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Article ; Online: Liang-Ge-San

Liling Yang / Lijun Yan / Weifu Tan / Xiangjun Zhou / Guangli Yang / Jingtao Yu / Zibin Lu / Yong Liu / Liyi Zou / Wei Li / Linzhong Yu

Frontiers in Pharmacology, Vol

a classic traditional Chinese medicine formula, attenuates acute inflammation via targeting GSK3β

2023 Volume 14

Abstract: ... that burden the world, but there is still a lack of more effective and reliable drug treatment. Liang-Ge-San ...

Abstract	Sepsis is a serious life-threatening health disorder with high morbidity and mortality rates that burden the world, but there is still a lack of more effective and reliable drug treatment. Liang-Ge-San (LGS) has been shown to have anti-inflammatory effects and is a promising candidate for the treatment of sepsis. However, the anti-sepsis mechanism of LGS has still not been elucidated. In this study, a set of genes related to inflammatory chemotaxis pathways was downloaded from Encyclopedia of Genes and Genomes (KEGG) and integrated with sepsis patient information from the Gene Expression Omnibus (GEO) database to perform differential gene expression analysis. Glycogen synthase kinase-3β (GSK-3β) was found to be the feature gene after these important genes were examined using the three algorithms Random Forest, support vector machine recursive feature elimination (SVM-REF), and least absolute shrinkage and selection operator (LASSO), and then intersected with possible treatment targets of LGS found through the search. Upon evaluation, the receiver operating characteristic (ROC) curve of GSK-3β indicated an important role in the pathogenesis of sepsis. Immune cell infiltration analysis suggested that GSK-3β expression was associated with a variety of immune cells, including neutrophils and monocytes. Next, lipopolysaccharide (LPS)-induced zebrafish inflammation model and macrophage inflammation model was used to validate the mechanism of LGS. We found that LGS could protect zebrafish against a lethal challenge with LPS by down-regulating GSK-3β mRNA expression in a dose-dependent manner, as indicated by a decreased neutrophils infiltration and reduction of inflammatory damage. The upregulated mRNA expression of GSK-3β in LPS-induced stimulated RAW 264.7 cells also showed the same tendency of depression by LGS. Critically, LGS could induce M1 macrophage polarization to M2 through promoting GSK-3β inactivation of phosphorylation. Taken together, we initially showed that anti-septic effects of LGS is related to the ...
Keywords	Liang-Ge-San ; traditional Chinese medicine ; sepsis ; acute inflammation ; LPS ; GSK-3β ; Therapeutics. Pharmacology ; RM1-950
Subject code	570
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs.

Duo, Tianqi / Liu, Xiaohong / Mo, Delin / Bian, Yu / Cai, Shufang / Wang, Min / Li, Ruiqiang / Zhu, Qi / Tong, Xian / Liang, Ziyun / Jiang, Weilun / Chen, Shiyi / Chen, Yaosheng / He, Zuyong

Journal of animal science and biotechnology

2023 Volume 14, Issue 1, Page(s) 141

Abstract: ... into porcine embryonic fibroblasts (PEFs) isolated from a male Liang Guang Small Spotted pig (LGSS), and single ...

