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  1. Article ; Online: The Role of Telomerase in Breast Cancer’s Response to Therapy

    Eliza Judasz / Natalia Lisiak / Przemysław Kopczyński / Magdalena Taube / Błażej Rubiś

    International Journal of Molecular Sciences, Vol 23, Iss 12844, p

    2022  Volume 12844

    Abstract: Currently, breast cancer appears to be the most widespread cancer in the world and the most common cause of cancer deaths. This specific type of cancer affects women in both developed and developing countries. Prevention and early diagnosis are very ... ...

    Abstract Currently, breast cancer appears to be the most widespread cancer in the world and the most common cause of cancer deaths. This specific type of cancer affects women in both developed and developing countries. Prevention and early diagnosis are very important factors for good prognosis. A characteristic feature of cancer cells is the ability of unlimited cell division, which makes them immortal. Telomeres, which are shortened with each cell division in normal cells, are rebuilt in cancer cells by the enzyme telomerase, which is expressed in more than 85% of cancers (up to 100% of adenocarcinomas, including breast cancer). Telomerase may have different functions that are related to telomeres or unrelated. It has been shown that high activity of the enzyme in cancer cells is associated with poor cell sensitivity to therapies. Therefore, telomerase has become a potential target for cancer therapies. The low efficacy of therapies has resulted in the search for new combined and more effective therapeutic methods, including the involvement of telomerase inhibitors and telomerase-targeted immunotherapy.
    Keywords telomerase ; breast cancer ; therapy ; resistance ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610 ; 616
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Neoadjuvant Therapy for Melanoma: A U.S. Food and Drug Administration-Melanoma Research Alliance Public Workshop.

    Mueller, Kristen L / Theoret, Marc R / Lemery, Steven J / Amiri-Kordestani, Laleh / Ariyan, Charlotte E / Atkins, Michael B / Berry, Donald A / Blank, Christian U / DeMichele, Angela M / Forde, Patrick M / Ibrahim, Nageatte / Keegan, Patricia / Mitchell, Tara C / Moss, Rebecca A / Robert, Caroline / Sridhara, Rajeshwari / Taube, Janis M / Tetzlaff, Michael T / Wargo, Jennifer A /
    Flaherty, Keith T / Kaplan, Michael J / Topalian, Suzanne L / Ward, Ashley F / Hurlbert, Marc S

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2020  Volume 27, Issue 2, Page(s) 394–401

    Abstract: Tremendous progress has been made in treating patients with metastatic melanoma over the past decade. In that timeframe, the FDA has approved 12 novel treatments for patients with advanced unresectable melanoma, comprising both kinase-targeted therapies ... ...

    Abstract Tremendous progress has been made in treating patients with metastatic melanoma over the past decade. In that timeframe, the FDA has approved 12 novel treatments for patients with advanced unresectable melanoma, comprising both kinase-targeted therapies and immune checkpoint inhibitors (ICI), and five treatments for adjuvant (postoperative) use in patients with high-risk resectable stage III melanoma. It is not known whether outcomes can be further improved by administering kinase inhibitors or ICI in the neoadjuvant (presurgical) setting in patients with high-risk resectable melanomas. Noting research community interest in exploring the neoadjuvant approach for treating melanoma and recognizing that early harmonization of methodologies may expedite the development of therapeutics in this space, the FDA and Melanoma Research Alliance convened a public workshop on November 6, 2019, in National Harbor, Maryland, to discuss key issues. The workshop consisted of 23 faculty and included more than 250 live participants. Topics discussed included opportunities for advancing novel endpoints for regulatory purposes as well as translational research, clinical trial design considerations, and strategies for optimizing patient selection while mitigating risk.
    MeSH term(s) Biomedical Research/methods ; Biomedical Research/organization & administration ; Chemotherapy, Adjuvant/methods ; Congresses as Topic ; Humans ; Immunotherapy/methods ; Melanoma/immunology ; Melanoma/metabolism ; Melanoma/therapy ; Neoadjuvant Therapy/methods ; Skin Neoplasms/immunology ; Skin Neoplasms/metabolism ; Skin Neoplasms/therapy ; United States ; United States Food and Drug Administration
    Language English
    Publishing date 2020-11-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-20-3285
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  3. Book ; Thesis: Examining the inter- and intraspecies variability in the polyphenolic profile and in vitro antimethanogenic potential of forage species

    Verma, Supriya / Taube, Friedhelm

    (Schriftenreihe des Instituts für Pflanzenbau und Pflanzenzüchtung, Christian-Albrechts-Universität zu Kiel : Grünland und Futterbau/Ökologischer Landbau ; 112)

