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Article ; Online: Posttraumatic stress disorder in people with dementia: study protocol.

Ruisch, J E / Havermans, D C D / Gielkens, E M J / Olff, M / Daamen, M A M J / van Alphen, S P J / van Kordenoordt, M / Schols, J M G A / Schruers, K R J / Sobczak, S

European journal of psychotraumatology

2024 Volume 15, Issue 1, Page(s) 2320040

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/therapy ; Stress Disorders, Post-Traumatic/diagnosis ; Prospective Studies ; Reproducibility of Results ; Eye Movement Desensitization Reprocessing/methods ; Dementia/epidemiology ; Dementia/therapy ; Dementia/complications ; Multicenter Studies as Topic
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2586642-4
ISSN	2000-8066 ; 2000-8066
ISSN (online)	2000-8066
ISSN	2000-8066
DOI	10.1080/20008066.2024.2320040
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Article ; Online: Treating Symptoms of Posttraumatic Stress in People with Dementia: Expert Consensus Using the Delphi Method.

Driessen, S / Ponds, R / van Alphen, S P J / Nederstigt, A / Deckers, K / Sobczak, S

Clinical gerontologist

2023 , Page(s) 1–15

Abstract: Objectives: Posttraumatic stress disorder is frequently present in people with dementia, but the symptoms are difficult to recognize and suitable treatments are lacking. The aim of the present study was to investigate which trauma-focused treatments are ...

Abstract	Objectives: Posttraumatic stress disorder is frequently present in people with dementia, but the symptoms are difficult to recognize and suitable treatments are lacking. The aim of the present study was to investigate which trauma-focused treatments are applicable to these patients. Methods: The Delphi method is a process which is used to reach consensus from a panel of experts. The study was conducted online and consisted of three rounds with statements about support for treatment, treatment, and implementation. Results: There are several treatment options available, but it depends on the symptoms, and the severity of PTSD and dementia which treatment is most suitable. Conclusions: The outcomes offer some practical tips for health care workers, and they provide a fundamental base for future research. Clinical implications: Clinicians should pay attention to the treatment of PTSD symptoms in people with dementia and it is necessary to examine the type and severity of both PTSD symptoms and dementia. Taking these factors into account, clinicians are able to focus on the best treatment option in order to improve the quality of life of these specific type of patients.
Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	226146-7
ISSN	1545-2301 ; 0731-7115
ISSN (online)	1545-2301
ISSN	0731-7115
DOI	10.1080/07317115.2023.2170842
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Article ; Online: Correction to: Capturing postural blood pressure dynamics with near‑infrared spectroscopy‑measured cerebral oxygenation.

Klop, Marjolein / de Heus, Rianne A A / Maier, Andrea B / van Alphen, Anne / Floor-Westerdijk, Marianne J / Bronkhorst, Mathijs / Melis, René J F / Meskers, Carel G M / Claassen, Jurgen A H R / van Wezel, Richard J A

GeroScience

2023 Volume 45, Issue 5, Page(s) 3095–3096

Language	English
Publishing date	2023-05-29
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2886586-8
ISSN	2509-2723 ; 2509-2715
ISSN (online)	2509-2723
ISSN	2509-2715
DOI	10.1007/s11357-023-00837-y
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Article ; Online: Implementing a deep learning model for automatic tongue tumour segmentation in ex-vivo 3-dimensional ultrasound volumes.

Bekedam, N M / Idzerda, L H W / van Alphen, M J A / van Veen, R L P / Karssemakers, L H E / Karakullukcu, M B / Smeele, L E

The British journal of oral & maxillofacial surgery

2024

Abstract: ... on automatic segmentation had a low correlation with histopathology (r = 0.12, p = 0.67); MS resulted ... in a moderate but insignificant correlation with histopathology (r = 0.4, p = 0.12, n = 16). Implementing the 3D ...

Abstract	Three-dimensional (3D) ultrasound can assess the margins of resected tongue carcinoma during surgery. Manual segmentation (MS) is time-consuming, labour-intensive, and subject to operator variability. This study aims to investigate use of a 3D deep learning model for fast intraoperative segmentation of tongue carcinoma in 3D ultrasound volumes. Additionally, it investigates the clinical effect of automatic segmentation. A 3D No New U-Net (nnUNet) was trained on 113 manually annotated ultrasound volumes of resected tongue carcinoma. The model was implemented on a mobile workstation and clinically validated on 16 prospectively included tongue carcinoma patients. Different prediction settings were investigated. Automatic segmentations with multiple islands were adjusted by selecting the best-representing island. The final margin status (FMS) based on automatic, semi-automatic, and manual segmentation was computed and compared with the histopathological margin. The standard 3D nnUNet resulted in the best-performing automatic segmentation with a mean (SD) Dice volumetric score of 0.65 (0.30), Dice surface score of 0.73 (0.26), average surface distance of 0.44 (0.61) mm, Hausdorff distance of 6.65 (8.84) mm, and prediction time of 8 seconds. FMS based on automatic segmentation had a low correlation with histopathology (r = 0.12, p = 0.67); MS resulted in a moderate but insignificant correlation with histopathology (r = 0.4, p = 0.12, n = 16). Implementing the 3D nnUNet yielded fast, automatic segmentation of tongue carcinoma in 3D ultrasound volumes. Correlation between FMS and histopathology obtained from these segmentations was lower than the moderate correlation between MS and histopathology.
Language	English
Publishing date	2024-01-03
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	605685-4
ISSN	1532-1940 ; 0266-4356
ISSN (online)	1532-1940
ISSN	0266-4356
DOI	10.1016/j.bjoms.2023.12.017
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Article ; Online: Comparison of image quality of 3D ultrasound: motorized acquisition versus freehand navigated acquisition, a phantom study.

