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Book ; Conference proceedings: Morphological investigations of single neurons in vitro

Meredith, Gloria E.

(IBRO handbook series: methods in the neurosciences ; 16)

1993

Institution	Workshop on the Subject of Marking Single Cells In Vitro with Lucifer Yellow and Related Dyes
Author's details	[IBRO Workshop on the Subject of Marking Single Cells In Vitro with Lucifer Yellow and Related Dyes in Montréal in August 1991]. Ed. by Gloria E. Meredith
Series title	IBRO handbook series: methods in the neurosciences ; 16 IBRO handbook series ; methods in the neurosciences IBRO handbook series ; methods in the neurosciences
Collection	IBRO handbook series ; methods in the neurosciences IBRO handbook series ; methods in the neurosciences
Keywords	Neurons / cytology / congresses ; Neurons / ultrastructure / congresses ; Brain / anatomy & histology / congresses ; Neuroanatomie ; Nervenzelle ; Ultrastruktur ; Histologie
Subject	Gewebelehre ; Mikroskopische Anatomie ; Mikroanatomie ; Ganglienzelle ; Neurozyt ; Neuron ; Nervensystem
Language	English
Size	XVI, 193 S. : Ill., graph. Darst.
Publisher	Wiley
Publishing place	Chichester u.a.
Publishing country	Great Britain
Document type	Book ; Conference proceedings
HBZ-ID	HT006187378
ISBN	0-471-93928-5 ; 978-0-471-93928-3
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Article ; Online: The Extracellular Electron Transport Pathway Reduces Copper for Sensing by the CopRS Two-Component System under Anaerobic Conditions in Listeria monocytogenes.

Rizk, Amena A / Komazin, Gloria / Maybin, Michael / Hoque, Nushrat / Weinert, Emily / Meredith, Timothy C

Journal of bacteriology

2023 Volume 205, Issue 1, Page(s) e0039122

Abstract: The renowned antimicrobial activity of copper stems in part from its ability to undergo redox cycling between ... ...

Abstract	The renowned antimicrobial activity of copper stems in part from its ability to undergo redox cycling between Cu
MeSH term(s)	Copper/metabolism ; Electron Transport ; Listeria monocytogenes/genetics ; Listeria monocytogenes/metabolism ; Histidine Kinase/metabolism ; Anaerobiosis ; Ligands ; Escherichia coli/metabolism ; Silver
Chemical Substances	Copper (789U1901C5) ; Histidine Kinase (EC 2.7.13.1) ; Ligands ; Silver (3M4G523W1G)
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2968-3
ISSN	1098-5530 ; 0021-9193
ISSN (online)	1098-5530
ISSN	0021-9193
DOI	10.1128/jb.00391-22
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Article ; Online: MPTP mouse models of Parkinson's disease: an update.

Meredith, Gloria E / Rademacher, David J

Journal of Parkinson's disease

2011 Volume 1, Issue 1, Page(s) 19–33

Abstract: Among the most widely used models of Parkinson's disease (PD) are those that employ toxins, especially 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Depending on the protocol used, MPTP yields large variations in nigral cell loss, striatal ... ...

Abstract	Among the most widely used models of Parkinson's disease (PD) are those that employ toxins, especially 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Depending on the protocol used, MPTP yields large variations in nigral cell loss, striatal dopamine loss and behavioral deficits. Motor deficits do not fully replicate those seen in PD. Nonetheless, MPTP mouse models mimic many aspects of the disease and are therefore important tools for understanding PD. In this review, we will discuss the ability of MPTP mouse models to replicate the pathophysiology of PD, the mechanisms of MPTP-induced neurotoxicity, strain differences in susceptibility to MPTP, and the models' roles in testing therapeutic approaches.
MeSH term(s)	Animals ; Biomedical Research/trends ; Disease Models, Animal ; Mice ; Parkinsonian Disorders
Language	English
Publishing date	2011-12-31
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	2620609-2
ISSN	1877-718X ; 1877-7171
ISSN (online)	1877-718X
ISSN	1877-7171
DOI	10.3233/JPD-2011-11023
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Article ; Online: Effects of context-drug learning on synaptic connectivity in the basolateral nucleus of the amygdala in rats.

Rademacher, David J / Mendoza-Elias, Nasya / Meredith, Gloria E

The European journal of neuroscience

2014 Volume 41, Issue 2, Page(s) 205–215

Abstract: Context-drug learning produces structural and functional synaptic changes in the circuitry of the basolateral nucleus of the amygdala (BLA). However, how the synaptic changes translated to the neuronal targets was not established. Thus, in the present ... ...

Abstract	Context-drug learning produces structural and functional synaptic changes in the circuitry of the basolateral nucleus of the amygdala (BLA). However, how the synaptic changes translated to the neuronal targets was not established. Thus, in the present study, immunohistochemistry with a cell-specific marker and the stereological quantification of synapses was used to determine if context-drug learning increases the number of excitatory and inhibitory/modulatory synapses contacting the gamma-aminobutyric acid (GABA) interneurons and/or the pyramidal neurons in the BLA circuitry. Amphetamine-conditioned place preference increased the number of asymmetric (excitatory) synapses contacting the spines and dendrites of pyramidal neurons and the number of multisynaptic boutons contacting pyramidal neurons and GABA interneurons. Context-drug learning increased asymmetric (excitatory) synapses onto dendrites of GABA interneurons and increased symmetric (inhibitory or modulatory) synapses onto dendrites but not perikarya of these same interneurons. The formation of context-drug associations alters the synaptic connectivity in the BLA circuitry, findings that have important implications for drug-seeking behavior.
MeSH term(s)	Animals ; Basolateral Nuclear Complex/drug effects ; Basolateral Nuclear Complex/physiology ; Basolateral Nuclear Complex/ultrastructure ; Central Nervous System Stimulants/pharmacology ; Conditioning, Psychological/drug effects ; Conditioning, Psychological/physiology ; Dendritic Spines/drug effects ; Dendritic Spines/physiology ; Dendritic Spines/ultrastructure ; Dextroamphetamine/pharmacology ; Drug-Seeking Behavior/physiology ; Immunohistochemistry ; Interneurons/drug effects ; Interneurons/physiology ; Interneurons/ultrastructure ; Male ; Microscopy, Electron ; Neural Inhibition/drug effects ; Neural Inhibition/physiology ; Pyramidal Cells/drug effects ; Pyramidal Cells/physiology ; Pyramidal Cells/ultrastructure ; Rats, Sprague-Dawley ; Spatial Learning/drug effects ; Spatial Learning/physiology ; Synapses/drug effects ; Synapses/physiology ; Synapses/ultrastructure ; gamma-Aminobutyric Acid/metabolism
Chemical Substances	Central Nervous System Stimulants ; gamma-Aminobutyric Acid (56-12-2) ; Dextroamphetamine (TZ47U051FI)
Language	English
Publishing date	2014-10-31
Publishing country	France
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.12781
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Article ; Online: Radical hysterectomy case volume and cervical cancer treatment in the era of COVID-19: A multi-site analysis of National Cancer Institute-designated Comprehensive Cancer Centers.

Gynecologic oncology

2023 Volume 179, Page(s) 70–78

Abstract: Objective: To compare radical hysterectomy case volume, cancer stage, and biopsy-to-treatment time of invasive cervical cancer diagnosed before and after onset of the COVID-19 pandemic.: Methods: In a multi-institution retrospective cohort study ... ...

Abstract	Objective: To compare radical hysterectomy case volume, cancer stage, and biopsy-to-treatment time of invasive cervical cancer diagnosed before and after onset of the COVID-19 pandemic. Methods: In a multi-institution retrospective cohort study conducted at 6 large, geographically diverse National Cancer Institute-designated cancer centers, patients treated for newly diagnosed invasive cervical cancer were classified into 2 temporal cohorts based on date of first gynecologic oncology encounter: (1) Pre-Pandemic: 3/1/2018-2/28/2020; (2) Pandemic & Recovery: 4/1/2020-12/31/2021. The primary outcome was total monthly radical hysterectomy case volume. Secondary outcomes were stage at diagnosis and diagnosis-to-treatment time. Statistical analyses used chi-squared and two sample t-tests. Results: Between 3/1/2018-12/31/2021, 561 patients were diagnosed with cervical cancer. The Pre-Pandemic and Pandemic & Recovery cohorts had similar age, race, ethnicity, smoking status, and Body Mass Index (BMI). During Pandemic & Recovery, the mean monthly radical hysterectomy case volume decreased from 7[SD 2.8] to 5[SD 2.0] (p = 0.001), the proportion of patients diagnosed with Stage I disease dropped from 278/561 (49.5%) to 155/381 (40.7%), and diagnosis of stage II-IV disease increased from 281/561 (50.1%) to 224/381 (58.8%). Primary surgical management was less frequent (38.3% Pandemic & Recovery versus 46.7% Pre-Pandemic, p = 0.013) and fewer surgically-treated patients received surgery within 6 weeks of diagnosis (27.4% versus 38.9%; p = 0.025). Conclusions: Lower radical hysterectomy case volume, a shift to higher cervical cancer stage, and delay in surgical therapy were observed across the United States following the COVID-19 outbreak. Decreased surgical volume may result from lower detection of early-stage disease or other factors.
MeSH term(s)	United States/epidemiology ; Humans ; Female ; Uterine Cervical Neoplasms/pathology ; COVID-19/epidemiology ; Retrospective Studies ; Pandemics ; National Cancer Institute (U.S.) ; Hysterectomy/adverse effects ; Neoplasm Staging
Language	English
Publishing date	2023-11-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2023.10.010
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Article ; Online: Early Evidence of Chronic Obstructive Pulmonary Disease Obscured by Race-Specific Prediction Equations.

Regan, Elizabeth A / Lowe, Melissa E / Make, Barry J / Curtis, Jeffrey L / Chen, Quan Grace / Crooks, James L / Wilson, Carla / Oates, Gabriela R / Gregg, Robert W / Baldomero, Arianne K / Bhatt, Surya P / Diaz, Alejandro A / Benos, Panayiotis V / O'Brien, James K / Young, Kendra A / Kinney, Gregory L / Conrad, Douglas J / Lowe, Katherine E / DeMeo, Dawn L /

Non, Amy / Cho, Michael H / Kallet, Julia / Foreman, Marilyn G / Westney, Gloria E / Hoth, Karin / MacIntyre, Neil R / Hanania, Nicola A / Wolfe, Amy / Amaza, Hannatu / Han, MeiLan / Beaty, Terri H / Hansel, Nadia N / McCormack, Meredith C / Balasubramanian, Aparna / Crapo, James D / Silverman, Edwin K / Casaburi, Richard / Wise, Robert A

American journal of respiratory and critical care medicine

2023 Volume 209, Issue 1, Page(s) 59–69

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Nutrition Surveys ; Cross-Sectional Studies ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Dyspnea/diagnosis ; Airway Obstruction ; Spirometry ; Forced Expiratory Volume
Language	English
Publishing date	2023-08-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202303-0444OC
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Article: Differential laminar effects of amphetamine on prefrontal parvalbumin interneurons.

Morshedi, M M / Meredith, Gloria E

Neuroscience

2007 Volume 149, Issue 3, Page(s) 617–624

Abstract: The increase in excitatory outflow from the medial prefrontal cortex is critical to the development of sensitization to amphetamine. There is evidence that psychostimulant-induced changes in dopamine-GABA interactions are key to understanding the ... ...

Abstract	The increase in excitatory outflow from the medial prefrontal cortex is critical to the development of sensitization to amphetamine. There is evidence that psychostimulant-induced changes in dopamine-GABA interactions are key to understanding the behaviorally sensitized response. The objective of this study was to characterize the effects of different amphetamine paradigms on the Fos activation of GABAergic interneurons that contain parvalbumin in the medial prefrontal cortex. Although a sensitizing, repeated regimen of amphetamine induced Fos in all cortical layers, only layer V parvalbumin-immunolabeled cells were activated in the infralimbic and prelimbic cortices. Repeated amphetamine treatment was also associated with a loss of parvalbumin immunoreactivity in layer V, but only in the prelimbic cortex. An acute amphetamine injection to naive rats was associated with an increase in Fos, but in parvalbumin-positive neurons of the prelimbic cortex, where it was preferentially induced in layer III. These data indicate that distinct substrates mediate the response to repeated or acute amphetamine treatment. They also suggest that a sensitizing amphetamine regimen directs medial prefrontal cortex (mPFC) outflow, via changes in inhibitory neuron activation, toward subcortical centers important in reward.
MeSH term(s)	Amphetamine/pharmacology ; Animals ; Central Nervous System Stimulants/pharmacology ; Image Processing, Computer-Assisted ; Immunohistochemistry ; In Vitro Techniques ; Interneurons/drug effects ; Interneurons/metabolism ; Male ; Microscopy, Confocal ; Motor Activity/drug effects ; Parvalbumins/physiology ; Prefrontal Cortex/cytology ; Prefrontal Cortex/drug effects ; Prolactin/metabolism ; Proto-Oncogene Proteins c-fos/biosynthesis ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Central Nervous System Stimulants ; Parvalbumins ; Proto-Oncogene Proteins c-fos ; Prolactin (9002-62-4) ; Amphetamine (CK833KGX7E)
Language	English
Publishing date	2007-08-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2007.07.047
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Article: Repeated amphetamine administration induces Fos in prefrontal cortical neurons that project to the lateral hypothalamus but not the nucleus accumbens or basolateral amygdala.

Morshedi, Maud M / Meredith, Gloria E

Psychopharmacology

2007 Volume 197, Issue 2, Page(s) 179–189

Abstract: Rationale: The development of sensitization to amphetamine (AMPH) is dependent on increases in excitatory outflow from the medial prefrontal cortex (mPFC) to subcortical centers. These projections are clearly important for the progressive enhancement of ...

Abstract	Rationale: The development of sensitization to amphetamine (AMPH) is dependent on increases in excitatory outflow from the medial prefrontal cortex (mPFC) to subcortical centers. These projections are clearly important for the progressive enhancement of the behavioral response during drug administration that persists through withdrawal. Objectives: The objective of this study was to identify the mPFC subcortical pathway(s) activated by a sensitizing regimen of AMPH. Materials and methods: Using retrograde labeling techniques, Fos activation was evaluated in the predominant projection pathways of the mPFC of sensitized rats after a challenge injection of AMPH. Results: There was a significant increase in Fos-immunoreactive cells in the mPFC, nucleus accumbens (NAc), basolateral amygdala (BLA), and lateral hypothalamus (LH) of rats treated repeatedly with AMPH when compared to vehicle-treated controls. The mPFC pyramidal neurons that project to the LH but not the NAc or BLA show a significant induction of Fos after repeated AMPH treatment. In addition, we found a dramatic increase in Fos-activated orexin neurons. Conclusions: The LH, a region implicated in natural and drug reward processes, may play a role in the development and persistence of sensitization to repeated AMPH through its connections with the mPFC and possibly through its orexin neurons.
MeSH term(s)	Amphetamine/pharmacology ; Amygdala/cytology ; Amygdala/drug effects ; Amygdala/metabolism ; Animals ; Central Nervous System Stimulants/pharmacology ; Hypothalamic Area, Lateral/cytology ; Hypothalamic Area, Lateral/drug effects ; Hypothalamic Area, Lateral/metabolism ; Image Processing, Computer-Assisted ; Immunohistochemistry ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Microinjections ; Motor Activity/drug effects ; Neural Pathways/drug effects ; Neural Pathways/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Neuropeptides/metabolism ; Nucleus Accumbens/cytology ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Orexins ; Perfusion ; Prefrontal Cortex/cytology ; Prefrontal Cortex/metabolism ; Proto-Oncogene Proteins c-fos/biosynthesis ; Proto-Oncogene Proteins c-fos/genetics ; Pyramidal Cells/drug effects ; Pyramidal Cells/metabolism ; Rats ; Rats, Sprague-Dawley ; Stilbamidines
Chemical Substances	2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt ; Central Nervous System Stimulants ; Intracellular Signaling Peptides and Proteins ; Neuropeptides ; Orexins ; Proto-Oncogene Proteins c-fos ; Stilbamidines ; Amphetamine (CK833KGX7E)
Language	English
Publishing date	2007-12-14
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-007-1021-7
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Article ; Online: Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1.

