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Article ; Online: A review of the effects of head-worn displays on teamwork for emergency response.

Davidson, Thomas J / Sanderson, Penelope M

2021 Volume 65, Issue 2, Page(s) 188–218

Abstract: Head-Worn Displays (HWD) can potentially support the mobile work of emergency responders, but it remains unclear whether teamwork is affected when emergency responders use HWDs. We reviewed studies that examined HWDs in emergency response contexts to ... ...

Abstract	Head-Worn Displays (HWD) can potentially support the mobile work of emergency responders, but it remains unclear whether teamwork is affected when emergency responders use HWDs. We reviewed studies that examined HWDs in emergency response contexts to evaluate the impact of HWDs on team performance and on team processes of situation awareness, communication, and coordination. Sixteen studies were identified through manual and systematic literature searches. HWDs appeared to improve the quality of team performance but they increased time to perform under some conditions; effects on team processes were mixed. We identify five challenges to explain the mixed results. We discuss four theoretical perspectives that might address the challenges and guide research needs-joint cognitive systems, distributed cognition, common ground, and dynamical systems. Researchers and designers should use process-based measures and apply greater theoretical guidance to uncover mechanisms by which HWDs shape team processes, and to understand the impact on team performance.
MeSH term(s)	Awareness ; Cognition ; Communication ; Data Display ; Humans ; Patient Care Team
Language	English
Publishing date	2021-10-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1920-3
ISSN	1366-5847 ; 0014-0139
ISSN (online)	1366-5847
ISSN	0014-0139
DOI	10.1080/00140139.2021.1968041
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Article ; Online: Exploring the Effect of Head-Worn Displays on Prehospital Teamwork Using Online Simulation: A Crossover Randomized Controlled Trial.

Davidson, Thomas J / Waxenegger, Harald / Mohamed, Ismail / McConnell, Duncan S / Sanderson, Penelope M

Simulation in healthcare : journal of the Society for Simulation in Healthcare

2024

Abstract: Introduction: Prehospital teamwork occurs in dynamic environments where paramedics work together using technologies to care for patients. Despite increasing interest in using head-worn displays (HWDs) to support prehospital workers, little is known ... ...

Abstract	Introduction: Prehospital teamwork occurs in dynamic environments where paramedics work together using technologies to care for patients. Despite increasing interest in using head-worn displays (HWDs) to support prehospital workers, little is known about how HWDs affect teamwork. Methods: We tested the effect of HWDs on the team processes and patient care of paramedic trainee teams in a laboratory study using an online prehospital simulation environment, SPECTRa. In a randomized crossover design, 20 two-person teams worked in the SPECTRa laptop environment from separate physical rooms to assess and treat 2 simulated patients in 3 prehospital patient care scenarios. In each scenario, each trainee used either an HWD, a tablet computer (TAB), or no mobile device (CON) to help them monitor the vital signs of both patients. We measured team processes based around 3 themes of mutual understanding, team performance, and administered an 18-item questionnaire about teamwork and use of the devices. Results: The mean number (HWD = 11; TAB = 7; P = 0.061) and duration (HWD = 1746 milliseconds; TAB = 1563 milliseconds; P = 0.504) of attention switches that teams made toward the mobile device did not differ with HWDs or TABs. However, teams switched attention between patients less with HWDs than with TABs (P = 0.026) or CON (P = 0.007) (medians: HWD = 5; TAB = 8; CON = 8). Teams communicated less when using HWDs than TABs (P = 0.017) (medians: HWD = 76; TAB = 96; CON = 83), but there were other mixed effects on communication. Team performance did not differ across device conditions on the timeliness to notice critical patient changes (P = 0.387) (medians: HWD = 244 seconds; TAB = 246 seconds; CON = 168 seconds) or to complete the scenarios (P = 0.212) (medians: HWD = 800 seconds; TAB = 913 seconds; CON = 835 seconds). Questionnaire results revealed some perceived benefits of the HWD. Conclusions: Head-worn displays may let prehospital teams monitor each other's performance more efficiently than TABs or CON, requiring less communication to maintain patient care performance with lower workload than with TABs. However, improvements in mutual understanding with HWDs compared with CON were more evident in teams' preferences than in actual behavior. Further research is needed to confirm and extend these results.
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2223429-9
ISSN	1559-713X ; 1559-2332
ISSN (online)	1559-713X
ISSN	1559-2332
DOI	10.1097/SIH.0000000000000770
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Article ; Online: A large-effect fitness trade-off across environments is explained by a single mutation affecting cold acclimation.

