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  1. Article: Joseph Snyder, M.D.: 1993-1994 Med Chi president.

    Smith, V

    Maryland medical journal (Baltimore, Md. : 1985)

    1993  Volume 42, Issue 4, Page(s) 351–354

    MeSH term(s) History, 20th Century ; Maryland ; Ophthalmology/history ; Societies, Medical/history
    Language English
    Publishing date 1993-04
    Publishing country United States
    Document type Biography ; Historical Article ; Portrait
    ZDB-ID 632504-x
    ISSN 0886-0572
    ISSN 0886-0572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 352: Show issues Location:
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  2. Article: [Besprechung von:] Yager, Joseph A. and Ralph T. Marby jr.: International cooperation in nuclear energy. Washington/D. C. 1981

    Smith, T. C / Marby jr., Ralph T / Yager, Joseph A

    Young children and social policy , p. 151-152

    1982  , Page(s) 151–152

    Author's details T. C. Smith
    Publisher Sage Publ.
    Publishing place Beverly Hills; London [u.a.]
    Document type Article
    Database ECONomics Information System

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  3. Article: Comparing methods for detection and quantification of plasmodesmal callose in

    Sankoh, Amie Fornah / Adjei, Joseph / Roberts, Daniel / Burch-Smith, Tessa M

    Molecular plant-microbe interactions : MPMI

    2024  

    Abstract: Callose, a beta-(1,3)-D-glucan polymer, is essential for regulating intercellular trafficking via ...

    Abstract Callose, a beta-(1,3)-D-glucan polymer, is essential for regulating intercellular trafficking via plasmodesmata (PD). Pathogens manipulate PD-localized proteins to enable intercellular trafficking by removing callose at PD, or conversely by increasing callose accumulation at PD to limit intercellular trafficking during infection. Plant defense hormones like salicylic acid regulate PD-localized proteins to control PD and intercellular trafficking during immune defense responses such as systemic acquired resistance. Measuring callose deposition at PD in plants has therefore emerged as a popular parameter for assessing likely intercellular trafficking activity during plant immunity. Despite the popularity of this metric there is no standard for how these measurements should be made. In this study, we compared three commonly used methods for identifying and quantifying PD callose by aniline blue staining were evaluated to determine the most effective in the Nicotiana benthamiana leaf model. The results reveal that the most reliable method used aniline blue staining and fluorescent microscopy to measure callose deposition in fixed tissue. Manual or semi-automated workflows for image analysis were also compared and found to produce similar results although the semi-automated workflow produced a wider distribution of data points.
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 743331-1
    ISSN 1943-7706 ; 0894-0282
    ISSN (online) 1943-7706
    ISSN 0894-0282
    DOI 10.1094/MPMI-09-23-0152-SC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prevention and management of acneiform rash associated with EGFR inhibitor therapy: A systematic review and meta-analysis.

    Gorji, Mahdieh / Joseph, Joseph / Pavlakis, Nick / Smith, Saxon D

    Asia-Pacific journal of clinical oncology

    2022  Volume 18, Issue 6, Page(s) 526–539

    Abstract: Introduction: Epidermal growth factor receptor (EGFR) inhibitors are established therapies for advanced lung, colorectal, and head and neck cancers. They commonly cause acneiform eruptions that affect patient quality of life and may lead to ... ...

    Abstract Introduction: Epidermal growth factor receptor (EGFR) inhibitors are established therapies for advanced lung, colorectal, and head and neck cancers. They commonly cause acneiform eruptions that affect patient quality of life and may lead to discontinuation of therapy.
    Methods: A systematic review and meta-analysis was undertaken to assess strategies for the prevention and reactive management of acneiform rash associated with EGFR inhibitor therapy for advanced lung, colorectal, and head and neck cancers. A systematic Medline, Embase, and EBM Reviews database search was conducted on the 2nd of January 2021. The Preferred Reporting Items for Systematic Reviews and Meta-analyses statement was followed and the studies were critically appraised. Studies were selected if they focused on preventing or treating acneiform eruptions in adults being treated for advanced lung cancer, colorectal cancer, and head and neck cancers with EGFR inhibitors.
    Results: Oral antibiotics had the greatest efficacy in preventing grade 2 or higher acneiform eruptions with a relative risk reduction of 40% (RR = .6, 95% CI .46-.79, p < .01). Other treatment modalities did not have statistically significant results. Topical antibiotics had a total relative risk reduction of 19% (RR = .81, 95% CI .45-1.48, p = .5). Vitamin K1 cream did not reduce the relative risk (RR = 1.08, 95% CI .45-1.48, p = .50). Sunscreen had a total relative risk reduction of 25% (RR = .75, 95% CI .49-1.14, p = .18).
    Conclusions: The results of this meta-analysis reinforce the fact that oral tetracycline antibiotics are the most efficacious prophylactic option for acneiform eruptions in EGFR inhibitors. They should be offered to suitable patients commencing treatment and used with a general skin-care routine involving emollients and avoidance of irritants.
    MeSH term(s) Adult ; Humans ; Cetuximab/therapeutic use ; ErbB Receptors ; Antineoplastic Agents/therapeutic use ; Quality of Life ; Acneiform Eruptions/chemically induced ; Acneiform Eruptions/drug therapy ; Acneiform Eruptions/prevention & control ; Exanthema/chemically induced ; Protein Kinase Inhibitors/adverse effects ; Head and Neck Neoplasms ; Colorectal Neoplasms/drug therapy ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Cetuximab (PQX0D8J21J) ; ErbB Receptors (EC 2.7.10.1) ; Antineoplastic Agents ; Protein Kinase Inhibitors ; Anti-Bacterial Agents ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2022-03-29
    Publishing country Australia
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2187409-8
    ISSN 1743-7563 ; 1743-7555
    ISSN (online) 1743-7563
    ISSN 1743-7555
    DOI 10.1111/ajco.13740
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  5. Article ; Online: Response to Drs. de Grooth and Parienti.

    Giganti, Mark J / Chew, Kara W / Eron, Joseph J / Smith, Davey M / Currier, Judith S / Hughes, Michael D

    The Journal of infectious diseases

    2024  

    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae053
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    Zs.MO 445: Show issues

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  6. Article: Design and simulation of a utility oilfield flare in Iraq/Kurdistan region using CFD and API-521 methodology.

    Maaroof, Ahmed A / Smith, Joseph D / Zangana, Mohammed H S

    Heliyon

    2023  Volume 9, Issue 8, Page(s) e18581

    Abstract: This paper aims at reviewing and analyzing the operation and design of a utility flare in an oilfield in the Iraq/Kurdistan region. The flare supports a gas separation unit that separates 100 MMSCFD of natural gas from other liquid compounds in petroleum ...

    Abstract This paper aims at reviewing and analyzing the operation and design of a utility flare in an oilfield in the Iraq/Kurdistan region. The flare supports a gas separation unit that separates 100 MMSCFD of natural gas from other liquid compounds in petroleum refining. The actual flare dimensions are 50 m high and 0.6 m diameter and works in summer where the crosswind speed is 9 m/s and a flow of 1.2 MMSCFD of treated natural gas is flaring through it. At the beginning, the flare design was performed using the API-521 recommended approach based on full operating capacity of the unit and composition of the gas to be flared. The API-521 based design resulted in a flare with a 0.76 m diameter and 48.19 m height. The effects of stack height on heat radiation in case of full capacity firing showed that as the flare height increases from 42.34 m to 133.05 m, the heat radiation decreases from 15.8 kW/m^2 to 1.6 kW/m^2 within 45.7 m dimeter. Furthermore, the relation between stack height and heat radiation was studied for the actual firing rate 1.2MMSCFD using simulation, where the results showed that as the stack height increasing from 10 m to 50 m the heat radiation decreasing from over 1000 w/m^2 to around 150 W/m^2. In fact, CFD code C3d was used to analyze flare performance at normal firing condition during summer operation of 1.2 MMSCFD with a flare diameter and height of 50 m and 0.6 m, respectively. The code was able to predict the flame shape and size during actual flare operation. The results of the simulation demonstrated by defining four locations in the domain to measure the average temperatures and emissions, and to calculate the Combustion Efficiency (CE) and Destruction and Removal Efficiency (DRE). These points were 6 m, 8 m, 10 m, 12 m far from the tip on x-axis and at height of 52 m. The results showed that the average temperature at 6 m far from the flare is 658 K and it decreasing to 490 K at 12 m away from the tip. The CO and CO2 also decreased from 7.27E-5 and 0.033 mass% to 4.53E-6 and 0.027 mass%, respectively. Generally, soot formation was low but at points 8 m and 10 m from the tip the soot formation was considerably lower, respectively at 6.16E-5 and 8.71E-5 mass%. The emissions of C1, C2, C3 and C6+ were measured at 7.46E-9, 5.39E-9, 5.13E-9 and 4.35E-9 mass% at 6 m away from the tip. The emissions increased slightly at 8 m and 10 m from the tip but at 12 m they were observed to decrease. The flare CE and DRE were estimated to be 98% and 100%, respectively. Analysis results confirmed that the flare design was safe and the flare operation was highly efficient with very little smoke produced as indicated by the predicted CE and DRE.
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e18581
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  7. Article: Management of Post-Dural Puncture Headaches in Pediatric Patients with Epidural Blood or Saline Patch: An Educational Focused Review.

    Elhamrawy, Amr / Syed, Ahsan / Smith, Timothy / Veneziano, Giorgio / Tobias, Joseph D

    Journal of pain research

    2024  Volume 17, Page(s) 1197–1207

    Abstract: Post-dural puncture headache (PDPH) is a common adverse outcome following puncture of the dura. It can occur after inadvertent dural puncture during epidural catheter placement or following diagnostic or therapeutic LP. The incidence of PDPH in pediatric ...

    Abstract Post-dural puncture headache (PDPH) is a common adverse outcome following puncture of the dura. It can occur after inadvertent dural puncture during epidural catheter placement or following diagnostic or therapeutic LP. The incidence of PDPH in pediatric patients has been estimated at 1-15% depending on patient factors (age, gender, body mass index) and needle factors (size and needle bevel/point type). The larger the needle gauge, the higher the incidence of PDPH. Various options have been proposed to treat PDPH including observation, bed rest, hydration, caffeine, and epidural blood/saline patch. The current manuscript provides a review of the use of epidural blood/saline patch in pediatric-aged patients with PDPH.
    Language English
    Publishing date 2024-03-19
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2495284-9
    ISSN 1178-7090
    ISSN 1178-7090
    DOI 10.2147/JPR.S444381
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  8. Article ; Online: Interrogating endothelial barrier regulation by temporally resolved kinase network generation.

    Wei, Ling / Dankwa, Selasi / Vijayan, Kamalakannan / Smith, Joseph D / Kaushansky, Alexis

    Life science alliance

    2024  Volume 7, Issue 5

    Abstract: Kinases are key players in endothelial barrier regulation, yet their temporal function and regulatory phosphosignaling networks are incompletely understood. We developed a novel methodology, Temporally REsolved KInase Network Generation (TREKING), which ... ...

    Abstract Kinases are key players in endothelial barrier regulation, yet their temporal function and regulatory phosphosignaling networks are incompletely understood. We developed a novel methodology, Temporally REsolved KInase Network Generation (TREKING), which combines a 28-kinase inhibitor screen with machine learning and network reconstruction to build time-resolved, functional phosphosignaling networks. We demonstrated the utility of TREKING for identifying pathways mediating barrier integrity after activation by thrombin with or without TNF preconditioning in brain endothelial cells. TREKING predicted over 100 kinases involved in barrier regulation and discerned complex condition-specific pathways. For instance, the MAPK-activated protein kinase 2 (MAPKAPK2/MK2) had early barrier-weakening activity in both inflammatory conditions but late barrier-strengthening activity exclusively with thrombin alone. Using temporal Western blotting, we confirmed that MAPKAPK2/MK2 was differentially phosphorylated under the two inflammatory conditions. We further showed with lentivirus-mediated knockdown of MAPK14/p38α and drug targeting the MAPK14/p38α-MAPKAPK2/MK2 complex that a MAP3K20/ZAK-MAPK14/p38α axis controlled the late activation of MAPKAPK2/MK2 in the thrombin-alone condition. Beyond the MAPKAPK2/MK2 switch, TREKING predicts extensive interconnected networks that control endothelial barrier dynamics.
    MeSH term(s) Endothelial Cells/metabolism ; Mitogen-Activated Protein Kinase 14 ; Thrombin/pharmacology ; p38 Mitogen-Activated Protein Kinases/metabolism ; Protein Kinase Inhibitors
    Chemical Substances Mitogen-Activated Protein Kinase 14 (EC 2.7.11.24) ; Thrombin (EC 3.4.21.5) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Protein Kinase Inhibitors
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202302522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Percutaneous Dembitsky bridge utilizing a dual-lumen cannula.

    Seadler, Benjamin D / Smith-Roberts, Terry Q / Hart, Joseph / Gasparri, Mario / Rossi, Peter / Joyce, David L / Joyce, Lyle D

    JTCVS techniques

    2023  Volume 18, Page(s) 78–80

    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Case Reports
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2023.01.016
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  10. Article ; Online: Physiological Effects of Centrifuge-Simulated Suborbital Spaceflight.

    Smith, Thomas G / Pollock, Ross D / Britton, Joseph K / Green, Nicholas D C / Hodkinson, Peter D / Mitchell, Stuart J / Stevenson, Alec T

    Aerospace medicine and human performance

    2023  Volume 93, Issue 12, Page(s) 830–839

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    MeSH term(s) Humans ; Aerospace Medicine ; Space Flight ; Centrifugation ; Hemodynamics ; Blood Pressure ; Acceleration
    Language English
    Publishing date 2023-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2809085-8
    ISSN 2375-6322 ; 2375-6314
    ISSN (online) 2375-6322
    ISSN 2375-6314
    DOI 10.3357/AMHP.6153.2022
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