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Article ; Online: Triptolide mitigates the inhibition of osteogenesis induced by TNF-α in human periodontal ligament stem cells via the p-IκBα/NF-κB signaling pathway: an in-vitro study.

Chen, Hao / Zhang, Lina / Du, Simeng / Yang, Daiwei / Cui, Xiaobin / Zhao, Huadong / Zhang, Jun

BMC complementary medicine and therapies

2024 Volume 24, Issue 1, Page(s) 113

Abstract: Background: Triptolide is a widely utilized natural anti-inflammatory drug in clinical practice. Aim of this study was to evaluate effects of triptolide on hPDLSCs osteogenesis in an inflammatory setting and to investigate underlying mechanisms.: ... ...

Abstract	Background: Triptolide is a widely utilized natural anti-inflammatory drug in clinical practice. Aim of this study was to evaluate effects of triptolide on hPDLSCs osteogenesis in an inflammatory setting and to investigate underlying mechanisms. Methods: Using the tissue block method to obtain hPDLSCs from extracted premolar or third molar. Flow cytometry, osteogenic and adipogenic induction were carried out in order to characterise the features of the cells acquired. hPDLSC proliferative activity was assessed by CCK-8 assay to determine the effect of TNF-α and/or triptolide. The impact of triptolide on the osteogenic differentiation of hPDLSCs was investigated by ALP staining and quantification. Osteogenesis-associated genes and proteins expression level were assessed through PCR and Western blotting assay. Finally, BAY-117,082 was used to study the NF-κB pathway. Results: In the group treated with TNF-α, there was an elevation in inflammation levels while osteogenic ability and the expression of both osteogenesis-associated genes and proteins decreased. In the group co-treated with TNF-α and triptolide, inflammation levels were reduced and osteogenic ability as well as the expression of both osteogenesis-associated genes and proteins were enhanced. At the end of the experiment, both triptolide and BAY-117,082 exerted similar inhibitory effects on the NF-κB pathway. Conclusion: The osteogenic inhibition of hPDLSCs by TNF-α can be alleviated through triptolide, with the involvement of the p-IκBα/NF-κB pathway in this mechanism.
MeSH term(s)	Humans ; NF-kappa B ; Tumor Necrosis Factor-alpha ; Osteogenesis ; NF-KappaB Inhibitor alpha ; Periodontal Ligament ; Signal Transduction ; Stem Cells ; Inflammation ; Diterpenes ; Epoxy Compounds ; Phenanthrenes
Chemical Substances	NF-kappa B ; Tumor Necrosis Factor-alpha ; triptolide (19ALD1S53J) ; NF-KappaB Inhibitor alpha (139874-52-5) ; Diterpenes ; Epoxy Compounds ; Phenanthrenes
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-024-04408-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: High expression of

Luo, Xue / Chen, Xinghong / Chen, Song / Gao, Qingjun / Yang, Huifang / Zhao, Daiwei

Gland surgery

2022 Volume 11, Issue 2, Page(s) 412–425

Abstract: Background: Seizure-related 6 homolog (mouse)-like 2 (: Methods: In this article ,we searched for the : Results: The article illustrated that a large number of cancers had a higher expression of : Conclusions: ... ...

Abstract	Background: Seizure-related 6 homolog (mouse)-like 2 ( Methods: In this article ,we searched for the Results: The article illustrated that a large number of cancers had a higher expression of Conclusions: SEZ6L2
Language	English
Publishing date	2022-02-28
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	3016969-0
ISSN	2227-8575 ; 2227-684X
ISSN (online)	2227-8575
ISSN	2227-684X
DOI	10.21037/gs-22-37
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Learning Capacity

Chen, Daiwei / Chang, Weikai / Chaudhari, Pratik

A Measure of the Effective Dimensionality of a Model

2023

Abstract: We exploit a formal correspondence between thermodynamics and inference, where the number of samples can be thought of as the inverse temperature, to define a "learning capacity'' which is a measure of the effective dimensionality of a model. We show ... ...