Lee, Gwonjin / Sanderson, Brian J / Ellis, Thomas J / Dilkes, Brian P / McKay, John K / Ågren, Jon / Oakley, Christopher G

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 6, Page(s) e2317461121

Abstract: Identifying the genetic basis of local adaptation and fitness trade-offs across environments is a central goal of evolutionary biology. Cold acclimation is an adaptive plastic response for surviving seasonal freezing, and costs of acclimation may be a ... ...

Abstract	Identifying the genetic basis of local adaptation and fitness trade-offs across environments is a central goal of evolutionary biology. Cold acclimation is an adaptive plastic response for surviving seasonal freezing, and costs of acclimation may be a general mechanism for fitness trade-offs across environments in temperate zone species. Starting with locally adapted ecotypes of
MeSH term(s)	Arabidopsis/genetics ; Mutation ; Acclimatization/genetics ; Arabidopsis Proteins/genetics ; Transcription Factors/genetics ; Cold Temperature ; Genetic Fitness
Chemical Substances	Arabidopsis Proteins ; Transcription Factors
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2317461121
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Article ; Online: AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula.

Simmons, Sarah C / Flerlage, William J / Langlois, Ludovic D / Shepard, Ryan D / Bouslog, Christopher / Thomas, Emily H / Gouty, Kaitlyn M / Sanderson, Jennifer L / Gouty, Shawn / Cox, Brian M / Dell'Acqua, Mark L / Nugent, Fereshteh S

Communications biology

2024 Volume 7, Issue 1, Page(s) 345

Abstract: The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability. Emerging evidence also suggests that AKAP150 signaling may play a key ... ...

Abstract	The scaffolding A-kinase anchoring protein 150 (AKAP150) is critically involved in kinase and phosphatase regulation of synaptic transmission/plasticity, and neuronal excitability. Emerging evidence also suggests that AKAP150 signaling may play a key role in brain's processing of rewarding/aversive experiences, however its role in the lateral habenula (LHb, as an important brain reward circuitry) is completely unknown. Using whole cell patch clamp recordings in LHb of male wildtype and ΔPKA knockin mice (with deficiency in AKAP-anchoring of PKA), here we show that the genetic disruption of PKA anchoring to AKAP150 significantly reduces AMPA receptor-mediated glutamatergic transmission and prevents the induction of presynaptic endocannabinoid-mediated long-term depression in LHb neurons. Moreover, ΔPKA mutation potentiates GABA
MeSH term(s)	Animals ; Male ; Mice ; A Kinase Anchor Proteins/genetics ; A Kinase Anchor Proteins/metabolism ; Corticotropin-Releasing Hormone/metabolism ; Endocannabinoids ; Habenula/metabolism ; Neuronal Plasticity/physiology ; Neurons/physiology ; Receptors, AMPA/genetics ; Receptors, AMPA/metabolism ; Receptors, GABA-A/metabolism ; Synaptic Transmission/physiology
Chemical Substances	A Kinase Anchor Proteins ; Corticotropin-Releasing Hormone (9015-71-8) ; Endocannabinoids ; Receptors, AMPA ; Receptors, GABA-A ; Akap5 protein, mouse
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-06041-8
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Article: Adsorption of Aldehyde-Functional Diblock Copolymer Spheres onto Surface-Grafted Polymer Brushes via Dynamic Covalent Chemistry Enables Friction Modification.

Johnson, Edwin C / Varlas, Spyridon / Norvilaite, Oleta / Neal, Thomas J / Brotherton, Emma E / Sanderson, George / Leggett, Graham J / Armes, Steven P

Chemistry of materials : a publication of the American Chemical Society

2023 Volume 35, Issue 15, Page(s) 6109–6122

Abstract: Dynamic covalent chemistry has been exploited to prepare numerous examples of adaptable polymeric materials that exhibit unique properties. Herein, the chemical adsorption of aldehyde-functional diblock copolymer spherical nanoparticles onto amine- ... ...

Abstract	Dynamic covalent chemistry has been exploited to prepare numerous examples of adaptable polymeric materials that exhibit unique properties. Herein, the chemical adsorption of aldehyde-functional diblock copolymer spherical nanoparticles onto amine-functionalized surface-grafted polymer brushes via dynamic Schiff base chemistry is demonstrated. Initially, a series of
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1500399-1
ISSN	1520-5002 ; 0897-4756
ISSN (online)	1520-5002
ISSN	0897-4756
DOI	10.1021/acs.chemmater.3c01227
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Article ; Online: SPECTRa: An Online Tool for Simulating Prehospital Patient Care.

Davidson, Thomas J / Waxenegger, Harald / Mohamed, Ismail / McConnell, Duncan S / Sanderson, Penelope M

HERD

2022 Volume 15, Issue 3, Page(s) 375–394

Abstract: Objectives: To (1) develop a simulation software environment to conduct prehospital research during the COVID-19 pandemic on paramedics' teamwork and use of mobile computing devices, and (2) establish its feasibility for use as a research and training ... ...

Abstract	Objectives: To (1) develop a simulation software environment to conduct prehospital research during the COVID-19 pandemic on paramedics' teamwork and use of mobile computing devices, and (2) establish its feasibility for use as a research and training tool. Background: Simulation-based research and training for prehospital environments has typically used live simulation, with highly realistic equipment and technology-enhanced manikins. However, such simulations are expensive, difficult to replicate, and require facilitators and participants to be at the same location. Although virtual simulation tools exist for prehospital care, it is unclear how best to use them for research and training. Methods: We present SPECTRa-Simulated Prehospital Emergency Care for Team Research-an online simulated prehospital environment that lets participants care concurrently for single or multiple patients remotely. Patient scenarios are designed using Laerdal's SimDesigner. SPECTRa records data about scenario states and participants' virtual interaction with the simulated patients. SPECTRa's supporting environment records participants' verbal communication and their visual and physical interactions with their interface and devices using Zoom conferencing and audiovisual recording. We discuss a pilot research implementation to assess SPECTRa's feasibility. Results: SPECTRa allows researchers to systematically test small-team interaction in single- or multipatient care scenarios and assess the impact of mobile devices on participants' assessment and care of patients. SPECTRa also supports pedagogical features that could allow prehospital educators to provide individual trainees or teams with online simulation training and evaluation. Conclusions: SPECTRa, an online tool for simulating prehospital patient care, shows potential for remote healthcare research and training.
MeSH term(s)	COVID-19 ; Emergency Medical Services ; Humans ; Manikins ; Pandemics ; Patient Care ; Patient Care Team
Language	English
Publishing date	2022-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2525547-2
ISSN	2167-5112 ; 1937-5867
ISSN (online)	2167-5112
ISSN	1937-5867
DOI	10.1177/19375867221090984
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Article ; Online: Effects of the menstrual cycle phase on anterior cruciate ligament neuromuscular and biomechanical injury risk surrogates in eumenorrheic and naturally menstruating women: A systematic review.

Dos'Santos, Thomas / Stebbings, Georgina K / Morse, Christopher / Shashidharan, Medha / Daniels, Katherine A J / Sanderson, Andy

PloS one

2023 Volume 18, Issue 1, Page(s) e0280800

Abstract: Background: Eumenorrheic women experience cyclic variations in sex hormones attributed to the menstrual cycle (MC) which can impact anterior cruciate ligament (ACL) properties, knee laxity, and neuromuscular function. This systematic review aimed to ... ...

