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  1. Article ; Online: The COVID-19 Experience: Creativity as an Identity Attractor for Young People Facing the Developmental Challenges.

    Sica, Luigia Simona

    International journal of environmental research and public health

    2022  Volume 19, Issue 15

    Abstract: The study focuses on identifying the impacts of the COVID experience on young people and exploring whether, during the pandemic period, adolescents and young adults resorted to flexible and creative coping strategies, which may have served as resources. ... ...

    Abstract The study focuses on identifying the impacts of the COVID experience on young people and exploring whether, during the pandemic period, adolescents and young adults resorted to flexible and creative coping strategies, which may have served as resources. The participants consisted of 70 Italian freshmen (18 males and 52 females) aged 18 to 21, attending their first year of university. Adopting a narrative approach, we identified seven creativity functions and two interpretative factors, supporting the idea that creativity may have constituted a psychological resource for young people during the COVID-19 pandemic. Furthermore, the findings suggest that creativity can be configured as an identity attractor. Implications and future research directions are discussed.
    MeSH term(s) Adaptation, Psychological ; Adolescent ; COVID-19/epidemiology ; Creativity ; Female ; Humans ; Male ; Pandemics ; Young Adult
    Language English
    Publishing date 2022-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19158913
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The COVID-19 Experience

    Luigia Simona Sica

    International Journal of Environmental Research and Public Health, Vol 19, Iss 8913, p

    Creativity as an Identity Attractor for Young People Facing the Developmental Challenges

    2022  Volume 8913

    Abstract: The study focuses on identifying the impacts of the COVID experience on young people and exploring whether, during the pandemic period, adolescents and young adults resorted to flexible and creative coping strategies, which may have served as resources. ... ...

    Abstract The study focuses on identifying the impacts of the COVID experience on young people and exploring whether, during the pandemic period, adolescents and young adults resorted to flexible and creative coping strategies, which may have served as resources. The participants consisted of 70 Italian freshmen (18 males and 52 females) aged 18 to 21, attending their first year of university. Adopting a narrative approach, we identified seven creativity functions and two interpretative factors, supporting the idea that creativity may have constituted a psychological resource for young people during the COVID-19 pandemic. Furthermore, the findings suggest that creativity can be configured as an identity attractor. Implications and future research directions are discussed.
    Keywords creativity ; individual resources ; identity ; Medicine ; R
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  3. Article: Editorial: The latest advances in transplantation for AML.

    Chiusolo, Patrizia / Ciceri, Fabio / Sica, Simona

    Frontiers in oncology

    2023  Volume 13, Page(s) 1189554

    Language English
    Publishing date 2023-04-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1189554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: CAR-T Cell Therapy in B-Cell Acute Lymphoblastic Leukemia.

    Testa, Ugo / Sica, Simona / Pelosi, Elvira / Castelli, Germana / Leone, Giuseppe

    Mediterranean journal of hematology and infectious diseases

    2024  Volume 16, Issue 1, Page(s) e2024010

    Abstract: Treatment of refractory and relapsed (R/R) B acute lymphoblastic leukemia (B-ALL) is an unmet medical need in both children and adults. Studies carried out in the last two decades have shown that autologous T cells engineered to express a chimeric ... ...

    Abstract Treatment of refractory and relapsed (R/R) B acute lymphoblastic leukemia (B-ALL) is an unmet medical need in both children and adults. Studies carried out in the last two decades have shown that autologous T cells engineered to express a chimeric antigen receptor (CAR-T) represent an effective technique for treating these patients. Antigens expressed on B-cells, such as CD19, CD20, and CD22, represent targets suitable for treating patients with R/R B-ALL. CD19 CAR-T cells induce a high rate (80-90%) of complete remissions in both pediatric and adult R/R B-ALL patients. However, despite this impressive rate of responses, about half of responding patients relapse within 1-2 years after CAR-T cell therapy. Allo-HSCT after CAR-T cell therapy might consolidate the therapeutic efficacy of CAR-T and increase long-term outcomes; however, not all the studies that have adopted allo-HSCT as a consolidative treatment strategy have shown a benefit deriving from transplantation. For B-ALL patients who relapse early after allo-HSCT or those with insufficient T-cell numbers for an autologous approach, using T cells from the original stem cell donor offers the opportunity for the successful generation of CAR-T cells and for an effective therapeutic approach. Finally, recent studies have introduced allogeneic CAR-T cells generated from healthy donors or unmatched, which are opportunely manipulated with gene editing to reduce the risk of immunological incompatibility, with promising therapeutic effects.
    Language English
    Publishing date 2024-01-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2024.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Systematic Review of Mobile Apps as an Adjunct to Psychological Interventions for Emotion Dysregulation.

    Diano, Federico / Sica, Luigia Simona / Ponticorvo, Michela

    International journal of environmental research and public health

    2023  Volume 20, Issue 2

    Abstract: Background: Mental health care has been enriched with the progressive use of technology during the last ten years, in particular after the COVID-19 pandemic. Mobile applications (apps) and smartphones have become the most widespread access point for ... ...

