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  1. Article: Generalized pustular psoriasis successfully treated with spesolimab: A case report.

    Brigenti, Noemi / Gisondi, Paolo / Bellinato, Francesco / Girolomoni, Giampiero

    SAGE open medical case reports

    2024  Volume 12, Page(s) 2050313X241235451

    Abstract: Generalized pustular psoriasis is defined as a primary, sterile, macroscopically visible pustular eruption on non-acral skin, which can occur with or without systemic inflammation and/or psoriasis vulgaris, and can either be relapsing or be persistent, ... ...

    Abstract Generalized pustular psoriasis is defined as a primary, sterile, macroscopically visible pustular eruption on non-acral skin, which can occur with or without systemic inflammation and/or psoriasis vulgaris, and can either be relapsing or be persistent, according to the European Rare and Severe Psoriasis Expert Network. The treatment of generalized pustular psoriasis may be challenging. We describe a 48-year-old woman with a 15-year history of severe generalized pustular psoriasis and plaque psoriasis resistant to multiple courses of treatments with conventional and biological agents who had a rapid, complete and durable (up to 12 months) clinical remission with spesolimab, an anti-interleukin-36 receptor antagonist monoclonal antibody recently approved for the treatment of generalized pustular psoriasis flares.
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X241235451
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  2. Article ; Online: Corymbose Syphilis.

    Gisondi, Paolo / Bellinato, Francesco

    Sexually transmitted diseases

    2022  Volume 49, Issue 7, Page(s) e85–e86

    MeSH term(s) Humans ; Syphilis/diagnosis ; Syphilis, Cutaneous
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 435191-5
    ISSN 1537-4521 ; 0148-5717
    ISSN (online) 1537-4521
    ISSN 0148-5717
    DOI 10.1097/OLQ.0000000000001630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1217: Show issues Location:
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  3. Article ; Online: Scurvy as Presenting Sign of Anorexia Nervosa.

    Gisondi, Paolo / Bellinato, Francesco

    Journal of cutaneous medicine and surgery

    2022  Volume 26, Issue 6, Page(s) 645

    MeSH term(s) Humans ; Scurvy/complications ; Scurvy/diagnosis ; Anorexia Nervosa/complications
    Language English
    Publishing date 2022-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/12034754221100193
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    Zs.A 4987: Show issues Location:
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  4. Article ; Online: Psoriasis: talking points from recent clinical trials.

    Chiricozzi, Andrea / Bellinato, Francesco / Romita, Paolo / Gisondi, Paolo

    Expert opinion on investigational drugs

    2022  Volume 31, Issue 12, Page(s) 1265–1267

    MeSH term(s) Humans ; Psoriasis/drug therapy ; Severity of Illness Index
    Language English
    Publishing date 2022-12-25
    Publishing country England
    Document type Editorial
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2022.2160314
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  5. Article ; Online: Eosinophilic annular erythema successfully treated with cyclosporine.

    Maurelli, Martina / Colato, Chiara / Gisondi, Paolo / Girolomoni, Giampiero

    Italian journal of dermatology and venereology

    2023  Volume 158, Issue 2, Page(s) 158–160

    MeSH term(s) Humans ; Cyclosporine/therapeutic use ; Erythema/drug therapy ; Skin Diseases, Genetic/drug therapy
    Chemical Substances Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2023-03-07
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.23.07431-5
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  6. Article ; Online: Tildrakizumab: the value of a personalized and flexible approach for treating moderate-to-severe plaque psoriasis in patients with high body weight or high disease burden.

    Dapavo, Paolo / Burlando, Martina / Guarneri, Claudio / Megna, Matteo / Narcisi, Alessandra / Talamonti, Marina / Gisondi, Paolo

    Expert opinion on biological therapy

    2024  Volume 24, Issue 3, Page(s) 133–138

    Abstract: Introduction: The introduction of biologics for the treatment of plaque psoriasis is one of the major therapeutic advances of the last decades in dermatology. The efficacy of this class of drugs can be influenced by multiple factors including obesity, ... ...

    Abstract Introduction: The introduction of biologics for the treatment of plaque psoriasis is one of the major therapeutic advances of the last decades in dermatology. The efficacy of this class of drugs can be influenced by multiple factors including obesity, being overweight, prior treatment failures, and disease severity.
    Areas covered: Most of the currently available approved biologics are limited by their lack of dosing flexibility for adapting the therapy to the complexity of real-world patients with psoriasis. Among the class of anti-interleukin-23, tildrakizumab allows a greater dosing flexibility, increasing clinical benefits of patients with high burden of the disease or body weight >90 kg.
    Expert opinion: This meta-opinion discusses the clinical data that were foundational for tildrakizumab dosage flexibility, elaborates on the definition of high burden of disease specifically linked to tildrakizumab dosage, and profiles the ideal patient that could benefit from treatment with the higher approved tildrakizumab dosage of 200 mg.
    MeSH term(s) Humans ; Antibodies, Monoclonal/therapeutic use ; Overweight/drug therapy ; Treatment Outcome ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Cost of Illness ; Severity of Illness Index ; Body Weight ; Biological Products/therapeutic use ; Antibodies, Monoclonal, Humanized
    Chemical Substances tildrakizumab (DEW6X41BEK) ; Antibodies, Monoclonal ; Biological Products ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2024.2325547
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    Zs.A 6094: Show issues Location:
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  7. Article: Recurrent cutaneous eosinophilic vasculitis characterized by annular purpuric lesions: A case report.

    Gisondi, Paolo / Geat, Davide / Colato, Chiara / Girolomoni, Giampiero

    SAGE open medical case reports

    2023  Volume 11, Page(s) 2050313X231163636

    Abstract: A 71-year-old woman presented with a persistent, intensely pruritic cutaneous eruption localized on the palmoplantar regions, lips and palate. The histological findings allowed to make the diagnosis of recurrent cutaneous eosinophilic vasculitis, a very ... ...

    Abstract A 71-year-old woman presented with a persistent, intensely pruritic cutaneous eruption localized on the palmoplantar regions, lips and palate. The histological findings allowed to make the diagnosis of recurrent cutaneous eosinophilic vasculitis, a very rare cutaneous vasculitis characterized clinically by multiple erythematous or purpuric erythematous papules or plaques or angioedema with a relapsing course in the absence of systemic involvement and histologically by a necrotizing vasculitis of the dermal small vessels with a dominant eosinophilic infiltration. The patient was treated with oral methylprednisolone and pentoxifylline which led to a rapid resolution of the cutaneous lesions.
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X231163636
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  8. Article: Advanced Glycation End Products and Psoriasis.

    Maurelli, Martina / Gisondi, Paolo / Girolomoni, Giampiero

    Vaccines

    2023  Volume 11, Issue 3

    Abstract: Advanced glycation end products (AGEs) are biologically active compounds formed physiologically throughout a sequence of chemical reactions, to generate highly oxidant-reactive aldehydes that combine covalently to proteins. They accumulate slowly in ... ...

    Abstract Advanced glycation end products (AGEs) are biologically active compounds formed physiologically throughout a sequence of chemical reactions, to generate highly oxidant-reactive aldehydes that combine covalently to proteins. They accumulate slowly in tissues during ageing but also in metabolic and selected inflammatory disorders. Accumulation of AGEs occurs more rapidly and intensely in the skin and serum of patients with type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and non-alcoholic fatty liver disease and also in the skin of patients with psoriasis. All of the above conditions are intimately associated with psoriasis. Interaction of AGEs with their receptors (RAGEs) stimulates cellular signaling with the formation of reactive oxygen species and activation of nuclear factor kappa light chain enhancer of activated B (NF-kB), which is a key regulator in the expression of inflammatory mediators and the production of oxidative stress. Thus, AGEs may play an interesting pathogenic role in the intersection of inflammatory and metabolic diseases, may represent a biomarker of inflammation and a potential target for novel therapeutic strategies. This is a narrative review with the objective to summarize current evidence on the role of AGEs in psoriasis.
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11030617
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  9. Article ; Online: Comparative dermoscopy assessment of nevus-associated versus de novo in situ melanoma.

    Bellinato, Francesco / Moar, Agata / Rosina, Paolo / Gisondi, Paolo / Girolomoni, Giampiero

    European journal of dermatology : EJD

    2023  Volume 33, Issue 2, Page(s) 121–125

    Abstract: Background: Dermoscopic features differentiating in situ nevus-associated melanoma (NAM) versus in situ de novo melanoma (DNM) are inconclusive.: Objectives: The aim of the study was to investigate the dermoscopic features associated with in situ NAM ...

    Abstract Background: Dermoscopic features differentiating in situ nevus-associated melanoma (NAM) versus in situ de novo melanoma (DNM) are inconclusive.
    Objectives: The aim of the study was to investigate the dermoscopic features associated with in situ NAM versus DNM.
    Materials & methods: This was a retrospective observational study. All consecutive in situ melanomas diagnosed in adult patients were retrieved and stratified as NAM vs DNM, and clinical and dermoscopic data were compared between the two.
    Results: A total of 183 patients with in situ melanoma were collected, of whom 98 (54%) were male with a mean age of 64±14 years. For 129 patients, standardized dermoscopic images were collected (51 for NAM and 78 for de novo MM). The most common dermoscopic features were an atypical pigment network (85%), atypical globules (63%) and regression (42%). No significant differences were found except for regression, which was detected in 54.9% NAM vs 33.3% DNM (p=0.016). Multivariate logistic regression confirmed the association between dermoscopic regression and NAM (OR=2.34, 95% CI: 1.15-4.91).
    Conclusion: Currently, the use of dermoscopy to determine whether a melanoma is associated with a nevus is unreliable, however, the presence of regression adjacent to atypical lesions may raise suspicion of in situ NAM.
    MeSH term(s) Adult ; Humans ; Male ; Middle Aged ; Aged ; Female ; Dermoscopy ; Nevus, Pigmented/diagnostic imaging ; Nevus/diagnostic imaging ; Melanoma/diagnostic imaging ; Skin Neoplasms/diagnostic imaging
    Language English
    Publishing date 2023-07-11
    Publishing country France
    Document type Observational Study ; Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2023.4454
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    Zs.A 3484: Show issues Location:
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  10. Article ; Online: Cost per responder of adalimumab biosimilars versus methotrexate in patients with psoriasis: a real-life experience.

    Maurelli, Martina / Girolomoni, Giampiero / Gisondi, Paolo

    The Journal of dermatological treatment

    2023  Volume 34, Issue 1, Page(s) 2218504

    Abstract: Background: Pharmacoeconomic studies examining the cost-effectiveness of adalimumab biosimilars versus methotrexate in real-life settings are limited.: Objectives: To assess the cost per responder from the perspective of the National Health System of ...

    Abstract Background: Pharmacoeconomic studies examining the cost-effectiveness of adalimumab biosimilars versus methotrexate in real-life settings are limited.
    Objectives: To assess the cost per responder from the perspective of the National Health System of adalimumab biosimilars versus methotrexate for psoriasis treatment in a real-life setting.
    Methods: A cost-per responder analysis comparing adalimumab biosimilars MSB11022 (Idacio®) and ABP 501 (Amgevita) versus subcutaneous methotrexate was performed. The incremental cost per responder was calculated by multiplying the cost of treatment (including the discounts, as published in the framework agreement of the Veneto region) and the number needed to treat each therapy. The clinical efficacy measures were defined as being on treatment (i.e., retention rate) at weeks 24 and 52.
    Results: A total of 712 adult patients with moderate-to-severe chronic plaque psoriasis consecutively admitted to the outpatient clinic from January 2021 to December 2022 were included; 160 were treated with ABP 501 (Amgevita), 250 with MSB11022 (Idacio) and 302 with methotrexate. The retention rates of Amgevita, Idacio and methotrexate at week 24 were 86%, 90% and 78%, and 81%, 82% and 63% at week 52, respectively. The cost per responder at week 24 was €674 for Amgevita, €366 for Idacio and €264 for methotrexate, respectively; at week 52, was €1430 for Amgevita
    Conclusions: The real-life cost-effectiveness of biosimilar drugs is largely influenced by discount rates. The week 52 cost-effectiveness of Idacio is comparable to subcutaneous methotrexate. The lowering of the cost of biosimilar drugs makes them a more accessible therapeutic option and they also can be introduced earlier in the treatment of moderate-to-severe psoriasis.
    MeSH term(s) Adult ; Humans ; Methotrexate/therapeutic use ; Adalimumab ; Biosimilar Pharmaceuticals/therapeutic use ; Psoriasis/drug therapy ; Treatment Outcome
    Chemical Substances Methotrexate (YL5FZ2Y5U1) ; Adalimumab (FYS6T7F842) ; Biosimilar Pharmaceuticals
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036299-x
    ISSN 1471-1753 ; 0954-6634
    ISSN (online) 1471-1753
    ISSN 0954-6634
    DOI 10.1080/09546634.2023.2218504
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