Abstract	Background: Eumenorrheic women experience cyclic variations in sex hormones attributed to the menstrual cycle (MC) which can impact anterior cruciate ligament (ACL) properties, knee laxity, and neuromuscular function. This systematic review aimed to examine the effects of the MC on ACL neuromuscular and biomechanical injury risk surrogates during dynamic tasks, to establish whether a particular MC phase predisposes women to greater ACL injury risk. Methods: PubMed, Medline, SPORTDiscus, and Web of Science were searched (May-July 2021) for studies that investigated the effects of the MC on ACL neuromuscular and biomechanical injury risk surrogates. Inclusion criteria were: 1) injury-free women (18-40 years); 2) verified MC phases via biochemical analysis and/or ovulation kits; 3) examined neuromuscular and/or biomechanical injury risk surrogates during dynamic tasks; 4) compared ≥1 outcome measure across ≥2 defined MC phases. Results: Seven of 418 articles were included. Four studies reported no significant differences in ACL injury risk surrogates between MC phases. Two studies showed evidence the mid-luteal phase may predispose women to greater risk of non-contact ACL injury. Three studies reported knee laxity fluctuated across the MC; two of which demonstrated MC attributed changes in knee laxity were associated with changes in knee joint loading (KJL). Study quality (Modified Downs and Black Checklist score: 7-9) and quality of evidence were low to very low (Grading of Recommendations Assessment Development and Evaluation: very low). Conclusion: It is inconclusive whether a particular MC phase predisposes women to greater non-contact ACL injury risk based on neuromuscular and biomechanical surrogates. Practitioners should be cautious manipulating their physical preparation, injury mitigation, and screening practises based on current evidence. Although variable (i.e., magnitude and direction), MC attributed changes in knee laxity were associated with changes in potentially hazardous KJLs. Monitoring knee laxity could therefore be a viable strategy to infer possible ACL injury risk.
MeSH term(s)	Humans ; Female ; Anterior Cruciate Ligament ; Anterior Cruciate Ligament Injuries ; Menstruation ; Joint Instability ; Knee Joint ; Menstrual Cycle ; Biomechanical Phenomena
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0280800
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Article: Inhibiting Mitochondrial Cytochrome

Shah, Ekta J / Hüttemann, Maik / Sanderson, Thomas H / Gurdziel, Katherine / Ruden, Douglas M

Frontiers in physiology

2021 Volume 12, Page(s) 628777

Abstract: Traumatic brain injuries (TBIs) caused by a sudden impact to the head alter behavior and impair physical and cognitive function. Besides the severity, type and area of the brain affected, the outcome of TBI is also influenced by the patient's biological ... ...

Abstract	Traumatic brain injuries (TBIs) caused by a sudden impact to the head alter behavior and impair physical and cognitive function. Besides the severity, type and area of the brain affected, the outcome of TBI is also influenced by the patient's biological sex. Previous studies reporting mitochondrial dysfunction mainly focused on exponential reactive oxygen species (ROS) generation, increased mitochondrial membrane potential, and altered mitochondrial dynamics as a key player in the outcome to brain injury. In this study, we evaluated the effect of a near-infrared (NIR) light exposure on gene expression in a
Language	English
Publishing date	2021-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.628777
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Article ; Online: Serotonin-estrogen interactions: What can we learn from pregnancy?

Hudon Thibeault, Andrée-Anne / Sanderson, J Thomas / Vaillancourt, Cathy

Biochimie

2019 Volume 161, Page(s) 88–108

Abstract: We have reviewed the scientific literature related to four diseases in which to serotonin (5-HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence is influenced by estrogenic status: depression, migraine, irritable ... ...

