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  1. Book: Breathborne biomarkers and the human volatilome

    Davis, Cristina E. / Beauchamp, Jonathan / Pleil, Joachim D.

    2020  

    Author's details edited by Jonathan Beauchamp, Cristina Davis, Joachim Pleil
    Language English
    Size xlv, 675 Seiten, Illustrationen, Diagramme
    Edition Second edition
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT020483882
    ISBN 978-0-12-819967-1 ; 0-12-819967-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 942 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Tenth anniversary special issue of the Journal of Breath Research: looking forward.

    Pleil, Joachim D

    Journal of breath research

    2018  Volume 12, Issue 1, Page(s) 10201

    Language English
    Publishing date 2018-01-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7163/aa9eac
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rationale for developing tunable laser spectroscopy (TLS) technology for high resolution real-time carbon dioxide monitoring (capnography) in human breath.

    Pleil, Joachim D / Christensen, Lance E

    Journal of breath research

    2021  Volume 15, Issue 4

    Abstract: Real-time monitoring of exhaled carbon dioxide ( ... ...

    Abstract Real-time monitoring of exhaled carbon dioxide (CO
    MeSH term(s) Breath Tests ; Capnography ; Carbon Dioxide ; Humans ; Lasers ; Monitoring, Physiologic ; Spectrum Analysis ; Technology
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2021-09-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7163/ac2723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cellular respiration: replicating in vivo systems biology for in vitro exploration of human exposome, microbiome, and disease pathogenesis biomarkers.

    Pleil, Joachim D

    Journal of breath research

    2016  Volume 10, Issue 1, Page(s) 10201

    Language English
    Publishing date 2016-03-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7155/10/1/010201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Centralized resource for chemicals from the human volatilome in an interactive open-sourced database.

    Pleil, Joachim D / Williams, Antony

    Journal of breath research

    2019  Volume 13, Issue 4, Page(s) 40201

    Language English
    Publishing date 2019-08-15
    Publishing country England
    Document type Editorial
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7163/ab2fa2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparing biomarker measurements to a normal range: when to use standard error of the mean (SEM) or standard deviation (SD) confidence intervals tests.

    Pleil, Joachim D

    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

    2016  Volume 21, Issue 3, Page(s) 195–199

    Abstract: This commentary is the second of a series outlining one specific concept in interpreting biomarkers data. In the first, an observational method was presented for assessing the distribution of measurements before making parametric calculations. Here, the ... ...

    Abstract This commentary is the second of a series outlining one specific concept in interpreting biomarkers data. In the first, an observational method was presented for assessing the distribution of measurements before making parametric calculations. Here, the discussion revolves around the next step, the choice of using standard error of the mean or the calculated standard deviation to compare or predict measurement results.
    MeSH term(s) Biomarkers ; Confidence Intervals ; Humans ; Reference Values ; Sample Size ; Statistics as Topic
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016
    Publishing country England
    Document type Journal Article
    ZDB-ID 1324372-x
    ISSN 1366-5804 ; 1354-750X
    ISSN (online) 1366-5804
    ISSN 1354-750X
    DOI 10.3109/1354750X.2015.1134666
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4864: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: QQ-plots for assessing distributions of biomarker measurements and generating defensible summary statistics.

    Pleil, Joachim D

    Journal of breath research

    2016  Volume 10, Issue 3, Page(s) 35001

    Abstract: One of the main uses of biomarker measurements is to compare different populations to each other and to assess risk in comparison to established parameters. This is most often done using summary statistics such as central tendency, variance components, ... ...

    Abstract One of the main uses of biomarker measurements is to compare different populations to each other and to assess risk in comparison to established parameters. This is most often done using summary statistics such as central tendency, variance components, confidence intervals, exceedance levels and percentiles. Such comparisons are only valid if the underlying assumptions of distribution are correct. This article discusses methodology for interpreting and evaluating data distributions using quartile-quartile plots (QQ-plots) and making decisions as to how to treat outliers, interpreting effects of mixed distributions, and identifying left-censored data. The QQ-plot graph is shown to be a simple and elegant tool for visual inspection of complex data and deciding if summary statistics should be performed after log-transformation.
    MeSH term(s) Biomarkers/analysis ; Breath Tests/methods ; Female ; Humans ; Limit of Detection ; Male ; Models, Statistical ; Toluene/analysis
    Chemical Substances Biomarkers ; Toluene (3FPU23BG52)
    Language English
    Publishing date 2016--05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7155/10/3/035001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Imputing defensible values for left-censored 'below level of quantitation' (LoQ) biomarker measurements.

    Pleil, Joachim D

    Journal of breath research

    2016  Volume 10, Issue 4, Page(s) 45001

    Abstract: Biomarker datasets often include entries 'below the level of quantitation' (LoQ) wherein the instrumentation is no longer able to provide values that meet required analytical quality standards, a phenomenon referred to as 'left-censored' data. Generally, ...

    Abstract Biomarker datasets often include entries 'below the level of quantitation' (LoQ) wherein the instrumentation is no longer able to provide values that meet required analytical quality standards, a phenomenon referred to as 'left-censored' data. Generally, some form of imputation for missing values is required to allow calculating distributions and summary statistics for comparing datasets to each other. This article discusses the available options for imputing (modeling) left-censored data, presents the methods for implementing different procedures, and provides examples and guidelines using realistic data to assess relative performance. Ultimately, multiple ordered value imputation is identified as the best method; therein, the overall distribution of actual measures is used in conjunction with an estimate of relative order of the missing values to provide the most likely estimates below the LoQ.
    MeSH term(s) Biomarkers/metabolism ; Breath Tests ; Cytokines/metabolism ; Data Interpretation, Statistical ; Humans ; Limit of Detection
    Chemical Substances Biomarkers ; Cytokines
    Language English
    Publishing date 2016--18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7155/10/4/045001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Breath biomarkers in toxicology.

    Pleil, Joachim D

    Archives of toxicology

    2016  Volume 90, Issue 11, Page(s) 2669–2682

    Abstract: Exhaled breath has joined blood and urine as a valuable resource for sampling and analyzing biomarkers in human media for assessing exposure, uptake metabolism, and elimination of toxic chemicals. This article focuses current use of exhaled gas, aerosols, ...

    Abstract Exhaled breath has joined blood and urine as a valuable resource for sampling and analyzing biomarkers in human media for assessing exposure, uptake metabolism, and elimination of toxic chemicals. This article focuses current use of exhaled gas, aerosols, and vapor in human breath, the methods for collection, and ultimately the use of the resulting data. Some advantages of breath are the noninvasive and self-administered nature of collection, the essentially inexhaustible supply, and that breath sampling does not produce potentially infectious waste such as needles, wipes, bandages, and glassware. In contrast to blood and urine, breath samples can be collected on demand in rapid succession and so allow toxicokinetic observations of uptake and elimination in any time frame. Furthermore, new technologies now allow capturing condensed breath vapor directly, or just the aerosol fraction alone, to gain access to inorganic species, lung pH, proteins and protein fragments, cellular DNA, and whole microorganisms from the pulmonary microbiome. Future applications are discussed, especially the use of isotopically labeled probes, non-targeted (discovery) analysis, cellular level toxicity testing, and ultimately assessing "crowd breath" of groups of people and the relation to dose of airborne and other environmental chemicals at the population level.
    MeSH term(s) Aerosols/chemistry ; Animals ; Biomarkers/analysis ; Biomedical Research/instrumentation ; Biomedical Research/methods ; Biomedical Research/trends ; Breath Tests/instrumentation ; Breath Tests/methods ; Environmental Exposure/adverse effects ; Environmental Illness/chemically induced ; Environmental Illness/diagnosis ; Environmental Illness/metabolism ; Environmental Illness/physiopathology ; Environmental Pollutants/metabolism ; Environmental Pollutants/toxicity ; Health Priorities/trends ; Humans ; Lung/drug effects ; Lung/metabolism ; Lung/physiopathology ; Miniaturization/instrumentation ; Miniaturization/methods ; Particle Size ; Toxicokinetics ; Toxicology/instrumentation ; Toxicology/methods ; Toxicology/trends ; Volatilization
    Chemical Substances Aerosols ; Biomarkers ; Environmental Pollutants
    Language English
    Publishing date 2016-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-016-1817-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Uf I Zs.90: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Tunable laser spectroscopy for carbon dioxide capnography and water vapor sensing inside a breathing mask: application to pilot life support.

    Christensen, Lance E / Mansour, Kamjou / Pleil, Joachim D / Troy, Robert F

    Journal of breath research

    2022  Volume 16, Issue 3

    Abstract: Tunable laser spectroscopy (TLS) near 2683 nm was used to measure carbon dioxide and water vapor inside a pilot mask during jet fighter flights. Measurement frequency was 100 Hz in order to capture breathing profiles and other gas flow dynamics. Analysis ...

    Abstract Tunable laser spectroscopy (TLS) near 2683 nm was used to measure carbon dioxide and water vapor inside a pilot mask during jet fighter flights. Measurement frequency was 100 Hz in order to capture breathing profiles and other gas flow dynamics. Analysis of the full inhalation and exhalation breathing cycle allowed precise monitoring of breathing performance and interaction of the pilot with the life-support system. Measurements revealed dynamic phenomena pertaining to mechanical gas flow and pilot respiration that may be used to understand gas delivery stresses imposed upon the pilot and pilot physiology during flight. Typically, such measurements are made with non-dispersive infrared instrumentation for only carbon dioxide with intrinsic challenges regarding time and optical resolution. The TLS approach is a major advance because the sensor is placed directly into the mask improving its time response and enabling use of water vapor measurements that are less impacted from memory effects. This article presents the implementation of TLS and shows highly time-resolved pilot breathing data for high-performance aircraft tests.
    MeSH term(s) Breath Tests ; Capnography/methods ; Carbon Dioxide ; Humans ; Lasers ; Respiration ; Spectrum Analysis ; Steam
    Chemical Substances Steam ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2022-06-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7163/ac740e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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