    Abstract Background: Mental health care has been enriched with the progressive use of technology during the last ten years, in particular after the COVID-19 pandemic. Mobile applications (apps) and smartphones have become the most widespread access point for many people who look for self-help in the psychological domain.
    Objective: We focused on a systematic review of mobile apps for mental health, focusing on the blending of apps with psychotherapy contexts, with a specific focus on emotional dysregulation.
    Methods: A comprehensive literature search (January 2017 to August 2022) in PubMed, PsycInfo, Web of Science, and the Cochrane Library was conducted. Abstracts were included if they described mental health mobile apps targeting emotional dysregulation and their use during ongoing psychological or psychotherapy treatment for adults and adolescents.
    Results: In total, 397 abstracts were identified; of these, 19 publications describing apps targeting borderline personality disorder, depression, anxiety, suicidal behaviors, and post-traumatic stress disorders met the inclusion criteria.
    Conclusions: App-enhanced psychotherapy might be a winning combination in many scenarios, but at the same time, many issues must still be faced in this yet emerging scientific field. In conclusion, we tried to put together some major guidelines for mental health mobile app development in the context of psychological treatments.
    MeSH term(s) Adult ; Adolescent ; Humans ; Mobile Applications ; Psychosocial Intervention ; Pandemics ; COVID-19 ; Anxiety
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20021431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Should the BCRA1/2-mutations healthy carriers be valid candidates for hematopoietic stem cell donation?

    Fresa, Alberto / Sica, Simona

    Hereditary cancer in clinical practice

    2021  Volume 19, Issue 1, Page(s) 22

    Abstract: It's still not clear whether the mutational status of BRCA-mutated healthy hematopoietic stem cells (HSCs) donors could have an impact on the engraftment. Comparing the studies present in literature, we focused on the correlation between BRCA mutations ... ...

    Abstract It's still not clear whether the mutational status of BRCA-mutated healthy hematopoietic stem cells (HSCs) donors could have an impact on the engraftment. Comparing the studies present in literature, we focused on the correlation between BRCA mutations and the development of hematological malignancies and Fanconi anemia (FA); then, we explored HSCs types, frequencies, and functions in the presence of BRCA mutations, as well as the reconstitution of hematopoiesis after chemotherapy and radiation treatments. The role of BRCA mutations in the FA showed a possible involvement in the onset of the disease; the mutation carriers, indeed, did not show any sign of the typical phenotype of the FA. BRCA mutational status can be considered as a risk factor for hematological malignancies, but only for secondary malignancies and/or in the presence of bone marrow stress factors. Currently we don't know if a conditioning regimen could be compensated by BRCA mutated HSCs, even if murine models tried to show the possible differences between fully mutated, haploinsufficient and normal HSCs. Thus, given the downregulating effect of the mutations on hematopoiesis, it could be questionable to use the HSCs of a BRCA-mutated donor in the presence of another available donor with the same compatibility.
    Language English
    Publishing date 2021-04-01
    Publishing country Poland
    Document type Journal Article ; Review
    ZDB-ID 2252512-9
    ISSN 1897-4287 ; 1731-2302
    ISSN (online) 1897-4287
    ISSN 1731-2302
    DOI 10.1186/s13053-021-00179-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6407: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: FLT3 Mutated Acute Myeloid Leukemia after CD19 CAR-t Cells.

    Galli, Eugenio / Frioni, Filippo / Malara, Tanja / Attardi, Enrico / Bellesi, Silvia / Hohaus, Stefan / Sica, Simona / Sorà, Federica / Chiusolo, Patrizia

    Mediterranean journal of hematology and infectious diseases

    2024  Volume 16, Issue 1, Page(s) e2024029

    Language English
    Publishing date 2024-03-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2024.029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Life Design for Youth as a Creativity-Based Intervention for Transforming a Challenging World.

    Fusco, Luca / Parola, Anna / Sica, Luigia Simona

    Frontiers in psychology

    2021  Volume 12, Page(s) 662072

    Language English
    Publishing date 2021-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.662072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Spontaneous resolution of "therapy-related myelodysplasia" occurred after treatment with CAR-T cells: All that glitters is not gold.

    Frioni, Filippo / Galli, Eugenio / Sorà, Federica / Zini, Gina / Sica, Simona / Chiusolo, Patrizia

    International journal of laboratory hematology

    2023  Volume 45, Issue 5, Page(s) 810–812

    MeSH term(s) Humans ; Myelodysplastic Syndromes/therapy ; T-Lymphocytes
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Letter
    ZDB-ID 2268590-X
    ISSN 1751-553X ; 1751-5521 ; 0141-9854
    ISSN (online) 1751-553X
    ISSN 1751-5521 ; 0141-9854
    DOI 10.1111/ijlh.14099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1499: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: The Ability to Manage Unexpected Events and the Vocational Identity in Young People: The Italian Validation of Planned Happenstance Career Inventory.

    Sica, Luigia Simona / Ponticorvo, Michela / Di Palma, Tiziana

    Frontiers in psychology

    2022  Volume 13, Page(s) 899411

    Abstract: The present study had two goals: to test the validity of Planned Happenstance Career Inventory (PHCI) in the Italian context and to explore the relations between PHC skills and vocational identity processes within a sample of 472 undergraduate students ... ...

    Abstract The present study had two goals: to test the validity of Planned Happenstance Career Inventory (PHCI) in the Italian context and to explore the relations between PHC skills and vocational identity processes within a sample of 472 undergraduate students attending university in the southern of Italy. Moreover, we examined relations between the PHCI and measures of vocational identity processes. With regard to the first goal, results show that for the Italian version of the instrument was confirmed the multifactor structure of the original version. The multi-group analyses showed that invariance between genders is supported. Convergent validity and divergent validity of the measure were reported. Concerning the second goal, the skills of planned happenstance show different associations with Vocational Identity Dimensions. As hypothesized, the exploration and commitment dimensions of vocational identity status are positive related to Planned Happenstance Skills. These findings suggest implications for career guidance and counseling.
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.899411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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