LIVIVO - Search results -

Search results

Result 1 - 10 of total 353

Search options

Article ; Online: Dopamine, Immunity, and Disease.

Channer, Breana / Matt, Stephanie M / Nickoloff-Bybel, Emily A / Pappa, Vasiliki / Agarwal, Yash / Wickman, Jason / Gaskill, Peter J

Pharmacological reviews

2022 Volume 75, Issue 1, Page(s) 62–158

Abstract: The neurotransmitter dopamine is a key factor in central nervous system (CNS) function, regulating many processes including reward, movement, and cognition. Dopamine also regulates critical functions in peripheral organs, such as blood pressure, renal ... ...

Abstract	The neurotransmitter dopamine is a key factor in central nervous system (CNS) function, regulating many processes including reward, movement, and cognition. Dopamine also regulates critical functions in peripheral organs, such as blood pressure, renal activity, and intestinal motility. Beyond these functions, a growing body of evidence indicates that dopamine is an important immunoregulatory factor. Most types of immune cells express dopamine receptors and other dopaminergic proteins, and many immune cells take up, produce, store, and/or release dopamine, suggesting that dopaminergic immunomodulation is important for immune function. Targeting these pathways could be a promising avenue for the treatment of inflammation and disease, but despite increasing research in this area, data on the specific effects of dopamine on many immune cells and disease processes remain inconsistent and poorly understood. Therefore, this review integrates the current knowledge of the role of dopamine in immune cell function and inflammatory signaling across systems. We also discuss the current understanding of dopaminergic regulation of immune signaling in the CNS and peripheral tissues, highlighting the role of dopaminergic immunomodulation in diseases such as Parkinson's disease, several neuropsychiatric conditions, neurologic human immunodeficiency virus, inflammatory bowel disease, rheumatoid arthritis, and others. Careful consideration is given to the influence of experimental design on results, and we note a number of areas in need of further research. Overall, this review integrates our knowledge of dopaminergic immunology at the cellular, tissue, and disease level and prompts the development of therapeutics and strategies targeted toward ameliorating disease through dopaminergic regulation of immunity. SIGNIFICANCE STATEMENT: Canonically, dopamine is recognized as a neurotransmitter involved in the regulation of movement, cognition, and reward. However, dopamine also acts as an immune modulator in the central nervous system and periphery. This review comprehensively assesses the current knowledge of dopaminergic immunomodulation and the role of dopamine in disease pathogenesis at the cellular and tissue level. This will provide broad access to this information across fields, identify areas in need of further investigation, and drive the development of dopaminergic therapeutic strategies.
MeSH term(s)	Humans ; Central Nervous System/immunology ; Dopamine/immunology ; Neurotransmitter Agents/immunology ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Receptors, Dopamine/immunology
Chemical Substances	Dopamine (VTD58H1Z2X) ; Neurotransmitter Agents ; Receptors, Dopamine
Language	English
Publishing date	2022-12-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	209898-2
ISSN	1521-0081 ; 0031-6997
ISSN (online)	1521-0081
ISSN	0031-6997
DOI	10.1124/pharmrev.122.000618
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uf I Zs.148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Animal models of psoriasis.

Nickoloff, B J

Expert opinion on investigational drugs

2005 Volume 8, Issue 4, Page(s) 393–401

Abstract: Psoriasis is a common and chronic skin disorder under active investigation around the world. Despite this, determination of its genetic basis, role of the immune system in the disease pathophysiology and development of effective therapy, have been ... ...

Abstract	Psoriasis is a common and chronic skin disorder under active investigation around the world. Despite this, determination of its genetic basis, role of the immune system in the disease pathophysiology and development of effective therapy, have been hampered severely by the absence of any spontaneous psoriatic skin disease in animals. Furthermore, until recently, validated animal models designed to create psoriasis were unavailable to investigative skin biologists and clinical scientists. However, there is at least one animal model which has been established and validated; it uses human skin engrafted on to severe combined immunodeficient (SCID) mice. In addition, there are several other rodent models which do not involve transplantation technology that share some (but not all) features in common with psoriasis. This review will summarise these available animal models and critique their relevance with respect to illuminating the immunogenetic basis of psoriasis and their value in screening novel treatments in a preclinical setting.
Language	English
Publishing date	2005-06-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1182884-5
ISSN	1744-7658 ; 0967-8298 ; 1354-3784
ISSN (online)	1744-7658
ISSN	0967-8298 ; 1354-3784
DOI	10.1517/13543784.8.4.393
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3739: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Canada's marine carbon sink

P.J. Duke / B. Richaud / R. Arruda / J. Länger / K. Schuler / P. Gooya / M.M.M. Ahmed / M.R. Miller / C.A. Braybrook / K. Kam / R. Piunno / Y. Sezginer / G. Nickoloff / A.C. Franco

FACETS, Vol 8, Iss , Pp 1-

an early career perspective on the state of research and existing knowledge gaps

2023 Volume 21

Abstract: Improving our understanding of how the ocean absorbs carbon dioxide is critical to climate change mitigation efforts. We, a group of early career ocean professionals working in Canada, summarize current research and identify steps forward to improve our ... ...

Abstract	Improving our understanding of how the ocean absorbs carbon dioxide is critical to climate change mitigation efforts. We, a group of early career ocean professionals working in Canada, summarize current research and identify steps forward to improve our understanding of the marine carbon sink in Canadian national and offshore waters. We have compiled an extensive collection of reported surface ocean air–sea carbon dioxide exchange values within each of Canada's three adjacent ocean basins. We review the current understanding of air–sea carbon fluxes and identify major challenges limiting our understanding in the Pacific, the Arctic, and the Atlantic Ocean. We focus on ways of reducing uncertainty to inform Canada's carbon stocktake, establish baselines for marine carbon dioxide removal projects, and support efforts to mitigate and adapt to ocean acidification. Future directions recommended by this group include investing in maturing and building capacity in the use of marine carbon sensors, improving ocean biogeochemical models fit-for-purpose in regional and ocean carbon dioxide removal applications, creating transparent and robust monitoring, verification, and reporting protocols for marine carbon dioxide removal, tailoring community-specific approaches to co-generate knowledge with First Nations, and advancing training opportunities for early career ocean professionals in marine carbon science and technology.
Keywords	early career ; future research ; oceans ; ocean carbon flux ; marine carbon cycle ; ocean biogeochemistry ; Education ; L ; Science ; Q
Subject code	551 ; 333
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Canadian Science Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Transfer RNA genes of Euglena gracilis chloroplast DNA : A review.

Hallick, R B / Hollingsworth, M J / Nickoloff, J A

Plant molecular biology

2013 Volume 3, Issue 3, Page(s) 169–175

Abstract: Transfer RNA genes have been mapped to at least nine different loci on the physical map of the Euglena gracilis chloroplast genome. One of these loci in the ribosomal RNA operons is present three times per genome. The DNA sequences of six of the nine ... ...

Abstract	Transfer RNA genes have been mapped to at least nine different loci on the physical map of the Euglena gracilis chloroplast genome. One of these loci in the ribosomal RNA operons is present three times per genome. The DNA sequences of six of the nine different loci, containing 21 different tRNA genes, have been determined. Genes corresponding to the amino acids Ala, Arg, Asn, Cys, Gln, Gly (2), Glu, His, Ile, Leu (2), Met (2), Phe, Ser, Thr, Trp, Tyr, Val, and one unassigned species have been identified. All genes except one are found in clusters of 2-6 genes. None of the known genes contains introns, nor codes for the 3'-CCA terminus. In addition to these genes, two pseudo tRNA genes are present in the rDNA leader region.
Language	English
Publishing date	2013-10-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	778032-1
ISSN	1573-5028 ; 0167-4412
ISSN (online)	1573-5028
ISSN	0167-4412
DOI	10.1007/BF00016064
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 3458: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Creation of psoriatic plaques: the ultimate tumor suppressor pathway. A new model for an ancient T-cell-mediated skin disease. Viewpoint.

Nickoloff, B J

Journal of cutaneous pathology

2001 Volume 28, Issue 2, Page(s) 57–64

Abstract: From an oncological and immunological perspective, the T-cell-mediated induction of psoriatic plaques should be prone to malignant transformation as the phenotype of psoriatic plaques includes: chronic inflammation, epidermal hyperplasia, prolonged ... ...