Abstract	We have reviewed the scientific literature related to four diseases in which to serotonin (5-HT) is involved in the etiology, herein named 5-HT-linked diseases, and whose prevalence is influenced by estrogenic status: depression, migraine, irritable bowel syndrome and eating disorders. These diseases all have in common a sex-dimorphic prevalence, with women more frequently affected than men. The co-occurrence between these 5-HT-linked diseases suggests that they have common physiopathological mechanisms. In most 5-HT-linked diseases (except for anorexia nervosa and irritable bowel syndrome), a decrease in the serotonergic tone is observed and estrogens are thought to contribute to the improvement of symptoms by stimulating the serotonergic system. Human pregnancy is characterized by a unique 5-HT and estrogen synthesis by the placenta. Pregnancy-specific disorders, such as hyperemesis gravidarum, gestational diabetes mellitus and pre-eclampsia, are associated with a hyperserotonergic state and decreased estrogen levels. Fetal programming of 5-HT-linked diseases is a complex phenomenon that involves notably fetal-sex differences, which suggest the implication of sex steroids. From a mechanistic point of view, we hypothesize that estrogens regulate the serotonergic system, resulting in a protective effect against 5-HT-linked diseases, but that, in turn, 5-HT affects estrogen synthesis in an attempt to retrieve homeostasis. These two processes (5-HT and estrogen biosynthesis) are crucial for successful pregnancy outcomes, and thus, a disruption of this 5-HT-estrogen relationship may explain pregnancy-specific pathologies or pregnancy complications associated with 5-HT-linked diseases.
MeSH term(s)	Drug Interactions ; Estrogens/metabolism ; Female ; Humans ; Placenta/metabolism ; Placenta/physiopathology ; Pregnancy ; Pregnancy Complications/metabolism ; Pregnancy Complications/physiopathology ; Serotonin/metabolism
Chemical Substances	Estrogens ; Serotonin (333DO1RDJY)
Language	English
Publishing date	2019-04-01
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	120345-9
ISSN	1638-6183 ; 0300-9084
ISSN (online)	1638-6183
ISSN	0300-9084
DOI	10.1016/j.biochi.2019.03.023
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Article ; Online: Toxicity of Pexacerfont, a Corticotropin-Releasing Factor Type 1 Receptor Antagonist, in Rats and Dogs.

White, Melvin R / Graziano, Michael J / Sanderson, Thomas P

International journal of toxicology

2019 Volume 38, Issue 2, Page(s) 110–120

Abstract: Pexacerfont is a corticotropin-releasing factor subtype 1 receptor antagonist that was developed for the treatment of anxiety- and stress-related disorders. This report describes the results of repeat-dose oral toxicity studies in rats (3 and 6 months) ... ...

Abstract	Pexacerfont is a corticotropin-releasing factor subtype 1 receptor antagonist that was developed for the treatment of anxiety- and stress-related disorders. This report describes the results of repeat-dose oral toxicity studies in rats (3 and 6 months) and dogs (3 months and 1 year). Pexacerfont was well tolerated in all of these studies at exposures equal to or greater than areas under the curve in humans (clinical dose of 100 mg). Microscopic changes in the liver (hepatocellular hypertrophy), thyroid glands (hypertrophy/hyperplasia and adenomas of follicular cells), and pituitary (hypertrophy/hyperplasia and vacuolation of thyrotrophs) were only observed in rats and were considered adaptive changes in response to hepatic enzyme induction and subsequent alterations in serum thyroid hormone levels. Evidence for hepatic enzyme induction in dogs was limited to increased liver weights and reduced thyroxine (T
MeSH term(s)	Administration, Oral ; Animals ; Dogs ; Female ; Male ; Mammary Glands, Animal/drug effects ; Mammary Glands, Animal/pathology ; Pyrazoles/pharmacokinetics ; Pyrazoles/toxicity ; Rats, Sprague-Dawley ; Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors ; Testis/drug effects ; Testis/pathology ; Toxicity Tests, Chronic ; Toxicity Tests, Subchronic ; Triazines/pharmacokinetics ; Triazines/toxicity
Chemical Substances	Pyrazoles ; Receptors, Corticotropin-Releasing Hormone ; Triazines ; CRF receptor type 1 (5CLY6W2H1M) ; pexacerfont (LF1VBG4ZUK)
Language	English
Publishing date	2019-02-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1379845-5
ISSN	1092-874X ; 1091-5818
ISSN (online)	1092-874X
ISSN	1091-5818
DOI	10.1177/1091581819827501
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