Bekedam, N M / Karssemakers, L H E / van Alphen, M J A / van Veen, R L P / Smeele, L E / Karakullukcu, M B

International journal of computer assisted radiology and surgery

2023 Volume 18, Issue 9, Page(s) 1649–1663

Abstract: Purpose: Intra-operative assessment of resection margins during oncological surgery is a field that needs improvement. Ultrasound (US) shows the potential to fulfill this need, but this imaging technique is highly operator-dependent. A 3D US image of ... ...

Abstract	Purpose: Intra-operative assessment of resection margins during oncological surgery is a field that needs improvement. Ultrasound (US) shows the potential to fulfill this need, but this imaging technique is highly operator-dependent. A 3D US image of the whole specimen may remedy the operator dependence. This study aims to compare and evaluate the image quality of 3D US between freehand acquisition (FA) and motorized acquisition (MA). Methods: Multiple 3D US volumes of a commercial phantom were acquired in motorized and freehand fashion. FA images were collected with electromagnetic navigation. An integrated algorithm reconstructed the FA images. MA images were stacked into a 3D volume. The image quality is evaluated following the metrics: contrast resolution, axial and elevation resolution, axial and elevation distance calibration, stability, inter-operator variability, and intra-operator variability. A linear mixed model determined statistical differences between FA and MA for these metrics. Results: The MA results in a statistically significant lower error of axial distance calibration (p < 0.0001) and higher stability (p < 0.0001) than FA. On the other hand, the FA has a better elevation resolution (p < 0.003) than the MA. Conclusion: MA results in better image quality of 3D US than the FA method based on axial distance calibration, stability, and variability. This study suggests acquiring 3D US volumes for intra-operative ex vivo margin assessment in a motorized fashion.
MeSH term(s)	Humans ; Image Processing, Computer-Assisted/methods ; Ultrasonography/methods ; Imaging, Three-Dimensional/methods ; Algorithms ; Electromagnetic Phenomena ; Phantoms, Imaging
Language	English
Publishing date	2023-05-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2365628-1
ISSN	1861-6429 ; 1861-6410
ISSN (online)	1861-6429
ISSN	1861-6410
DOI	10.1007/s11548-023-02934-x
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Article ; Online: Features and Needs of Autistic Older Adults: A Delphi Study of Clinical Experiences.

Heijnen-Kohl, S M J / Hitzert, B / Schmidt, R / Geurts, H M / van Alphen, S P J

Clinical gerontologist

2022 , Page(s) 1–11

Abstract: ... in the Netherlands and Belgium (Flanders).: Results: R: Conclusions: D: Clinical implications: A ...

Abstract	Objectives: I Methods: A Delphi study outlines the point of view of 11 clinical experts in the Netherlands and Belgium (Flanders). Results: R Conclusions: D Clinical implications: A
Language	English
Publishing date	2022-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	226146-7
ISSN	1545-2301 ; 0731-7115
ISSN (online)	1545-2301
ISSN	0731-7115
DOI	10.1080/07317115.2022.2060157
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Article ; Conference proceedings: Exploring red blood cells as a novel tolerogenic approach for Factor VIII inhibitors employing immuno-dominant FVIII derived peptides presented on MHC class II

Miranda, M / Brandsma, E / Kaijen, P / Van Alphen, F / Van Bruggen, R / Fijnvandraat, K / Lacroix-Desmazes, S / Voorberg, J

Hämostaseologie

2023 Volume 43, Issue S 01

Event/congress	GTH Congress 2023 - 67th Annual Meeting of the Society of Thrombosis and Haemostasis Research - The patient as a benchmark, Frankfurt, Germany, 2023-02-21
Language	English
Publishing date	2023-02-01
Publisher	Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	801512-0
ISSN	2567-5761 ; 0720-9355
ISSN (online)	2567-5761
ISSN	0720-9355
DOI	10.1055/s-0042-1760520
Database	Thieme publisher's database

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Article ; Online: Multi-omics delineation of cytokine-induced endothelial inflammatory states.

Groten, Stijn A / Smit, Eva R / Janssen, Esmée F J / van den Eshof, Bart L / van Alphen, Floris P J / van der Zwaan, Carmen / Meijer, Alexander B / Hoogendijk, Arie J / van den Biggelaar, Maartje

Communications biology

2023 Volume 6, Issue 1, Page(s) 525

Abstract: Vascular endothelial cells (ECs) form a dynamic interface between blood and tissue and play a crucial role in the progression of vascular inflammation. Here, we aim to dissect the system-wide molecular mechanisms of inflammatory endothelial-cytokine ... ...

Abstract	Vascular endothelial cells (ECs) form a dynamic interface between blood and tissue and play a crucial role in the progression of vascular inflammation. Here, we aim to dissect the system-wide molecular mechanisms of inflammatory endothelial-cytokine responses. Applying an unbiased cytokine library, we determined that TNFα and IFNγ induced the largest EC response resulting in distinct proteomic inflammatory signatures. Notably, combined TNFα + IFNγ stimulation induced an additional synergetic inflammatory signature. We employed a multi-omics approach to dissect these inflammatory states, combining (phospho-) proteome, transcriptome and secretome and found, depending on the stimulus, a wide-array of altered immune-modulating processes, including complement proteins, MHC complexes and distinct secretory cytokines. Synergy resulted in cooperative activation of transcript induction. This resource describes the intricate molecular mechanisms that are at the basis of endothelial inflammation and supports the adaptive immunomodulatory role of the endothelium in host defense and vascular inflammation.
MeSH term(s)	Humans ; Cytokines/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Endothelial Cells/metabolism ; Proteomics ; Multiomics ; Inflammation/metabolism ; Endothelium, Vascular
Chemical Substances	Cytokines ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-04897-w
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Article: Musical Attention Control Training for Psychotic Psychiatric Patients: An Experimental Pilot Study in a Forensic Psychiatric Hospital.

van Alphen, R / Stams, G J J M / Hakvoort, L

Frontiers in neuroscience

2019 Volume 13, Page(s) 570

Abstract: Poor attention skills constitute a major problem for psychiatric patients with psychotic symptoms, and increase their chances of treatment drop-out. This study investigated possible benefits of musical attention control training (MACT). To examine the ... ...

Abstract	Poor attention skills constitute a major problem for psychiatric patients with psychotic symptoms, and increase their chances of treatment drop-out. This study investigated possible benefits of musical attention control training (MACT). To examine the effect of MACT on attention skills of psychiatric patients with psychotic features a randomized controlled trial (RCT) was conducted in a forensic psychiatric clinic. Participants (
Language	English
Publishing date	2019-06-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2019.00570
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Article ; Online: A hybrid registration method using the mandibular bone surface for electromagnetic navigation in mandibular surgery.

de Geer, A F / van Alphen, M J A / Zuur, C L / Loeve, A J / van Veen, R L P / Karakullukcu, M B

International journal of computer assisted radiology and surgery

2022 Volume 17, Issue 7, Page(s) 1343–1353

Abstract: Purpose: To utilize navigated mandibular (reconstructive) surgery, accurate registration of the preoperative CT scan with the actual patient in the operating room (OR) is required. In this phantom study, the feasibility of a noninvasive hybrid ... ...

Abstract	Purpose: To utilize navigated mandibular (reconstructive) surgery, accurate registration of the preoperative CT scan with the actual patient in the operating room (OR) is required. In this phantom study, the feasibility of a noninvasive hybrid registration method is assessed. This method consists of a point registration with anatomic landmarks for initialization and a surface registration using the bare mandibular bone surface for optimization. Methods: Three mandible phantoms with reference notches on two osteotomy planes were 3D printed. An electromagnetic tracking system in combination with 3D Slicer software was used for navigation. Different configurations, i.e., different surface point areas and number and configuration of surface points, were tested with a dentate phantom (A) in a metal-free environment. To simulate the intraoperative environment and different anatomies, the registration procedure was also performed with an OR bed using the dentate phantom and two (partially) edentulous phantoms with atypical anatomy (B and C). The accuracy of the registration was calculated using the notches on the osteotomy planes and was expressed as the target registration error (TRE). TRE values of less than 2.0 mm were considered as clinically acceptable. Results: In all experiments, the mean TRE was less than 2.0 mm. No differences were found using different surface point areas or number or configurations of surface points. Registration accuracy in the simulated intraoperative setting was-mean (SD)-0.96 (0.22), 0.93 (0.26), and 1.50 (0.28) mm for phantom A, phantom B, and phantom C. Conclusion: Hybrid registration is a noninvasive method that requires only a small area of the bare mandibular bone surface to obtain high accuracy in phantom setting. Future studies should test this method in clinical setting during actual surgery.
MeSH term(s)	Electromagnetic Phenomena ; Humans ; Imaging, Three-Dimensional/methods ; Mandible/diagnostic imaging ; Mandible/surgery ; Orthognathic Surgical Procedures ; Phantoms, Imaging ; Surgery, Computer-Assisted/methods
Language	English
Publishing date	2022-04-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2365628-1
ISSN	1861-6429 ; 1861-6410
ISSN (online)	1861-6429
ISSN	1861-6410
DOI	10.1007/s11548-022-02610-6
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