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  1. Book: Henry's clinical diagnosis and management by laboratory methods

    Henry, John Bernard / McPherson, Richard A. / Pincus, Matthew R.

    2022  

    Abstract: The current edition continues the tradition of partnership between laboratory examinations and the formulation and confirmation of clinical diagnoses followed by monitoring of body functions, therapeutic drug levels, other results of medical treatments, ...

    Title variant Clinical diagnosis and management by laboratory methods
    Author's details Richard A McPherson, Matthew R Pincus
    Abstract "The current edition continues the tradition of partnership between laboratory examinations and the formulation and confirmation of clinical diagnoses followed by monitoring of body functions, therapeutic drug levels, other results of medical treatments, and risk assessment for disease. Covers the organization, purposes, and practices of analysis, interpretation of results, and management of the clinical laboratory from quality control through informatics and finances. Presents laboratory examinations according to organ systems and their disorders. Some of the most commonly ordered laboratory tests are directed at the evaluation of renal function, water, electrolytes, metabolic intermediates and nitrogenous wastes, and acid-base balance, all of which are critically important for monitoring acutely ill patients and in the management of patients with kidney and pulmonary disorder. Provide a clear and useful account of laboratory tests that generate the solid scientific information upon which medical decisions are based"--
    Keywords Clinical Laboratory Services ; Clinical Laboratory Techniques
    Language English
    Size xviii, 1663 Seiten, Illustrationen
    Edition 24. edition
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    Accompanying material Zugang zu enhanced digital version über Code
    HBZ-ID HT021075508
    ISBN 978-0-323-67320-4 ; 0-323-67320-1
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Approaches to nonlinear curve fitting in laboratory medicine.

    McPherson, Peter A C

    Laboratory medicine

    2023  Volume 55, Issue 2, Page(s) 111–116

    Abstract: Nonlinear curve fitting is an important process in laboratory medicine, particularly with the increased use of highly sensitive antibody-based assays. Although the process is often automated in commercially available software, it is important that ... ...

    Abstract Nonlinear curve fitting is an important process in laboratory medicine, particularly with the increased use of highly sensitive antibody-based assays. Although the process is often automated in commercially available software, it is important that clinical scientists and physicians recognize the limitations of the various approaches used and are able to select the most appropriate model. This article summarizes the key nonlinear functions and demonstrates their application to common laboratory data. Following this, a basic overview of the statistical comparison of models is presented and then a discussion of important algorithms used in nonlinear curve fitting. An accompanying Microsoft Excel workbook is available that can be used to explore the content of this article.
    MeSH term(s) Humans ; Software ; Algorithms
    Language English
    Publishing date 2023-07-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 391758-7
    ISSN 1943-7730 ; 0007-5027
    ISSN (online) 1943-7730
    ISSN 0007-5027
    DOI 10.1093/labmed/lmad069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Structures of additional crystal forms of Satellite tobacco mosaic virus grown from a variety of salts.

    McPherson, Alexander

    Acta crystallographica. Section F, Structural biology communications

    2021  Volume 77, Issue Pt 12, Page(s) 473–483

    Abstract: The structures of new crystal forms of Satellite tobacco mosaic virus (STMV) are described. These belong to space groups I2, ... ...

    Abstract The structures of new crystal forms of Satellite tobacco mosaic virus (STMV) are described. These belong to space groups I2, P2
    MeSH term(s) Capsid ; Crystallography, X-Ray ; Salts/analysis ; Tobacco mosaic satellite virus/chemistry
    Chemical Substances Salts
    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Journal Article
    ISSN 2053-230X
    ISSN (online) 2053-230X
    DOI 10.1107/S2053230X21011547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A quick glance at noteworthy articles for May 2021.

    McPherson, Amy

    American journal of botany

    2021  Volume 108, Issue 5, Page(s) 727–728

    Language English
    Publishing date 2021-05-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2935-x
    ISSN 1537-2197 ; 0002-9122
    ISSN (online) 1537-2197
    ISSN 0002-9122
    DOI 10.1002/ajb2.1663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A medical need for chemistry.

    McPherson, Peter A C

    Nature reviews. Chemistry

    2022  Volume 6, Issue 5, Page(s) 297–298

    Language English
    Publishing date 2022-10-13
    Publishing country England
    Document type Journal Article
    ISSN 2397-3358
    ISSN (online) 2397-3358
    DOI 10.1038/s41570-022-00371-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Paradoxical Hypercholesterolemia in an Otherwise Healthy Adult Man.

    Mcpherson, Peter A

    Laboratory medicine

    2019  Volume 51, Issue 2, Page(s) 217–220

    Abstract: Hypercholesterolemia is characterized by serum cholesterol levels greater than 5 mmol per L. However, the distribution of cholesterol among lipoprotein classes has a significant bearing on diagnosis: high-low-density lipoprotein (LDL) cholesterol ... ...

