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  1. Article ; Online: From Mendel to multi-omics: shifting paradigms.

    Mersha, Tesfaye B

    European journal of human genetics : EJHG

    2023  Volume 32, Issue 2, Page(s) 139–142

    MeSH term(s) Humans ; Multiomics
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1141470-4
    ISSN 1476-5438 ; 1018-4813
    ISSN (online) 1476-5438
    ISSN 1018-4813
    DOI 10.1038/s41431-023-01420-x
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  2. Article ; Online: Leveraging genetic ancestry to study severe asthma exacerbations in an admixed population.

    Gautam, Yadu / Mersha, Tesfaye B

    Thorax

    2022  Volume 78, Issue 3, Page(s) 220–221

    MeSH term(s) Humans ; Asthma/genetics
    Language English
    Publishing date 2022-11-18
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2022-219459
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  3. Article ; Online: Atopic dermatitis and ocular allergy: common mechanisms and uncommon questions.

    Ghosh, Debajyoti / Mersha, Tesfaye B

    Current opinion in allergy and clinical immunology

    2023  Volume 23, Issue 5, Page(s) 383–389

    Abstract: Purpose of review: Atopic dermatitis (AD) and ocular allergy aka allergic eye disease (AED) are two common conditions that often coexist in patients. However, molecular connections between these two conditions are incompletely understood. While common ... ...

    Abstract Purpose of review: Atopic dermatitis (AD) and ocular allergy aka allergic eye disease (AED) are two common conditions that often coexist in patients. However, molecular connections between these two conditions are incompletely understood. While common etiologic components including Th2 immune signaling have been suggested for AD and AED, the mechanism how current Th2-targetd therapies (dupilumab, tralokinumab) for AD can augment conjunctivitis is not well understood.
    Recent findings: Differentially regulated genes and pathways relevant for AD disease manifestation are known. In contrast, similar information is not yet available for AED, which could be largely addressed by emerging noninvasive ocular sampling techniques. Emerging evidence indicated a reduction in goblet cell number and mucin production in a subpopulation of AD patients with AD leading to adverse ocular outcomes, while other potential mechanisms could also be involved. Involvement of particular barrier function protein(s) in AED needs further investigation.
    Summary: Modern cytokine-targeted therapies for AD showed elevated risk for developing conjunctivitis. Recently developed noninvasive sampling techniques should be leveraged to identify AD endotypes associated with AED and with dupilumab-associated ocular outcomes.
    MeSH term(s) Humans ; Dermatitis, Atopic/complications ; Conjunctivitis/complications
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2088710-3
    ISSN 1473-6322 ; 1528-4050
    ISSN (online) 1473-6322
    ISSN 1528-4050
    DOI 10.1097/ACI.0000000000000931
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  4. Article ; Online: Publicly available cytokine data: Limitations and opportunities.

    Ghosh, Debajyoti / Mersha, Tesfaye B

    The Journal of allergy and clinical immunology

    2022  Volume 150, Issue 5, Page(s) 1053–1056

    MeSH term(s) Humans ; Cytokines ; Interleukins ; Biomarkers
    Chemical Substances Cytokines ; Interleukins ; Biomarkers
    Language English
    Publishing date 2022-08-13
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.08.002
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  5. Article ; Online: Integrative analysis identifies gene signatures mediating the effect of DNA methylation on asthma severity and lung function.

    Dessie, Eskezeia Y / Ding, Lili / Mersha, Tesfaye B

    Clinical epigenetics

    2024  Volume 16, Issue 1, Page(s) 15

    Abstract: DNA methylation (DNAm) changes play a key role in regulating gene expression in asthma. To investigate the role of epigenetics and transcriptomics change in asthma, we used publicly available DNAm (asthmatics, n = 96 and controls, n = 46) and gene ... ...

    Abstract DNA methylation (DNAm) changes play a key role in regulating gene expression in asthma. To investigate the role of epigenetics and transcriptomics change in asthma, we used publicly available DNAm (asthmatics, n = 96 and controls, n = 46) and gene expression (asthmatics, n = 79 and controls, n = 39) data derived from bronchial epithelial cells (BECs). We performed differential methylation/expression and weighted co-methylation/co-expression network analyses to identify co-methylated and co-expressed modules associated with asthma severity and lung function. For subjects with both DNAm and gene expression data (asthmatics, n = 79 and controls, n = 39), machine-learning technique was used to prioritize CpGs and differentially expressed genes (DEGs) for asthma risk prediction, and mediation analysis was used to uncover DEGs that mediate the effect of DNAm on asthma severity and lung function in BECs. Finally, we validated CpGs and their associated DEGs and the asthma risk prediction model in airway epithelial cells (AECs) dataset. The asthma risk prediction model based on 18 CpGs and 28 DEGs showed high accuracy in both the discovery BEC dataset with area under the receiver operating characteristic curve (AUC) = 0.99 and the validation AEC dataset (AUC = 0.82). Genes in the three co-methylated and six co-expressed modules were enriched in multiple pathways including WNT/beta-catenin signaling and notch signaling. Moreover, we identified 35 CpGs correlated with DEGs in BECs, of which 17 CpGs including cg01975495 (SERPINE1), cg10528482 (SLC9A3), cg25477769 (HNF1A) and cg26639146 (CD9), cg17945560 (TINAGL1) and cg10290200 (FLNC) were replicated in AECs. These DEGs mediate the association between DNAm and asthma severity and lung function. Overall, our study investigated the role of DNAm and gene expression change in asthma and provided an insight into the mechanisms underlying the effects of DNA methylation on asthma, asthma severity and lung function.
    MeSH term(s) Humans ; DNA Methylation ; Asthma/genetics ; Epigenesis, Genetic ; Transcription Factors/genetics ; Lung
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2024-01-20
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2553921-8
    ISSN 1868-7083 ; 1868-7075
    ISSN (online) 1868-7083
    ISSN 1868-7075
    DOI 10.1186/s13148-023-01611-9
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  6. Article ; Online: WHO's surveillance system for attacks on health care is failing Ethiopia.

    Dadi, Abel F / Mersha, Tesfaye B

    Lancet (London, England)

    2022  Volume 399, Issue 10331, Page(s) 1225–1226

    MeSH term(s) Delivery of Health Care ; Ethiopia/epidemiology ; Health Facilities ; Humans ; Population Surveillance ; World Health Organization
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00337-3
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  7. Article ; Online: Racial differences in emergency encounters related to pediatric allergic diseases during the COVID-19 pandemic.

    Correa-Agudelo, Esteban / Beck, Andrew F / Mersha, Tesfaye B

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 7, Page(s) 2232–2234.e1

    MeSH term(s) Humans ; Child ; Pandemics ; Race Factors ; COVID-19/epidemiology ; Hypersensitivity/epidemiology ; Emergency Service, Hospital ; Retrospective Studies
    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.04.007
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    Zs.A 7086: Show issues Location:
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  8. Article ; Online: Racial differences in length of stay and readmission for asthma in the all of us research program.

    Correa-Agudelo, Esteban / Gautam, Yadu / Mendy, Angelico / Mersha, Tesfaye B

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 22

    Abstract: Background: This study addresses the limited research on racial disparities in asthma hospitalization outcomes, specifically length of stay (LOS) and readmission, across the U.S.: Methods: We analyzed in-patient and emergency department visits from ... ...

    Abstract Background: This study addresses the limited research on racial disparities in asthma hospitalization outcomes, specifically length of stay (LOS) and readmission, across the U.S.
    Methods: We analyzed in-patient and emergency department visits from the All of Us Research Program, identifying various risk factors (demographic, comorbid, temporal, and place-based) associated with asthma LOS and 30-day readmission using Bayesian mixed-effects models.
    Results: Of 17,233 patients (48.0% White, 30.7% Black, 19.7% Hispanic/Latino, 1.3% Asian, and 0.3% Middle Eastern and North African) with 82,188 asthma visits, Black participants had 20% shorter LOS and 12% higher odds of readmission, compared to White participants in multivariate analyses. Public-insured patients had 14% longer LOS and 39% higher readmission odds than commercially insured patients. Weekend admissions resulted in a 12% shorter LOS but 10% higher readmission odds. Asthmatics with chronic diseases had a longer LOS (range: 6-39%) and higher readmission odds (range: 9-32%) except for those with allergic rhinitis, who had a 23% shorter LOS.
    Conclusions: A comprehensive understanding of the factors influencing asthma hospitalization, in conjunction with diverse datasets and clinical-community partnerships, can help physicians and policymakers to systematically address racial disparities, healthcare utilization and equitable outcomes in asthma care.
    MeSH term(s) Humans ; Asthma/therapy ; Bayes Theorem ; Length of Stay ; Patient Readmission ; Population Health ; Race Factors ; Retrospective Studies ; United States/epidemiology
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-023-04826-9
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  9. Article ; Online: Correction to: Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities.

    Mersha, Tesfaye B / Abebe, Tilahun

    Human genomics

    2021  Volume 15, Issue 1, Page(s) 35

    Language English
    Publishing date 2021-06-15
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2147618-4
    ISSN 1479-7364 ; 1479-7364
    ISSN (online) 1479-7364
    ISSN 1479-7364
    DOI 10.1186/s40246-021-00322-7
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  10. Article ; Online: Comorbidities in childhood-onset and adult-onset asthma.

    Mendy, Angelico / Mersha, Tesfaye B

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2022  Volume 129, Issue 3, Page(s) 327–334

    Abstract: Background: Age of asthma onset has emerged as an important determinant of asthma phenotypes; however, the comorbidities that predominate in either childhood- or adult-onset asthma are not known.: Objective: To identify comorbidities associated with ... ...

    Abstract Background: Age of asthma onset has emerged as an important determinant of asthma phenotypes; however, the comorbidities that predominate in either childhood- or adult-onset asthma are not known.
    Objective: To identify comorbidities associated with adult-onset asthma vs childhood-onset asthma and with age of asthma diagnosis.
    Methods: We analyzed data on 27,437 adult participants in the National Health and Nutrition Examination Surveys conducted from 2001 to 2018. Logistic regression adjusted for covariates was used to identify comorbidities associated with the asthma phenotypes and age of asthma diagnosis.
    Results: Approximately 12.6% of participants were ever diagnosed with asthma; the prevalence of childhood-onset (before 18 years old) and adult-onset (≥ 18 years old) current asthma was 2.7% and 5.5%, respectively. After adjustment for covariates including age, adult-onset asthma was associated with higher odds of obesity (odds ratio [OR], 1.46; 95% confidence interval [CI], 1.09-1.96), hypercholesterolemia (OR, 1.67; 95% CI, 1.08-2.56), borderline high serum triglycerides (OR, 1.78; 95% CI, 1.17-2.71), and osteoarthritis (OR, 1.52; 95% CI, 1.04-2.20) than was childhood-onset asthma. Older age of asthma diagnosis (per 5-year increase) was also associated with higher odds of diabetes (OR, 1.04; 95% CI, 1.00-1.07) and hypertension (OR, 1.05; 95% CI, 1.02-1.07), whereas younger age of asthma diagnosis was associated with higher odds of chronic obstructive pulmonary disease (OR, 1.12; 95% CI, 1.04-1.19).
    Conclusion: Age- and covariates-adjusted prevalence of obesity, dyslipidemia, arthritis, diabetes, and hypertension is higher in adult-onset asthma than in childhood-onset asthma, and with older age of asthma diagnosis. Conversely, the prevalence of chronic obstructive pulmonary disease increases with younger age of asthma diagnosis.
    MeSH term(s) Asthma/diagnosis ; Humans ; Hypertension/epidemiology ; Obesity ; Prevalence ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Risk Factors
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2022.05.005
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