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  1. Article: Stool-Based Tests Vs Screening Colonoscopy for the Detection of Colorectal Cancer.

    Ahlquist, David A

    Gastroenterology & hepatology

    2019  Volume 15, Issue 8, Page(s) 437–440

    Language English
    Publishing date 2019-10-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2386402-3
    ISSN 1554-7914
    ISSN 1554-7914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Universal cancer screening: revolutionary, rational, and realizable.

    Ahlquist, David A

    NPJ precision oncology

    2018  Volume 2, Page(s) 23

    Abstract: Cancer remains the second leading cause of mortality worldwide, and overall cancer-related deaths are increasing. Despite the survival benefit from early detection, screening has to date targeted only those few organs that harbor tumors of sufficient ... ...

    Abstract Cancer remains the second leading cause of mortality worldwide, and overall cancer-related deaths are increasing. Despite the survival benefit from early detection, screening has to date targeted only those few organs that harbor tumors of sufficient prevalence to show cost-effectiveness at population levels, leaving most cancer types unscreened. In this perspective overview, a case is made for universal cancer screening as a logical and more inclusive approach with potentially high impact. The centrally important conceptual drivers to universal screening are biological and epidemiological. The shared biology of tumor marker release into a common distant medium, like blood, can be exploited for multi-cancer detection from a single test. And, by aggregating prevalence rates, universal screening allows all cancers (including less common ones) to be included as targets, increases screening efficiency and integration across tumor types, and potentially improves cost-effectiveness over single-organ approaches. The identification of new tumor marker classes with both broad expression across tumor types and site-prediction, remarkable advances in assay technologies, and compelling early clinical data increase the likelihood of actualizing this new paradigm. Multi-organ screening could be achieved by targeting markers within or stemming from the circulation (including blood, urine, saliva, and expired breath) or those exfoliated into common excretory pathways (including the gastrointestinal and female reproductive tracts). Rigorous clinical studies in intended use populations and collaborations between academia, industry, professional societies, and government will be required to bring this lofty vision to a population application.
    Language English
    Publishing date 2018-10-29
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-018-0066-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Comment on "Fecal occult blood versus DNA testing: indirect comparison in a colorectal cancer screening population".

    Ahlquist, David A

    Clinical epidemiology

    2017  Volume 9, Page(s) 435–438

    Language English
    Publishing date 2017-08-28
    Publishing country New Zealand
    Document type Journal Article ; Comment
    ZDB-ID 2494772-6
    ISSN 1179-1349
    ISSN 1179-1349
    DOI 10.2147/CLEP.S148780
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Colorectal cancer prevention and detection

    Ahlquist, David A.

    (Gastroenterology clinics of North America ; 31,4)

    2002  

    Author's details David A. Ahlquist, guest ed
    Series title Gastroenterology clinics of North America ; 31,4
    Collection
    Language English
    Size XII S., S. 925 - 1181 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013543918
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 123 -31,4- verfügbar in Königswinter Königswinter

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  5. Article: Stool DNA testing: a new, noninvasive option for colorectal cancer screening.

    Ahlquist, David A

    Clinical advances in hematology & oncology : H&O

    2015  Volume 13, Issue 7, Page(s) 432–434

    MeSH term(s) Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/prevention & control ; DNA, Neoplasm/analysis ; DNA, Neoplasm/genetics ; Early Detection of Cancer/methods ; Early Detection of Cancer/trends ; Feces/chemistry ; Humans
    Chemical Substances DNA, Neoplasm
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Interview
    ZDB-ID 2271951-9
    ISSN 1543-0790
    ISSN 1543-0790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Multi-target stool DNA test: a new high bar for noninvasive screening.

    Ahlquist, David A

    Digestive diseases and sciences

    2015  Volume 60, Issue 3, Page(s) 623–633

    Abstract: Stool DNA testing has evolved into what is now a highly accurate and well-validated test for the screen detection of colorectal neoplasia. An optimized and automated multi-target stool DNA test (MT-sDNA) has achieved the same high point-sensitivities as ... ...

    Abstract Stool DNA testing has evolved into what is now a highly accurate and well-validated test for the screen detection of colorectal neoplasia. An optimized and automated multi-target stool DNA test (MT-sDNA) has achieved the same high point-sensitivities as reported for colonoscopy and significantly higher sensitivity than by fecal immunochemical blood testing for detection of early-stage cancer and advanced precancer. Thus, MT-sDNA sets a new high criterion standard for the noninvasive screen detection of colorectal neoplasia. With clinical application, MT-sDNA has potential to meaningfully address current gaps in our approach to CRC screening through benefits of its high accuracy on screening effectiveness, user-friendly features on patient compliance, and easy mail-out distribution on test access. The US Food and Drug Administration and Center for Medicaid and Medicare Services have recently completed their parallel reviews of MT-sDNA, which has just become available for clinical use. This review summarizes the recent clinical validation data on MT-sDNA, addresses central clinical questions at this front end of implementation, and touches on innovative future applications of stool DNA testing.
    MeSH term(s) Colonic Polyps/diagnosis ; Colorectal Neoplasms/diagnosis ; DNA/analysis ; Feces/chemistry ; Humans ; Mass Screening/methods ; Sensitivity and Specificity
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-014-3451-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Response to Kosmidou et al.

    Iyer, Prasad G / Ahlquist, David A

    The American journal of gastroenterology

    2018  Volume 113, Issue 11, Page(s) 1723

    MeSH term(s) Barrett Esophagus ; Genetic Markers ; Humans
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2018-10-17
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.1038/s41395-018-0362-7
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  8. Article ; Online: The Case for a Multitarget Stool DNA Test: A Closer Look at the Cost Effectiveness Model.

    Itzkowitz, Steven H / Ahlquist, David A

    Gastroenterology

    2017  Volume 152, Issue 6, Page(s) 1620–1621

    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Letter
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2016.11.058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Colorectal Adenomas.

    Itzkowitz, Steven H / Ahlquist, David A

    The New England journal of medicine

    2016  Volume 375, Issue 4, Page(s) 388–389

    MeSH term(s) Adenoma/diagnosis ; Colorectal Neoplasms/diagnosis ; Early Detection of Cancer/methods ; Female ; Humans ; Male
    Language English
    Publishing date 2016-07-28
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1604867#SA2
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  10. Article ; Online: Multicancer early detection: International summit to Clarify the Roadmap.

    Limburg, Paul J / Ahlquist, David A / Johnson, Sonali / Jayasekar Zurn, Shalini / Kisiel, John B / Smith, Robert A

    Cancer

    2022  Volume 128 Suppl 4, Page(s) 859–860

    MeSH term(s) Early Detection of Cancer ; Humans ; Neoplasms/diagnosis ; Neoplasms/epidemiology
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.33964
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