LIVIVO - Search results -

Search results

Result 1 - 10 of total 48

Search options

Article ; Online: Tissue tropisms in group A Streptococcus: what virulence factors distinguish pharyngitis from impetigo strains?

Bessen, Debra E

2016 Volume 29, Issue 3, Page(s) 295–303

Abstract: Purpose of review: Group A streptococci (GAS) are a common cause of pharyngitis and impetigo, and distinct throat strains and skin strains have been long recognized. This review aims to describe recent advances in molecular differences between throat ... ...

Abstract	Purpose of review: Group A streptococci (GAS) are a common cause of pharyngitis and impetigo, and distinct throat strains and skin strains have been long recognized. This review aims to describe recent advances in molecular differences between throat and skin strains, and the pathogenic mechanisms used by virulence factors that may distinguish between these two groups. Recent findings: Recent findings include a new typing scheme for GAS strains based on sequence clusters of genes encoding the entire surface-exposed portion of M protein; correlations between emm-based typing schemes, clinical disease and surface adhesins; covalent bond formation mediated by GAS pili and other adhesins in binding to host ligands; a key role for superantigens in oropharyngeal infection via binding major histocompatibility complex class II antigen; and migration of GAS-specific Th17 cells from the upper respiratory tract to the brain, which may be relevant to autoimmune sequelae. Summary: The gap between molecular markers of disease (correlation) and virulence mechanisms (causation) in the establishment of tissue tropisms for GAS infection currently remains wide, but the gap also continues to narrow. Whole genome sequencing combined with mutant construction and improvements in animal models for oropharyngeal infection by GAS may help pave the way for new discoveries.
MeSH term(s)	Bacterial Proteins ; Humans ; Impetigo/microbiology ; Pharyngitis/microbiology ; Streptococcal Infections/microbiology ; Streptococcus pyogenes/classification ; Streptococcus pyogenes/pathogenicity ; Viral Tropism ; Virulence Factors
Chemical Substances	Bacterial Proteins ; Virulence Factors
Language	English
Publishing date	2016-02-19
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	645085-4
ISSN	1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
ISSN (online)	1473-6527 ; 1535-3877
ISSN	0951-7375 ; 1355-834X
DOI	10.1097/QCO.0000000000000262
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2462: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Population genomics: an investigative tool for epidemics.

Bessen, Debra E

The American journal of pathology

2012 Volume 180, Issue 4, Page(s) 1358–1361

MeSH term(s)	Animals ; Female ; Humans ; Male ; Streptococcal Infections/epidemiology ; Streptococcus pyogenes/genetics
Language	English
Publishing date	2012-02-28
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2943-9
ISSN	1525-2191 ; 0002-9440
ISSN (online)	1525-2191
ISSN	0002-9440
DOI	10.1016/j.ajpath.2012.01.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ud II Zs.76: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Recombinational exchange of M-fibril and T-pilus genes generates extensive cell surface diversity in the global group A

Bessen, Debra E / Beall, Bernard W / Hayes, Andrew / Huang, Weihua / DiChiara, Jeanne M / Velusamy, Srinivasan / Tettelin, Hervé / Jolley, Keith A / Fallon, John T / Chochua, Sopio / Alobaidallah, Mosaed S A / Higgs, Charlie / Barnett, Timothy C / Steemson, John T / Proft, Thomas / Davies, Mark R

mBio

2024 , Page(s) e0069324

Abstract: Among genes present in all group A streptococci (GAS), those encoding M-fibril and T-pilus proteins display the highest levels of sequence diversity, giving rise to the two primary serological typing schemes historically used to define strain. A new ... ...

Abstract	Among genes present in all group A streptococci (GAS), those encoding M-fibril and T-pilus proteins display the highest levels of sequence diversity, giving rise to the two primary serological typing schemes historically used to define strain. A new genotyping scheme for the pilin adhesin and backbone genes is developed and, when combined with
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.00693-24
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Molecular Epidemiology, Ecology, and Evolution of Group A Streptococci.

Bessen, Debra E / Smeesters, Pierre R / Beall, Bernard W

Microbiology spectrum

2018 Volume 6, Issue 5

Abstract: The clinico-epidemiological features of diseases caused by group A streptococci (GAS) is presented through the lens of the ecology, population genetics, and evolution of the organism. The serological targets of three typing schemes (M, T, SOF) are ... ...

Abstract	The clinico-epidemiological features of diseases caused by group A streptococci (GAS) is presented through the lens of the ecology, population genetics, and evolution of the organism. The serological targets of three typing schemes (M, T, SOF) are themselves GAS cell surface proteins that have a myriad of virulence functions and a diverse array of structural forms. Horizontal gene transfer expands the GAS antigenic cell surface repertoire by generating numerous combinations of M, T, and SOF antigens. However, horizontal gene transfer of the serotype determinant genes is not unconstrained, and therein lies a genetic organization that may signify adaptations to a narrow ecological niche, such as the primary tissue reservoirs of the human host. Adaptations may be further shaped by selection pressures such as herd immunity. Understanding the molecular evolution of GAS on multiple levels-short, intermediate, and long term-sheds insight on mechanisms of host-pathogen interactions, the emergence and spread of new clones, rational vaccine design, and public health interventions.
MeSH term(s)	Ecology ; Evolution, Molecular ; Gene Transfer, Horizontal ; Host-Pathogen Interactions ; Humans ; Molecular Epidemiology ; Streptococcal Infections/epidemiology ; Streptococcal Infections/microbiology ; Streptococcus pyogenes/genetics ; Streptococcus pyogenes/pathogenicity ; Virulence
Language	English
Publishing date	2018-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	2165-0497
ISSN (online)	2165-0497
DOI	10.1128/microbiolspec.CPP3-0009-2018
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Population biology of the human restricted pathogen, Streptococcus pyogenes.

Bessen, Debra E

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2009 Volume 9, Issue 4, Page(s) 581–593

Abstract: Streptococcus pyogenes, also referred to as beta-hemolytic group A streptococci, are strictly human pathogens with a global distribution and high prevalence of infection. The organisms are characterized by high levels of genetic recombination, extensive ... ...

Abstract	Streptococcus pyogenes, also referred to as beta-hemolytic group A streptococci, are strictly human pathogens with a global distribution and high prevalence of infection. The organisms are characterized by high levels of genetic recombination, extensive strain diversity, and a narrow habitat. This review highlights many key features of the population genetics and molecular epidemiology of this biologically diverse bacterial species, with special emphasis on ecological subdivisions and tissue-specific infections, strain diversity and population dynamics in communities, selection pressures arising from the specific host immune response and antibiotic exposure, and within-host selection during the course of invasive disease.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial ; Ecology ; Evolution, Molecular ; Genetics, Population ; Humans ; Molecular Epidemiology ; Phylogeny ; Selection, Genetic ; Streptococcal Infections/classification ; Streptococcal Infections/epidemiology ; Streptococcal Infections/microbiology ; Streptococcus pyogenes/classification ; Streptococcus pyogenes/drug effects ; Streptococcus pyogenes/genetics ; Streptococcus pyogenes/pathogenicity
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2009-03-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2009.03.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5645: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The search for a genetic divide between streptococcal pathogens and commensals.

Bessen, Debra E

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2007 Volume 44, Issue 11, Page(s) 1455–1456

MeSH term(s)	Cluster Analysis ; Gene Expression Profiling ; Humans ; Oligonucleotide Array Sequence Analysis ; Phylogeny ; Streptococcus/genetics ; Streptococcus/isolation & purification ; Streptococcus/pathogenicity ; Virulence Factors/genetics
Chemical Substances	Virulence Factors
Language	English
Publishing date	2007-06-01
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1086/517533
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis.

Xie, Ouli / Morris, Jacqueline M / Hayes, Andrew J / Towers, Rebecca J / Jespersen, Magnus G / Lees, John A / Ben Zakour, Nouri L / Berking, Olga / Baines, Sarah L / Carter, Glen P / Tonkin-Hill, Gerry / Schrieber, Layla / McIntyre, Liam / Lacey, Jake A / James, Taylah B / Sriprakash, Kadaba S / Beatson, Scott A / Hasegawa, Tadao / Giffard, Phil /

Steer, Andrew C / Batzloff, Michael R / Beall, Bernard W / Pinho, Marcos D / Ramirez, Mario / Bessen, Debra E / Dougan, Gordon / Bentley, Stephen D / Walker, Mark J / Currie, Bart J / Tong, Steven Y C / McMillan, David J / Davies, Mark R

Nature communications

2024 Volume 15, Issue 1, Page(s) 2286

Abstract: Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic genomic ... ...

Abstract	Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic genomic analyses of 501 disseminated SDSE strains, we demonstrate extensive overlap between the genomes of SDSE and S. pyogenes. More than 75% of core genes are shared between the two species with one third demonstrating evidence of cross-species recombination. Twenty-five percent of mobile genetic element (MGE) clusters and 16 of 55 SDSE MGE insertion regions were shared across species. Assessing potential cross-protection from leading S. pyogenes vaccine candidates on SDSE, 12/34 preclinical vaccine antigen genes were shown to be present in >99% of isolates of both species. Relevant to possible vaccine evasion, six vaccine candidate genes demonstrated evidence of inter-species recombination. These findings demonstrate previously unappreciated levels of genomic overlap between these closely related pathogens with implications for streptococcal pathobiology, disease surveillance and prevention.
MeSH term(s)	Humans ; Streptococcus pyogenes/genetics ; Gene Flow ; Streptococcal Infections ; Vaccines ; Streptococcus
Chemical Substances	Vaccines
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46530-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Tissue tropisms in group A streptococcal infections.

Bessen, Debra E / Lizano, Sergio

Future microbiology

2010 Volume 5, Issue 4, Page(s) 623–638

Abstract: Group A Streptococcus (GAS) is a human-specific pathogen that is highly prevalent throughout the world. The vast majority of GAS infections lead to a mild disease involving the epithelial surfaces of either the throat or skin. The concept of distinct ... ...

Abstract	Group A Streptococcus (GAS) is a human-specific pathogen that is highly prevalent throughout the world. The vast majority of GAS infections lead to a mild disease involving the epithelial surfaces of either the throat or skin. The concept of distinct sets of 'throat' and 'skin' strains of GAS has long been conceived. From an ecological standpoint, the epithelium of the throat and skin are important because it is where the organism is most successful in reproducing and transmitting to new hosts. This article examines key features of the epidemiology, population biology and molecular pathogenesis that underlie the tissue site preferences for infection exhibited by GAS, with an emphasis on work from our laboratory on skin tropisms. Recombinational replacement with orthologous gene forms, following interspecies transfer, appears to be an important genetic step leading up to the exploitation of new niches by GAS.
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Proteins/physiology ; Bacterial Typing Techniques ; Epithelium/microbiology ; Genotype ; Humans ; Pharynx/microbiology ; Skin/microbiology ; Streptococcal Infections/epidemiology ; Streptococcal Infections/microbiology ; Streptococcus pyogenes/classification ; Streptococcus pyogenes/genetics ; Streptococcus pyogenes/isolation & purification ; Streptococcus pyogenes/pathogenicity ; Virulence Factors/genetics ; Virulence Factors/physiology
Chemical Substances	Bacterial Proteins ; Virulence Factors
Language	English
Publishing date	2010-03-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	1746-0921
ISSN (online)	1746-0921
DOI	10.2217/fmb.10.28
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Wiring the streptococcal network for alternative lifestyles.

Bessen, Debra E / Tengra, Farah K

The Journal of infectious diseases

2010 Volume 201, Issue 6, Page(s) 800–802

MeSH term(s)	Animals ; Antigens, Bacterial/genetics ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Proteins/biosynthesis ; Bacterial Proteins/genetics ; Carrier Proteins/genetics ; Disease Models, Animal ; Exotoxins/biosynthesis ; Exotoxins/genetics ; Histidine Kinase ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Membrane Proteins/biosynthesis ; Membrane Proteins/genetics ; Mice ; Mutation ; Streptococcal Infections/microbiology ; Streptococcus pyogenes/genetics ; Streptococcus pyogenes/pathogenicity
Chemical Substances	Antigens, Bacterial ; Bacterial Outer Membrane Proteins ; Bacterial Proteins ; Carrier Proteins ; Exotoxins ; Intracellular Signaling Peptides and Proteins ; Membrane Proteins ; SpeA protein, Streptococcus pyogenes ; erythrogenic toxin ; streptococcal M protein ; CovS protein, Streptococcus pyogenes (EC 2.7.13.1) ; Histidine Kinase (EC 2.7.13.1)
Language	English
Publishing date	2010-02-12
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1086/651020
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh II Zs.50: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 445: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Incremental Contributions of FbaA and Other Impetigo-Associated Surface Proteins to Fitness and Virulence of a Classical Group A Streptococcal Skin Strain.

Rouchon, Candace N / Ly, Anhphan T / Noto, John P / Luo, Feng / Lizano, Sergio / Bessen, Debra E

Infection and immunity

2017 Volume 85, Issue 11

Abstract: Group A streptococci (GAS) are highly prevalent human pathogens whose primary ecological niche is the superficial epithelial layers of the throat and/or skin. Many GAS strains with a strong tendency to cause pharyngitis are distinct from strains that ... ...

Abstract	Group A streptococci (GAS) are highly prevalent human pathogens whose primary ecological niche is the superficial epithelial layers of the throat and/or skin. Many GAS strains with a strong tendency to cause pharyngitis are distinct from strains that tend to cause impetigo; thus, genetic differences between them may confer host tissue-specific virulence. In this study, the FbaA surface protein gene was found to be present in most skin specialist strains but largely absent from a genetically related subset of pharyngitis isolates. In an Δ
MeSH term(s)	Animals ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Blood Cells/immunology ; Blood Cells/microbiology ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Disease Models, Animal ; Gene Expression Regulation, Bacterial ; Genetic Fitness ; Host-Pathogen Interactions ; Humans ; Impetigo/immunology ; Impetigo/microbiology ; Impetigo/pathology ; Mice ; Pharyngitis/immunology ; Pharyngitis/microbiology ; Pharyngitis/pathology ; Pharynx/immunology ; Pharynx/microbiology ; Pharynx/pathology ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Skin/immunology ; Skin/microbiology ; Skin/pathology ; Streptococcal Infections/immunology ; Streptococcal Infections/microbiology ; Streptococcal Infections/pathology ; Streptococcus pyogenes/genetics ; Streptococcus pyogenes/metabolism ; Streptococcus pyogenes/pathogenicity ; Virulence
Chemical Substances	Bacterial Proteins ; Carrier Proteins ; Fba protein, Streptococcus pyogenes ; Protein Isoforms ; plasminogen-binding protein, bacteria
Language	English
Publishing date	2017-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/IAI.00374-17
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 684: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito