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Article: Lung cancer screening by volume computed tomography: thriving to high performance.

Schillebeeckx, Eline / Lamote, Kevin

2022 Volume 17, Issue 4, Page(s) 210063

Abstract: Low-dose volume CT screening for lung cancer leads to a significant decrease in lung-cancer-related mortality. However, optimisation of the post-screening protocol will be crucial for optimal healthcare. ...

Abstract	Low-dose volume CT screening for lung cancer leads to a significant decrease in lung-cancer-related mortality. However, optimisation of the post-screening protocol will be crucial for optimal healthcare.
Language	English
Publishing date	2022-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2562899-9
ISSN	2073-4735 ; 1810-6838
ISSN (online)	2073-4735
ISSN	1810-6838
DOI	10.1183/20734735.0063-2021
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Article ; Online: Where the nose is going to help the eye: Sniffing lung cancer.

Lamote, Kevin / Van den Heuvel, Michel M

Lung cancer (Amsterdam, Netherlands)

2021 Volume 154, Page(s) 195–196

MeSH term(s)	Biomarkers ; Humans ; Lung Neoplasms ; Nose ; Respiratory System
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-02-10
Publishing country	Ireland
Document type	Editorial ; Comment
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2021.02.003
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Zs.A 2135: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Management of incidental nodules in lung cancer screening: ready for prime-time?

Kanellakis, Nikolaos I / Lamote, Kevin

Breathe (Sheffield, England)

2019 Volume 15, Issue 4, Page(s) 346–349

Abstract: Current clinical management of lung nodule patients is inefficient and therefore causes patient misclassification, which increases healthcare expenses. A precise and robust lung nodule classifier could minimise healthcare costs and discomfort for ... ...

Abstract	Current clinical management of lung nodule patients is inefficient and therefore causes patient misclassification, which increases healthcare expenses. A precise and robust lung nodule classifier could minimise healthcare costs and discomfort for patients.
Language	English
Publishing date	2019-11-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2562899-9
ISSN	2073-4735 ; 1810-6838
ISSN (online)	2073-4735
ISSN	1810-6838
DOI	10.1183/20734735.0247-2019
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Article ; Online: Clinical utility of diagnostic biomarkers in malignant pleural mesothelioma: a systematic review and meta-analysis.

Schillebeeckx, Eline / van Meerbeeck, Jan P / Lamote, Kevin

European respiratory review : an official journal of the European Respiratory Society

2021 Volume 30, Issue 162

Abstract: Malignant pleural mesothelioma (MPM) is characterised by late-stage diagnosis and poor prognosis. Currently, no screening tool is advocated and diagnosis is based on invasive techniques, which are not well tolerated. Non-invasive diagnostic biomarkers ... ...

Abstract	Malignant pleural mesothelioma (MPM) is characterised by late-stage diagnosis and poor prognosis. Currently, no screening tool is advocated and diagnosis is based on invasive techniques, which are not well tolerated. Non-invasive diagnostic biomarkers have shown potential and could have a huge clinical benefit. However, despite extensive research, there is no consensus yet on their clinical use, with many articles reporting contradicting results, limiting their clinical implementation. The aim of this systematic review is therefore to explore the different semi- and non-invasive diagnostic markers in several human matrices and identify those that might clinically be relevant. A total of 100 articles were selected through Web of Science and PubMed, with 56 articles included in the quantitative analysis. Although many studies have reported on the diagnostic accuracy of MPM biomarkers such as serum mesothelin and high-mobility group box protein 1 and plasma fibulin-3, none have resulted in a validated test for early detection. Future research should focus on external validation, combinations into biomarker panels, the inclusion of early stage MPM patients and a combination of different biomarker matrices, as well as new markers.
MeSH term(s)	Biomarkers, Tumor ; Humans ; Lung Neoplasms/diagnosis ; Mesothelioma/diagnosis ; Mesothelioma, Malignant ; Pleural Neoplasms/diagnosis ; Prognosis
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2021-11-17
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1077620-5
ISSN	1600-0617 ; 0905-9180
ISSN (online)	1600-0617
ISSN	0905-9180
DOI	10.1183/16000617.0057-2021
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Article ; Online: Volatile organic compounds in human matrices as lung cancer biomarkers: a systematic review.

Janssens, Eline / van Meerbeeck, Jan P / Lamote, Kevin

Critical reviews in oncology/hematology

2020 Volume 153, Page(s) 103037

Abstract: Volatile organic compounds (VOCs) have shown potential as non-invasive breath biomarkers for lung cancer, but their unclear biological origin currently limits clinical applications. This systematic review explores headspace analysis of VOCs in patient- ... ...

Abstract	Volatile organic compounds (VOCs) have shown potential as non-invasive breath biomarkers for lung cancer, but their unclear biological origin currently limits clinical applications. This systematic review explores headspace analysis of VOCs in patient-derived body fluids and lung cancer cell lines to pinpoint lung cancer-specific VOCs and uncover their biological origin. A search was performed in the databases MEDLINE and Web of Science. Twenty-two articles were included in this systematic review. Since there is no standardised approach to analyse VOCs, a plethora of techniques and matrices/cell lines were explored, which is reflected in the various VOCs identified. However, comparing VOCs in the headspace of urine, blood and pleural effusions from patients and lung cancer cell lines showed some overlapping VOCs, indicating their potential use in lung cancer diagnosis. This review demonstrates that VOCs are promising biomarkers for lung cancer. However, due to lack of inter-matrix consensus, standardised prospective trials will have to be conducted to validate clinically relevant biomarkers.
MeSH term(s)	Biomarkers ; Biomarkers, Tumor ; Breath Tests ; Humans ; Lung Neoplasms/diagnosis ; Prospective Studies ; Volatile Organic Compounds
Chemical Substances	Biomarkers ; Biomarkers, Tumor ; Volatile Organic Compounds
Language	English
Publishing date	2020-07-01
Publishing country	Netherlands
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	605680-5
ISSN	1879-0461 ; 0737-9587 ; 1040-8428
ISSN (online)	1879-0461
ISSN	0737-9587 ; 1040-8428
DOI	10.1016/j.critrevonc.2020.103037
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Article: Headspace Volatile Organic Compound Profiling of Pleural Mesothelioma and Lung Cancer Cell Lines as Translational Bridge for Breath Research.

Janssens, Eline / Mol, Zoë / Vandermeersch, Lore / Lagniau, Sabrina / Vermaelen, Karim Y / van Meerbeeck, Jan P / Walgraeve, Christophe / Marcq, Elly / Lamote, Kevin

Frontiers in oncology

2022 Volume 12, Page(s) 851785

Abstract: Introduction: Malignant pleural mesothelioma (MPM) is a lethal cancer for which early-stage diagnosis remains a major challenge. Volatile organic compounds (VOCs) in breath proved to be potential biomarkers for MPM diagnosis, but translational studies ... ...

Abstract	Introduction: Malignant pleural mesothelioma (MPM) is a lethal cancer for which early-stage diagnosis remains a major challenge. Volatile organic compounds (VOCs) in breath proved to be potential biomarkers for MPM diagnosis, but translational studies are needed to elucidate which VOCs originate from the tumor itself and thus are specifically related to MPM cell metabolism. Methods: An Results: VOC profiles were identified capable of distinguishing MPM (subtypes) and lung cancer cells with high accuracy. Alkanes, aldehydes, ketones and alcohols represented many of the discriminating VOCs. Discrepancies with clinical findings were observed, supporting the need for studies examining breath and tumor cells of the same patients and studying metabolization and kinetics of Conclusion: While the relationship between
Language	English
Publishing date	2022-05-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.851785
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Article ; Online: Determining the clinical utility of a breath test for screening an asbestos-exposed population for pleural mesothelioma: baseline results.

Zwijsen, Kathleen / Schillebeeckx, Eline / Janssens, Eline / Cleemput, Joris Van / Richart, Tom / Surmont, Veerle F / Nackaerts, Kristiaan / Marcq, Elly / van Meerbeeck, Jan P / Lamote, Kevin

Journal of breath research

2023 Volume 17, Issue 4

Abstract: Pleural mesothelioma (PM) is an aggressive cancer of the serosal lining of the thoracic cavity, predominantly caused by asbestos exposure. Due to nonspecific symptoms, PM is characterized by an advanced-stage diagnosis, resulting in a dismal prognosis. ... ...

Abstract	Pleural mesothelioma (PM) is an aggressive cancer of the serosal lining of the thoracic cavity, predominantly caused by asbestos exposure. Due to nonspecific symptoms, PM is characterized by an advanced-stage diagnosis, resulting in a dismal prognosis. However, early diagnosis improves patient outcome. Currently, no diagnostic biomarkers or screening tools are available. Therefore, exhaled breath was explored as this can easily be obtained and contains volatile organic compounds, which are considered biomarkers for multiple (patho)physiological processes. A breath test, which differentiates asbestos-exposed (AEx) individuals from PM patients with 87% accuracy, was developed. However, before being implemented as a screening tool, the clinical utility of the test must be determined. Occupational AEx individuals underwent annual breath tests using multicapillary column/ion mobility spectrometry. A baseline breath test was taken and their individual risk of PM was estimated. PM patients were included as controls. In total, 112 AEx individuals and six PM patients were included in the first of four screening rounds. All six PM patients were correctly classified as having mesothelioma (100% sensitivity) and out of 112 AEx individuals 78 were classified by the breath-based model as PM patients (30% specificity). Given the large false positive outcome, the breath test will be repeated annually for three more consecutive years to adhere to the 'test, re-test' principle and improve the false positivity rate. A low-dose computed tomography scan in those with two consecutive positive tests will correlate test positives with radiological findings and the possible growth of a pleural tumor. Finally, the evaluation of the clinical value of a breath-based prediction model may lead to the initiation of a screening program for early detection of PM in Aex individuals, which is currently lacking. This clinical study received approval from the Antwerp University Hospital Ethics Committee (B300201837007).
MeSH term(s)	Humans ; Breath Tests ; Mesothelioma/diagnostic imaging ; Pleural Neoplasms/diagnostic imaging ; Asbestos/adverse effects ; Body Fluids
Chemical Substances	Asbestos (1332-21-4)
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2381007-5
ISSN	1752-7163 ; 1752-7155
ISSN (online)	1752-7163
ISSN	1752-7155
DOI	10.1088/1752-7163/acf7e3
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Article ; Online: DNA Methylation as a Diagnostic Biomarker for Malignant Mesothelioma: A Systematic Review and Meta-Analysis.

Vandenhoeck, Janah / van Meerbeeck, Jan P / Fransen, Erik / Raskin, Jo / Van Camp, Guy / Op de Beeck, Ken / Lamote, Kevin

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2021 Volume 16, Issue 9, Page(s) 1461–1478

Abstract: Malignant mesothelioma is an aggressive cancer type linked to asbestos exposure. Because of several intrinsic challenges, mesothelioma is often diagnosed in an advanced disease stage. Therefore, there is a need for diagnostic biomarkers that may ... ...

