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  1. Article: Know DBS: patient perceptions and knowledge of deep brain stimulation in Parkinson's disease.

    Salinas, Meagen / Yazdani, Umar / Oblack, Austin / McDaniels, Bradley / Ahmed, Nida / Haque, Bilal / Pouratian, Nader / Chitnis, Shilpa

    Therapeutic advances in neurological disorders

    2024  Volume 17, Page(s) 17562864241233038

    Abstract: Introduction: Deep brain stimulation (DBS) is an established therapy for Parkinson's disease (PD) that can significantly improve motor symptoms and quality of life. Despite its effectiveness, little is known about patient perceptions of DBS.: ... ...

    Abstract Introduction: Deep brain stimulation (DBS) is an established therapy for Parkinson's disease (PD) that can significantly improve motor symptoms and quality of life. Despite its effectiveness, little is known about patient perceptions of DBS.
    Objectives: To evaluate patient perceptions of DBS for PD, focusing on understanding, satisfaction, and factors influencing their outlook. This study aims to enhance patient education and counseling by identifying key determinants of patient perceptions.
    Design: A patient survey.
    Methods: We surveyed 77 PD patients who had undergone DBS at multiple centers using a comprehensive questionnaire. The questionnaire included questions on demographic information, disease history, and detailed understanding about the indications for DBS, side effects, outlook, and other common misconceptions. We summarize data using measures of central tendency and dispersion appropriate to the data type (categorical, continuous, proportional) and model relationships among variables using fractional and linear regression methods.
    Results: Participants had a median age of 66 years, were predominantly male (66%), Caucasian (90%), well-educated (79% with at least college degrees), and had a disease duration of greater than 5 years (97%). They conveyed good understanding of the signs and symptoms addressed by DBS across the motor and non-motor domains and associated side effects. Regression analysis identified age, disease duration, and education level as key determinants of patient understanding and outlook of DBS.
    Conclusion: Our study provides a detailed understanding of patient perceptions of DBS for PD, including the benefits, challenges, and misconceptions. Our findings underscore the importance of identifying the causes of disparities in patient knowledge and perceptions regarding DBS to tailor patient counseling and ensure optimal treatment outcomes.
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442245-9
    ISSN 1756-2864 ; 1756-2856
    ISSN (online) 1756-2864
    ISSN 1756-2856
    DOI 10.1177/17562864241233038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Features and roles of T helper 22 cells in immunological diseases and malignancies.

    Hossein-Khannazer, Nikoo / Zian, Zeineb / Bakkach, Joaira / Kamali, Ali N / Hosseinzadeh, Ramin / Anka, Abubakar Umar / Yazdani, Reza / Azizi, Gholamreza

    Scandinavian journal of immunology

    2021  Volume 93, Issue 5, Page(s) e13030

    Abstract: T helper 22 (Th22) cell populations are a newly identified subset of ... ...

    Abstract T helper 22 (Th22) cell populations are a newly identified subset of CD4
    MeSH term(s) Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/pathology ; Inflammation/immunology ; Inflammation/pathology ; Interleukins/immunology ; Lymphocyte Subsets/immunology ; Neoplasms/immunology ; Neoplasms/pathology ; T-Lymphocytes, Helper-Inducer/immunology ; Interleukin-22
    Chemical Substances Interleukins
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 120476-2
    ISSN 1365-3083 ; 0300-9475
    ISSN (online) 1365-3083
    ISSN 0300-9475
    DOI 10.1111/sji.13030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comparison of Globus Pallidus Interna and Subthalamic Nucleus in Deep Brain Stimulation for Parkinson Disease: An Institutional Experience and Review.

    Mirza, Shazia / Yazdani, Umar / Dewey Iii, Richard / Patel, Neepa / Dewey, Richard B / Miocinovic, Svjetlana / Chitnis, Shilpa

    Parkinson's disease

    2017  Volume 2017, Page(s) 3410820

    Abstract: Deep Brain Stimulation (DBS) has revolutionized the lives of patients of Parkinson disease, offering therapeutic options to those not benefiting entirely from medications alone. With its proven track record of outperforming the best medical management, ... ...

    Abstract Deep Brain Stimulation (DBS) has revolutionized the lives of patients of Parkinson disease, offering therapeutic options to those not benefiting entirely from medications alone. With its proven track record of outperforming the best medical management, the goal is to unlock the full potential of this therapy. Currently, the Globus Pallidus Interna (GPi) and Subthalamic Nucleus (STN) are both viable targets for DBS, and the choice of site should focus on the constellation of symptoms, both motor and nonmotor, which are key determinants to quality of life. Our article sheds light on the specific advantages and drawbacks of the two sites, highlighting the need for matching the inherent properties of a target with specific desired effects in patients. UT Southwestern Medical Center has a robust and constantly evolving DBS program and the narrative from our center provides invaluable insight into the practical realities of DBS. The ultimate decision in selecting a DBS target is complex, ideally made by a multidisciplinary team, tailored towards each patient's profile and their expectations, by drawing upon scientific evidence coupled with experience. Ongoing research is expanding our knowledge base, which should be dynamically incorporated into an institute's DBS paradigm to ensure that patients receive the optimal therapy.
    Language English
    Publishing date 2017-06-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573854-9
    ISSN 2042-0080 ; 2090-8083
    ISSN (online) 2042-0080
    ISSN 2090-8083
    DOI 10.1155/2017/3410820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Blood biomarker for Parkinson disease: peptoids.

    Yazdani, Umar / Zaman, Sayed / Hynan, Linda S / Brown, L Steven / Dewey, Richard B / Karp, David / German, Dwight C

    NPJ Parkinson's disease

    2016  Volume 2

    Abstract: Parkinson disease (PD) is the second most common neurodegenerative disease. Because dopaminergic neuronal loss begins years before motor symptoms appear, a biomarker for the early identification of the disease is critical for the study of putative ... ...

    Abstract Parkinson disease (PD) is the second most common neurodegenerative disease. Because dopaminergic neuronal loss begins years before motor symptoms appear, a biomarker for the early identification of the disease is critical for the study of putative neuroprotective therapies. Brain imaging of the nigrostriatal dopamine system has been used as a biomarker for early disease along with cerebrospinal fluid analysis of α-synuclein, but a less costly and relatively non-invasive biomarker would be optimal. We sought to identify an antibody biomarker in the blood of PD patients using a combinatorial peptoid library approach. We examined serum samples from 75 PD patients, 25
    Language English
    Publishing date 2016-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2819218-7
    ISSN 2373-8057
    ISSN 2373-8057
    DOI 10.1038/npjparkd.2016.12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The semaphorins.

    Yazdani, Umar / Terman, Jonathan R

    Genome biology

    2006  Volume 7, Issue 3, Page(s) 211

    Abstract: Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses; ...

    Abstract Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses; semaphorins are also found in nematodes and crustaceans but not in non-animals. They are grouped into eight classes on the basis of phylogenetic tree analyses and the presence of additional protein motifs. The expression of semaphorins has been described most fully in the nervous system, but they are also present in most, or perhaps all, other tissues. Functionally, semaphorins were initially characterized for their importance in the development of the nervous system and in axonal guidance. More recently, they have been found to be important for the formation and functioning of the cardiovascular, endocrine, gastrointestinal, hepatic, immune, musculoskeletal, renal, reproductive, and respiratory systems. A common theme in the mechanisms of semaphorin function is that they alter the cytoskeleton and the organization of actin filaments and the microtubule network. These effects occur primarily through binding of semaphorins to their receptors, although transmembrane semaphorins also serve as receptors themselves. The best characterized receptors for mediating semaphorin signaling are members of the neuropilin and plexin families of transmembrane proteins. Plexins, in particular, are thought to control many of the functional effects of semaphorins; the molecular mechanisms of semaphorin signaling are still poorly understood, however. Given the importance of semaphorins in a wide range of functions, including neural connectivity, angiogenesis, immunoregulation, and cancer, much remains to be learned about these proteins and their roles in pathology and human disease.
    MeSH term(s) Animals ; Cytoskeleton/physiology ; Humans ; Multigene Family ; Nerve Net/physiology ; Neurons/physiology ; Semaphorins/genetics
    Chemical Substances Semaphorins
    Language English
    Publishing date 2006
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1465-6914 ; 1465-6906
    ISSN (online) 1474-760X ; 1465-6914
    ISSN 1465-6906
    DOI 10.1186/gb-2006-7-3-211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inducible neuronal inactivation of Sim1 in adult mice causes hyperphagic obesity.

    Tolson, Kristen P / Gemelli, Terry / Meyer, Donna / Yazdani, Umar / Kozlitina, Julia / Zinn, Andrew R

    Endocrinology

    2014  Volume 155, Issue 7, Page(s) 2436–2444

    Abstract: Germline haploinsufficiency of human or mouse Sim1 is associated with hyperphagic obesity. Sim1 encodes a transcription factor required for proper formation of the paraventricular (PVN), supraoptic, and anterior periventricular hypothalamic nuclei. Sim1 ... ...

    Abstract Germline haploinsufficiency of human or mouse Sim1 is associated with hyperphagic obesity. Sim1 encodes a transcription factor required for proper formation of the paraventricular (PVN), supraoptic, and anterior periventricular hypothalamic nuclei. Sim1 expression persists in these neurons in adult mice, raising the question of whether it plays a physiologic role in regulation of energy balance. We previously showed that Sim1 heterozygous mice had normal numbers of PVN neurons that were hyporesponsive to melanocortin 4 receptor agonism and showed reduced oxytocin expression. Furthermore, conditional postnatal neuronal inactivation of Sim1 also caused hyperphagic obesity and decreased hypothalamic oxytocin expression. PVN projections to the hindbrain, where oxytocin is thought to act to modulate satiety, were anatomically intact in both Sim1 heterozygous and conditional knockout mice. These experiments provided evidence that Sim1 functions in energy balance apart from its role in hypothalamic development but did not rule out effects of Sim1 deficiency on postnatal hypothalamic maturation. To address this possibility, we used a tamoxifen-inducible, neural-specific Cre transgene to conditionally inactivate Sim1 in adult mice with mature hypothalamic circuitry. Induced Sim1 inactivation caused increased food and water intake and decreased expression of PVN neuropeptides, especially oxytocin and vasopressin, with no change in energy expenditure. Sim1 expression was not required for survival of PVN neurons. The results corroborate previous evidence that Sim1 acts physiologically as well as developmentally to regulate body weight. Inducible knockout mice provide a system for studying Sim1's physiologic function in energy balance and identifying its relevant transcriptional targets in the hypothalamus.
    MeSH term(s) Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Body Weight/drug effects ; Bone Density Conservation Agents/pharmacology ; Eating/drug effects ; Energy Metabolism/drug effects ; Female ; Homeostasis/drug effects ; Hyperphagia/metabolism ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Neurons/metabolism ; Neuropeptides/metabolism ; Obesity/metabolism ; Oxytocin/metabolism ; Paraventricular Hypothalamic Nucleus/metabolism ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Tamoxifen/pharmacology
    Chemical Substances Basic Helix-Loop-Helix Transcription Factors ; Bone Density Conservation Agents ; Neuropeptides ; Repressor Proteins ; Sim1 protein, mouse ; Tamoxifen (094ZI81Y45) ; Oxytocin (50-56-6)
    Language English
    Publishing date 2014-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/en.2013-2125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The semaphorins

    Yazdani, Umar / Jonathan R Terman

    Genome biology. 2006 Mar., v. 7, no. 3

    2006  

    Abstract: Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses; ...

    Abstract Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses; semaphorins are also found in nematodes and crustaceans but not in non-animals. They are grouped into eight classes on the basis of phylogenetic tree analyses and the presence of additional protein motifs. The expression of semaphorins has been described most fully in the nervous system, but they are also present in most, or perhaps all, other tissues. Functionally, semaphorins were initially characterized for their importance in the development of the nervous system and in axonal guidance. More recently, they have been found to be important for the formation and functioning of the cardiovascular, endocrine, gastrointestinal, hepatic, immune, musculoskeletal, renal, reproductive, and respiratory systems. A common theme in the mechanisms of semaphorin function is that they alter the cytoskeleton and the organization of actin filaments and the microtubule network. These effects occur primarily through binding of semaphorins to their receptors, although transmembrane semaphorins also serve as receptors themselves. The best characterized receptors for mediating semaphorin signaling are members of the neuropilin and plexin families of transmembrane proteins. Plexins, in particular, are thought to control many of the functional effects of semaphorins; the molecular mechanisms of semaphorin signaling are still poorly understood, however. Given the importance of semaphorins in a wide range of functions, including neural connectivity, angiogenesis, immunoregulation, and cancer, much remains to be learned about these proteins and their roles in pathology and human disease.
    Keywords angiogenesis ; Crustacea ; DNA viruses ; Drosophila ; gastrointestinal system ; human diseases ; humans ; immunomodulation ; microfilaments ; microtubules ; Nematoda ; neoplasms ; nervous system ; neurodevelopment ; phylogeny ; receptors ; transmembrane proteins
    Language English
    Dates of publication 2006-03
    Size p. 1197.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1465-6914 ; 1465-6906
    ISSN (online) 1474-760X ; 1465-6914
    ISSN 1465-6906
    DOI 10.1186/gb-2006-7-3-211
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: The glucose transporter (GLUT4) enhancer factor is required for normal wing positioning in Drosophila.

    Yazdani, Umar / Huang, Zhiyu / Terman, Jonathan R

    Genetics

    2008  Volume 178, Issue 2, Page(s) 919–929

    Abstract: Many of the transcription factors and target genes that pattern the developing adult remain unknown. In the present study, we find that an ortholog of the poorly understood transcription factor, glucose transporter (GLUT4) enhancer factor (Glut4EF, GEF) [ ...

    Abstract Many of the transcription factors and target genes that pattern the developing adult remain unknown. In the present study, we find that an ortholog of the poorly understood transcription factor, glucose transporter (GLUT4) enhancer factor (Glut4EF, GEF) [also known as the Huntington's disease gene regulatory region-binding protein (HDBP) 1], plays a critical role in specifying normal wing positioning in adult Drosophila. Glut4EF proteins are zinc-finger transcription factors named for their ability to regulate expression of GLUT4 but nothing is known of Glut4EF's in vivo physiological functions. Here, we identify a family of Glut4EF proteins that are well conserved from Drosophila to humans and find that mutations in Drosophila Glut4EF underlie the wing-positioning defects seen in stretch mutants. In addition, our results indicate that previously uncharacterized mutations in Glut4EF are present in at least 11 publicly available fly lines and on the widely used TM3 balancer chromosome. These results indicate that previous observations utilizing these common stocks may be complicated by the presence of Glut4EF mutations. For example, our results indicate that Glut4EF mutations are also present on the same chromosome as two gain-of-function mutations of the homeobox transcription factor Antennapedia (Antp) and underlie defects previously attributed to Antp. In fact, our results support a role for Glut4EF in the modulation of morphogenetic processes mediated by Antp, further highlighting the importance of Glut4EF transcription factors in patterning and morphogenesis.
    MeSH term(s) Animals ; Drosophila/anatomy & histology ; Drosophila/genetics ; Drosophila/growth & development ; Drosophila Proteins/genetics ; Enhancer Elements, Genetic ; Gene Expression Regulation, Developmental ; Glucose Transporter Type 4/genetics ; Molecular Sequence Data ; Mutation ; Phenotype ; Polymerase Chain Reaction ; Wings, Animal/anatomy & histology ; Wings, Animal/growth & development
    Chemical Substances Drosophila Proteins ; Glucose Transporter Type 4
    Language English
    Publishing date 2008-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1534/genetics.107.078030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Serum thyroid-stimulating hormone and interleukin-8 levels in boys with autism spectrum disorder.

    Singh, Sarika / Yazdani, Umar / Gadad, Bharathi / Zaman, Sayed / Hynan, Linda S / Roatch, Nichole / Schutte, Claire / Marti, C Nathan / Hewitson, Laura / German, Dwight C

    Journal of neuroinflammation

    2017  Volume 14, Issue 1, Page(s) 113

    Abstract: Background: Autism spectrum disorder (ASD) affects approximately 1 in 68 children in the USA. An ASD blood biomarker may enable early diagnosis and/or identification of new therapeutic targets. Serum samples from ASD and typically developing (TD) boys ( ... ...

    Abstract Background: Autism spectrum disorder (ASD) affects approximately 1 in 68 children in the USA. An ASD blood biomarker may enable early diagnosis and/or identification of new therapeutic targets. Serum samples from ASD and typically developing (TD) boys (n = 30/group) were screened for differences in 110 proteins using a multiplex immunoassay.
    Results: Eleven proteins were found that together could confirm ASD with modest accuracy using multiple training and test sets. Two of the 11 proteins identified here were further tested using a different detection platform and with a larger sample of ASD and TD boys. The two proteins, thyroid-stimulating hormone (TSH) and interleukin-8 (IL-8), have been previously identified as putative biomarkers for ASD. TSH levels were significantly lower in ASD boys, whereas IL-8 levels were significantly elevated. The diagnostic accuracy for ASD based upon TSH or IL-8 levels alone varied from 74 to 76%, but using both proteins together, the diagnostic accuracy increased to 82%. In addition, TSH levels were negatively correlated with the Autism Diagnostic Observation Schedule subdomain scores.
    Conclusions: These data suggest that a panel of proteins may be useful as a putative blood biomarker for ASD.
    MeSH term(s) Autism Spectrum Disorder/blood ; Child ; Child, Preschool ; Humans ; Interleukin-8/blood ; Luminescent Measurements ; Male ; ROC Curve ; Regression Analysis ; Severity of Illness Index ; Thyrotropin/blood
    Chemical Substances Interleukin-8 ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2017--02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1742-2094
    ISSN (online) 1742-2094
    DOI 10.1186/s12974-017-0888-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Search for Blood Biomarkers for Autism: Peptoids.

    Zaman, Sayed / Yazdani, Umar / Deng, Yan / Li, Wenhao / Gadad, Bharathi S / Hynan, Linda / Karp, David / Roatch, Nichole / Schutte, Claire / Nathan Marti, C / Hewitson, Laura / German, Dwight C

    Scientific reports

    2016  Volume 6, Page(s) 19164

    Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, and restricted, repetitive patterns of behavior. In order to identify individuals with ASD and initiate interventions at ...

    Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, and restricted, repetitive patterns of behavior. In order to identify individuals with ASD and initiate interventions at the earliest possible age, biomarkers for the disorder are desirable. Research findings have identified widespread changes in the immune system in children with autism, at both systemic and cellular levels. In an attempt to find candidate antibody biomarkers for ASD, highly complex libraries of peptoids (oligo-N-substituted glycines) were screened for compounds that preferentially bind IgG from boys with ASD over typically developing (TD) boys. Unexpectedly, many peptoids were identified that preferentially bound IgG from TD boys. One of these peptoids was studied further and found to bind significantly higher levels (>2-fold) of the IgG1 subtype in serum from TD boys (n = 60) compared to ASD boys (n = 74), as well as compared to older adult males (n = 53). Together these data suggest that ASD boys have reduced levels (>50%) of an IgG1 antibody, which resembles the level found normally with advanced age. In this discovery study, the ASD1 peptoid was 66% accurate in predicting ASD.
    MeSH term(s) Autism Spectrum Disorder/blood ; Autism Spectrum Disorder/immunology ; Autoantibodies/blood ; Autoantibodies/immunology ; Autoantibodies/metabolism ; Biomarkers ; Child ; Child, Preschool ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Immunoglobulin G/metabolism ; Male ; Peptoids/metabolism ; Protein Binding
    Chemical Substances Autoantibodies ; Biomarkers ; Immunoglobulin G ; Peptoids
    Language English
    Publishing date 2016-01-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep19164
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