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  1. Article ; Online: A szubjektív egészségi állapot és a dohányzás összefüggése rendfenntartó dolgozók körében.

    Ambrusz, Aliz / Németh, Ferenc / Borbély, Zsuzsanna / Malét-Szabó, Erika

    Orvosi hetilap

    2024  Volume 165, Issue 15, Page(s) 584–594

    Title translation Relationship between the subjective health status and smoking among police officers.
    MeSH term(s) Humans ; Police ; Diagnostic Self Evaluation ; Smoking/adverse effects ; Smoking/epidemiology
    Language Hungarian
    Publishing date 2024-04-14
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2024.33006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 301: Show issues Location:
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  2. Article: Hybrid

    Csótó, András / Nagy, Antal / Laurinyecz, Nóra / Nagy, Zóra Annamária / Németh, Csaba / Németh, Erzsébet Krisztina / Csikász-Krizsics, Anna / Rakonczás, Nándor / Fontaine, Florence / Fekete, Erzsébet / Flipphi, Michel / Karaffa, Levente / Sándor, Erzsébet

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 12

    Abstract: Grape production worldwide is increasingly threatened by grapevine trunk diseases (GTDs). No grapevine cultivar is known to be entirely resistant to GTDs, but susceptibility varies greatly. To quantify these differences, four Hungarian grape germplasm ... ...

    Abstract Grape production worldwide is increasingly threatened by grapevine trunk diseases (GTDs). No grapevine cultivar is known to be entirely resistant to GTDs, but susceptibility varies greatly. To quantify these differences, four Hungarian grape germplasm collections containing 305 different cultivars were surveyed to determine the ratios of GTDs based on symptom expression and the proportion of plant loss within all GTD symptoms. The cultivars of monophyletic
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12122328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Az obstruktív alvási apnoe főbb jellemzőinek vizsgálata.

    Molnár, Viktória / Molnár, András / Lakner, Zoltán / Kunos, László / Angyal, Emese / Németh, Fruzsina / Tamás, László

    Orvosi hetilap

    2022  Volume 163, Issue 15, Page(s) 586–592

    MeSH term(s) Cardiovascular Diseases ; Diabetes Mellitus, Type 2 ; Female ; Humans ; Hungary ; Hypoxia ; Male ; Prospective Studies ; Quality of Life ; Sleep Apnea, Obstructive/diagnosis
    Language English
    Publishing date 2022-04-10
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2022.32428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Natural and Pathological Autoantibodies Show Age-Related Changes in a Spontaneous Autoimmune Mouse (NZB) Model.

    Gál, Szonja / Gajdócsi, Erzsébet / Khanfar, Esam / Olasz, Katalin / Simon, Diána / Balogh, Péter / Berki, Tímea / Németh, Péter / Boldizsár, Ferenc

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: The natural autoantibody (natAAb) network is thought to play a role in immune regulation. These IgM antibodies react with evolutionary conserved antigens; however, they do not lead to pathological tissue destruction as opposed to pathological ... ...

    Abstract The natural autoantibody (natAAb) network is thought to play a role in immune regulation. These IgM antibodies react with evolutionary conserved antigens; however, they do not lead to pathological tissue destruction as opposed to pathological autoantibodies (pathAAb). The exact relation between the natAAbs and pathAAbs is still not completely understood; therefore, in the present study, we set out to measure nat- and pathAAb levels against three conserved antigens in a spontaneous autoimmune disease model: the NZB mouse strain which develops autoimmune hemolytic anemia (AIHA) from six months of age. There was an age dependent increase in the natAAb levels in the serum against Hsp60, Hsp70, and the mitochondrial citrate synthase until 6-9 months of age, followed by a gradual decrease. The pathological autoantibodies appeared after six months of age, which corresponded with the appearance of the autoimmune disease. The changes in nat/pathAAb levels were coupled with decreasing B1- and increasing plasma cell and memory B cell percentages. Based on this, we propose that there is a switch from natAAbs towards pathAAbs in aged NZB mice.
    MeSH term(s) Mice ; Animals ; Autoantibodies ; Anemia, Hemolytic, Autoimmune ; Autoimmune Diseases
    Chemical Substances Autoantibodies
    Language English
    Publishing date 2023-06-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24129809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Acute coronary syndrome associated cardiogenic shock in the catheterization laboratory: peripheral veno-arterial extracorporeal membrane oxygenator management and recommendations.

    Ehrenberger, Réka / Németh, Balázs T / Kulyassa, Péter / Fülöp, Gábor A / Becker, Dávid / Kiss, Boldizsár / Zima, Endre / Merkely, Béla / Édes, István F

    Frontiers in medicine

    2023  Volume 10, Page(s) 1277504

    Abstract: Cardiogenic shock (CS) in acute coronary syndrome (ACS) is a critical disease with high mortality rates requiring complex treatment to maximize patient survival chances. Emergent coronary revascularization along with circulatory support are keys to ... ...

    Abstract Cardiogenic shock (CS) in acute coronary syndrome (ACS) is a critical disease with high mortality rates requiring complex treatment to maximize patient survival chances. Emergent coronary revascularization along with circulatory support are keys to saving lives. Mechanical circulatory support may be instigated in severe, yet still reversible instances. Of these, the peripheral veno-arterial extracorporeal membrane oxygenator (pVA-ECMO) is the most widely used system for both circulatory and respiratory support. The aim of our work is to provide a review of our current understanding of the pVA-ECMO when used in the catheterization laboratory in a CS ACS setting. We detail the workings of a Shock Team: pVA-ECMO specifics, circumstances, and timing of implantations and discuss possible complications. We place emphasis on how to select the appropriate patients for potential pVA-ECMO support and what characteristics and parameters need to be assessed. A detailed, stepwise implantation algorithm indicating crucial steps is also featured for practitioners in the catheter laboratory. To provide an overall aspect of pVA-ECMO use in CS ACS we further gave pointers including relevant human resource, infrastructure, and consumables management to build an effective Shock Team to treat CS ACS via the pVA-ECMO method.
    Language English
    Publishing date 2023-11-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1277504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: DNA mismatch repair protects the genome from oxygen-induced replicative mutagenesis.

    Lózsa, Rita / Németh, Eszter / Gervai, Judit Z / Márkus, Bence G / Kollarics, Sándor / Gyüre, Zsolt / Tóth, Judit / Simon, Ferenc / Szüts, Dávid

    Nucleic acids research

    2023  Volume 51, Issue 20, Page(s) 11040–11055

    Abstract: DNA mismatch repair (MMR) corrects mismatched DNA bases arising from multiple sources including polymerase errors and base damage. By detecting spontaneous mutagenesis using whole genome sequencing of cultured MMR deficient human cell lines, we show that ...

    Abstract DNA mismatch repair (MMR) corrects mismatched DNA bases arising from multiple sources including polymerase errors and base damage. By detecting spontaneous mutagenesis using whole genome sequencing of cultured MMR deficient human cell lines, we show that a primary role of MMR is the repair of oxygen-induced mismatches. We found an approximately twofold higher mutation rate in MSH6 deficient DLD-1 cells or MHL1 deficient HCT116 cells exposed to atmospheric conditions as opposed to mild hypoxia, which correlated with oxidant levels measured using electron paramagnetic resonance spectroscopy. The oxygen-induced mutations were dominated by T to C base substitutions and single T deletions found primarily on the lagging strand. A broad sequence context preference, dependence on replication timing and a lack of transcriptional strand bias further suggested that oxygen-induced mutations arise from polymerase errors rather than oxidative base damage. We defined separate low and high oxygen-specific MMR deficiency mutation signatures common to the two cell lines and showed that the effect of oxygen is observable in MMR deficient cancer genomes, where it best correlates with the contribution of mutation signature SBS21. Our results imply that MMR corrects oxygen-induced genomic mismatches introduced by a replicative process in proliferating cells.
    MeSH term(s) Humans ; Base Pair Mismatch ; DNA Mismatch Repair ; DNA Repair ; DNA Replication ; Mutagenesis ; Mutation ; Oxygen ; Cell Line
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
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  7. Article: A Modified Ridge Splitting Technique Using Autogenous Bone Blocks-A Case Series.

    Pénzes, Dorottya / Simon, Fanni / Mijiritsky, Eitan / Németh, Orsolya / Kivovics, Márton

    Materials (Basel, Switzerland)

    2020  Volume 13, Issue 18

    Abstract: Background: Alveolar atrophy following tooth loss is a common limitation of rehabilitation with dental implant born prostheses. Ridge splitting is a well-documented surgical method to restore the width of the alveolar ridge prior to implant placement. ... ...

    Abstract Background: Alveolar atrophy following tooth loss is a common limitation of rehabilitation with dental implant born prostheses. Ridge splitting is a well-documented surgical method to restore the width of the alveolar ridge prior to implant placement. The aim of this case series is to present a novel approach to ridge expansion using only autogenous bone blocks. Methods
    Results: Upon re-entry, all sites healed uneventfully. Mean ridge width gain was 2.86 mm, range: 2.0-5.0 mm.
    Conclusions: Clinical results of our study show that the modified ridge splitting technique is a safe and predictable method to restore width of the alveolar ridge prior to implant placement.
    Language English
    Publishing date 2020-09-11
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13184036
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  8. Article ; Online: Allosteric modulators of the extracellular calcium receptor.

    Nemeth, E F

    Drug discovery today. Technologies

    2013  Volume 10, Issue 2, Page(s) e277–84

    Abstract: The extracellular calcium receptor (CaR) is a Family C G protein-coupled receptor that controls systemic Ca2+ homeostasis, largely by regulating the secretion of parathyroid hormone (PTH). Ligands that activate the CaR have been termed calcimimetics and ... ...

    Abstract The extracellular calcium receptor (CaR) is a Family C G protein-coupled receptor that controls systemic Ca2+ homeostasis, largely by regulating the secretion of parathyroid hormone (PTH). Ligands that activate the CaR have been termed calcimimetics and are classified as either Type I (agonists) or Type II (allosteric activators) and effectively inhibit the secretion of PTH. CaR antagonists have been termed calcilytics and all act allosterically to stimulate secretion of PTH. The calcimimetic cinacalcet has been approved for treating parathyroid cancer and secondary hyperparathyroidism in patients on renal replacement therapy. Cinacalcet was the first allosteric modulator of a G proteincoupled receptor to achieve regulatory approval. This review will focus on the technologies used to discover and develop allosterically acting calcimimetics and calcilytics as novel therapies for bone and mineral-related disorders.
    MeSH term(s) Allosteric Regulation ; Animals ; Bone Diseases/drug therapy ; Calcimimetic Agents/pharmacology ; Calcimimetic Agents/therapeutic use ; Disease Models, Animal ; Drug Discovery ; High-Throughput Screening Assays ; Humans ; Receptors, Calcium-Sensing/agonists ; Receptors, Calcium-Sensing/antagonists & inhibitors ; Receptors, Calcium-Sensing/metabolism
    Chemical Substances Calcimimetic Agents ; Receptors, Calcium-Sensing
    Language English
    Publishing date 2013
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1740-6749
    ISSN (online) 1740-6749
    DOI 10.1016/j.ddtec.2012.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Resting network architecture of theta oscillations reflects hyper-learning of sensorimotor information in Gilles de la Tourette syndrome.

    Takacs, Adam / Toth-Faber, Eszter / Schubert, Lina / Tárnok, Zsanett / Ghorbani, Foroogh / Trelenberg, Madita / Nemeth, Dezso / Münchau, Alexander / Beste, Christian

    Brain communications

    2024  Volume 6, Issue 2, Page(s) fcae092

    Abstract: ... propensity to learn probabilistic stimulus-response contingencies (i.e. statistical learning), the nature ...

    Abstract Gilles de la Tourette syndrome is a neurodevelopmental disorder characterized by motor and vocal tics. It is associated with enhanced processing of stimulus-response associations, including a higher propensity to learn probabilistic stimulus-response contingencies (i.e. statistical learning), the nature of which is still elusive. In this study, we investigated the hypothesis that resting-state theta network organization is a key for the understanding of superior statistical learning in these patients. We investigated the graph-theoretical network architecture of theta oscillations in adult patients with Gilles de la Tourette syndrome and healthy controls during a statistical learning task and in resting states both before and after learning. We found that patients with Gilles de la Tourette syndrome showed a higher statistical learning score than healthy controls, as well as a more optimal (small-world-like) theta network before the task. Thus, patients with Gilles de la Tourette syndrome had a superior facility to integrate and evaluate novel information as a trait-like characteristic. Additionally, the theta network architecture in Gilles de la Tourette syndrome adapted more to the statistical information during the task than in HC. We suggest that hyper-learning in patients with Gilles de la Tourette syndrome is likely a consequence of increased sensitivity to perceive and integrate sensorimotor information leveraged through theta oscillation-based resting-state dynamics. The study delineates the neural basis of a higher propensity in patients with Gilles de la Tourette syndrome to pick up statistical contingencies in their environment. Moreover, the study emphasizes pathophysiologically endowed abilities in patients with Gilles de la Tourette syndrome, which are often not taken into account in the perception of this common disorder but could play an important role in destigmatization.
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcae092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: High fat diet and PCSK9 knockout modulates lipid profile of the liver and changes the expression of lipid homeostasis related genes.

    Németh, Krisztina / Tóth, Blanka / Sarnyai, Farkas / Koncz, Anna / Lenzinger, Dorina / Kereszturi, Éva / Visnovitz, Tamás / Kestecher, Brachyahu Meir / Osteikoetxea, Xabier / Csala, Miklós / Buzás, Edit I / Tamási, Viola

    Nutrition & metabolism

    2023  Volume 20, Issue 1, Page(s) 19

    Abstract: Background: High fat diet (HFD) increases the likelihood of dyslipidemia, which can be a serious risk factor for atherosclerosis, diabetes or hepatosteatosis. Although changes in different blood lipid levels were broadly investigated, such alterations ... ...

    Abstract Background: High fat diet (HFD) increases the likelihood of dyslipidemia, which can be a serious risk factor for atherosclerosis, diabetes or hepatosteatosis. Although changes in different blood lipid levels were broadly investigated, such alterations in the liver tissue have not been studied before. The aim of the current study was to investigate the effect of HFD on hepatic triglyceride (TG), diglyceride (DG) and ceramide (CER) levels and on the expression of four key genes involved in lipid homeostasis (Pcsk9, Ldlr, Cd36 and Anxa2) in the liver. In addition, the potential role of PCSK9 in the observed changes was further investigated by using PCSK9 deficient mice.
    Methods: We used two in vivo models: mice kept on HFD for 20 weeks and PCSK9
    Results: In HFD mice, hepatic PCSK9 expression was decreased and ANXA2 expression was increased both on mRNA and protein levels, and the amount of LDLR and CD36 receptor proteins was increased. While LDLR protein level was also elevated in the livers of PCSK9
    Conclusions: Our results show that obesogenic HFD downregulates PCSK9 expression in the liver and causes alterations in the hepatic lipid accumulation, which resemble those observed in PCSK9 deficiency. These findings suggest that PCSK9-mediated modulation of LDLR and CD36 expression might contribute to the HFD-induced changes in lipid homeostasis.
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2160376-5
    ISSN 1743-7075
    ISSN 1743-7075
    DOI 10.1186/s12986-023-00738-z
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