    2022  

    Institution Christian-Albrechts-Universität zu Kiel
    Author's details Supriya Verma
    Series title Schriftenreihe des Instituts für Pflanzenbau und Pflanzenzüchtung, Christian-Albrechts-Universität zu Kiel : Grünland und Futterbau/Ökologischer Landbau ; 112
    Schriftenreihe des Instituts für Pflanzenbau und Pflanzenzüchtung, Christian-Albrechts-Universität zu Kiel
    Schriftenreihe des Instituts für Pflanzenbau und Pflanzenzüchtung, Christian-Albrechts-Universität zu Kiel
    Collection Schriftenreihe des Instituts für Pflanzenbau und Pflanzenzüchtung, Christian-Albrechts-Universität zu Kiel
    Schriftenreihe des Instituts für Pflanzenbau und Pflanzenzüchtung, Christian-Albrechts-Universität zu Kiel
    Language English
    Size viii, 165 Seiten, Illustrationen
    Publisher Institut für Pflanzenbau und Pflanzenzüchtung, Christian-Albrechts-Universität zu Kiel
    Publishing place Kiel
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Christian-Albrechts-Universität zu Kiel, 2022
    Note Kumulatives Verfahren, enthält 4 Aufsätze aus Zeitschriften ; Elektronischer Volltext erscheint nach zwei Jahren ab Datum der Publikation der Printausgabe
    HBZ-ID HT030655297
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    Shelf markLoan statusLocation
    248/19 available for loan (reading room) Freihandmagazin (U1)

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  4. Book ; Thesis: Vorkommen und Typ des Alpha-1-Antirypsinmangels bei erstmaliger oder Wiedervorstellung von Patienten mit chronisch-obstruktiver Lungenerkrankung oder Lungenemphysem im Ambulanten Lungenzentrum der Universitätsmedizin Essen im Zeitraum Juli 2019 bis Juni 2021

    Albrecht, Sven / Taube, Christian

    2022  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Sven Albrecht ; 1. Gutachter: Herr Univ.-Prof. Dr. med. C. Taube, 2. Gutachter: Herr Prof. Dr. med. R. A. Jànosi
    Language German
    Size 60 Seiten, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2022
    HBZ-ID HT021684206
    Database Catalogue ZB MED Medicine, Health

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    2023 E 381 order for loan Magazin

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  5. Article ; Online: Editorial: The evolving landscape of asthma: recent advances and challenges.

    Khurana, Sandhya / Taube, Christian

    Current opinion in pulmonary medicine

    2024  Volume 30, Issue 3, Page(s) 266–267

    MeSH term(s) Humans ; Asthma/therapy ; Inflammation
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000001069
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  6. Article ; Online: The Anterior Thalamus Preferentially Drives Allocentric But Not Egocentric Orientation Tuning in Postrhinal Cortex.

    LaChance, Patrick A / Taube, Jeffrey S

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2024  Volume 44, Issue 10

    Abstract: Navigating a complex world requires integration of multiple spatial reference frames, including information about one's orientation in both allocentric and egocentric coordinates. Combining these two information sources can provide additional information ...

    Abstract Navigating a complex world requires integration of multiple spatial reference frames, including information about one's orientation in both allocentric and egocentric coordinates. Combining these two information sources can provide additional information about one's spatial location. Previous studies have demonstrated that both egocentric and allocentric spatial signals are reflected by the firing of neurons in the rat postrhinal cortex (POR), an area that may serve as a hub for integrating allocentric head direction (HD) cell information with egocentric information from center-bearing and center-distance cells. However, we have also demonstrated that POR HD cells are uniquely influenced by the visual properties and locations of visual landmarks, bringing into question whether the POR HD signal is truly allocentric as opposed to simply being a response to visual stimuli. To investigate this issue, we recorded HD cells from the POR of female rats while bilaterally inactivating the anterior thalamus (ATN), a region critical for expression of the "classic" HD signal in cortical areas. We found that ATN inactivation led to a significant decrease in both firing rate and tuning strength for POR HD cells, as well as a disruption in the encoding of allocentric location by conjunctive HD/egocentric cells. In contrast, POR egocentric cells without HD tuning were largely unaffected in a consistent manner by ATN inactivation. These results indicate that the POR HD signal originates at least partially from projections from the ATN and supports the view that the POR acts as a hub for the integration of egocentric and allocentric spatial representations.
    MeSH term(s) Rats ; Female ; Animals ; Anterior Thalamic Nuclei ; Orientation/physiology ; Space Perception/physiology
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.0861-23.2024
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  7. Article ; Online: Asthma – was ist neu?

    Westhölter, Dirk / Reuter, Sebastian / Taube, Christian

    Laryngo- rhino- otologie

    2024  

    Abstract: Asthma is a heterogeneous inflammatory airway disease that causes relevant morbidity across individuals of all age cohorts. In recent years, advances in the understanding of asthma pathophysiology have led to the development of treatments tailored to ... ...

    Title translation Advances in the management of asthma.
    Abstract Asthma is a heterogeneous inflammatory airway disease that causes relevant morbidity across individuals of all age cohorts. In recent years, advances in the understanding of asthma pathophysiology have led to the development of treatments tailored to specific pheno- and endotypes of the disease. This has significantly changed asthma management, especially for patients with severe disease. These new treatment options offer individuals with asthma access to personalized and disease-modifying therapies. The present paper is a comprehensive overview of recent clinical studies and of German and international guideline updates on asthma management.
    Language German
    Publishing date 2024-02-08
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0340-1588 ; 0935-8943
    ISSN (online) 1438-8685
    ISSN 0340-1588 ; 0935-8943
    DOI 10.1055/a-2249-2207
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  8. Article ; Online: Microbes little helpers and suppliers for therapeutic asthma approaches.

    Reuter, Sebastian / Raspe, Jonas / Taube, Christian

    Respiratory research

    2024  Volume 25, Issue 1, Page(s) 29

    Abstract: Bronchial asthma is a prevalent and increasingly chronic inflammatory lung disease affecting over 300 million people globally. Initially considered an allergic disorder driven by mast cells and eosinophils, asthma is now recognized as a complex syndrome ... ...

    Abstract Bronchial asthma is a prevalent and increasingly chronic inflammatory lung disease affecting over 300 million people globally. Initially considered an allergic disorder driven by mast cells and eosinophils, asthma is now recognized as a complex syndrome with various clinical phenotypes and immunological endotypes. These encompass type 2 inflammatory endotypes characterized by interleukin (IL)-4, IL-5, and IL-13 dominance, alongside others featuring mixed or non-eosinophilic inflammation. Therapeutic success varies significantly based on asthma phenotypes, with inhaled corticosteroids and beta-2 agonists effective for milder forms, but limited in severe cases. Novel antibody-based therapies have shown promise, primarily for severe allergic and type 2-high asthma. To address this gap, novel treatment strategies are essential for better control of asthma pathology, prevention, and exacerbation reduction. One promising approach involves stimulating endogenous anti-inflammatory responses through regulatory T cells (Tregs). Tregs play a vital role in maintaining immune homeostasis, preventing autoimmunity, and mitigating excessive inflammation after pathogenic encounters. Tregs have demonstrated their ability to control both type 2-high and type 2-low inflammation in murine models and dampen human cell-dependent allergic airway inflammation. Furthermore, microbes, typically associated with disease development, have shown immune-dampening properties that could be harnessed for therapeutic benefits. Both commensal microbiota and pathogenic microbes have demonstrated potential in bacterial-host interactions for therapeutic purposes. This review explores microbe-associated approaches as potential treatments for inflammatory diseases, shedding light on current and future therapeutics.
    MeSH term(s) Humans ; Animals ; Mice ; Asthma/drug therapy ; Lung ; Hypersensitivity ; Eosinophils ; Inflammation
    Language English
    Publishing date 2024-01-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-023-02660-7
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  9. Article ; Online: Data-Rich Spatial Profiling of Cancer Tissue: Astronomy Informs Pathology.

    Szalay, Alexander S / Taube, Janis M

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2022  Volume 28, Issue 16, Page(s) 3417–3424

    Abstract: Astronomy was among the first disciplines to embrace Big Data and use it to characterize spatial relationships between stars and galaxies. Today, medicine, in particular pathology, has similar needs with regard to characterizing the spatial relationships ...

    Abstract Astronomy was among the first disciplines to embrace Big Data and use it to characterize spatial relationships between stars and galaxies. Today, medicine, in particular pathology, has similar needs with regard to characterizing the spatial relationships between cells, with an emphasis on understanding the organization of the tumor microenvironment. In this article, we chronicle the emergence of data-intensive science through the development of the Sloan Digital Sky Survey and describe how analysis patterns and approaches similarly apply to multiplex immunofluorescence (mIF) pathology image exploration. The lessons learned from astronomy are detailed, and the new AstroPath platform that capitalizes on these learnings is described. AstroPath is being used to generate and display tumor-immune maps that can be used for mIF immuno-oncology biomarker development. The development of AstroPath as an open resource for visualizing and analyzing large-scale spatially resolved mIF datasets is underway, akin to how publicly available maps of the sky have been used by astronomers and citizen scientists alike. Associated technical, academic, and funding considerations, as well as extended future development for inclusion of spatial transcriptomics and application of artificial intelligence, are also addressed.
    MeSH term(s) Artificial Intelligence ; Astronomy/methods ; Fluorescent Antibody Technique ; Humans ; Neoplasms/diagnosis ; Neoplasms/genetics ; Tumor Microenvironment
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-19-3748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reply to Laurens and Angelaki: A model-based reassessment of the three-dimensional tuning of head direction cells in rats.

    Taube, Jeffrey S

    Journal of neurophysiology

    2019  Volume 122, Issue 3, Page(s) 1288–1289

    MeSH term(s) Animals ; Head ; Models, Neurological ; Movement ; Rats
    Language English
    Publishing date 2019-09-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80161-6
    ISSN 1522-1598 ; 0022-3077
    ISSN (online) 1522-1598
    ISSN 0022-3077
    DOI 10.1152/jn.00525.2019
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