Abstract	Background: Chinese indigenous pigs are popular with consumers for their juiciness, flavour and meat quality, but they have lower meat production. Insulin-like growth factor 2 (IGF2) is a maternally imprinted growth factor that promotes skeletal muscle growth by regulating cell proliferation and differentiation. A single nucleotide polymorphism (SNP) within intron 3 of porcine IGF2 disrupts a binding site for the repressor, zinc finger BED-type containing 6 (ZBED6), leading to up-regulation of IGF2 and causing major effects on muscle growth, heart size, and backfat thickness. This favorable mutation is common in Western commercial pig populations, but absent in most Chinese indigenous pig breeds. To improve meat production of Chinese indigenous pigs, we used cytosine base editor 3 (CBE3) to introduce IGF2-intron3-C3071T mutation into porcine embryonic fibroblasts (PEFs) isolated from a male Liang Guang Small Spotted pig (LGSS), and single-cell clones harboring the desired mutation were selected for somatic cell nuclear transfer (SCNT) to generate the founder line of IGF2 Results: We found the heterozygous progeny IGF2 Conclusions: We demonstrated the introduction of IGF2-intron3-C3071T in Chinese LGSS can improve both meat production and quality, and first identified the regulation of IMF deposition by IGF2 through SREBP1 via the PI3K-AKT/AMPK signaling pathways. Our study provides a further understanding of the biological functions of IGF2 and an example for improving porcine economic traits through precise base editing.
Language	English
Publishing date	2023-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2630162-3
ISSN	2049-1891 ; 1674-9782
ISSN (online)	2049-1891
ISSN	1674-9782
DOI	10.1186/s40104-023-00930-4
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Article ; Online: "Liu-Liang-Chung" syndrome with multiple congenital anomalies and the distinctive craniofacial features caused by dominant ZEB2 gene gain mutation.

Liu, Wei-Liang / Li, Fang / Chen, Wei / Liu, Lu / Cheng, Hai-Jian / He, Zhi-Xu / Ai, Rong

BMC pediatrics

2023 Volume 23, Issue 1, Page(s) 480

Abstract: ... gain mutation, which is recommended to be named "Liu-Liang-Chung" syndrome. We diagnose this novel ...

Abstract	Background: Contiguous gene gain syndrome including entire ZEB2 may be a novel syndrome. In the past, there were no easily distinct and recognizable features as a guide for precise clinical and genetic diagnosis of the syndrome. Case presentation: We report a novel case with the syndrome with a novel de novo 22.16 Mb duplication at 2q21.2-q24.1. The syndrome is characterized by multiple anomalies including the same typical craniofacial phenotype that is entirely different from Mowat-Wilson syndrome (MWS), and other quite similar features of MWS consisting of development delay, congenital heart disease, abdominal abnormalities, urogenital abnormalities, behavioral problems and so on, in which the distinctive craniofacial features can be more easily recognized. Conclusions: Contiguous gene gain syndrome including entire ZEB2 characterized with similar multiple congenital anomalies of MWS and the distinctive craniofacial features is mainly caused by large 2q22 repeats including ZEB2 leading to dominant singe ZEB2 gene gain mutation, which is recommended to be named "Liu-Liang-Chung" syndrome. We diagnose this novel syndrome to distinguish it from MWS. Some variable additional features in the syndrome including remarkable growth and development retardation and protruding ears were recognized for the first time.
MeSH term(s)	Humans ; Abnormalities, Multiple/genetics ; Mutation ; Hirschsprung Disease/diagnosis ; Hirschsprung Disease/genetics ; Phenotype ; Zinc Finger E-box Binding Homeobox 2/genetics
Chemical Substances	ZEB2 protein, human ; Zinc Finger E-box Binding Homeobox 2
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-023-04314-5
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Article ; Online: Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs

Tianqi Duo / Xiaohong Liu / Delin Mo / Yu Bian / Shufang Cai / Min Wang / Ruiqiang Li / Qi Zhu / Xian Tong / Ziyun Liang / Weilun Jiang / Shiyi Chen / Yaosheng Chen / Zuyong He

Journal of Animal Science and Biotechnology, Vol 14, Iss 1, Pp 1-

2023 Volume 19

Abstract: ... into porcine embryonic fibroblasts (PEFs) isolated from a male Liang Guang Small Spotted pig (LGSS), and single ...

Abstract	Abstract Background Chinese indigenous pigs are popular with consumers for their juiciness, flavour and meat quality, but they have lower meat production. Insulin-like growth factor 2 (IGF2) is a maternally imprinted growth factor that promotes skeletal muscle growth by regulating cell proliferation and differentiation. A single nucleotide polymorphism (SNP) within intron 3 of porcine IGF2 disrupts a binding site for the repressor, zinc finger BED-type containing 6 (ZBED6), leading to up-regulation of IGF2 and causing major effects on muscle growth, heart size, and backfat thickness. This favorable mutation is common in Western commercial pig populations, but absent in most Chinese indigenous pig breeds. To improve meat production of Chinese indigenous pigs, we used cytosine base editor 3 (CBE3) to introduce IGF2-intron3-C3071T mutation into porcine embryonic fibroblasts (PEFs) isolated from a male Liang Guang Small Spotted pig (LGSS), and single-cell clones harboring the desired mutation were selected for somatic cell nuclear transfer (SCNT) to generate the founder line of IGF2 T/T pigs. Results We found the heterozygous progeny IGF2 C/T pigs exhibited enhanced expression of IGF2, increased lean meat by 18%–36%, enlarged loin muscle area by 3%–17%, improved intramuscular fat (IMF) content by 18%–39%, marbling score by 0.75–1, meat color score by 0.53–1.25, and reduced backfat thickness by 5%–16%. The enhanced accumulation of intramuscular fat in IGF2 C/T pigs was identified to be regulated by the PI3K-AKT/AMPK pathway, which activated SREBP1 to promote adipogenesis. Conclusions We demonstrated the introduction of IGF2-intron3-C3071T in Chinese LGSS can improve both meat production and quality, and first identified the regulation of IMF deposition by IGF2 through SREBP1 via the PI3K-AKT/AMPK signaling pathways. Our study provides a further understanding of the biological functions of IGF2 and an example for improving porcine economic traits through precise base editing.
Keywords	CBE3 ; IGF2 ; Intramuscular fat ; Meat production ; PI3K-AKT/AMPK ; ZBED6 ; Animal culture ; SF1-1100 ; Veterinary medicine ; SF600-1100
Subject code	630 ; 500
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Metabolomic analysis reveals spermatozoa and seminal plasma differences between Duroc and Liang guang Small-spotted pig.

Li, Zhili / Sun, Jingshuai / Li, Kebiao / Qin, Jiali / Sun, Yanmei / Zeng, Jianhua / El-Ashram, Saeed / Zhao, Yunxiang

Frontiers in veterinary science

2023 Volume 9, Page(s) 1078928

Abstract: The Liang guang Small-spotted pig is a well-known Chinese indigenous pig that is valued ... for its exceptional meat quality. However, the Liang guang Small-spotted pig has a lower semen storage capacity ... losses and short shelf life of the semen are particularly prominent in Liang guang Small-spotted pig ...

Abstract	The Liang guang Small-spotted pig is a well-known Chinese indigenous pig that is valued for its exceptional meat quality. However, the Liang guang Small-spotted pig has a lower semen storage capacity, shorter storage time and worse semen quality compared to Duroc. Pig sperm used for artificial insemination (AI) loses part of vitality and quality when being stored in commercial solutions. Serious vitality losses and short shelf life of the semen are particularly prominent in Liang guang Small-spotted pig. In this study, the metabolites in seminal plasma and spermatozoa of Duroc and Liang guang Small-spotted pigs were identified using UHPLC-Q-TOF/MS technology. The findings indicated forty distinct metabolites concentrating on energy metabolic substrates and antioxidant capacity in Liang guang Small-spotted pig and Duroc seminal plasma, including D-Fructose, succinate, 2-dehydro-3-deoxy-d-gluconate, alanine betaine, citrate, carnitine, acetylcarnitine and so on. Seventeen different metabolites were explored, with a focus on glycerophospholipid metabolism in Liang guang Small-spotted pig and Duroc spermatozoa, primarily including glycerol 3-phosphate, acetylcarnitine, phosphatidylcholine (PC) 16:0/16:0, palmitoyl sphingomyelin, acetylcholine, choline, glycerophosphocholine, betaine, L-carnitine, creatinine and others. This study reveals the metabolite profile of spermatozoa and seminal plasma among different pig breeds and might be valuable for understanding the mechanisms that lead to sperm storage capacity. Metabolites involved in energy metabolism, antioxidant capacity and glycerophospholipid metabolism might be key to the poor sperm storage capacity in Liang guang Small-spotted pig.
Language	English
Publishing date	2023-01-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2022.1078928
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Article ; Online: Redescription of two species of Capillogryllus Xie, Zheng & Liang, 2003, with a new species from China (Orthoptera: Gryllidae; Gryllinae).