    Abstract Hypercholesterolemia is characterized by serum cholesterol levels greater than 5 mmol per L. However, the distribution of cholesterol among lipoprotein classes has a significant bearing on diagnosis: high-low-density lipoprotein (LDL) cholesterol suggests familial hypercholesterolemia, whereas high-high-density lipoprotein (HDL) cholesterol is associated with hyperalphalipoproteinemia. On routine screening, a 23-year-old man presented with a total cholesterol level of 7.6 mmol per L but was subsequently found to have an HDL cholesterol level of 5.6 mmol per L. The clinical picture was confounded by his use of red yeast rice extract, a popular health supplement with hypolipidemic effects. In this case individual, the use of red yeast rice extract caused a hyperlipidemic state, ostensibly through downregulation of cholesteryl ester transfer protein. This case emphasizes the extended role of laboratory medicine in complex cases of hyperlipidemia.
    MeSH term(s) Adult ; Cholesterol Ester Transfer Proteins/antagonists & inhibitors ; Cholesterol, HDL/blood ; Dietary Supplements/adverse effects ; Feeding Behavior ; Humans ; Hypercholesterolemia/diagnosis ; Hypercholesterolemia/pathology ; Male ; Oryza ; Young Adult
    Chemical Substances Cholesterol Ester Transfer Proteins ; Cholesterol, HDL
    Language English
    Publishing date 2019-08-14
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 391758-7
    ISSN 1943-7730 ; 0007-5027
    ISSN (online) 1943-7730
    ISSN 0007-5027
    DOI 10.1093/labmed/lmz036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The quantum mechanics of skincare: A context for the biochemistry curriculum.

    McPherson, Peter A C / Alphonso, Lynsey / Johnston, Ben M

    Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology

    2024  

    Abstract: Designing a relevant and engaging curriculum for biochemistry undergraduates can be challenging for topics which are at the periphery of the subject. We have used the framework of context-based learning as a means of assessing understanding of quantum ... ...

    Abstract Designing a relevant and engaging curriculum for biochemistry undergraduates can be challenging for topics which are at the periphery of the subject. We have used the framework of context-based learning as a means of assessing understanding of quantum theory in a group of students in their junior year. Our context, the role of retinol in skincare, provides a basis for the simple application of quantum mechanical principles to a biological context in an adaptation of the polyene in a box concept. As part of the learner journey, they gain experience of practical computational chemistry, which provided an in silico alternative to traditional laboratory work during the SARS-CoV-19 pandemic. Student feedback was overwhelmingly positive, and this approach is now firmly embedded in the undergraduate curriculum.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2039717-3
    ISSN 1539-3429 ; 1470-8175
    ISSN (online) 1539-3429
    ISSN 1470-8175
    DOI 10.1002/bmb.21827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Qualitative Study of the Psychological Morbidity in Paediatric Survivors of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

    Phillips, Chris / Russell, Emily / McNiven, Abigail / McPherson, Tess

    The British journal of dermatology

    2024  

    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljae154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Toward Personalized Orthopedic Care: Validation of a Smart Knee Brace.

    McPherson, Annah / McDaid, Andrew J / Ward, Sarah

    Digital biomarkers

    2024  Volume 8, Issue 1, Page(s) 75–82

    Abstract: Introduction: Wearable technology offers a promising solution to advance current rehabilitation strategies for post-operative orthopedic care. The aim of this study was to determine the level of agreement and concurrent validity of a smart knee brace ... ...

    Abstract Introduction: Wearable technology offers a promising solution to advance current rehabilitation strategies for post-operative orthopedic care. The aim of this study was to determine the level of agreement and concurrent validity of a smart knee brace compared to the gold standard measurement system GAITRite
    Methods: Thirty-four healthy participants were fitted with the smart knee brace (Digital Knee
    Results: At a comfortable walking speed, stride time was moderately valid (ICC
    Conclusion: The Digital Knee
    Language English
    Publishing date 2024-04-23
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2504-110X
    ISSN (online) 2504-110X
    DOI 10.1159/000538487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Binding of benzoic acid and anions within the cupin domains of the vicilin protein canavalin from jack bean (Canavalia ensiformis): Crystal structures.

    McPherson, Alexander

    Biochemical and biophysical research communications

    2020  Volume 524, Issue 1, Page(s) 268–271

    Abstract: X-ray intensities extending to 1.4 Å resolution were collected on the ... ...

    Abstract X-ray intensities extending to 1.4 Å resolution were collected on the P6
    MeSH term(s) Anions ; Benzoic Acid/metabolism ; Canavalia/metabolism ; Crystallography, X-Ray ; Hydrogen Bonding ; Ligands ; Peptides/metabolism ; Protein Domains ; Seed Storage Proteins/chemistry ; Seed Storage Proteins/metabolism
    Chemical Substances Anions ; Ligands ; Peptides ; Seed Storage Proteins ; Benzoic Acid (8SKN0B0MIM) ; vicilin protein, plant (9067-60-1)
    Language English
    Publishing date 2020-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2020.01.101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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