical examination. After the intervention was put into practice, its impact was assessed by performing a retrospective review of the admission clerking notes of the next 100 admissions to Prospect Park Hospital. Following the introduction of the PIPHAS form there was an increase in the number of patients undergoing physical examination on admission to hospital (75 out of 100 patients, 75%). There was also an increase in the thorough documentation of all examination domains (e.g. respiratory examination) for patients that had a completed PIPHAS form scanned within their medical records. This quality improvement project demonstrates that the PIPHAS form is a useful tool to improve the speed, efficiency, and documentation of a thorough physical examination in new psychiatric inpatients.
Language	English
Publishing date	2015-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2677829-4
ISSN	2050-1315
ISSN	2050-1315
DOI	10.1136/bmjquality.u206294.w2558
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A Pilot Study of Heart Rate Variability Synchrony as a Marker of Intraoperative Surgical Teamwork and Its Correlation to the Length of Procedure.

Powezka, Katarzyna / Pettipher, Allan / Hemakom, Apit / Adjei, Tricia / Normahani, Pasha / Mandic, Danilo P / Jaffer, Usman

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 22

Abstract: ... correlated with: FS (p = 0.043; R = 0.358) and intraoperative STAI score of the whole team (p = 0.007; R = 0 ...

Abstract	Objective: Quality of intraoperative teamwork may have a direct impact on patient outcomes. Heart rate variability (HRV) synchrony may be useful for objective assessment of team cohesion and good teamwork. The primary aim of this study was to investigate the feasibility of using HRV synchrony in surgical teams. Secondary aims were to investigate the association of HRV synchrony with length of procedure (LOP), complications, number of intraoperative glitches and length of stay (LOS). We also investigated the correlation between HRV synchrony and team familiarity, pre- and intraoperative stress levels (STAI questionnaire), NOTECHS score and experience of team members. Methods: Ear, nose and throat (ENT) and vascular surgeons (consultant and registrar team members) were recruited into the study. Baseline demographics including level of team members’ experience were gathered before each procedure. For each procedure, continuous electrocardiogram (ECG) recording was performed and questionnaires regarding pre- and intraoperative stress levels and non-technical skills (NOTECHS) scores were collected for each team member. An independent observer documented the time of each intraoperative glitch. Statistical analysis was conducted using stepwise multiple linear regression. Results: Four HRV synchrony metrics which may be markers of efficient surgical collaboration were identified from the data: 1. number of HRV synchronies per hour of procedure, 2. number of HRV synchrony trends per hour of procedure, 3. length of HRV synchrony trends per hour of procedure, 4. area under the HRV synchrony trend curve per hour of procedure. LOP was inversely correlated with number of HRV synchrony trends per hour of procedure (p < 0.0001), area under HRV synchrony trend curve per hour of procedure (p = 0.001), length of HRV synchrony trends per hour of procedure (p = 0.002) and number of HRV synchronies per hour of procedure (p < 0.0001). LOP was positively correlated with: FS (p = 0.043; R = 0.358) and intraoperative STAI score of the whole team (p = 0.007; R = 0.493). Conclusions: HRV synchrony metrics within operating teams may be used as an objective marker to quantify surgical teamwork. We have shown that LOP is shorter when the intraoperative surgical teams’ HRV is more synchronised.
MeSH term(s)	Humans ; Heart Rate ; Pilot Projects
Language	English
Publishing date	2022-11-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22228998
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A prospective study of anti-tumor necrosis factor therapy in South African rheumatoid arthritis patients.

Pettipher, Clive / Rudolph, Riana / Musenge, Eustasius / Tikly, Mohammed

International journal of rheumatic diseases

2016 Volume 19, Issue 6, Page(s) 594–599

Abstract: Objective: To quantify primary and secondary anti-tumour necrosis factor inadequate response (aTNF-IR) and intolerance in South Africans with rheumatoid arthritis (RA) over 1 year.: Methods: Rheumatologists from nine independent private practices ... ...

Abstract	Objective: To quantify primary and secondary anti-tumour necrosis factor inadequate response (aTNF-IR) and intolerance in South Africans with rheumatoid arthritis (RA) over 1 year. Methods: Rheumatologists from nine independent private practices monitored RA patients commencing on aTNF therapy (incident cases) or already on aTNF therapy (prevalent cases). Observations at baseline and quarterly intervals recorded discontinuation of therapy for either lack of response or adverse effects. Results: Of the 98 patients screened, 86 were eligible to participate. Mean time from onset of symptoms of RA to start of aTNF treatment was 9.7 years (range: 0.5-32 years). Only 58 (67.4%) continued on aTNF therapy at 12 months, including five judged to have an aTNF-IR. Overall 12 patients had a secondary aTNF-IR with seven discontinuing for this reason. Seven patients discontinued due to adverse events, four due to funding problems and 10 were lost to follow-up. Infections were the most common adverse events, but only two stopped treatment as a result. No cases of active tuberculosis (TB) were recorded, despite nine patients having a positive tuberculin skin test and one, a past history of pulmonary TB. Conclusions: Almost a third of patients discontinued aTNF therapy over the 1-year period, with infections and inadequate response to treatment being the main reasons for discontinuation. The study highlights the need for biologics with alternative modes of action for patients with moderate to severe RA in South Africa.
MeSH term(s)	Adult ; Aged ; Antirheumatic Agents/adverse effects ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/immunology ; Drug Resistance ; Female ; Humans ; Immunocompromised Host ; Incidence ; Male ; Middle Aged ; Opportunistic Infections/epidemiology ; Opportunistic Infections/immunology ; Prevalence ; Private Sector ; Prospective Studies ; South Africa/epidemiology ; Time Factors ; Treatment Outcome ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/immunology
Chemical Substances	Antirheumatic Agents ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2016-06
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.12299
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6098: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.

Pettipher, Roy / Whittaker, Mark

Journal of medicinal chemistry

2012 Volume 55, Issue 7, Page(s) 2915–2931

MeSH term(s)	Acetates/chemistry ; Acetates/pharmacology ; Acetates/therapeutic use ; Animals ; Asthma/drug therapy ; Asthma/metabolism ; Aza Compounds/chemistry ; Aza Compounds/pharmacology ; Aza Compounds/therapeutic use ; Carbazoles/chemistry ; Carbazoles/pharmacology ; Carbazoles/therapeutic use ; Clinical Trials as Topic ; Humans ; Indoleacetic Acids/chemistry ; Indoleacetic Acids/pharmacology ; Indoleacetic Acids/therapeutic use ; Pyrazoles/chemistry ; Pyrazoles/therapeutic use ; Pyrimidines/chemistry ; Pyrimidines/therapeutic use ; Pyrroles/chemistry ; Pyrroles/pharmacology ; Pyrroles/therapeutic use ; Receptors, Immunologic/antagonists & inhibitors ; Receptors, Immunologic/metabolism ; Receptors, Prostaglandin/antagonists & inhibitors ; Receptors, Prostaglandin/metabolism ; Rhinitis, Allergic, Perennial/drug therapy ; Rhinitis, Allergic, Perennial/immunology ; Rhinitis, Allergic, Perennial/metabolism ; Rhinitis, Allergic, Seasonal/drug therapy ; Rhinitis, Allergic, Seasonal/immunology ; Rhinitis, Allergic, Seasonal/metabolism ; Sulfonamides/chemistry ; Sulfonamides/pharmacology ; Sulfonamides/therapeutic use ; Th2 Cells/metabolism ; Thiazoles/chemistry ; Thiazoles/therapeutic use
Chemical Substances	Acetates ; Aza Compounds ; Carbazoles ; Indoleacetic Acids ; Pyrazoles ; Pyrimidines ; Pyrroles ; Receptors, Immunologic ; Receptors, Prostaglandin ; Sulfonamides ; Thiazoles ; prostaglandin D2 receptor ; thienopyrrole ; ramatroban (P1ALI72U6C)
Language	English
Publishing date	2012-04-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/jm2013997
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book: Mechanisms and models in rheumatoid arthritis

Henderson, Brian / Edwards, Jonathan C. W. / Pettipher, E. R.

1995

Author's details	B. Henderson ; J. C. W. Edwards and E. R. Pettipher
Keywords	Arthritis, Rheumatoid / pathology ; Arthritis, Rheumatoid / immunology ; Disease Models, Animal ; Rheumatoide Arthritis
Subject	Arthritis rheumatica ; Chronische Polyarthritis ; Chronisch-entzündlicher Gelenkrheumatismus ; Entzündlicher Gelenkrheumatismus ; PCP ; Polyarthritis rheumatica acuta ; Primär chronische Polyarthritis ; Progrediente chronische Polyarthritis ; Rheumatische Arthritis ; Rheumatische Gelenkerkrankung
Language	English
Size	XIV, 548 S. : Ill., graph. Darst.
Publisher	Acad. Press
Publishing place	London u.a.
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT006661533
ISBN	0-12-340440-1 ; 978-0-12-340440-4
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
1995 A 2925	order for loan	Magazin

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Antagonists of the prostaglandin D2 receptor CRTH2.

Pettipher, Roy / Hansel, Trevor T

Drug news & perspectives

2008 Volume 21, Issue 6, Page(s) 317–322

Abstract: Prostaglandin D(2) (PGD(2)) is produced by mast cells, Th2 lymphocytes and dendritic cells and causes activation of Th2 lymphocytes, eosinophils and basophils through a high-affinity interaction with the G protein-coupled receptor chemoattractant ... ...

Abstract	Prostaglandin D(2) (PGD(2)) is produced by mast cells, Th2 lymphocytes and dendritic cells and causes activation of Th2 lymphocytes, eosinophils and basophils through a high-affinity interaction with the G protein-coupled receptor chemoattractant homologous receptor expressed on Th2 cells (CRTH2, also known as DP(2)). Activation of CRTH2 induces chemotaxis of Th2 lymphocytes and eosinophils and has the unusual property of promoting cytokine production by Th2 lymphocytes in the absence of allergen or co-stimulation. The ability of supernatants from immunologically activated mast cells to activate Th2 cells and eosinophils is mediated by CRTH2. This receptor also plays an important role in amplifying allergic responses through paracrine activation of Th2 cells. Pharmacological blockade or genetic ablation of CRTH2 is associated with a reduction in airways inflammation and reduced levels of mucus, Th2 cytokines and immunoglobulin E. The central role played by CRTH2 in mediating these effects suggests that antagonism of this receptor is an attractive approach to the treatment of chronic allergic disease.
MeSH term(s)	Aminoquinolines/pharmacology ; Animals ; Anti-Allergic Agents/pharmacology ; Asthma/drug therapy ; Asthma/immunology ; Basophils/drug effects ; Basophils/immunology ; Carbazoles/pharmacology ; Dendritic Cells/drug effects ; Dendritic Cells/immunology ; Disease Models, Animal ; Eosinophils/drug effects ; Eosinophils/immunology ; Humans ; Hypersensitivity/drug therapy ; Hypersensitivity/immunology ; Indoleacetic Acids/pharmacology ; Mast Cells/drug effects ; Mast Cells/immunology ; Prostaglandin D2/metabolism ; Receptors, Immunologic/antagonists & inhibitors ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism ; Receptors, Prostaglandin/antagonists & inhibitors ; Receptors, Prostaglandin/genetics ; Receptors, Prostaglandin/metabolism ; Signal Transduction/drug effects ; Sulfonamides/pharmacology ; Th2 Cells/drug effects ; Th2 Cells/immunology
Chemical Substances	Aminoquinolines ; Anti-Allergic Agents ; Carbazoles ; Indoleacetic Acids ; Receptors, Immunologic ; Receptors, Prostaglandin ; Sulfonamides ; prostaglandin D2 receptor ; ramatroban (P1ALI72U6C) ; Prostaglandin D2 (RXY07S6CZ2)
Language	English
Publishing date	2008-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	885125-6
ISSN	2013-0139 ; 0214-0934
ISSN (online)	2013-0139
ISSN	0214-0934
DOI	10.1358/dnp.2008.21.6.1246831
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2393: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on Th2 cells mediates cytokine production by Th2 lymphocytes in response to activated mast cells.

Xue, L / Barrow, A / Pettipher, R

Clinical and experimental immunology

2009 Volume 156, Issue 1, Page(s) 126–133

Abstract: The mechanisms by which immunologically activated mast cells stimulate the production of proinflammatory cytokines by T helper type 2 (Th2) lymphocytes were investigated in a human cell culture system. Supernatants collected from cord blood-derived mast ... ...

