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Article ; Online: Physical activity service provision in hospice care: A national mixed-methods study.

Burke, Shaunna / Hopkins, Natalie / Divine, Alison / Ebenso, Bassey / Allsop, Matthew

2023 , Page(s) 1–9

Abstract: Background: Physical activity (PA) interventions help people with advanced incurable diseases to manage symptoms and improve their quality of life. However, little is known about the extent to which PA is currently delivered in hospice care in England.!# ...

Abstract	Background: Physical activity (PA) interventions help people with advanced incurable diseases to manage symptoms and improve their quality of life. However, little is known about the extent to which PA is currently delivered in hospice care in England. Objectives: To determine the extent of and intervention features of PA service provision in hospice care in England alongside barriers and facilitators to their delivery. Methods: An embedded mixed-methods design using (1) a nationwide online survey of 70 adult hospices in England and (2) focus groups and individual interviews with health professionals from 18 hospices. Analysis of the data involved applying descriptive statistics to the numeric items and thematic analysis to the open-ended questions. Quantitative and qualitative data were collected and analyzed separately. Results: The majority of responding hospices ( Significance of results: While many hospices in England deliver PA, there is considerable variation in its delivery across sites. Funding and policy action may be needed to support hospices to initiate or scale up services and address inequity in access to high-quality interventions.
Language	English
Publishing date	2023-06-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2454009-2
ISSN	1478-9523 ; 1478-9515
ISSN (online)	1478-9523
ISSN	1478-9515
DOI	10.1017/S1478951523000822
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Article ; Online: A cognitive behavioural model of the bidirectional relationship between disordered eating and diabetes self care in adult men with Type 1 diabetes mellitus.

Harrison, Amy / Konstantara, Emmanouela / Zaremba, Natalie / Brown, Jennie / Allan, Jacqueline / Pillay, Divina / Hopkins, David / Treasure, Janet / Ismail, Khalida / Stadler, Marietta

Diabetic medicine : a journal of the British Diabetic Association

2024 Volume 41, Issue 5, Page(s) e15287

Abstract: Aims: This qualitative study aimed to develop the first cognitive behavioural (CBT) model outlining the development and maintenance of disordered eating in adult men living with Type 1 diabetes to improve on previous theoretical models of Type 1 ... ...

Abstract	Aims: This qualitative study aimed to develop the first cognitive behavioural (CBT) model outlining the development and maintenance of disordered eating in adult men living with Type 1 diabetes to improve on previous theoretical models of Type 1 diabetes and disordered eating and to draw comparisons to women with Type 1 diabetes and disordered eating. Methods: Twenty-seven men (n = 16 with Type 1 diabetes and disordered eating, n = 11 with Type 1 diabetes without disordered eating) participated in semi-structured interviews. Data were analysed using thematic analysis and individual CBT formulations were developed for each participant to inform the model. Results: Men with Type 1 diabetes and disordered eating experience negative thoughts about food, insulin, weight/shape and diabetes itself, which cause negative emotions such as fear and vulnerability and difficulties with diabetes self care such as problems with hyper and hypoglycaemia and problems accessing structured education and technology result in men feeling more dissatisfied about their body weight/shape. Conclusions: This CBT model of disordered eating in men with Type 1 diabetes can guide new interventions.
MeSH term(s)	Adult ; Male ; Humans ; Female ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/therapy ; Diabetes Mellitus, Type 1/psychology ; Self Care ; Feeding and Eating Disorders/complications ; Feeding and Eating Disorders/epidemiology ; Feeding and Eating Disorders/therapy ; Emotions ; Cognition
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/dme.15287
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Article ; Online: Protocol for the STEADY intervention for type 1 diabetes and disordered eating: Safe management of people with Type 1 diabetes and EAting Disorders studY.

Zaremba, Natalie / Harrison, Amy / Brown, Jennie / Allan, Jacqueline / Pillay, Divina / Treasure, Janet / Ayis, Salma / Hopkins, David / Ismail, Khalida / Stadler, Marietta

Diabetic medicine : a journal of the British Diabetic Association

2024 Volume 41, Issue 4, Page(s) e15273

Abstract: This paper describes the protocol to test the feasibility of the Safe management of people with Type 1 diabetes and EAting Disorders studY (STEADY) intervention. STEADY is a novel complex intervention for people with type 1 diabetes and disordered eating ...

Abstract	This paper describes the protocol to test the feasibility of the Safe management of people with Type 1 diabetes and EAting Disorders studY (STEADY) intervention. STEADY is a novel complex intervention for people with type 1 diabetes and disordered eating (T1DE) of mild to moderate severity. The STEADY intervention integrates cognitive behavioural therapy (CBT) with diabetes education, and was developed using Experience-Based Co-Design. METHODS: The feasibility of STEADY will be tested using a randomised controlled feasibility trial. Forty adults with T1DE will be recruited and randomised into the STEADY intervention or treatment as usual control group. We will collect demographic, biomedical and psychometric data, routine glucose metrics and conduct the Structured Clinical Interview for DSM-5. Participants randomised to the STEADY intervention will receive 12 STEADY therapy sessions with a diabetes specialist nurse trained in CBT, delivered via videoconference and an optional smartphone app. The main outcome at 6 months will be the feasibility of STEADY (recruitment, dropout rates, feasibility of delivery). The secondary outcomes are biomedical (HbA1c and glucose time in range) and psychological (person-reported outcome measures in disordered eating, diabetes distress, depression and anxiety). A process evaluation will evaluate the fidelity, feasibility, acceptability and appropriateness of STEADY, and participant experiences. ETHICS AND DISSEMINATION: The protocol was approved by the East of England-Essex Research Ethics Committee (21/EE/0235). Study findings will be shared with study participants and disseminated through peer-reviewed publications and conference presentations.
MeSH term(s)	Adult ; Humans ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/therapy ; Feeding and Eating Disorders/therapy ; Anxiety ; Anxiety Disorders ; Glucose ; Randomized Controlled Trials as Topic
Chemical Substances	Glucose (IY9XDZ35W2)
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	605769-x
ISSN	1464-5491 ; 0742-3071 ; 1466-5468
ISSN (online)	1464-5491
ISSN	0742-3071 ; 1466-5468
DOI	10.1111/dme.15273
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Article ; Online: Basic Salt Additives Modulate the Acidic Microenvironment Around In Situ Forming Implants.

Hopkins, Kelsey / Wakelin, Elizabeth / Romick, Natalie / Kennedy, Jacqueline / Simmons, Emma / Solorio, Luis

Annals of biomedical engineering

2022 Volume 51, Issue 5, Page(s) 966–976

Abstract: There is a growing number of protein drugs, yet their limited oral bioavailability requires that patients receive frequent, high dose injections. In situ forming implants (ISFIs) for controlled release of biotherapeutics have the potential to greatly ... ...

Abstract	There is a growing number of protein drugs, yet their limited oral bioavailability requires that patients receive frequent, high dose injections. In situ forming implants (ISFIs) for controlled release of biotherapeutics have the potential to greatly reduce the injection frequency and improve patient compliance. However, protein release from ISFIs is a challenge due to their proclivity for instability. Specifically, factors such as the acidic microclimate within ISFIs can lead to protein aggregation and denaturation. Basic salts have been shown in PLGA microparticle and microcylinder formulations to significantly reduce protein instability by neutralizing this acidic environment. The overall objective of the study was to demonstrate that basic salts can be used with an ISFI system to neutralize the implant acidification. To this end, the basic salts MgCO3 and Mg(OH)2 were added to a protein-releasing ISFI and the effect on drug release, pH, implant swelling, implant diffusivity, and implant erosion were evaluated. Either salt added at 3 wt% neutralized the acidic environment surrounding the implants, keeping the pH at 6.64 ± 0.03 (MgCO
MeSH term(s)	Humans ; Drug Implants ; Drug Liberation ; Prostheses and Implants
Chemical Substances	Drug Implants
Language	English
Publishing date	2022-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	185984-5
ISSN	1573-9686 ; 0191-5649 ; 0090-6964
ISSN (online)	1573-9686
ISSN	0191-5649 ; 0090-6964
DOI	10.1007/s10439-022-03109-6
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Article ; Online: Characterizing the Movement of Per- and Polyfluoroalkyl Substances in an Avian Aquatic-Terrestrial Food Web.

Hopkins, Kailee E / McKinney, Melissa A / Saini, Amandeep / Letcher, Robert J / Karouna-Renier, Natalie K / Fernie, Kim J

Environmental science & technology

2023 Volume 57, Issue 48, Page(s) 20249–20260

Abstract: The movement of per- and polyfluoroalkyl substances (PFAS) through linked aquatic-terrestrial food webs is not well understood. Tree swallows ( ...

Abstract	The movement of per- and polyfluoroalkyl substances (PFAS) through linked aquatic-terrestrial food webs is not well understood. Tree swallows (
MeSH term(s)	Animals ; Food Chain ; Fluorocarbons/analysis ; Invertebrates ; Water ; Alkanesulfonic Acids ; Birds
Chemical Substances	perfluorotridecanoic acid ; Fluorocarbons ; Water (059QF0KO0R) ; perfluorooctane sulfonic acid (9H2MAI21CL) ; perfluorodecanoic acid (335-76-2) ; Alkanesulfonic Acids
Language	English
Publishing date	2023-11-24
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c06944
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Article ; Online: A review of sociocultural factors that may underlie differences in African American and European American anxiety.

Hopkins, Patricia D / Shook, Natalie J

Journal of anxiety disorders

2017 Volume 49, Page(s) 104–113

Abstract: Preliminary evidence indicates there may be differences in the prevalence and severity of anxiety in African Americans and European Americans. A number of sociocultural risk and protective factors have been suggested to contribute to these group ... ...

Abstract	Preliminary evidence indicates there may be differences in the prevalence and severity of anxiety in African Americans and European Americans. A number of sociocultural risk and protective factors have been suggested to contribute to these group differences, such as salience of physical illnesses, discrimination, stigma toward mental illness, religiosity, and ethnic identity. In this paper, the literature concerning each of these factors is reviewed. Overall, the strongest evidence was found for ethnic identity and stigma toward mental illness as factors underlying group differences in anxiety. Ethnic identity and stigma toward mental illness consistently differed by racial group and were associated with anxiety in African Americans. Ethnic identity may buffer against the negative consequences of anxiety, reducing prevalence rates in African Americans. Stigma toward mental illness may decrease African Americans willingness to report anxiety symptoms, reducing overall prevalence rates but increasing the severity of treated cases. The research regarding discrimination, salience of physical illnesses, and religiosity was less clear. Much more research is required, but the findings of this review suggest that future studies should put particular emphasis on stigma toward mental illness and ethnic identity as important factors in understanding African American anxiety outcomes.
Language	English
Publishing date	2017-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	619417-5
ISSN	1873-7897 ; 0887-6185
ISSN (online)	1873-7897
ISSN	0887-6185
DOI	10.1016/j.janxdis.2017.04.003
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Article ; Online: Tight Junctions of the Outer Blood Retina Barrier.

Naylor, Aisling / Hopkins, Alan / Hudson, Natalie / Campbell, Matthew

International journal of molecular sciences

2019 Volume 21, Issue 1

Abstract: The outer blood retina barrier (oBRB) formed by the retinal pigment epithelium (RPE) is critical for maintaining retinal homeostasis. Critical to this modified neuro-epithelial barrier is the presence of the tight junction structure that is formed at the ...

Abstract	The outer blood retina barrier (oBRB) formed by the retinal pigment epithelium (RPE) is critical for maintaining retinal homeostasis. Critical to this modified neuro-epithelial barrier is the presence of the tight junction structure that is formed at the apical periphery of contacting cells. This tight junction complex mediates size-selective passive diffusion of solutes to and from the outer segments of the retina. Unlike other epithelial cells, the apical surface of the RPE is in direct contact with neural tissue and it is centrally involved in the daily phagocytosis of the effete tips of photoreceptor cells. While much is known about the intracellular trafficking of material within the RPE, less is known about the role of the tight junction complexes in health and diseased states. Here, we provide a succinct overview of the molecular composition of the RPE tight junction complex in addition to highlighting some of the most common retinopathies that involve a dysregulation of RPE integrity.
MeSH term(s)	Animals ; Blood-Retinal Barrier/physiology ; Humans ; Retina/physiology ; Retinal Diseases/physiopathology ; Retinal Pigment Epithelium/physiology ; Tight Junctions/physiology
Language	English
Publishing date	2019-12-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21010211
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Article ; Online: Fruit and Vegetable Intake, Food Security, Barriers to Healthy Eating, and Empowerment among Dietetic Interns and Physician Assistant Interns: A Cross-Sectional Pilot Study.

Campbell, Alison / Stirling, Maren / Keele, Natalie / Larkin, Alisse / Crandall, Rachel / Wilcox, Aubree N / Adair, Meghan / Malan, Cloie / Thomson, Jaidyn / Bennett, Alexis / Jensen, Heather / Flygare, Hadyn / Peterson, Lacie / Hopkins, Holly / Kendrick, Nikki / Givler, Maria / Charlton, Rebecca / Kraus, Katie N

Nutrients

2024 Volume 16, Issue 7

Abstract: Students are required to complete supervised practice hours prior to becoming Registered Dietitians and Physician Assistants. Research suggests that environmental and social factors affect dietetic interns' diets during their internship, although these ... ...

Abstract	Students are required to complete supervised practice hours prior to becoming Registered Dietitians and Physician Assistants. Research suggests that environmental and social factors affect dietetic interns' diets during their internship, although these factors have not been studied among physician assistant interns. This cross-sectional study utilized an online survey to compare dietetic interns' (
MeSH term(s)	Humans ; Fruit ; Diet, Healthy ; Cross-Sectional Studies ; Dietetics ; Pilot Projects ; Vegetables ; Physician Assistants ; Food Security
Language	English
Publishing date	2024-04-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16071034
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Article: Functional Activation of Newborn Neurons Following Alcohol-Induced Reactive Neurogenesis.

Nawarawong, Natalie N / Nickell, Chelsea G / Hopkins, Deann M / Pauly, James R / Nixon, Kimberly

Brain sciences

2021 Volume 11, Issue 4

Abstract: Abstinence after alcohol dependence leads to structural and functional recovery in many regions of the brain, especially the hippocampus. Significant increases in neural stem cell (NSC) proliferation and subsequent "reactive neurogenesis" coincides with ... ...

Abstract	Abstinence after alcohol dependence leads to structural and functional recovery in many regions of the brain, especially the hippocampus. Significant increases in neural stem cell (NSC) proliferation and subsequent "reactive neurogenesis" coincides with structural recovery in hippocampal dentate gyrus (DG). However, whether these reactively born neurons are integrated appropriately into neural circuits remains unknown. Therefore, adult male rats were exposed to a binge model of alcohol dependence. On day 7 of abstinence, the peak of reactive NSC proliferation, rats were injected with bromodeoxyuridine (BrdU) to label dividing cells. After six weeks, rats underwent Morris Water Maze (MWM) training then were sacrificed ninety minutes after the final training session. Using fluorescent immunohistochemistry for c-Fos (neuronal activation), BrdU, and Neuronal Nuclei (NeuN), we investigated whether neurons born during reactive neurogenesis were incorporated into a newly learned MWM neuronal ensemble. Prior alcohol exposure increased the number of BrdU+ cells and newborn neurons (BrdU+/NeuN+ cells) in the DG versus controls. However, prior ethanol exposure had no significant impact on MWM-induced c-Fos expression. Despite increased BrdU+ neurons, no difference in the number of activated newborn neurons (BrdU+/c-Fos+/NeuN+) was observed. These data suggest that neurons born during alcohol-induced reactive neurogenesis are functionally integrated into hippocampal circuitry.
Language	English
Publishing date	2021-04-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci11040499
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Book: Prenatal development of postnatal functions

Hopkins, Brian

(Advances in infancy research ; [14])

2005

Author's details	ed. by Brian Hopkins
Series title	Advances in infancy research ; [14]
Collection
Keywords	Fetal Development ; Sensation ; Fetal Movement ; Child Development ; Prenatal influences ; Fetal behavior ; Fetus/Growth ; Fetus/Development ; Maternal-fetal exchange ; Pränatale Entwicklung
Subject	Kind ; Mensch ; Vorgeburtliche Entwicklung
Subject code	618.24
Language	English
Size	XXI, 276 S. : graph. Darst.
Publisher	Praeger
Publishing place	Westport, Conn. u.a.
Publishing country	United States
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT014538995
ISBN	0-275-98126-6 ; 978-0-275-98126-6
Database	Catalogue ZB MED Medicine, Health

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