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  1. Artikel ; Online: Chemical profile of Xian-He-Cao-Chang-Yan formula and its effects on ulcerative colitis.

    Li, Jun / Li, Ming / Ye, Ke / Jiang, Qixin / Wang, Mi / Wen, Xiaodong / Yang, Jie

    Journal of ethnopharmacology

    2020  Band 267, Seite(n) 113517

    Abstract: Ethnopharmacological relevance: Xian-He-Cao-Chang-Yan formula (XHCF) is consisting of six crude ...

    Abstract Ethnopharmacological relevance: Xian-He-Cao-Chang-Yan formula (XHCF) is consisting of six crude drugs including Agrimoniae Herba, Coptidis Rhizoma, Aucklandiae Radix, Cicadae Periostracum, Acori Tatarinowii Rhizoma, and Platycodonis Radix at the ratio of 5:1.5:1.5:1.5:1.5:1. It has been used to improve syndromes of ulcerative colitis (UC) for many years.
    Aim of the study: This study was designed to study the bioactive ingredients and therapeutic mechanisms of XHCF.
    Materials and methods: The chemical profile of XHCF was characterized by UHPLC-QTOF-MS/MS. The effects and mechanisms of XHCF on UC were investigated in colitis mice induced by dextran sulfate sodium (DSS) and LPS-stimulated RAW 264.7 cells.
    Results: A total of 103 compounds were characterized in XHCF. XHCF could effectively improve acute colitis induced by DSS. More importantly, XHCF significantly decreased M1 macrophage markers (CD11c, IL-6 and IL-1β) whereas increased M2 macrophage markers (CD206) in colitis mice, suggesting it could regulate macrophage polarization. Furthermore, the levels of HK2 and lactic acid in colon tissues were significantly reduced by XHCF, indicating that XHCF could inhibit glycolysis. It also down-regulated HK2 expression in macrophages challenged by LPS. In addition, XHCF enhanced the phosphorylation of AMPK both in vivo and in vitro, suggesting the involvement of AMPK in XHCF function.
    Conclusions: XHCF ameliorated DSS-induced colitis in mice via inhibition of M1 macrophage polarization, probably by the modulation of macrophage metabolic reprogramming via AMPK, contributing to its anti-inflammatory activity. The synergistic actions of multiple ingredients might be responsible for the therapeutic benefits of XHCF on UC.
    Mesh-Begriff(e) AMP-Activated Protein Kinases/metabolism ; Animals ; Anti-Infective Agents/pharmacology ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/metabolism ; Colitis, Ulcerative/pathology ; Colitis, Ulcerative/prevention & control ; Colon/drug effects ; Colon/metabolism ; Colon/pathology ; Cytokines/metabolism ; Dextran Sulfate ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Glycolysis/drug effects ; Inflammation Mediators/metabolism ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Phenotype ; Phosphorylation ; RAW 264.7 Cells
    Chemische Substanzen Anti-Infective Agents ; Cytokines ; Drugs, Chinese Herbal ; Inflammation Mediators ; Dextran Sulfate (9042-14-2) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
    Sprache Englisch
    Erscheinungsdatum 2020-10-23
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2020.113517
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  2. Artikel: Chemical profile of Xian-He-Cao-Chang-Yan formula and its effects on ulcerative colitis

    Li, Jun / Li, Ming / Ye, Ke / Jiang, Qixin / Wang, Mi / Wen, Xiaodong / Yang, Jie

    Journal of ethnopharmacology. 2021 Mar. 01, v. 267

    2021  

    Abstract: Xian-He-Cao-Chang-Yan formula (XHCF) is consisting of six crude drugs including Agrimoniae Herba ...

    Abstract Xian-He-Cao-Chang-Yan formula (XHCF) is consisting of six crude drugs including Agrimoniae Herba, Coptidis Rhizoma, Aucklandiae Radix, Cicadae Periostracum, Acori Tatarinowii Rhizoma, and Platycodonis Radix at the ratio of 5:1.5:1.5:1.5:1.5:1. It has been used to improve syndromes of ulcerative colitis (UC) for many years.This study was designed to study the bioactive ingredients and therapeutic mechanisms of XHCF.The chemical profile of XHCF was characterized by UHPLC-QTOF-MS/MS. The effects and mechanisms of XHCF on UC were investigated in colitis mice induced by dextran sulfate sodium (DSS) and LPS-stimulated RAW 264.7 cells.A total of 103 compounds were characterized in XHCF. XHCF could effectively improve acute colitis induced by DSS. More importantly, XHCF significantly decreased M1 macrophage markers (CD11c, IL-6 and IL-1β) whereas increased M2 macrophage markers (CD206) in colitis mice, suggesting it could regulate macrophage polarization. Furthermore, the levels of HK2 and lactic acid in colon tissues were significantly reduced by XHCF, indicating that XHCF could inhibit glycolysis. It also down-regulated HK2 expression in macrophages challenged by LPS. In addition, XHCF enhanced the phosphorylation of AMPK both in vivo and in vitro, suggesting the involvement of AMPK in XHCF function.XHCF ameliorated DSS-induced colitis in mice via inhibition of M1 macrophage polarization, probably by the modulation of macrophage metabolic reprogramming via AMPK, contributing to its anti-inflammatory activity. The synergistic actions of multiple ingredients might be responsible for the therapeutic benefits of XHCF on UC.
    Schlagwörter anti-inflammatory activity ; colon ; dextran sulfate ; glycolysis ; interleukin-6 ; lactic acid ; macrophages ; phosphorylation ; rhizomes ; therapeutics ; traditional medicine ; ulcerative colitis
    Sprache Englisch
    Erscheinungsverlauf 2021-0301
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2020.113517
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  3. Artikel ; Online: Research on urban three-dimensional greening design from the perspective of climate change-a case study of Beilin District, Xi'an, Shaanxi Province, China.

    Wang, Wei / Zhang, Jinbang / Li, Jiaying

    Environmental science and pollution research international

    2023  Band 31, Heft 4, Seite(n) 6067–6081

    Abstract: ... on Local Climate in Beilin District of Xi'an, Shaanxi Province, the mechanism of three-dimensional greening ... in the east section of Jianshe Road, Beilin District, Xi'an City, Shaanxi Province, China, and applied ENVI ... Climate change is an important issue for cities today and in the future. At present, China has ...

    Abstract Climate change is an important issue for cities today and in the future. At present, China has a large population and complex climate conditions, and cities are also vulnerable to the adverse effects of climate change (Tian, Environ Sustain Dev 6: 153-155 2020). Three-dimensional greening can not only improve the green space system of a city but also have a far-reaching impact on the ecology, image, and economic benefits of a city. Therefore, the study of urban three-dimensional greening is an effective means to deal with climate change strategies. By exploring the influence of traditional greening and three-dimensional greening on Local Climate in Beilin District of Xi'an, Shaanxi Province, the mechanism of three-dimensional greening on urban ecological environment was discussed, and the ecological theory, urban three-dimensional greening theory, and urban local climate zone (LCZ) were referred to. Based on the methods of national climate monitoring, ENVI-met simulation, and field independent measurement, this paper selected a research sample site in the east section of Jianshe Road, Beilin District, Xi'an City, Shaanxi Province, China, and applied ENVI-met software to simulate the thermal stress relationship among building exterior surfaces, plants, and air in the street; quantified the overall ecology of the area; and used measuring instruments. The influence of different types of greening in the base on the site temperature, humidity, CO
    Mesh-Begriff(e) Humans ; Ecosystem ; Carbon Dioxide ; Climate Change ; Cities ; Cold Temperature ; China
    Chemische Substanzen Carbon Dioxide (142M471B3J)
    Sprache Englisch
    Erscheinungsdatum 2023-12-26
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-31386-8
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  4. Artikel ; Online: Changing trends of birth weight with maternal age: a cross-sectional study in Xi'an city of Northwestern China.

    Wang, Shanshan / Yang, Liren / Shang, Li / Yang, Wenfang / Qi, Cuifang / Huang, Liyan / Xie, Guilan / Wang, Ruiqi / Chung, Mei Chun

    BMC pregnancy and childbirth

    2020  Band 20, Heft 1, Seite(n) 744

    Abstract: ... data for all live births from 2015 to 2018 were obtained from the Medical Birth Registry of Xi'an ...

    Abstract Background: Most studies have shown that maternal age is associated with birth weight. However, the specific relationship between each additional year of maternal age and birth weight remains unclear. The study aimed to analyze the specific association between maternal age and birth weight.
    Methods: Raw data for all live births from 2015 to 2018 were obtained from the Medical Birth Registry of Xi'an, China. A total of 490,143 mother-child pairs with full-term singleton live births and the maternal age ranging from 20 to 40 years old were included in our study. Birth weight, gestational age, neonatal birth date, maternal birth date, residence and ethnicity were collected. Generalized additive model and two-piece wise linear regression model were used to analyze the specific relationships between maternal age and birth weight, risk of low birth weight, and risk of macrosomia.
    Results: The relationships between maternal age and birth weight, risk of low birth weight, and risk of macrosomia were nonlinear. Birth weight increased 16.204 g per year when maternal age was less than 24 years old (95%CI: 14.323, 18.086), and increased 12.051 g per year when maternal age ranged from 24 to 34 years old (95%CI: 11.609, 12.493), then decreased 0.824 g per year (95% CI: -3.112, 1.464). The risk of low birth weight decreased with the increase of maternal age until 36 years old (OR = 0.917, 95%CI: 0.903, 0.932 when maternal age was younger than 27 years old; OR = 0.965, 95%CI: 0.955, 0.976 when maternal age ranged from 27 to 36 years old), then increased when maternal age was older than 36 years old (OR = 1.133, 95%CI: 1.026, 1.250). The risk of macrosomia increased with the increase of maternal age (OR = 1.102, 95%CI: 1.075, 1.129 when maternal age was younger than 24 years old; OR = 1.065, 95%CI: 1.060, 1.071 when maternal age ranged from 24 to 33 years old; OR = 1.029, 95%CI: 1.012, 1.046 when maternal age was older than 33 years old).
    Conclusions: For women of childbearing age (20-40 years old), the threshold of maternal age on low birth weight was 36 years old, and the risk of macrosomia increased with the increase of maternal age.
    Mesh-Begriff(e) Adult ; Birth Weight ; China/epidemiology ; Cross-Sectional Studies ; Female ; Fetal Macrosomia/etiology ; Gestational Age ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Linear Models ; Live Birth/epidemiology ; Maternal Age ; Pregnancy ; Registries
    Sprache Englisch
    Erscheinungsdatum 2020-11-30
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1471-2393
    ISSN (online) 1471-2393
    DOI 10.1186/s12884-020-03445-2
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  5. Buch: Cheng xian wei xi bao sheng chang yin zi ji chu yu ying yong yan jiu

    Li, Xiaokun

    Basic and applied researches on fibroblast growth factor

    2007  

    Titelvarianten Basic and applied researches on fibroblast growth factor
    Verfasserangabe zhu bian Li Xiaokun, Gong Shouliang
    Mesh-Begriff(e) Fibroblast Growth Factors/physiology ; Fibroblast Growth Factors/therapeutic use
    Sprache Chinesisch ; Englisch
    Umfang 2, 2, 4, 600 p., [6] p. of plates :, ill.
    Ausgabenhinweis Di 1 ban.
    Verlag Ji lin da xue chu ban she
    Erscheinungsort Changchun Shi
    Dokumenttyp Buch
    ISBN 9787560136899 ; 7560136893
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  6. Artikel ; Online: Exploring the response of ecosystem service value to land use changes under multiple scenarios coupling a mixed-cell cellular automata model and system dynamics model in Xi'an, China

    Zhang, Ping / Liu, Lei / Yang, Lianwei / Zhao, Juan / Li, Yangyang / Qi, Yuting / Ma, Xuenan / Cao, Lei

    Ecological Indicators. 2023 Mar., v. 147 p.110009-

    2023  

    Abstract: ... its quantitative continuous dynamic change, and lacks the exploration of land use quantity structure and spatial ... accuracy and robustness. The main changes in land use in 2000-2015 were due to urban expansion ... scenario (NIS), economic development scenario (EDS) and ecological protection scenario (EPS) in Xi'an ...

    Abstract Land use is a crucial factor affecting ecosystem service value (ESV), and forecasting future land use changes and ESV response can guide urban planning and sustainable development decisions. However, the traditional Cellular Automata (CA) model supposes that each cell has only one land use type at each time step, neglects the mixed structure and proportional distribution of land use units, does not take into account its quantitative continuous dynamic change, and lacks the exploration of land use quantity structure and spatial pattern optimization. This study employed a novel mixed-cell cellular automata (MCCA) approach, coupled with the system dynamics (SD) model to predict the spatiotemporal pattern of land use under the natural increase scenario (NIS), economic development scenario (EDS) and ecological protection scenario (EPS) in Xi'an, China, in 2030. The equivalent coefficient method was utilized to investigate the heterogeneity distribution and sensitivity of ESV. The results demonstrated that SD-MCCA exhibited remarkable prediction accuracy and robustness. The main changes in land use in 2000-2015 were due to urban expansion, the conversion of arable land into construction land, and the conversion between grassland and arable land. The total ESV increased from 19554.36×10⁶ CNY in 2000 to 19618.39×10⁶ CNY under the EPS in 2030, and the contribution of climate regulation and hydrological regulation to ESV was the highest. Spatial heterogeneity of ESV revealed a certain regularity, and the high value region was chiefly concentrated in woodland and grassland with favorable ecological conditions. Land use variations under NIS and EPS improved ESV, while the ESV had a negative response to land use transformations under the EDS. This research provides a new way to identify the relationship between future land utilization scenarios and ESV, which is of great significance for the management of land resources and formulation of ecological compensation standards.
    Schlagwörter arable soils ; climate ; dynamic models ; ecosystem services ; grasslands ; hydrology ; land use ; prediction ; spatial variation ; sustainable development ; urbanization ; woodlands ; China ; Ecosystem service value ; MCCA ; SD ; Scenario prediction ; Sensitivity analysis
    Sprache Englisch
    Erscheinungsverlauf 2023-03
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung Use and reproduction
    ZDB-ID 2036774-0
    ISSN 1872-7034 ; 1470-160X
    ISSN (online) 1872-7034
    ISSN 1470-160X
    DOI 10.1016/j.ecolind.2023.110009
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    Z 7436: Hefte anzeigen

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  7. Artikel ; Online: Exploring the response of ecosystem service value to land use changes under multiple scenarios coupling a mixed-cell cellular automata model and system dynamics model in Xi'an, China

    Ping Zhang / Lei Liu / Lianwei Yang / Juan Zhao / Yangyang Li / Yuting Qi / Xuenan Ma / Lei Cao

    Ecological Indicators, Vol 147, Iss , Pp 110009- (2023)

    2023  

    Abstract: ... its quantitative continuous dynamic change, and lacks the exploration of land use quantity structure and spatial ... accuracy and robustness. The main changes in land use in 2000–2015 were due to urban expansion ... land use changes and ESV response can guide urban planning and sustainable development decisions ...

    Abstract Land use is a crucial factor affecting ecosystem service value (ESV), and forecasting future land use changes and ESV response can guide urban planning and sustainable development decisions. However, the traditional Cellular Automata (CA) model supposes that each cell has only one land use type at each time step, neglects the mixed structure and proportional distribution of land use units, does not take into account its quantitative continuous dynamic change, and lacks the exploration of land use quantity structure and spatial pattern optimization. This study employed a novel mixed-cell cellular automata (MCCA) approach, coupled with the system dynamics (SD) model to predict the spatiotemporal pattern of land use under the natural increase scenario (NIS), economic development scenario (EDS) and ecological protection scenario (EPS) in Xi’an, China, in 2030. The equivalent coefficient method was utilized to investigate the heterogeneity distribution and sensitivity of ESV. The results demonstrated that SD-MCCA exhibited remarkable prediction accuracy and robustness. The main changes in land use in 2000–2015 were due to urban expansion, the conversion of arable land into construction land, and the conversion between grassland and arable land. The total ESV increased from 19554.36×106 CNY in 2000 to 19618.39×106 CNY under the EPS in 2030, and the contribution of climate regulation and hydrological regulation to ESV was the highest. Spatial heterogeneity of ESV revealed a certain regularity, and the high value region was chiefly concentrated in woodland and grassland with favorable ecological conditions. Land use variations under NIS and EPS improved ESV, while the ESV had a negative response to land use transformations under the EDS. This research provides a new way to identify the relationship between future land utilization scenarios and ESV, which is of great significance for the management of land resources and formulation of ecological compensation standards.
    Schlagwörter Ecosystem service value ; MCCA ; SD ; Scenario prediction ; Sensitivity analysis ; Ecology ; QH540-549.5
    Thema/Rubrik (Code) 710 ; 910
    Sprache Englisch
    Erscheinungsdatum 2023-03-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Spatial and temporal variation of precipitation characteristics in the semiarid region of Xi'an, northwest China

    Hao Han / Jingming Hou / Rengui Jiang / Jiahui Gong / Ganggang Bai / Yongde Kang / Wenchao Qi / Yuan Li / Bingyao Li

    Journal of Water and Climate Change, Vol 12, Iss 6, Pp 2697-

    2021  Band 2715

    Abstract: ... Thus, understanding the precipitation variation in Xi'an city can provide a theoretical foundation of future ... The monthly precipitation had different change trends, showing the precipitation from June to September ... had a significant periodic change, with the periods of 6, 13, 19, and 27 years. For the spatial ...

    Abstract Precipitation variations mostly affect the water resource planning in semi-arid regions of northwest China. The objective of this study is to quantitatively explore the spatial and temporal variations of precipitation in different time scales in Xi'an city area. The Mann–Kendall test and wavelet analysis methods were applied to analyze the precipitation variability. In terms of temporal variation of precipitation, the results indicated that the annual precipitation exhibited a significant decreasing trend during 1951–2018. Except for summer precipitation representing a slightly increasing trend, the other seasonal precipitations had a similar decreasing trend to annual precipitation throughout 1951–2018. The monthly precipitation had different change trends, showing the precipitation from June to September could account for 58.4% of the total annual precipitation. In addition, it was clear that annual precipitation had a significant periodic change, with the periods of 6, 13, 19, and 27 years. For the spatial variation of precipitation during 1961–2018, the results showed that annual and seasonal precipitation exhibited obvious spatial differences, indicating an increasing spatial trend from north to south. Thus, understanding the precipitation variation in Xi'an city can provide a theoretical foundation of future water resources management for other cities in semi-arid regions of northwest China. HIGHLIGHTS There were different variation trends in annual, seasonal and monthly precipitation at a temporal scale.; The annual precipitation in Xi'an city had a significantly increasing trend during 1951–2018.; The annual and seasonal precipitation exhibited obvious spatial differences during 1961–2018.; Findings could guide future water resource management and allocation of other cities in semiarid regions of northwest China.;
    Schlagwörter mann–kendall test ; periodicity analysis ; precipitation ; spatial and temporal variations ; wavelet analysis ; xi'an city ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 910 ; 550
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag IWA Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Spatiotemporal variation, sources, and secondary transformation potential of volatile organic compounds in Xi'an, China

    M. Song / X. Li / S. Yang / X. Yu / S. Zhou / Y. Yang / S. Chen / H. Dong / K. Liao / Q. Chen / K. Lu / N. Zhang / J. Cao / L. Zeng / Y. Zhang

    Atmospheric Chemistry and Physics, Vol 21, Pp 4939-

    2021  Band 4958

    Abstract: ... of comprehensive field observations and VOC grid sampling was conducted in Xi'an, China, from 20 June to 20 July ... 8.4 ppb, respectively. Vehicle exhaust was the primary source of VOC emissions in Xi'an, and ... appeared in eastern and southern Xi'an near the sampling site, which indicates that Xi'an exhibits a strong ...

    Abstract As critical precursors of ozone (O 3 ) and secondary organic aerosols, volatile organic compounds (VOCs) play a vital role in air quality, human health, and climate change. In this study, a campaign of comprehensive field observations and VOC grid sampling was conducted in Xi'an, China, from 20 June to 20 July 2019 to identify the spatiotemporal concentration levels, sources, and secondary transformation potential of VOCs. During the observation period, the average VOC concentrations at the Chanba (CB), Di Huan Suo (DHS), Qinling (QL), and gridded sampling sites were 27.8 ± 8.9, 33.8 ± 10.5, 15.5 ± 5.8, and 29.1 ± 8.4 ppb, respectively. Vehicle exhaust was the primary source of VOC emissions in Xi'an, and the contributions of vehicle exhaust to VOCs at the CB, DHS, and QL sites were 41.3 %, 30.6 %, and 23.6 %–41.4 %, respectively. While industrial emissions were the second-largest source of VOCs in urban areas, contributions from aging sources were high in rural areas. High potential source contribution function values primarily appeared in eastern and southern Xi'an near the sampling site, which indicates that Xi'an exhibits a strong local VOC source. Moreover, alkenes, aromatics, and oxygenated VOCs played a dominant role in secondary transformation, which is a major concern in reducing O 3 pollution in Xi'an.
    Schlagwörter Physics ; QC1-999 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 333
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag Copernicus Publications
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Buch: Xian dai Han yu chang yong ci yong fa ci dian

    Li, Yimin / Long, Decheng / Zhu, Bingyao

    1995  

    Titelvarianten Dictionary of Chinese usage
    Verfasserangabe zhu bian Li Yimin; fu zhu bian Zhu Bingyao, Long Decheng
    Schlagwörter Chinese language
    Sprache Chinesisch
    Umfang 38, 1652 S., 19 cm
    Ausgabenhinweis Di 1 ban, di 2 ci yin shua
    Verlag Bei jing yu yan wen hua da xue chu ban she
    Erscheinungsort Bei jing
    Dokumenttyp Buch
    Anmerkung Includes index
    ISBN 7561902794 ; 9787561902790
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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