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  1. Book: Cartilage restoration

    Farr, Jack / Gomoll, Andreas H.

    practical clinical application

    2014  

    Author's details Jack Farr ; Andreas H. Gomoll ed
    Keywords Cartilage--Surgery ; Cartilage--Wounds and injuries
    Language English
    Size XIV, 253 S. : zahlr. Ill., graph. Darst., 25 cm
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017907504
    ISBN 978-1-4614-0426-2 ; 9781461404279 ; 1-4614-0426-6 ; 1461404274
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Cartilage Injury of the Knee

    Krych, Aaron J. / Biant, Leela C. / Nakamura, Norimasa / Espregueira-Mendes, João / Gobbi, Alberto / Gomoll, Andreas H.

    State-of-the-Art Treatment and Controversies

    2021  

    Author's details Aaron Krych is a Professor of Orthopaedic Surgery and Co-Chair of Sports Medicine at the Mayo Clinic in Rochester, MN, USA. He also serves as Director of the Orthopedic Surgery Sports Medicine Fellowship, Orthopedic Surgery Sports Medicine Research Fellowship, and Medical Director of the Mayo Clinic Bone and Tissue Bank. He is an orthopedic surgeon and his clinical focus has been on cartilage restoration in the knee, as well as knee osteotomy and meniscus. His research interests include improving cartilage allograft, adipose-derived MSC injection for hip and knee arthritis, meniscus repair and restoration, and single stage cell-based cartilage repair with recycled autologous cartilage and mesenchymal stem cells. Leela Biant is Academic Head of Dept Trauma & Orthopaedics University of Manchester, Honorary Consultant Orthopaedic Surgeon at Manchester University Foundation Trust, and Honorary Professor at Salford University. Her clinical and research interests include cartilage assessm
    Keywords ArticularCartilage ; MRI ; patellofemoral ; Osteotomy ; Meniscus ; Non-operative ; Microfracture ; Osteochondral ; Rehabilitation ; Returntosport ; stemcells ; Cell-basedrepair ; Athletictraining ; CartilageRepair ; Articular cartilage ; Patellofemoral ; Return to sport ; Stem cells ; Cartilage repair ; Cell-based repair ; Athletic training
    Language English
    Size 356 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_11
    Format 183 x 260 x 24
    ISBN 9783030780500 ; 3030780503
    Database PDA

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  3. Article ; Online: Editorial Commentary: Aragonite-Based Implants for Osteochondral Defects-Could Coral Make Old Goats Run Again?

    Gomoll, Andreas H

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

    2020  Volume 36, Issue 7, Page(s) 1895–1896

    Abstract: The population of patients with early arthritis remains a treatment challenge because of the specifics of their disease (diffuse chondrosis rather than focal defect, frequent associated morbidities such as instability or meniscal deficiency) and where ... ...

    Abstract The population of patients with early arthritis remains a treatment challenge because of the specifics of their disease (diffuse chondrosis rather than focal defect, frequent associated morbidities such as instability or meniscal deficiency) and where they are in life (young, active, working). Too young with "not enough damage" for arthroplasty but frequently unresponsive to conservative care, they are in the midst of life yet functionally quite limited. The next generation of non-arthroplasty implants is being investigated to potentially bridge this treatment gap and provide relief for the ever-growing number of young patients with arthritis.
    MeSH term(s) Animals ; Anthozoa ; Calcium Carbonate ; Cartilage, Articular ; Goats ; Humans ; Prostheses and Implants
    Chemical Substances Calcium Carbonate (H0G9379FGK)
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 632528-2
    ISSN 1526-3231 ; 0749-8063
    ISSN (online) 1526-3231
    ISSN 0749-8063
    DOI 10.1016/j.arthro.2020.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of Wiberg Patellar Type on Outcomes and Survival Following Cell-Based Cartilage Repair for Patellar Chondral Lesions at Midterm Follow-up.

    Retzky, Julia S / Thacher, Ryan R / Palhares, Guilherme H / Gomoll, Andreas H / Strickland, Sabrina M

    The American journal of sports medicine

    2024  Volume 52, Issue 3, Page(s) 705–709

    Abstract: Background: Cell-based cartilage repair procedures of the patellofemoral joint have less reliable outcomes than those of the tibiofemoral joint. No previous studies have evaluated the influence of patellar shape on cell-based cartilage repair outcomes. ... ...

    Abstract Background: Cell-based cartilage repair procedures of the patellofemoral joint have less reliable outcomes than those of the tibiofemoral joint. No previous studies have evaluated the influence of patellar shape on cell-based cartilage repair outcomes. Patellar dysplasia may predispose patients to worse outcomes after cell-based cartilage repair.
    Purpose/hypothesis: The purpose of this study was to evaluate the relationship between Wiberg patellar type and outcomes after cell-based cartilage repair (autologous chondrocyte implantation or particulated juvenile allograft cartilage transplantation) for the treatment of patellar chondral lesions at a minimum 2-year follow-up. It was hypothesized that Wiberg classification of patellar shape would have no effect on patient-reported outcome measures (PROMs) or graft survival.
    Study design: Cohort study; Level of evidence, 3.
    Methods: Patients undergoing autologous chondrocyte implantation or particulated juvenile allograft cartilage transplantation for full-thickness patellar chondral defects between 2016 and 2020 were retrospectively reviewed after institutional review board approval. The change in PROMs, including International Knee Documentation Committee (IKDC), Kujala, and Veterans RAND 12-item Health Survey Mental and Physical scores, from pre- to postoperatively and the percentage of patients who achieved the minimal clinically important difference (MCID) for IKDC and Kujala scores were compared for the Wiberg type A versus Wiberg type B versus Wiberg type C groups. The log-rank test was used to evaluate for differences in survival between subgroups.
    Results: A total of 59 patients (63 knees) were included, with a mean age of 33.3 ± 8.6 years, median body mass index of 26.0 (IQR, 21.8-30.2), and median follow-up time of 3.5 years (IQR, 2.6-4.2 years). In total, 26 (41%) patellae were Wiberg type A, 29 (46%) were Wiberg type B, and 8 (13%) were Wiberg type C. There were no differences between Wiberg type A versus Wiberg type B versus Wiberg type C groups with respect to change in PROMs from pre- to postoperatively or the percentage of patients who achieved the MCID for IKDC or Kujala scores (P > .05 for all). There were no differences in survival between groups (P = .45).
    Conclusion: Wiberg patellar type has no effect on patient-reported outcomes or graft survival at midterm follow-up. Patellar dysplasia should not be seen as a contraindication for cell-based cartilage repair procedures.
    MeSH term(s) Humans ; Young Adult ; Adult ; Cartilage, Articular/surgery ; Cohort Studies ; Follow-Up Studies ; Retrospective Studies ; Chondrocytes/transplantation ; Transplantation, Autologous
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197482-8
    ISSN 1552-3365 ; 0363-5465
    ISSN (online) 1552-3365
    ISSN 0363-5465
    DOI 10.1177/03635465231220028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Decreased Effective Patellar Tendon Length following Distalization Tibial Tubercle Osteotomy without Patellar Tendon Tenodesis.

    Uppstrom, Tyler J / Fletcher, Connor F / Green, Daniel W / Gomoll, Andreas H / Strickland, Sabrina M

    Orthopaedic journal of sports medicine

    2024  Volume 12, Issue 2, Page(s) 23259671241227201

    Abstract: Background: Distalization tibial tubercle osteotomy (TTO) is an effective treatment for improving patellar height in patients with patella alta associated with patellofemoral instability and cartilage lesions. The addition of a patellar tendon tenodesis ...

    Abstract Background: Distalization tibial tubercle osteotomy (TTO) is an effective treatment for improving patellar height in patients with patella alta associated with patellofemoral instability and cartilage lesions. The addition of a patellar tendon tenodesis has been suggested; nonetheless, concerns exist regarding possible increased patellofemoral cartilage stresses.
    Purpose: To evaluate pre- and postoperative patellar tendon length and alignment parameters on magnetic resonance imaging (MRI), as well as patient-reported outcome measures (PROMs) after distalization TTO without patellar tendon tenodesis.
    Study design: Case series; Level of evidence, 4.
    Methods: Twenty skeletally mature patients who underwent distalization TTO with or without anteromedialization at our institution between December 2014 and August 2021 were included. All patients underwent pre- and postoperative MRIs of the affected knee. The Caton-Deschamps index (CDI), the axial and sagittal tibial tubercle-trochlear groove (TT-TG) distances, the distances from the tibial plateau to the patellar tendon insertion and the tibial tubercle, and the patellar tendon length were assessed. PROMs included the International Knee Documentation Committee Subjective Knee Evaluation Form, the Knee injury and Osteoarthritis Outcome Score-Quality of Life subscale, the Kujala Anterior Knee Pain Scale, and the Veterans RAND 12-Item Health Survey mental and physical component scores.
    Results: The mean patient age at surgery was 27.4 years (range, 14-42 years). Radiographic parameters demonstrated improved patellar height (CDI decreased from 1.36 to 1.11;
    Conclusion: Distalization TTO without patellar tendon tenodesis was associated with improved radiographic outcomes and PROMs. It provides an additional tool for surgical management of patellofemoral pathology with associated patella alta.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706251-X
    ISSN 2325-9671
    ISSN 2325-9671
    DOI 10.1177/23259671241227201
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  6. Article ; Online: Incidence of Complications After Tibial Tubercle Osteotomy and Tibial Tubercle Osteotomy With Distalization.