Abstract	From an oncological and immunological perspective, the T-cell-mediated induction of psoriatic plaques should be prone to malignant transformation as the phenotype of psoriatic plaques includes: chronic inflammation, epidermal hyperplasia, prolonged survival and elevated telomerase levels in lesional keratinocytes, as well as angiogenesis, exposure to carcinogens and immunosuppressants. However, conversion of a psoriatic plaque to squamous cell carcinoma is exceedingly rare. This paper explores the possible molecular mechanism for the tumor suppressor pathway in psoriatic lesions, with an emphasis on a putative senescence-switch involving p16.
MeSH term(s)	Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/pathology ; Cell Transformation, Neoplastic ; Genes, Tumor Suppressor ; Humans ; Keratinocytes/pathology ; Models, Biological ; Precancerous Conditions ; Psoriasis/complications ; Psoriasis/genetics ; Psoriasis/immunology ; Psoriasis/pathology ; Skin Neoplasms/etiology ; Skin Neoplasms/pathology ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology
Language	English
Publishing date	2001-02
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1034/j.1600-0560.2001.280201.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1043: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: The many molecular mysteries of melanoma.

Nickoloff, B J

Methods in molecular medicine

2001 Volume 61, Page(s) 3–14

Abstract: Melanoma of the skin is one of the most rapidly increasing malignancies in both young and old patients (1,2). Not only is the incidence increasing, but the number of annual deaths from melanoma is also on the rise worldwide (3). In the United States, ... ...

Abstract	Melanoma of the skin is one of the most rapidly increasing malignancies in both young and old patients (1,2). Not only is the incidence increasing, but the number of annual deaths from melanoma is also on the rise worldwide (3). In the United States, melanoma will be diagnosed in 43,000 new patients each year and be responsible for 7300 deaths (1 death every 72 min). The capacity of melanoma to develop in young patients is reflected by the rather alarming statistic that it has become one of the top causes of death in both men and women between the ages of 25 and 40 (3). Indeed, among Caucasian females, melanoma is the leading cause of death from malignancy between the ages of 25 and 29 (3). It is expected that by 2002, 1 in 70 Americans will develop melanoma during their lifetime (2). Also, melanoma is second only to adult leukemia as the leader in the number of potential years of life lost, which is significantly greater than for patients with cervical, breast, and colon malignancies (4). Despite the frequent presence of melanoma and major associated health problems around the globe, only recently have clinicians and laboratory-based researchers begun to unravel some of the molecular mysteries of melanoma (5,6). The purpose of Melanoma: Methods and Protocols, published as part of the Methods in Molecular Medicine™ series, is to provide an up-to-date review of the many advances that have taken place during the past several years involving the pathophysiology, diagnosis, genetic analysis, and treatment approaches for patients with melanoma (7).
Language	English
Publishing date	2001
Publishing country	United States
Document type	Journal Article
ISSN	1543-1894
ISSN	1543-1894
DOI	10.1385/1-59259-145-0:3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: The search for pathogenic T cells and the genetic basis of psoriasis using a severe combined immunodeficient mouse model.

Nickoloff, B J

Cutis

2000 Volume 65, Issue 2, Page(s) 110–114

Abstract: The immunologic and genetic bases of psoriasis are under active investigation throughout the world. Rather than pursue the genetic linkage to psoriasis to discover the gene(s) responsible for causing the disease, we have focused on the cellular ... ...

Abstract	The immunologic and genetic bases of psoriasis are under active investigation throughout the world. Rather than pursue the genetic linkage to psoriasis to discover the gene(s) responsible for causing the disease, we have focused on the cellular immunology and basic biology using a novel animal model. We reasoned by identifying specific cellular and molecular abnormalities involved in the biologic responses that initiate lesion formation, that the genes involved in such a pathologic process would lead us to the correct causative DNA-based abnormality that determines disease susceptibility and inheritance. To pursue this line of inquiry, we utilized an animal model in which severe combined immunodeficient (SCID) mice were engrafted with symptomless skin (PN skin), and bona fide psoriatic plaques (PP skin) were created using specific pathogenic T cell subsets. This model can be used experimentally not only to study the mechanism by which PP skin is converted to PN skin, but also to create PP skin from PN skin. The clinical, histologic, immunologic, and pharmacologic validation of this SCID mouse model will be presented. This summary will also highlight the value of such a model, which has recently led to the discovery of previously overlooked types of immunocytes that are associated with induction of psoriatic lesions. Finally, a novel hypothesis linking the immunology and the genetics of psoriasis, based on findings using this animal model, will conclude this presentation.
MeSH term(s)	Animals ; Disease Models, Animal ; Mice ; Mice, SCID ; Psoriasis/genetics ; Psoriasis/immunology ; Psoriasis/pathology ; Skin/pathology ; Skin Transplantation ; T-Lymphocytes/immunology
Language	English
Publishing date	2000-02
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	391840-3
ISSN	0011-4162 ; 0151-9522
ISSN	0011-4162 ; 0151-9522
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1315: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 44: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Characterization of lymphocyte-dependent angiogenesis using a SCID mouse: human skin model of psoriasis.

Nickoloff, B J

The journal of investigative dermatology. Symposium proceedings

2000 Volume 5, Issue 1, Page(s) 67–73

Abstract: From a clinical perspective, angiogenesis is an important component of acute and chronic psoriatic skin lesions as they are erythematous and display a tendency to bleed after superficial removal of scale. By routine histology, numerous microscopic ... ...

Abstract	From a clinical perspective, angiogenesis is an important component of acute and chronic psoriatic skin lesions as they are erythematous and display a tendency to bleed after superficial removal of scale. By routine histology, numerous microscopic vascular abnormalities are also present. The structural expansion of capillaries and distinctive activated phenotype of lesional endothelial cells are believed not only to be clinical and pathologic hallmarks of the disease, but to play a central role in the pathogenesis of psoriatic plaques. Despite over 20 years of research by leading angiogenesis experts and numerous studies, many details regarding the cellular and molecular basis for angiogenesis in psoriasis remain unknown. In this review, 10 different sections are presented to update recent progress in this active field of investigative skin biology. Highlights of this review include the phenotypic characterization of endothelial cells in acute and chronic psoriatic plaques, and a review of a novel animal model of psoriasis using human skin engrafted onto severe combined immunodeficient mice followed by injection of activated immunocytes. This new experimental model represents a reproducible and pharmacologically validated method to trigger neovascularization and bona fide psoriatic plaque formation. In addition, the potential contribution of epidermal keratinocytes and dermal macrophages to the angiogenic tissue reaction is presented, and a series of questions are then posed that can be answered using the severe combined immunodeficient mouse model of psoriasis. Finally, a model is proposed integrating all available data into a coherent multistep reaction schema that includes active participation by multiple cell types including natural killer T cells, keratinocytes, macrophages, and microvascular endothelial cells.
MeSH term(s)	Animals ; Disease Models, Animal ; Humans ; Lymphocytes/physiology ; Mice ; Mice, SCID ; Neovascularization, Pathologic/immunology ; Neovascularization, Pathologic/pathology ; Psoriasis/immunology ; Psoriasis/pathology ; Psoriasis/physiopathology ; Skin/blood supply ; Skin/immunology ; Skin/pathology
Language	English
Publishing date	2000-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1338142-8
ISSN	1087-0024
ISSN	1087-0024
DOI	10.1046/j.1087-0024.2000.00006.x
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4510: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The immunologic and genetic basis of psoriasis.

Nickoloff, B J

Archives of dermatology

1999 Volume 135, Issue 9, Page(s) 1104–1110

MeSH term(s)	Animals ; Antigens, CD/immunology ; Cytokines/immunology ; Gene Expression Regulation/immunology ; Humans ; Immunophenotyping ; Keratinocytes/immunology ; Psoriasis/genetics ; Psoriasis/immunology ; T-Lymphocytes/immunology
Chemical Substances	Antigens, CD ; Cytokines
Language	English
Publishing date	1999-09
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	212139-6
ISSN	1538-3652 ; 0003-987X
ISSN (online)	1538-3652
ISSN	0003-987X
DOI	10.1001/archderm.135.9.1104
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui VI Zs.32: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Skin innate immune system in psoriasis: friend or foe?

Nickoloff, B J

The Journal of clinical investigation

1999 Volume 104, Issue 9, Page(s) 1161–1164

MeSH term(s)	Animals ; Humans ; Immunity, Innate ; Keratinocytes/immunology ; Killer Cells, Natural/immunology ; Lymphocyte Subsets/immunology ; Mice ; Mice, Knockout ; Models, Immunological ; Phenotype ; Psoriasis/etiology ; Psoriasis/immunology ; Psoriasis/pathology ; Psoriasis/therapy ; Skin/immunology ; Skin/pathology
Language	English
Publishing date	1999-11
Publishing country	United States
Document type	Comment ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI8633
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.184: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito