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  1. Article ; Online: Editorial for the special issue on language and epilepsy.

    Bonilha, Leonardo / Small, Steven S / Lin, Jack J

    Brain and language

    2019  Volume 193, Page(s) 1–3

    Language English
    Publishing date 2019-03-28
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 7448-2
    ISSN 1090-2155 ; 0093-934X
    ISSN (online) 1090-2155
    ISSN 0093-934X
    DOI 10.1016/j.bandl.2019.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Efficacy and Tolerability of

    Dagogo-Jack, Ibiayi / Kiedrowski, Lesli A / Heist, Rebecca S / Lin, Jessica J / Meador, Catherine B / Krueger, Elizabeth A / Do, Andrew / Peterson, Jennifer / Sequist, Lecia V / Gainor, Justin F / Lennerz, Jochen K / Digumarthy, Subba R

    JTO clinical and research reports

    2023  Volume 4, Issue 8, Page(s) 100534

    Abstract: Introduction: MET: Methods: We assembled a cohort of patients with ALK+ lung cancer and acquired : Results: A total of 12 patients were included in the series. : Conclusions: Combined ALK and MET inhibition is associated with moderate antitumor ...

    Abstract Introduction: MET
    Methods: We assembled a cohort of patients with ALK+ lung cancer and acquired
    Results: A total of 12 patients were included in the series.
    Conclusions: Combined ALK and MET inhibition is associated with moderate antitumor activity in patients with ALK+ NSCLC with concurrent
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3643
    ISSN (online) 2666-3643
    DOI 10.1016/j.jtocrr.2023.100534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Consumers' Knowledge and Handling Practices Associated with Fresh-Cut Produce in the United States.

    Yu, Heyao / Lin, Zhihong / Lin, Michael S / Neal, Jack A / Sirsat, Sujata A

    Foods (Basel, Switzerland)

    2022  Volume 11, Issue 14

    Abstract: ... to assess U.S. consumers' food safety knowledge, practices, and risk perception associated ...

    Abstract Previous studies have shown that three factors influence fresh-cut produce safety from farm to fork: (1) post-harvest practices in processing facilities, (2) employees' handling practices in retail facilities, and (3) consumers' handling practices in domestic kitchens or cooking facilities. However, few studies have examined consumers' food safety knowledge, risk perceptions, and their handling practices associated with fresh-cut produce. To fill this gap, the present study conducted a nationwide survey to assess U.S. consumers' food safety knowledge, practices, and risk perception associated with fresh-cut produce among various demographic groups and investigated factors influencing consumers' food safety practices related to fresh-cut produce. The results showed that consumers lack the knowledge and safe handling practices toward fresh-cut produce regarding storage hierarchy, surface cleaning and sanitizing, and time and temperature control of fresh-cut produce. The men and millennial consumers exhibit a lower level of safe fresh-cut produce handling practices. In addition, a significant interaction was observed between food safety knowledge and risk perceptions on consumers' fresh-cut produce handling practices, such that food safety knowledge can transfer to practice more effectively for consumers with high levels of risk perception. The results can be utilized to design effective consumer food safety education tools for targeted audiences.
    Language English
    Publishing date 2022-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods11142167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Consumers’ Knowledge and Handling Practices Associated with Fresh-Cut Produce in the United States

    Yu, Heyao / Lin, Zhihong / Lin, Michael S. / Neal, Jack A. / Sirsat, Sujata A.

    Foods. 2022 July 21, v. 11, no. 14

    2022  

    Abstract: ... to assess U.S. consumers’ food safety knowledge, practices, and risk perception associated ...

    Abstract Previous studies have shown that three factors influence fresh-cut produce safety from farm to fork: (1) post-harvest practices in processing facilities, (2) employees’ handling practices in retail facilities, and (3) consumers’ handling practices in domestic kitchens or cooking facilities. However, few studies have examined consumers’ food safety knowledge, risk perceptions, and their handling practices associated with fresh-cut produce. To fill this gap, the present study conducted a nationwide survey to assess U.S. consumers’ food safety knowledge, practices, and risk perception associated with fresh-cut produce among various demographic groups and investigated factors influencing consumers’ food safety practices related to fresh-cut produce. The results showed that consumers lack the knowledge and safe handling practices toward fresh-cut produce regarding storage hierarchy, surface cleaning and sanitizing, and time and temperature control of fresh-cut produce. The men and millennial consumers exhibit a lower level of safe fresh-cut produce handling practices. In addition, a significant interaction was observed between food safety knowledge and risk perceptions on consumers’ fresh-cut produce handling practices, such that food safety knowledge can transfer to practice more effectively for consumers with high levels of risk perception. The results can be utilized to design effective consumer food safety education tools for targeted audiences.
    Keywords farm to fork ; food safety education ; fresh-cut produce ; national surveys ; produce safety ; risk perception ; temperature
    Language English
    Dates of publication 2022-0721
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods11142167
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: MiR-302-Mediated Somatic Cell Reprogramming and Method for Generating Tumor-Free iPS Cells Using miR-302.

    Lin, Shi-Lung / Chen, Jack S / Ying, Shao-Yao

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2115, Page(s) 199–219

    Abstract: ... and potential tumorigenicity. To overcome this major hurdle, we examined the mechanism(s ... through co-suppression of both cyclin E-CDK2 and cyclin D-CDK4/6 cell cycle pathways during G1-S phase transition. MiR ... associated tumor suppressor genes, p16Ink4a and p14/p19Arf. Together, the combinatory effect of reducing G1-S ...

    Abstract Human induced pluripotent stem cells (iPSCs) by four factors have the risks of teratoma formation and potential tumorigenicity. To overcome this major hurdle, we examined the mechanism(s) by which the cell cycle genes of embryonic cells were regulated. Naturally occurring embryonic stem cells (ESCs) possess two unique stemness properties: pluripotent differentiation into all cell types and self-renewal with no risk of tumor formation. Despite overwhelming reports describing iPSC pluripotency, there have been no observations of tumor prevention mechanism that suppresses tumor formation similar to that in naturally occurring ESCs. The ESC-specific microRNA (miRNA), miR-302, regulates human iPSC tumorigenicity through co-suppression of both cyclin E-CDK2 and cyclin D-CDK4/6 cell cycle pathways during G1-S phase transition. MiR-302 also silenced BMI-1, a cancer stem cell marker gene, to promote the expression of two senescence-associated tumor suppressor genes, p16Ink4a and p14/p19Arf. Together, the combinatory effect of reducing G1-S cell cycle transition and increasing p16/p14(p19) expression resulted in a relatively attenuated cell cycle rate similar to that of 2-to-8-cell-stage embryonic cells in early mammalian zygotes (20-24 h/cycle), as compared to the fast proliferation rate of iPSCs induced by four defined factors Oct4-Sox2-Klf4-c-Myc (12-16 h/cycle). In addition to the prevention of stem cell tumorigenicity, the mechanism underlying miR-302-mediated iPSCs also includes the initiation of global genomic DNA methylation, activation of ESC-specific gene expression, and inhibition of developmental signaling. Overall, we have established an effective protocol to express the intronic miR-302 cluster, according to its own natural biogenesis mechanism to generate tumor-free iPSCs for use in biology and therapy.
    MeSH term(s) Carcinogenesis/genetics ; Cellular Reprogramming ; Cellular Reprogramming Techniques/methods ; Electroporation/methods ; Genetic Vectors/genetics ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Introns ; MicroRNAs/genetics ; Transfection/methods
    Chemical Substances MIRN302A microRNA, human ; MicroRNAs
    Language English
    Publishing date 2020-01-31
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-0290-4_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clinicopathologic Characteristics and Outcomes for Patients With

    Cooper, Alissa J / Muzikansky, Alona / Lennerz, Jochen / Narinesingh, Farhaana / Mino-Kenudson, Mari / Hung, Yin P / Piotrowska, Zofia / Dagogo-Jack, Ibiayi / Sequist, Lecia V / Gainor, Justin F / Lin, Jessica J / Heist, Rebecca S

    JTO clinical and research reports

    2022  Volume 3, Issue 9, Page(s) 100390

    Abstract: Introduction: Co-occurring mutations in : Methods: This was a retrospective single-institution study. Patients with NSCLC and : Results: A total of 107 patients with : Conclusions: Co-occurring mutations were common in patients ... ...

    Abstract Introduction: Co-occurring mutations in
    Methods: This was a retrospective single-institution study. Patients with NSCLC and
    Results: A total of 107 patients with
    Conclusions: Co-occurring mutations were common in patients with
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3643
    ISSN (online) 2666-3643
    DOI 10.1016/j.jtocrr.2022.100390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reidentification With Birth-Registered Sex in a Western Australian Pediatric Gender Clinic Cohort.

    Cavve, Blake S / Bickendorf, Xander / Ball, Jack / Saunders, Liz A / Thomas, Cati S / Strauss, Penelope / Chaplyn, Georgia / Marion, Larissa / Siafarikas, Aris / Ganti, Uma / Wiggins, Aaron / Lin, Ashleigh / Moore, Julia K

    JAMA pediatrics

    2024  

    Abstract: Importance: Some young people who identify as transgender and seek gender-affirming medical care subsequently reidentify with their sex registered at birth. Evidence regarding the frequency and characteristics of this experience is lacking.: Objective! ...

    Abstract Importance: Some young people who identify as transgender and seek gender-affirming medical care subsequently reidentify with their sex registered at birth. Evidence regarding the frequency and characteristics of this experience is lacking.
    Objective: To determine the frequency of reidentification and explore associated characteristics in a pediatric gender clinic setting.
    Design, setting, and participants: This retrospective cohort study examined all referrals to the Child and Adolescent Health Service Gender Diversity Service at Perth Children's Hospital between January 1, 2014, and December 31, 2020. The Gender Diversity Service is the sole statewide specialist service in Western Australia that provides children and adolescents up to age 18 years with multidisciplinary assessment, information, support, and gender-affirming medical care. All closed referrals for this study were audited between May 1, 2021, and August 8, 2022.
    Exposure: Reidentification with birth-registered sex.
    Main outcomes and measures: The number of referrals closed due to reported reidentification with birth-registered sex was determined, as well as descriptives and frequencies of patient demographics (age, birth-registered sex), informant source, International Statistical Classification of Diseases, Tenth Revision gender-related diagnoses, pubertal status, any gender-affirming medical treatment received, and whether subsequent re-referrals were received.
    Results: Of 552 closed referrals during the study period, a reason for closure could be determined for 548 patients, including 211 birth-registered males (mean [SD] age, 13.88 [2.00] years) and 337 birth-registered females (mean [SD] age, 15.81 [2.22] years). Patients who reidentified with their birth-registered sex comprised 5.3% (29 of 548; 95% CI, 3.6%-7.5%) of all referral closures. Except for 2 patients, reidentification occurred before or during early stages of assessment (93.1%; 95% CI, 77.2%-99.2%). Two patients who reidentified with their birth-registered sex did so following initiation of puberty suppression or gender-affirming hormone treatment (1.0% of 196 patients who initiated any gender-affirming medical treatment; 95% CI, 0.1%-3.6%).
    Conclusions and relevance: These findings from a pediatric gender clinic audit indicate that a small proportion of patients, and a very small proportion of those who initiated medical gender-affirming treatment, reidentified with their birth-registered sex during the study period. Longitudinal follow-up studies, including qualitative self-report, are required to understand different pathways of gender identity experience.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2024.0077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: i-shaped antibody engineering enables conformational tuning of biotherapeutic receptor agonists.

    Romei, Matthew G / Leonard, Brandon / Katz, Zachary B / Le, Daniel / Yang, Yanli / Day, Eric S / Koo, Christopher W / Sharma, Preeti / Bevers Iii, Jack / Kim, Ingrid / Dai, Huiguang / Farahi, Farzam / Lin, May / Shaw, Andrey S / Nakamura, Gerald / Sockolosky, Jonathan T / Lazar, Greg A

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 642

    Abstract: The ability to leverage antibodies to agonize disease relevant biological pathways has tremendous potential for clinical investigation. Yet while antibodies have been successful as antagonists, immune mediators, and targeting agents, they are not readily ...

    Abstract The ability to leverage antibodies to agonize disease relevant biological pathways has tremendous potential for clinical investigation. Yet while antibodies have been successful as antagonists, immune mediators, and targeting agents, they are not readily effective at recapitulating the biology of natural ligands. Among the important determinants of antibody agonist activity is the geometry of target receptor engagement. Here, we describe an engineering approach inspired by a naturally occurring Fab-Fab homotypic interaction that constrains IgG in a unique i-shaped conformation. i-shaped antibody (iAb) engineering enables potent intrinsic agonism of five tumor necrosis factor receptor superfamily (TNFRSF) targets. When applied to bispecific antibodies against the heterodimeric IL-2 receptor pair, constrained bispecific IgG formats recapitulate IL-2 agonist activity. iAb engineering provides a tool to tune agonist antibody function and this work provides a framework for the development of intrinsic antibody agonists with the potential for generalization across broad receptor classes.
    MeSH term(s) Antibodies, Bispecific ; Receptors, Tumor Necrosis Factor ; Immunoglobulin G/genetics ; Protein Engineering
    Chemical Substances Antibodies, Bispecific ; Receptors, Tumor Necrosis Factor ; Immunoglobulin G
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-44985-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Gently does it!:

    Gibson, Joshua S / Narayanan, Sudarshan / Swallow, Jack E N / Kumar-Thakur, Pardeep / Pasta, Mauro / Lee, Tien-Lin / Weatherup, Robert S

    Faraday discussions

    2022  Volume 236, Page(s) 267–287

    Abstract: The key charge transfer processes in electrochemical energy storage devices occur at electrode-electrolyte interfaces, which are typically buried, making it challenging to access their interfacial chemistry. In the case of Li-ion batteries, metallic Li ... ...

    Abstract The key charge transfer processes in electrochemical energy storage devices occur at electrode-electrolyte interfaces, which are typically buried, making it challenging to access their interfacial chemistry. In the case of Li-ion batteries, metallic Li electrodes hold promise for increasing energy and power densities and, when used in conjunction with solid electrolytes, the adverse safety implications associated with dendrite formation in organic liquid electrolytes can potentially be overcome. To better understand the stability of solid electrolytes when in contact with alkali metals and the reactions that occur, here we consider the deposition of thin (∼10 nm) alkali metal films onto solid electrolyte surfaces, where the metal is thin enough that X-ray photoelectron spectroscopy can probe the buried electrode-electrolyte interface. We highlight the importance of
    Language English
    Publishing date 2022-08-25
    Publishing country England
    Document type Journal Article
    ISSN 1364-5498
    ISSN (online) 1364-5498
    DOI 10.1039/d1fd00118c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Phase II Study of Lorlatinib in Patients With Anaplastic Lymphoma Kinase-Positive Lung Cancer and CNS-Specific Relapse.

    Dagogo-Jack, Ibiayi / Oxnard, Geoffrey R / Evangelist, Makenzi / Digumarthy, Subba R / Lin, Jessica J / Gainor, Justin F / Murphy, John F / Rabin, Michael S / Heist, Rebecca S / Muzikansky, Alona / Shaw, Alice T

    JCO precision oncology

    2022  Volume 6, Page(s) e2100522

    Abstract: Purpose: The CNS is a recurrent site of progression in anaplastic lymphoma kinase (ALK)-rearranged (ALK+) lung cancer. Lorlatinib is a third-generation ALK inhibitor developed to penetrate the CNS and overcome : Methods: Patients with ALK+ lung ... ...

    Abstract Purpose: The CNS is a recurrent site of progression in anaplastic lymphoma kinase (ALK)-rearranged (ALK+) lung cancer. Lorlatinib is a third-generation ALK inhibitor developed to penetrate the CNS and overcome
    Methods: Patients with ALK+ lung cancer who had intracranial progression on ≥ 1 ALK inhibitor without measurable extracranial disease received lorlatinib 100 mg once daily. The primary end point was intracranial disease control rate at 12 weeks per modified RECIST v1.1. Secondary end points included intracranial progression-free survival, intracranial objective response rate, and safety/tolerability.
    Results: Twenty-three patients were enrolled between November 2016 and January 2019. Fifteen (65%) patients had irradiated CNS metastases, with a median of 20.2 months between radiation and lorlatinib. Control of intracranial disease was observed in 21 (95%) evaluable patients at 12 weeks. The intracranial objective response rate was 59% with six complete and seven partial responses. The median intracranial progression-free survival was 24.6 months (95% CI, 20.2 to not reached). With a median follow-up of 16.8 months, nine patients developed disease progression, including four patients with CNS progression. The most common treatment-related adverse events were hypercholesterolemia (96%), hypertriglyceridemia (87%), edema (65%), cognitive effects (52%), and mood effects (43%). Three patients discontinued treatment because of toxicity, including two patients with fatal respiratory events.
    Conclusion: Lorlatinib induced durable intracranial disease control in patients with CNS-only relapse on second-generation ALK inhibitors, suggesting that tumors with CNS-limited progression on brain-penetrant ALK tyrosine kinase inhibitors remain ALK-dependent.
    MeSH term(s) Aminopyridines ; Anaplastic Lymphoma Kinase/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Humans ; Lactams ; Lactams, Macrocyclic/therapeutic use ; Lung Neoplasms/drug therapy ; Neoplasm Recurrence, Local/drug therapy ; Protein Kinase Inhibitors/adverse effects ; Pyrazoles
    Chemical Substances Aminopyridines ; Lactams ; Lactams, Macrocyclic ; Protein Kinase Inhibitors ; Pyrazoles ; Anaplastic Lymphoma Kinase (EC 2.7.10.1) ; lorlatinib (OSP71S83EU)
    Language English
    Publishing date 2022-05-18
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.21.00522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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