Abstract	The mechanisms by which immunologically activated mast cells stimulate the production of proinflammatory cytokines by T helper type 2 (Th2) lymphocytes were investigated in a human cell culture system. Supernatants collected from cord blood-derived mast cells after treatment with immunoglobulin E (IgE)/anti-IgE contained an activity that stimulated the production of interleukin (IL)-4, IL-5 and IL-13 (both mRNA and protein) by Th2 lymphocytes. This activity was not detected in supernatants from unactivated mast cells and its production was inhibited by treatment of activated mast cells with the cyclo-oxygenase inhibitor diclofenac. The concentration of diclofenac used inhibited completely the production of prostaglandin D(2) (PGD(2)) but did not inhibit the release of histamine or leukotriene C(4). The effect of supernatants from activated mast cells was mimicked by exogenous PGD(2) at concentrations similar to those detected in the cultures of activated mast cells, and addition of exogenous PGD(2) to supernatants from diclofenac-treated mast cells restored their ability to stimulate Th2 cytokine production. The ability of the mast cell supernatants to stimulate production of Th2 cytokines was not affected by addition of diclofenac to the Th2 cells directly, indicating that the production, but not the action, of the factor was sensitive to diclofenac treatment. Inhibition of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) abolished the effect of the mast cell supernatants on Th2 cytokine production. These data indicate that mast cells have the ability to stimulate Th2 cells to elaborate cytokines independently of T cell receptor activation or co-stimulation and this response is mediated by PGD(2) acting upon CRTH2 expressed by Th2 cells.
MeSH term(s)	Cells, Cultured ; Culture Media, Conditioned ; Cytokines/biosynthesis ; Cytokines/genetics ; Gene Expression Regulation/immunology ; Humans ; Mast Cells/immunology ; Prostaglandin D2/immunology ; Prostaglandin D2/metabolism ; RNA, Messenger/analysis ; Receptors, Immunologic/immunology ; Receptors, Immunologic/metabolism ; Receptors, Prostaglandin/immunology ; Receptors, Prostaglandin/metabolism ; Th2 Cells/immunology
Chemical Substances	Culture Media, Conditioned ; Cytokines ; RNA, Messenger ; Receptors, Immunologic ; Receptors, Prostaglandin ; Prostaglandin D2 (RXY07S6CZ2) ; prostaglandin D2 receptor (XZF106QU24)
Language	English
Publishing date	2009-02-11
Publishing country	England
Document type	Journal Article
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1111/j.1365-2249.2008.03871.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 337: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway.

Xue, Luzheng / Barrow, Anna / Pettipher, Roy

Journal of immunology (Baltimore, Md. : 1950)

2009 Volume 182, Issue 12, Page(s) 7580–7586

Abstract: It is now well established that interaction of PGD(2) with chemoattractant receptor- homologous molecule expressed on Th2 cells (CRTH2) promotes chemotaxis and proinflammatory cytokine production by Th2 lymphocytes. In this study we show a novel function ...

Abstract	It is now well established that interaction of PGD(2) with chemoattractant receptor- homologous molecule expressed on Th2 cells (CRTH2) promotes chemotaxis and proinflammatory cytokine production by Th2 lymphocytes. In this study we show a novel function of CRTH2 in mediating an inhibitory effect of PGD(2) on the apoptosis of human Th2 cells induced by cytokine deprivation. This effect was mimicked by the selective CRTH2 agonist 13,14-dihydro-15-keto-PGD(2), inhibited by the CRTH2 antagonists ramatroban and TM30089, and not observed in CRTH2-negative T cells. D prostanoid receptor 1 (DP(1)) or the thromboxane-like prostanoid (TP) receptor did not play a role in mediating the effects of PGD(2) on the apoptosis of Th2 cells because neither the DP(1) antagonist BW868C nor the TP antagonist SQ29548 had any effect on the antiapoptotic effect of PGD(2). Apoptosis of Th2 cells induced by Fas ligation was not suppressed by treatment with PGD(2), illustrating that activation of CRTH2 only inhibits apoptosis induced by cytokine deprivation. Treatment with PGD(2) induced phosphorylation of Akt and BAD, prevented release of cytochrome c from mitochondria, and suppressed cleavage of caspase-3 and poly(ADP-ribose) polymerase in Th2 cells deprived of IL-2. The PI3K inhibitor LY294002 blocked the effect of PGD(2) both on the signaling events and on the apoptotic death of Th2 cells. These data suggest that in addition to promoting the recruitment and activation of Th2 cells, PGD(2) may also impede the resolution of allergic inflammation through inhibiting apoptosis of Th2 cells.
MeSH term(s)	Apoptosis/drug effects ; Apoptosis/immunology ; Cells, Cultured ; Enzyme Activation ; Humans ; Interleukin-2/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Prostaglandin D2/pharmacology ; Receptors, Immunologic/metabolism ; Receptors, Prostaglandin/metabolism ; Signal Transduction ; Th2 Cells/cytology ; Th2 Cells/drug effects ; Th2 Cells/immunology ; Th2 Cells/metabolism ; fas Receptor/metabolism
Chemical Substances	Interleukin-2 ; Receptors, Immunologic ; Receptors, Prostaglandin ; fas Receptor ; prostaglandin D2 receptor ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Prostaglandin D2 (RXY07S6CZ2)
Language	English
Publishing date	2009-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.0804090
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito