Article ; Online: The signal peptide as a new target for drug design.
Bioorganic & medicinal chemistry letters
2020 Volume 30, Issue 10, Page(s) 127115
Abstract: Many current and potential drug targets are membrane-bound or secreted proteins that are expressed and transported via the Sec61 secretory pathway. They are targeted to translocon channels across the membrane of the endoplasmic reticulum (ER) by signal ... ...
| Abstract | Many current and potential drug targets are membrane-bound or secreted proteins that are expressed and transported via the Sec61 secretory pathway. They are targeted to translocon channels across the membrane of the endoplasmic reticulum (ER) by signal peptides (SPs), which are temporary structures on the N-termini of their nascent chains. During translation, such proteins enter the lumen and membrane of the ER by a process known as co-translational translocation. Small molecules have been found that interfere with this process, decreasing protein expression by recognizing the unique structures of the SPs of particular proteins. The SP may thus become a validated target for designing drugs for numerous disorders, including certain hereditary diseases. |
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| MeSH term(s) | Adaptor Proteins, Vesicular Transport/genetics ; Adaptor Proteins, Vesicular Transport/metabolism ; CD4 Antigens/genetics ; CD4 Antigens/metabolism ; Drug Design ; Endoplasmic Reticulum/metabolism ; Humans ; Protein Sorting Signals/drug effects ; Protein Transport/drug effects ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology |
| Chemical Substances | Adaptor Proteins, Vesicular Transport ; CD4 Antigens ; Protein Sorting Signals ; Small Molecule Libraries ; sortilin (Z020Y8WIJ4) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-03-17 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review |
| ZDB-ID | 1063195-1 |
| ISSN | 1464-3405 ; 0960-894X |
| ISSN (online) | 1464-3405 |
| ISSN | 0960-894X |
| DOI | 10.1016/j.bmcl.2020.127115 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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