Abstract	Malignant mesothelioma is an aggressive cancer type linked to asbestos exposure. Because of several intrinsic challenges, mesothelioma is often diagnosed in an advanced disease stage. Therefore, there is a need for diagnostic biomarkers that may contribute to early detection. Recently, the epigenome of tumors is being extensively investigated to identify biomarkers. This manuscript is a systematic review summarizing the state-of-the-art research investigating DNA methylation in mesothelioma. Four literature databases (PubMed, Scopus, Web of Science, MEDLINE) were systematically searched for studies investigating DNA methylation in mesothelioma up to October 16, 2020. A meta-analysis was performed per gene investigated in at least two independent studies. A total of 53 studies investigated DNA methylation of 97 genes in mesothelioma and are described in a qualitative overview. Furthermore, ten studies investigating 13 genes (APC, CDH1, CDKN2A, DAPK, ESR1, MGMT, miR-34b/c, PGR, RARβ, RASSF1, SFRP1, SFRP4, WIF1) were included in the quantitative meta-analysis. In this meta-analysis, the APC gene is significantly hypomethylated in mesothelioma, whereas CDH1, ESR1, miR-34b/c, PGR, RARβ, SFRP1, and WIF1 are significantly hypermethylated in mesothelioma. The three genes that are the most appropriate candidate biomarkers from this meta-analysis are APC, miR-34b/c, and WIF1. Nevertheless, both study number and study objects comprised in this meta-analysis are too low to draw final conclusions on their clinical applications. The elucidation of the genome-wide DNA methylation profile of mesothelioma is desirable in the future, using a standardized genome-wide methylation analysis approach. The most informative CpG sites from this signature could then form the basis of a panel of highly sensitive and specific biomarkers that can be used for the diagnosis of mesothelioma and even for the screening of an at high-risk population of asbestos-exposed individuals.
MeSH term(s)	Asbestos/adverse effects ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; DNA Methylation ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Mesothelioma/diagnosis ; Mesothelioma/genetics ; Mesothelioma, Malignant
Chemical Substances	Biomarkers, Tumor ; Asbestos (1332-21-4)
Language	English
Publishing date	2021-05-31
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1016/j.jtho.2021.05.015
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Zs.MO 652: Show issues

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Article ; Online: The scent of COVID-19: viral (semi-)volatiles as fast diagnostic biomarkers?

Lamote, Kevin / Janssens, Eline / Schillebeeckx, Eline / Lapperre, Therese S / De Winter, Benedicte Y / van Meerbeeck, Jan P

Journal of breath research

2020 Volume 14, Issue 4, Page(s) 42001

Keywords	covid19
Language	English
Publishing date	2020-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2381007-5
ISSN	1752-7163 ; 1752-7155
ISSN (online)	1752-7163
ISSN	1752-7155
DOI	10.1088/1752-7163/aba105
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Article: Volatile organic compound profiling as a potential biomarker in irritable bowel syndrome: A feasibility study.

Van Malderen, Kathleen / Hanning, Nikita / Lambrechts, Helen / Haverhals, Tine / Van Marcke, Silke / Ceuleers, Hannah / De Man, Joris G / De Winter, Benedicte Y / Lamote, Kevin / De Schepper, Heiko U

Frontiers in medicine

2022 Volume 9, Page(s) 960000

Abstract: Background: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder for which no diagnostic tools are currently available. Patients are diagnosed using the Rome IV criteria and subtyped into a diarrhea, constipation, or mixed phenotype ... ...

Abstract	Background: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder for which no diagnostic tools are currently available. Patients are diagnosed using the Rome IV criteria and subtyped into a diarrhea, constipation, or mixed phenotype based on their dominant stool pattern. A recent development in the biomarker area is the analysis of volatile organic compounds (VOCs). The aim of this study was to evaluate the potential of VOCs as diagnostic and phenotypic biomarkers for IBS in breath and fecal samples. Materials and methods: Breath and fecal samples from IBS patients and healthy asymptomatic controls (HC) were analyzed with multicapillary column/ion mobility spectrometry (MCC/IMS) and classification models were created based upon VOCs and clinical characteristics. Discussion: Irritable bowel syndrome patients were differentiated from HC by means of volatile profiling in both breath and fecal samples with area under the curve (AUCs) of respectively 0.62 and 0.80. Patient subtypes could also be differentiated from each other with AUCs ranging between 0.65 and 0.78. Furthermore, VOC models could differentiate IBS patients based on clinical characteristics like psychological comorbidities and microbiota-influencing therapies. Conclusion: This study is the first to demonstrate the use of VOC profiling with the help of MCC/IMS to differentiate IBS patients. Furthermore, the importance of clinical characteristics beside the dominant stool pattern in the differentiation of IBS patients was emphasized.
Language	English
Publishing date	2022-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.960000
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