Abstract	We exploit a formal correspondence between thermodynamics and inference, where the number of samples can be thought of as the inverse temperature, to define a "learning capacity'' which is a measure of the effective dimensionality of a model. We show that the learning capacity is a tiny fraction of the number of parameters for many deep networks trained on typical datasets, depends upon the number of samples used for training, and is numerically consistent with notions of capacity obtained from the PAC-Bayesian framework. The test error as a function of the learning capacity does not exhibit double descent. We show that the learning capacity of a model saturates at very small and very large sample sizes; this provides guidelines, as to whether one should procure more data or whether one should search for new architectures, to improve performance. We show how the learning capacity can be used to understand the effective dimensionality, even for non-parametric models such as random forests and $k$-nearest neighbor classifiers.
Keywords	Computer Science - Machine Learning ; Computer Science - Information Theory
Subject code	006
Publishing date	2023-05-26
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Load forecasting analysis for regional and industry power systems-based on ARIMA model and LSTM model

Chen Jiongcheng / Qian Yuchen / Wu Daiwei / Tang Xinlei / Liu Xiangdong

E3S Web of Conferences, Vol 360, p

2022 Volume 01079

Abstract: The forecasting and analysis for the power system load profoundly affect the security of electricity for production and daily life. Based on the load data of 15- minute interval in a regional power grid in China, this paper forecasts the load of 15 - ... ...

Abstract	The forecasting and analysis for the power system load profoundly affect the security of electricity for production and daily life. Based on the load data of 15- minute interval in a regional power grid in China, this paper forecasts the load of 15 - minute interval in the next 10 days, the maximum values of daily load in the next 3 months, and the maximum and minimum values of daily load in the next 3 months for each industry in the region on the basis of the ARIMA model and the LSTM model respectively, and then compares the forecasting effects of the two models. The conclusions show that (1) The LSTM model has a higher forecasting accuracy than that of the ARIMA model in general. (2) Daily electricity load levels are higher for large industry and commerce and lower for non-general industry and general industry. (3) The sudden changes of electricity load in each industry occur mainly on holidays and days with rainy weather. And the magnitude of the sudden change in the load of large industries is the largest. Finally, innovative suggestions are made for different industries in the context of the “Double Carbon Plan”.
Keywords	load forecasting ; load abrupt change ; arima model ; lstm model ; Environmental sciences ; GE1-350
Subject code	621
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Highly fluorescent g-C

Cai, Zhuang / Chen, Jingru / Xing, Shanshan / Zheng, Daiwei / Guo, Liangqia

Journal of hazardous materials

2021 Volume 416, Page(s) 126195

Abstract: The fluorescent emission wavelengths of nanostructures derived from bulk graphitic carbon nitride were commonly lower than those of their bulk due to the quantum confinement effect, which are disadvantageous for bioimaging and sensing applications. ... ...

Abstract	The fluorescent emission wavelengths of nanostructures derived from bulk graphitic carbon nitride were commonly lower than those of their bulk due to the quantum confinement effect, which are disadvantageous for bioimaging and sensing applications. Herein, a new strategy to engineer graphitic carbon nitride nanomaterials with tunable fluorescent wavelength and intensity was proposed via thermal treatment of bulk graphitic carbon nitride at high temperature and then hydrolysis in alkali solution. Highly fluorescent g-C
Language	English
Publishing date	2021-05-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2021.126195
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Article ; Online: Characteristics of Volatile Organic Compounds Emitted from Airport Sources and Their Effects on Ozone Production.

Chen, Mubai / Li, Shiping / Yun, Long / Xu, Yongjiang / Chen, Daiwei / Lin, Chuxiong / Qiu, Zhicheng / You, Yinong / Liu, Ming / Luo, Zhenrong / Zhang, Liyun / Cheng, Chunlei / Li, Mei

Toxics

2024 Volume 12, Issue 4

Abstract: In recent years, commercial air transport has increased considerably. However, the compositions and source profiles of volatile organic compounds (VOCs) emitted from aircraft are still not clear. In this study, the characteristics of VOCs (including ... ...

Abstract	In recent years, commercial air transport has increased considerably. However, the compositions and source profiles of volatile organic compounds (VOCs) emitted from aircraft are still not clear. In this study, the characteristics of VOCs (including oxygenated VOCs (OVOCs)) emitted from airport sources were measured at Shenzhen Bao'an International Airport. The results showed that the compositions and proportions of VOC species showed significant differences as the aircraft operating state changed. OVOCs were the dominant species and accounted for 63.17%, 58.44%, and 51.60% of the total VOC mass concentration during the taxiing, approach, and take-off stages. Propionaldehyde and acetone were the main OVOCs, and dichloromethane and 1,2-dichloroethane were the main halohydrocarbons. Propane had the highest proportion among all alkanes, while toluene and benzene were the predominant aromatic hydrocarbons. Compared with the source profiles of VOCs from construction machinery, the proportions of halogenated hydrocarbons and alkanes emitted from aircraft were significantly higher, as were those of propionaldehyde and acetone. OVOCs were still the dominant VOC species in aircraft emissions, and their calculated ozone formation potential (OFP) was much higher than that of other VOC species at all stages of aircraft operations. Acetone, propionaldehyde, formaldehyde, acetaldehyde, and ethylene were the greatest contributors to ozone production. This study comprehensively measured the distribution characteristics of VOCs, and its results will aid in the construction of a source profile inventory of VOCs emitted from aircraft sources in real atmospheric environments.
Language	English
Publishing date	2024-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics12040243
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dissimilar cavitation dynamics and damage patterns produced by parallel fiber alignment to the stone surface in holmium:yttrium aluminum garnet laser lithotripsy.

Xiang, Gaoming / Li, Daiwei / Chen, Junqin / Mishra, Arpit / Sankin, Georgy / Zhao, Xuning / Tang, Yuqi / Wang, Kevin / Yao, Junjie / Zhong, Pei

Physics of fluids (Woodbury, N.Y. : 1994)

2023 Volume 35, Issue 3, Page(s) 33303

Abstract: Recent studies indicate that cavitation may play a vital role in laser lithotripsy. However, the underlying bubble dynamics and associated damage mechanisms are largely unknown. In this study, we use ultra-high-speed shadowgraph imaging, hydrophone ... ...

Abstract	Recent studies indicate that cavitation may play a vital role in laser lithotripsy. However, the underlying bubble dynamics and associated damage mechanisms are largely unknown. In this study, we use ultra-high-speed shadowgraph imaging, hydrophone measurements, three-dimensional passive cavitation mapping (3D-PCM), and phantom test to investigate the transient dynamics of vapor bubbles induced by a holmium:yttrium aluminum garnet laser and their correlation with solid damage. We vary the standoff distance (
Language	English
Publishing date	2023-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1472743-2
ISSN	1089-7666 ; 1070-6631
ISSN (online)	1089-7666
ISSN	1070-6631
DOI	10.1063/5.0139741
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Article: Heat stress reduces brown adipose tissue activity by exacerbating mitochondrial damage in type 2 diabetic mice.

Lai, Penghua / Zhang, Linlin / Qiu, Yan / Ren, Jie / Sun, Xue / Zhang, Ting / Wang, Liuyi / Cheng, Sijie / Liu, Sijia / Zhuang, Hongli / Lu, Daiwei / Zhang, Shaoliang / Liang, Huiqing / Chen, Shaodong

Journal of thermal biology

2024 Volume 119, Page(s) 103799

Abstract: Epidemiological evidence shows that diabetic patients are susceptible to high temperature weather, and brown adipose tissue (BAT) activity is closely related to type 2 diabetes (T2DM). Activation of BAT under cold stress helps improve T2DM. However, the ... ...

Abstract	Epidemiological evidence shows that diabetic patients are susceptible to high temperature weather, and brown adipose tissue (BAT) activity is closely related to type 2 diabetes (T2DM). Activation of BAT under cold stress helps improve T2DM. However, the impact of high temperature on the activity of BAT is still unclear. The study aimed to investigate the impact of heat stress on glucose and lipid metabolism in T2DM mice by influencing BAT activity. High-fat feeding and injecting streptozotocin (STZ) induced model of T2DM mice. All mice were randomly divided into three groups: a normal(N) group, a diabetes (DM) group and a heat stress diabetes (DMHS) group. The DMHS group received heat stress intervention for 3 days. Fasting blood glucose, fasting serum insulin and blood lipids were measured in all three groups. The activity of BAT was assessed by using quantitative real-time PCR (qRT-PCR), electron microscopy, and PET CT. Furthermore, the UHPLC-Q-TOF MS technique was employed to perform metabolomics analysis of BAT on both DM group and DMHS group. The results of this study indicated that heat stress aggravated the dysregulation of glucose and lipid metabolism, exacerbated mitochondrial dysfunction in BAT and reduced the activity of BAT in T2DM mice. This may be related to the abnormal accumulation of branched-chain amino acids (BCAAs) in the mitochondria of BAT.
MeSH term(s)	Humans ; Mice ; Animals ; Adipose Tissue, Brown/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Experimental/metabolism ; Glucose/metabolism ; Lipid Metabolism
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1498364-3
ISSN	1879-0992 ; 0306-4565
ISSN (online)	1879-0992
ISSN	0306-4565
DOI	10.1016/j.jtherbio.2024.103799
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Photo-crosslinking ionic conductive PVA-SbQ/FeCl3 hydrogel sensors

Bai, Huiyu / Chen, Daiwei / Zhu, Haiyan / Zhang, Shengwen / Wang, Wei / Ma, Piming / Dong, Weifu

Colloids and surfaces. 2022 Sept. 05, v. 648

2022

Abstract: Conductive hydrogels are attracting intensive attention as promising materials for versatile applications such as human motion sensors, sensory skin and soft robotics. However, traditional hydrogels with single-network always have poor mechanical ... ...

Abstract	Conductive hydrogels are attracting intensive attention as promising materials for versatile applications such as human motion sensors, sensory skin and soft robotics. However, traditional hydrogels with single-network always have poor mechanical properties, while those with double-network are difficult to be prepared and inevitable to utilize chemical crosslinking agents which are poisonous. Herein, a polyvinyl alcohol bearing styrylpyridinium group (PVA-SbQ) /FeCl₃ hydrogel sensor with unique double-crosslinked single network was prepared by UV photo-crosslinking and ionic coordination interaction. The PVA-SbQ/FeCl₃ hydrogel possessed remarkable stretchability (~858%), good tensile stress (~0.3 MPa), high ionic conductivity (0.29 S/m), fine sensitivity, and excellent water retention ability due to the photo-crosslinking, physical crosslinking and hydrogen bond interaction worked in tandem and the introduction of Fe³⁺ ions. These properties endowed the PVA-SbQ/FeCl₃ hydrogel with the potential for practical applications as flexible electronic components.
Keywords	crosslinking ; humans ; hydrogels ; hydrogen bonding ; mechanical stress ; polyvinyl alcohol
Language	English
Dates of publication	2022-0905
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500517-3
ISSN	0927-7757
ISSN	0927-7757
DOI	10.1016/j.colsurfa.2022.129205
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Optimal combination of potassium coupled with water and nitrogen for strawberry quality based on consumer-orientation

Yang, Xiaoqing / Du, Rongcheng / He, Daiwei / Li, Dayong / Chen, Jingru / Han, Xiaole / Wang, Ziqing / Zhang, Zhi

Agricultural Water Management. 2023 Sept., v. 287 p.108461-

2023

Abstract: The quality of strawberry fruits is a key factor in consumer choice. This study investigated the effect of potassium coupled with water and nitrogen on multiple strawberry fruits quality categories over two growing seasons (from August 2021 to April 2022 ...

Abstract	The quality of strawberry fruits is a key factor in consumer choice. This study investigated the effect of potassium coupled with water and nitrogen on multiple strawberry fruits quality categories over two growing seasons (from August 2021 to April 2022 and August 2022 to April 2023) in China, to aid in the determination of water and fertilizer decisions based on consumer-orientation. In particular, a composite quadratic orthogonal rotation design with three factors and five levels was adopted to characterize volume water content (W), nitrogen (N) and potassium (K). Twelve quality indicators at three harvest stages were measured respectively. The indicators related to commodity quality, flavor quality and nutritional quality of strawberry fruits were assigned weights based on consumer orientation using analytic hierarchy process. Total soluble solid was regarded as the most important quality indicator with the weight value of 0.1387, followed by single fruit weight (0.1183). All the quality indicators of strawberry fruits were systematically evaluated based on grey relational analysis, and the response model of the comprehensive quality to the combined application of W, N and K was established for each harvest stages. The response trends of consumer-oriented quality were shown as negative parabolas basically to W, N and K in all the three harvests, except a negative linear trend to W in the third harvest and an increased linear to K in the second harvest. Notably, the low level of K supply limited the quality of strawberries, regardless of the input amount of W and N. And the coded values of the optimal combinations for W, N and K were (−0.728, 0, 0.512), (−0.440, 0, 1.682) and (−1.682, 0, 0.834) for the three harvest stages, respectively. By weighting the comprehensive quality based on the corresponding yield of strawberry for the three harvest stages over the two study seasons, the optimal application interval of W, N and K for the entire growth period was determined as: 55.05–76.45%, 3.32 – 4.49 g N/plant and 4.06 – 5.47 g K₂O/plant, respectively. The results of this experiment provide a theoretical basis for water and fertilizer management, as well as the in-depth research of strawberry.
Keywords	consumer preferences ; fertilizers ; flavor ; fruit weight ; models ; nitrogen ; nutritive value ; potassium ; strawberries ; total soluble solids ; water content ; water management ; China ; Consumer-orientation ; Strawberry ; Water
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	751144-9
ISSN	1873-2283 ; 0378-3774
ISSN (online)	1873-2283
ISSN	0378-3774
DOI	10.1016/j.agwat.2023.108461
Database	NAL-Catalogue (AGRICOLA)

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