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Article ; Online: Rare Cutaneous Presentation of Burkitt Lymphoma.

Wu, Julie H / Pulavarty, Akshay N / Brinster, Nooshin / Soter, Nicholas / Adotama, Prince

2024 Volume 113, Issue 3, Page(s) E13–E15

MeSH term(s)	Humans ; Burkitt Lymphoma/diagnosis ; Burkitt Lymphoma/pathology ; Skin Neoplasms/pathology ; Skin Neoplasms/diagnosis ; Male
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	391840-3
ISSN	2326-6929 ; 0011-4162 ; 0151-9522
ISSN (online)	2326-6929
ISSN	0011-4162 ; 0151-9522
DOI	10.12788/cutis.0982
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Article ; Online: What we would (but shouldn't) do for those we love: Universalism versus partiality in responding to others' moral transgressions.

Soter, Laura K / Berg, Martha K / Gelman, Susan A / Kross, Ethan

Cognition

2021 Volume 217, Page(s) 104886

Abstract: ... Across four experiments (N = 2002), we show that people believe they morally should protect close others ...

Abstract	Recent work indicates that people are more likely to protect a close (vs. distant) other who commits a crime. But do people think it is morally right to treat close others differently? On the one hand, universalist moral principles dictate that people should be treated equally. On the other hand, close relationships are the source of special moral obligations, which may lead people to believe they ought to preferentially protect close others. Here we attempt to adjudicate between these competing considerations by examining what people think they would and should do when a close (vs. distant) other behaves immorally. Across four experiments (N = 2002), we show that people believe they morally should protect close others more than distant others. However, we also document a striking discrepancy: participants reported that they would protect close others far more than they should protect them. These findings demonstrate that people believe close relationships influence what they morally ought to do-but also that moral decisions about close others may be a context in which people are particularly likely to fail to do what they think is morally right.
MeSH term(s)	Humans ; Love ; Moral Obligations ; Morals
Language	English
Publishing date	2021-08-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1499940-7
ISSN	1873-7838 ; 0010-0277
ISSN (online)	1873-7838
ISSN	0010-0277
DOI	10.1016/j.cognition.2021.104886
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Article ; Online: The introduction of health behavior profiles in the Hungarian Defense Forces: a cluster analysis of lifestyle factors according to the health screening tests performed in 2011–2015

Novak, Attila / Hornyák, Beatrix / Rázsó, Zsófia / Szalánczi, Szabolcs / Sótér, Andrea / Juhász, Zsolt / Nyakas, Csaba

International journal of occupational medicine and environmental health

2019 Volume 32, Issue 1, Page(s) 99–114

Abstract: ... of lifestyle factors.: Material and methods: The soldiers (N = 5475) who underwent health tests in 2011–2015 ...

Abstract	Objectives: The main aim of this study was to examine the health behavior patterns of soldiers in the Hungarian Defense Forces and to introduce health behavior profiles according to the cluster analysis of lifestyle factors. Material and methods: The soldiers (N = 5475) who underwent health tests in 2011–2015 participated in this cross-sectional study. The factors included in the analysis are the following: age, sex, diseases diagnosed, the body mass index, eating habits, the smoking status, daily physical activity, sporting habits, the presence of psychosomatic symptoms, mental toughness and sleep apnea. The response options for each factor were scored on a linear scale; the minimum number of points available was –47.5 pts and the maximum number was 48.5 pts according to the 24 factors. Finally, the authors created health profiles typical of the pattern with the cluster analysis of the data. Results: As a result of the cluster analysis, 16 distinct profiles were found, 10 of which differed significantly (p < 0.05) from each other. The lowest point value achieved was 3.1 pts and the highest was 26.2 pts. The lowest number of points was achieved by the cluster, 1.8% of the sample, with the highest average age (43.5±7.2 years) in which women showed the highest participation (46%). The 2 clusters with the highest numbers of points, 2.9% and 5.5% of the sample, were the 2 groups with the lowest average age (33.7±7.1 years and 34.3±7.9 years). Conclusions: The significance of the health profiles obtained during this examination with the Hungarian Defense Forces is that the health promotion intervention opportunities may be determined by clusters, the health behavior factor with which the authors can reach higher health benefits can be chosen and the effectiveness of the interventions carried out can be traced easily. Int J Occup Med Environ Health. 2019;32(1):99–114
MeSH term(s)	Adult ; Aged ; Cluster Analysis ; Cross-Sectional Studies ; Female ; Health Behavior ; Health Status ; Humans ; Hungary ; Life Style ; Male ; Mental Health ; Middle Aged ; Military Personnel/statistics & numerical data ; Occupational Health ; Surveys and Questionnaires
Language	English
Publishing date	2019-02-20
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1199049-1
ISSN	1896-494X ; 0867-8383 ; 1232-1087
ISSN (online)	1896-494X
ISSN	0867-8383 ; 1232-1087
DOI	10.13075/ijomeh.1896.01206
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Article ; Online: Polycystic ovary syndrome: clinical and laboratory variables related to new phenotypes using machine-learning models.

Silva, I S / Ferreira, C N / Costa, L B X / Sóter, M O / Carvalho, L M L / de C Albuquerque, J / Sales, M F / Candido, A L / Reis, F M / Veloso, A A / Gomes, K B

Journal of endocrinological investigation

2021 Volume 45, Issue 3, Page(s) 497–505

Abstract: Purpose: Polycystic Ovary Syndrome (PCOS) is the most frequent endocrinopathy in women of reproductive age. Machine learning (ML) is the area of artificial intelligence with a focus on predictive computing algorithms. We aimed to define the most ... ...

Abstract	Purpose: Polycystic Ovary Syndrome (PCOS) is the most frequent endocrinopathy in women of reproductive age. Machine learning (ML) is the area of artificial intelligence with a focus on predictive computing algorithms. We aimed to define the most relevant clinical and laboratory variables related to PCOS diagnosis, and to stratify patients into different phenotypic groups (clusters) using ML algorithms. Methods: Variables from a database comparing 72 patients with PCOS and 73 healthy women were included. The BorutaShap method, followed by the Random Forest algorithm, was applied to prediction and clustering of PCOS. Results: Among the 58 variables investigated, the algorithm selected in decreasing order of importance: lipid accumulation product (LAP); abdominal circumference; thrombin activatable fibrinolysis inhibitor (TAFI) levels; body mass index (BMI); C-reactive protein (CRP), high-density lipoprotein cholesterol (HDL-c), follicle-stimulating hormone (FSH) and insulin levels; HOMA-IR value; age; prolactin, 17-OH progesterone and triglycerides levels; and family history of diabetes mellitus in first-degree relative as the variables associated to PCOS diagnosis. The combined use of these variables by the algorithm showed an accuracy of 86% and area under the ROC curve of 97%. Next, PCOS patients were gathered into two clusters in the first, the patients had higher BMI, abdominal circumference, LAP and HOMA-IR index, as well as CRP and insulin levels compared to the other cluster. Conclusion: The developed algorithm could be applied to select more important clinical and biochemical variables related to PCOS and to classify into phenotypically different clusters. These results could guide more personalized and effective approaches to the treatment of PCOS.
MeSH term(s)	Adult ; Algorithms ; Artificial Intelligence ; Biological Variation, Population ; Body Mass Index ; Disease Hotspot ; Female ; Humans ; Insulin Resistance ; Machine Learning ; Metabolic Networks and Pathways/genetics ; Polycystic Ovary Syndrome/diagnosis ; Polycystic Ovary Syndrome/genetics ; Polycystic Ovary Syndrome/metabolism ; Precision Medicine/methods ; Preventive Health Services/methods ; Preventive Health Services/trends
Language	English
Publishing date	2021-09-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-021-01672-8
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Article ; Online: Differences in the clinical presentation of bullous pemphigoid in patients with skin of colour and patients with white skin.

Shah, P / Svigos, K / Yin, L / Soter, N / Lo Sicco, K / Adotama, P

The British journal of dermatology

2021 Volume 185, Issue 2, Page(s) 430–432

Language	English
Publishing date	2021-04-26
Publishing country	England
Document type	Letter
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.20068
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Article: Vesiculobullous Darier Disease Symptomatically Responsive to Cetirizine

Wang, Jason F. / Lederhandler, Margo H. / Brinster, Nooshin / Soter, Nicholas A.

Journal of drugs in dermatology : JDD

2019 Volume 18, Issue 2, Page(s) 213–214

MeSH term(s)	Anti-Allergic Agents/pharmacology ; Anti-Allergic Agents/therapeutic use ; Cetirizine/pharmacology ; Cetirizine/therapeutic use ; Darier Disease/complications ; Darier Disease/diagnosis ; Darier Disease/drug therapy ; Dose-Response Relationship, Drug ; Eosinophils/drug effects ; Female ; Humans ; Middle Aged ; Skin Diseases, Vesiculobullous/complications ; Skin Diseases, Vesiculobullous/diagnosis ; Skin Diseases, Vesiculobullous/drug therapy ; Treatment Outcome
Chemical Substances	Anti-Allergic Agents ; Cetirizine (YO7261ME24)
Language	English
Publishing date	2019-02-27
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
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Article ; Online: Developments in the chemistry and biology of 1,2,3-triazolyl-C-nucleosides.

Nascimento, Sarah Moreira Rodrigues do / Ferry, Angélique / Gallier, Florian / Lubin-Germain, Nadège / Uziel, Jacques / Gonzales, Simon / Miranda, Leandro Soter de Mariz E

Archiv der Pharmazie

2023 Volume 357, Issue 3, Page(s) e2300580

Abstract: ... of nucleoside treatment drugs, ribavirin (RBV) is a synthetic N-nucleoside with a 1,2,4-triazole moiety ...

Abstract	In the last 50 years, nucleoside analogs have been introduced to drug therapy as antivirals for different types of cancer due to their interference in cellular proliferation. Among the first line of nucleoside treatment drugs, ribavirin (RBV) is a synthetic N-nucleoside with a 1,2,4-triazole moiety that acts as a broad-spectrum antiviral. It is on the World Health Organization (WHO) list of essential medicines. However, this important drug therapy causes several side effects due to its nonspecific mechanism of action. There is thus a need for a continuous study of its scaffold. A particular approach consists of connecting d-ribose to the nitrogen-containing base with a C-C bond. It provides more stability against enzymatic action and a better pharmacologic profile. The coronavirus disease (COVID) pandemic has increased the need for more solutions for the treatment of viral infections. Among these solutions, remdesivir, the first C-nucleoside, has been approved by the Food and Drug Administration (FDA) for clinical use against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It drew attention to the study of the C-nucleoside scaffold. Different C-nucleoside patterns have been synthesized over the years. They show many important activities against viruses and cancer cell lines. 1,2,3-Triazolyl-C-nucleoside derivatives are a prolific and efficient subclass of RBV analogs close to the already-known RBV with a C-C bond modification. These compounds are often prepared by alkynylation of the d-ribose ring followed by azide-alkyne cycloaddition. They are reported to be active against the Crimean-Congo hemorrhagic fever virus and several tumoral cell lines, showing promising biological potential. In this review, we explore such approaches to 1,2,3-triazolyl-C-nucleosides and their evolution over the years.
MeSH term(s)	Nucleosides/pharmacology ; Nucleosides/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Ribose/pharmacology ; Structure-Activity Relationship ; SARS-CoV-2 ; Cell Line, Tumor ; Biology
Chemical Substances	Nucleosides ; Antiviral Agents ; Ribose (681HV46001)
Language	English
Publishing date	2023-12-27
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	6381-2
ISSN	1521-4184 ; 0365-6233 ; 1437-1014
ISSN (online)	1521-4184
ISSN	0365-6233 ; 1437-1014
DOI	10.1002/ardp.202300580
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Article ; Online: Why can we see our narrowband UVB lights?

Soleymani, Teo / Soter, Nicholas A / Folan, Lorcan M / Elbuluk, Nada / Cohen, David E

Journal of the American Academy of Dermatology

2020 Volume 82, Issue 6, Page(s) e251–e252

MeSH term(s)	Spectrum Analysis ; Ultraviolet Rays ; Ultraviolet Therapy/instrumentation
Language	English
Publishing date	2020-02-25
Publishing country	United States
Document type	Letter
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2020.02.051
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Article ; Online: The hallmark of pro- and anti-inflammatory cytokine ratios in women with polycystic ovary syndrome.

Tosatti, Jéssica A G / Sóter, Mirelle O / Ferreira, Cláudia N / Silva, Ieda de F O / Cândido, Ana L / Sousa, Marinez O / Reis, Fernando M / Gomes, Karina B

Cytokine

2020 Volume 134, Page(s) 155187

Abstract: Polycystic Ovary Syndrome (PCOS) is a heterogeneous endocrinopathy considered to be the most common metabolic disorder in women of reproductive age. Women with PCOS present with an increased risk of noncommunicable diseases (NCDs), especially low-grade ... ...

Abstract	Polycystic Ovary Syndrome (PCOS) is a heterogeneous endocrinopathy considered to be the most common metabolic disorder in women of reproductive age. Women with PCOS present with an increased risk of noncommunicable diseases (NCDs), especially low-grade chronic inflammation mediated by proinflammatory cytokines, and insulin resistance. This study aimed to investigate cytokine levels and their ratios in PCOS women compared to a healthy control group. This study evaluated 97 women with PCOS and 99 healthy women as controls. The PCOS diagnosis was performed according to ESHRE/ASRM. Plasma cytokines were evaluated by flow cytometry. We observed lower TNF levels, and decreased TNF/IL-6, TNF/IL-2, and TNF/IL-4 ratios in PCOS patients compared to the control group (p < 0.05). These results indicate an imbalance between pro- and anti-inflammatory cytokines, with prominent counter-regulatory cytokine production. These changes may be important in explaining the phenotypes present in PCOS and to direct better interventions for patients with this syndrome.
MeSH term(s)	Adolescent ; Adult ; Biomarkers ; Case-Control Studies ; Cytokines/blood ; Female ; Humans ; Inflammation Mediators/blood ; Middle Aged ; Polycystic Ovary Syndrome/immunology ; Young Adult
Chemical Substances	Biomarkers ; Cytokines ; Inflammation Mediators
Language	English
Publishing date	2020-07-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2020.155187
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Article ; Online: Collective Narcissism: Americans Exaggerate the Role of Their Home State in Appraising U.S. History.

Putnam, Adam L / Ross, Morgan Q / Soter, Laura K / Roediger, Henry L

Psychological science

2018 Volume 29, Issue 9, Page(s) 1414–1422

Abstract: ... group-is ubiquitous in studies of small groups. We examined how Americans from the 50 U.S. states ( N ...

Abstract	Collective narcissism-a phenomenon in which individuals show excessively high regard for their own group-is ubiquitous in studies of small groups. We examined how Americans from the 50 U.S. states ( N = 2,898) remembered U.S. history by asking them, "In terms of percentage, what do you think was your home state's contribution to the history of the United States?" The mean state estimates ranged from 9% (Iowa) to 41% (Virginia), with the total contribution for all states equaling 907%, indicating strong collective narcissism. In comparison, ratings provided by nonresidents for states were much lower (but still high). Surprisingly, asking people questions about U.S. history before they made their judgment did not lower estimates. We argue that this ethnocentric bias is due to ego protection, selective memory retrieval processes involving the availability heuristic, and poor statistical reasoning. This study shows that biases that influence individual remembering also influence collective remembering.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bias ; Female ; Geography ; History ; Humans ; Judgment ; Male ; Memory ; Middle Aged ; Narcissism ; Personality ; Social Perception ; United States ; Young Adult
Language	English
Publishing date	2018-06-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2022256-7
ISSN	1467-9280 ; 0956-7976
ISSN (online)	1467-9280
ISSN	0956-7976
DOI	10.1177/0956797618772504
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