Vollmer, Kathryn J / Burns, Anna C / Sauer, Hannah E / Williams, John D / Komazin-Meredith, Gloria / Cardinale, Steve / Butler, Michelle / Aron, Zachary / Hussein, Islam / Busch, Marc G / Bowlin, Terry L / Gentry, Brian G

Antimicrobial agents and chemotherapy

2019 Volume 63, Issue 10

Abstract: To determine the mechanism of action of third-generation methylenecyclopropane nucleoside analogs (MCPNAs), DNA sequencing of herpes simplex virus 1 (HSV-1) isolates resistant to third-generation MCPNAs resulted in the discovery of G841S and N815S ... ...

Abstract	To determine the mechanism of action of third-generation methylenecyclopropane nucleoside analogs (MCPNAs), DNA sequencing of herpes simplex virus 1 (HSV-1) isolates resistant to third-generation MCPNAs resulted in the discovery of G841S and N815S mutations in HSV-1 UL30. Purified HSV-1 UL30 or human cytomegalovirus (HCMV) UL54 was then subjected to increasing concentrations of MBX-2168-triphosphate (TP), with results demonstrating a 50% inhibitory concentration (IC
MeSH term(s)	Adenosine Deaminase/genetics ; Adenosine Deaminase/metabolism ; Animals ; Chlorocebus aethiops ; Chromatography, High Pressure Liquid ; Cyclopropanes/chemistry ; Cyclopropanes/pharmacology ; Cytomegalovirus/drug effects ; Cytomegalovirus/pathogenicity ; DNA, Viral/genetics ; Guanine/analogs & derivatives ; Guanine/pharmacology ; Herpesvirus 1, Human/drug effects ; Herpesvirus 1, Human/pathogenicity ; Humans ; Nucleosides/analogs & derivatives ; Nucleosides/pharmacology ; Sequence Analysis, DNA/methods ; Vero Cells ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication/genetics ; Virus Replication/physiology
Chemical Substances	Cyclopropanes ; DNA, Viral ; MBX 2168 ; Nucleosides ; Viral Proteins ; methylenecyclopropane ; Guanine (5Z93L87A1R) ; Adenosine Deaminase (EC 3.5.4.4)
Language	English
Publishing date	2019-09-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.01301-19
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Article: The role of oxidative stress in the dysregulation of gene expression and protein metabolism in neurodegenerative disease.

Potashkin, Judith A / Meredith, Gloria E

Antioxidants & redox signaling

2006 Volume 8, Issue 1-2, Page(s) 144–151

Abstract: There are few examples for which the genetic basis for neurodegenerative disease has been identified. For the majority of these disorders, the key to their understanding lies in knowledge of the molecular changes that contribute to altered gene ... ...

Abstract	There are few examples for which the genetic basis for neurodegenerative disease has been identified. For the majority of these disorders, the key to their understanding lies in knowledge of the molecular changes that contribute to altered gene expression and the translational modification of the protein products. Environmental factors play a role in the development and chronicity of neurodegenerative disorders. Environmental stimuli such as hypoxia, toxins, or heavy metals, increase production of reactive oxygen species and lower energy reserves. Chronic exposure to oxidative radicals can adversely affect gene expression and proteolysis. This review summarizes what is currently known about some of the changes in gene expression and protein metabolism that occur after oxidative stress which contribute to neurodegeneration, and reveals areas where more research is clearly needed.
MeSH term(s)	DNA Damage ; Gene Expression Regulation ; Humans ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurodegenerative Diseases/metabolism ; Neurodegenerative Diseases/physiopathology ; Oxidative Stress ; Protein Conformation ; RNA/genetics ; RNA/metabolism ; RNA, Messenger/genetics
Chemical Substances	Nerve Tissue Proteins ; RNA, Messenger ; RNA (63231-63-0)
Language	English
Publishing date	2006-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2006.8.144
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