    Shah, Aakash K / Uppstrom, Tyler J / Rizy, Morgan E / Gomoll, Andreas H / Strickland, Sabrina M

    The American journal of sports medicine

    2024  Volume 52, Issue 5, Page(s) 1274–1281

    Abstract: Background: Tibial tubercle osteotomy (TTO) is a well-established surgical treatment option for patellofemoral instability and pain. TTO with distalization (TTO-D) is indicated for patients with patellofemoral instability, patellar malalignment, and ... ...

    Abstract Background: Tibial tubercle osteotomy (TTO) is a well-established surgical treatment option for patellofemoral instability and pain. TTO with distalization (TTO-D) is indicated for patients with patellofemoral instability, patellar malalignment, and patella alta. The current literature demonstrates several complications that may be associated with TTO, with reportedly higher rates of complications associated with TTO-D.
    Purpose: To analyze and compare complication rates after TTO without distalization (TTO-ND) and TTO-D and assess risk factors associated with complications.
    Study design: Cohort study; Level of evidence, 3.
    Methods: All skeletally mature patients who underwent TTO with or without distalization by a single surgeon between September 2014 and May 2023 with a minimum of 6 months of clinical follow-up were retrospectively reviewed. Patient factors, surgical indications, perioperative data, and complications were collected via a retrospective review of electronic medical records. Concomitant procedures were categorized as intra-articular, extra-articular, and osteotomies.
    Results: A total of 251 TTOs (117 TTO-D, 134 TTO-ND) were included in the study group. Postoperative complications were observed in 15 operations (6%), with arthrofibrosis as the most common complication (10 operations [4%]). TTO-D and TTO-ND had similar rates of complication (5% vs 7%;
    Conclusion: TTO with and without distalization is a safe procedure with low rates of complication. TTO-D was not associated with a higher rate of complications compared with TTO-ND. There was no association between complications and surgical variables for TTO procedures.
    MeSH term(s) Humans ; Retrospective Studies ; Cohort Studies ; Incidence ; Osteotomy/adverse effects ; Osteotomy/methods ; Patellar Dislocation/surgery ; Tibia/surgery ; Joint Instability/surgery ; Patellofemoral Joint/surgery
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197482-8
    ISSN 1552-3365 ; 0363-5465
    ISSN (online) 1552-3365
    ISSN 0363-5465
    DOI 10.1177/03635465241235883
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  7. Article ; Online: Improved 2-Year Freedom from Arthroplasty in Patients with High-Risk SIFK Scores and Medial Knee Osteoarthritis Treated with an Implantable Shock Absorber versus Non-Operative Care.

    Pareek, Ayoosh / Parkes, Chad W / Gomoll, Andreas H / Krych, Aaron J

    Cartilage

    2023  Volume 14, Issue 2, Page(s) 164–171

    Abstract: Objective: Subchondral insufficiency fracture of the knee (SIFK) is associated with high rates of osteoarthritis (OA) and arthroplasty. The implantable shock absorber (ISA) is an extra-capsular implant that unloads the medial knee compartment. This ... ...

    Abstract Objective: Subchondral insufficiency fracture of the knee (SIFK) is associated with high rates of osteoarthritis (OA) and arthroplasty. The implantable shock absorber (ISA) is an extra-capsular implant that unloads the medial knee compartment. This study compared the 2-year freedom from arthroplasty rates in subjects with medial knee OA and SIFK when treated with an ISA versus a matched cohort of patients treated non-surgically.
    Design: This retrospective case-control study compared 2-year conversion rates to arthroplasty in SIFK score-, age-, and body mass index (BMI)-matched control subjects without prior surgical history with ISA-implanted subjects from an ongoing prospective study. Baseline and final radiographs, and MRIs were reviewed for evaluation of meniscus or ligament injuries, insufficiency fractures, and subchondral edema. Kaplan-Meier analysis assessed survival.
    Results: Forty-two patients (21 Control: 21 ISA), mean age = 52.3 ± 8.7 years, BMI = 29.5 ± 3.9 kg/m
    Conclusions: ISA intervention was strongly associated with avoidance of arthroplasty at a minimum 2 years, especially in patients with high-risk SIFK scores. SIFK severity scoring predicted relative risk of conversion to arthroplasty through at least 2 years in non-surgically treated subjects.
    MeSH term(s) Humans ; Female ; Adult ; Middle Aged ; Male ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/surgery ; Osteoarthritis, Knee/etiology ; Fractures, Stress/surgery ; Retrospective Studies ; Case-Control Studies ; Prospective Studies ; Arthroplasty, Replacement, Knee/adverse effects ; Knee Fractures
    Language English
    Publishing date 2023-03-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515870-3
    ISSN 1947-6043 ; 1947-6035
    ISSN (online) 1947-6043
    ISSN 1947-6035
    DOI 10.1177/19476035231154513
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  8. Book ; Thesis: Untersuchungen zur Dynamik der Knochendefektheilung am standardisierten Bohrlochdefekt mit und ohne autogene Spongiosatransplantation beim Kaninchen und Vergleich mit den Spezies Schaf und Schwein

    Gomoll, Andreas H.

    1998  

    Author's details Andreas H. Gomoll
    Language German
    Size III, 131 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Techn. Univ., Diss., 1998
    HBZ-ID HT009009514
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    98 D 2862 order for loan Magazin

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  9. Article ; Online: Management of Chondral Defects Associated with Patella Instability.

    Langhans, Mark T / Strickland, Sabrina M / Gomoll, Andreas H

    Clinics in sports medicine

    2021  Volume 41, Issue 1, Page(s) 137–155

    Abstract: Cartilage defects of the patellofemoral joint are commonly found in association with patellar instability owing to abnormal biomechanics. Strategies to address chondral defects of the patellofemoral joint secondary to instability should first address ... ...

    Abstract Cartilage defects of the patellofemoral joint are commonly found in association with patellar instability owing to abnormal biomechanics. Strategies to address chondral defects of the patellofemoral joint secondary to instability should first address causes of recurrent instability. Most patellofemoral chondral defects associated with instability are less than 2 cm2 and do not generally require intervention beyond chondroplasty. Larger defects of the patella and/or the trochlea can be repaired with osteochondral or surface cartilage repair.
    MeSH term(s) Cartilage Diseases ; Humans ; Joint Instability/surgery ; Patella/surgery ; Patellofemoral Joint/diagnostic imaging ; Patellofemoral Joint/surgery
    Language English
    Publishing date 2021-11-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 779944-5
    ISSN 1556-228X ; 0278-5919
    ISSN (online) 1556-228X
    ISSN 0278-5919
    DOI 10.1016/j.csm.2021.07.005
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  10. Article ; Online: Multi-Surface Cartilage Defects about the Knee Treated with Cartilage Restoration Procedures Show Good Outcomes and Survivorship at Minimum 2-Year Follow-Up.

    Retzky, Julia S / Palhares, Guilherme M / Rizy, Morgan / Hinkley, Paige / Gomoll, Andreas H / Strickland, Sabrina M

    Cartilage

    2023  , Page(s) 19476035231207780

    Abstract: Objective: We aimed to evaluate the outcomes, survivorship, and complications following multi-surface cartilage procedures at minimum 2-year follow-up.: Design: Patients with either (1) single-surface osteochondral allograft transplantation (OCAT) ... ...

    Abstract Objective: We aimed to evaluate the outcomes, survivorship, and complications following multi-surface cartilage procedures at minimum 2-year follow-up.
    Design: Patients with either (1) single-surface osteochondral allograft transplantation (OCAT) with third-generation matrix-induced autologous cultured chondrocyte implantation (MACI) or particulated juvenile cartilage implantation (DeNovo), or (2) multiple-surface OCAT ± associated MACI/DeNovo procedures for grade IV chondral or osteochondral defects about the knee with minimum 2-year follow-up were analyzed. Patient-reported outcome measures (PROMs), including International Knee Documentation Committee (IKDC) and Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales, were obtained preoperatively and at minimum 2 years postoperatively. The percentage of patients who met the minimal clinically important difference (MCID) for each PROM was reported. Failure was defined as revision OCAT, conversion to patellofemoral/total/unicompartmental joint arthroplasty, or Arthrosurface HemiCAP placement.
    Results: Of 257 patients identified, 35 were included. There was a significant increase in IKDC, KOOS-pain, KOOS-symptom, KOOS-sport, and KOOS-quality of life scores from preoperative to postoperative evaluation (
    Discussion: Multi-surface cartilage procedures are a safe, efficacious treatment option for multifocal cartilage defects about the knee at short-term follow-up.
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2515870-3
    ISSN 1947-6043 ; 1947-6035
    ISSN (online) 1947-6043
    ISSN 1947-6035
    DOI 10.1177/19476035231207780
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