Wu, Qian / Ma, Li-Bin

Zootaxa

2023 Volume 5336, Issue 1, Page(s) 135–140

Abstract: ... Liang in 2003 are reviewed. Capillogryllus has presently two species, Capillogryllus exilipalpis Xie ...

Abstract	The species with a strongly pubescent body with the genus name Capillogryllus by Xie, Zheng, and Liang in 2003 are reviewed. Capillogryllus has presently two species, Capillogryllus exilipalpis Xie & Zheng, 2003 (type specimen is a female), and Capillogryllus dolabripalpis Xie & Zheng, 2003 (type species), both of which are only known from China at this time. In Gyirong County, Tibet, we discovered a new species of this genus that is distinct from the two species mentioned above. Here, three species of Capillogryllus are described and illustrated.
MeSH term(s)	Female ; Animals ; Gryllidae ; Orthoptera ; Animal Distribution ; Organ Size ; Animal Structures ; Body Size ; China
Language	English
Publishing date	2023-08-21
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5336.1.7
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Article ; Online: Differences in the costs and benefits of choosiness may explain variation in cuckoo egg-matching strategy: a reply to Wang and Liang (2023).

Zhang, Jinggang / Santema, Peter / Lin, Zixuan / Yang, Lixing / Liu, Meijun / Li, Jianqiang / Deng, Wenhong / Kempenaers, Bart

Proceedings. Biological sciences

2023 Volume 290, Issue 2006, Page(s) 20231219

MeSH term(s)	Cost-Benefit Analysis ; Animals ; Nesting Behavior ; Birds
Language	English
Publishing date	2023-09-13
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	209242-6
ISSN	1471-2954 ; 0080-4649 ; 0962-8452 ; 0950-1193
ISSN (online)	1471-2954
ISSN	0080-4649 ; 0962-8452 ; 0950-1193
DOI	10.1098/rspb.2023.1219
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Article ; Online: Preparation of leaf protoplasts from Populus (Populus × xiaohei T. S. Hwang et Liang) and establishment of transient expression system.

Yang, Chengjun / Yu, Ruiqiang / Li, Jinbo / Wang, Kai / Liu, Guanjun

Journal of plant physiology

2023 Volume 291, Page(s) 154122

Abstract: ... system of Populus (Populus × xiaohei T. S. Hwang et Liang) is described. Firstly, we proposed ...

Abstract	Poplar, as a typical woody plant, is an ideal raw material for the production of lignocellulose biofuel. However, the longer life cycle is not conducive to the rapid identification of poplar genes. At present, protoplasts have been used for gene function identification and high-throughput analysis in many model plants. In this paper, a simplified and efficient protoplast isolation and transient expression system of Populus (Populus × xiaohei T. S. Hwang et Liang) is described. Firstly, we proposed an efficient enzyme hydrolysis method for isolating protoplasts from leaves of Populus × xiaohei. Secondly, we optimized the conditions of protoplast transformation mediated by PEG, and established an efficient transient expression system of protoplasts of Populus × xiaohei. Finally, the subcellular localization of three identified Dof transcription factors (PnDof19, PnDof20 and PnDof30) was also observed in the nucleus by using this scheme, which proved that the method was feasible. In general, this efficient method of protoplast isolation and transformation can be used for the study of protein subcellular localization and can be applied to other fields of molecular biology, such as protein interaction, gene activation and so on.
MeSH term(s)	Populus/genetics ; Protoplasts/metabolism ; Plant Leaves/genetics ; Plant Leaves/metabolism ; Plants, Genetically Modified/genetics ; Phenotype
Language	English
Publishing date	2023-11-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	283647-6
ISSN	1618-1328 ; 0176-1617
ISSN (online)	1618-1328
ISSN	0176-1617
DOI	10.1016/j.jplph.2023.154122
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Article ; Online: A morphological study of the ovipositor of the genus Capillogryllus Xie, Zheng & Liang, 2003 with a new species of the genus from China (Orthoptera: Gryllidae; Gryllinae).

Wu, Qian / Zhang, Tao / Ma, Li-Bin

Zootaxa

2023 Volume 5383, Issue 3, Page(s) 391–397

Abstract: The genus Capillogryllus includes three species, Capillogryllus dolabripalpis Xie & Zheng, 2003, Capillogryllus exilipalpis Xie & Zheng, 2003, Capillogryllus spinae Wu & Ma, 2023. Recently, we found a new species of this genus in Yadong County, Xizang ... ...

Abstract	The genus Capillogryllus includes three species, Capillogryllus dolabripalpis Xie & Zheng, 2003, Capillogryllus exilipalpis Xie & Zheng, 2003, Capillogryllus spinae Wu & Ma, 2023. Recently, we found a new species of this genus in Yadong County, Xizang Autonomous Region, and described it here. In addition, we found that the ovipositor varies greatly within this taxon, so we compare and characterize their ovipositor and discuss the feasibility of using the ovipositor alone to identify them. We also provide two keys based on the genitalia of males and females.
MeSH term(s)	Male ; Female ; Animals ; Gryllidae ; Orthoptera ; Animal Distribution ; Organ Size ; Animal Structures ; Body Size ; China
Language	English
Publishing date	2023-12-12
Publishing country	New Zealand
Document type	Journal Article
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.5383.3.8
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Article ; Online: Altered default mode network causal connectivity patterns in autism spectrum disorder revealed by Liang information flow analysis.

Cong, Jing / Zhuang, Wenwen / Liu, Yunhong / Yin, Shunjie / Jia, Hai / Yi, Chanlin / Chen, Kai / Xue, Kaiqing / Li, Fali / Yao, Dezhong / Xu, Peng / Zhang, Tao

Human brain mapping

2023 Volume 44, Issue 6, Page(s) 2279–2293

Abstract: ... remains largely unclear. Here, we introduced the Liang information flow method, widely applied to climate ... our findings indicated that the Liang information flow method could serve as an important way to explore ...

Abstract	Autism spectrum disorder (ASD) is a pervasive developmental disorder with severe cognitive impairment in social communication and interaction. Previous studies have reported that abnormal functional connectivity patterns within the default mode network (DMN) were associated with social dysfunction in ASD. However, how the altered causal connectivity pattern within the DMN affects the social functioning in ASD remains largely unclear. Here, we introduced the Liang information flow method, widely applied to climate science and quantum mechanics, to uncover the brain causal network patterns in ASD. Compared with the healthy controls (HC), we observed that the interactions among the dorsal medial prefrontal cortex (dMPFC), ventral medial prefrontal cortex (vMPFC), hippocampal formation, and temporo-parietal junction showed more inter-regional causal connectivity differences in ASD. For the topological property analysis, we also found the clustering coefficient of DMN and the In-Out degree of anterior medial prefrontal cortex were significantly decreased in ASD. Furthermore, we found that the causal connectivity from dMPFC to vMPFC was correlated with the clinical symptoms of ASD. These altered causal connectivity patterns indicated that the DMN inter-regions information processing was perturbed in ASD. In particular, we found that the dMPFC acts as a causal source in the DMN in HC, whereas it plays a causal target in ASD. Overall, our findings indicated that the Liang information flow method could serve as an important way to explore the DMN causal connectivity patterns, and it also can provide novel insights into the nueromechanisms underlying DMN dysfunction in ASD.
MeSH term(s)	Humans ; Autism Spectrum Disorder/diagnostic imaging ; Brain Mapping/methods ; Default Mode Network ; Magnetic Resonance Imaging/methods ; Neural Pathways/diagnostic imaging ; Brain/diagnostic imaging
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1197207-5
ISSN	1097-0193 ; 1065-9471
ISSN (online)	1097-0193
ISSN	1065-9471
DOI	10.1002/hbm.26209
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