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Article ; Online: Correction to: Robot‑assisted and traditional intensive rehabilitation therapy in the treatment of post‑acute stroke patient: the experience of a standard rehabilitation ward.

Hamedani, Mehrnaz / Prada, Valeria / Tognetti, Paola / Leoni, Valeria / Schenone, Angelo

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2022 Volume 43, Issue 11, Page(s) 6619

Language	English
Publishing date	2022-04-21
Publishing country	Italy
Document type	Published Erratum
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-022-06073-0
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Article ; Online: Robot-assisted and traditional intensive rehabilitation therapy in the treatment of post-acute stroke patient: the experience of a standard rehabilitation ward.

Hamedani, Mehrnaz / Prada, Valeria / Tognetti, Paola / Leoni, Valeria / Schenone, Angelo

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2022 Volume 43, Issue 6, Page(s) 3999–4001

MeSH term(s)	Humans ; Recovery of Function ; Robotics ; Stroke/complications ; Stroke Rehabilitation ; Upper Extremity
Language	English
Publishing date	2022-04-02
Publishing country	Italy
Document type	Letter
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-022-06041-8
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Article ; Online: The role of sensory systems in the association between balance and walking in people with multiple sclerosis.

Tacchino, Andrea / Skjerbæk, Anders Guldhammer / Podda, Jessica / Prada, Valeria / Monti Bragadin, Margherita / Bergamaschi, Valeria / Susini, Alessia / Hvid, Lars G / Pedullà, Ludovico / Brichetto, Giampaolo

Multiple sclerosis and related disorders

2024 Volume 83, Page(s) 105440

Abstract: Background: In Multiple Sclerosis, it has been demonstrated that balance is related to performances in walking tasks at different levels of complexity. However, it is unknown how the different sensory systems involved in balance control contribute to ... ...

Abstract	Background: In Multiple Sclerosis, it has been demonstrated that balance is related to performances in walking tasks at different levels of complexity. However, it is unknown how the different sensory systems involved in balance control contribute to walking. This observational study investigates the associations between somatosensory, vestibular, and visual systems and measures of self-reported walking and walking capacity at different complexity levels (i.e. low, medium, and high). Methods: People with MS with EDSS<6 were assessed through the Sensory Organization Test (SOT), 12-Item MS Walking Scale (MSWS-12), Timed 25-Foot Walk (T25FW), Timed Up-and-Go Test (TUG), and Six-Spot-Step-Test (SSST). T25FW, TUG and SSST are measures of low, medium and high walking capacity, respectively. Results: Forty-five PwMS were enrolled (EDSS: 3.4 ± 1.3). Capacity/ability walking measures were moderate-to-highly significantly associated (p < 0.01). Balance measures from SOT showed significant correlation (p < 0.05) between vestibular system and all the walking measures; between visual system and T25FW, SSST and MSWS-12; between the degree to which the patient relies on the visual system to maintain balance with conflicting visual surroundings information (VIS PREF) and T25FW and TUG. In the multivariate analyses, only VIS PREF significantly correlated (p < 0.05) with T25FW (std. Beta=0.42) and TUG (std. Beta=0.38). Conclusions: Vestibular and visual systems are associated with walking capacity. However, tasks with higher complexity levels require more visual attention towards ground obstacles, as often seen in real-life activities, whereas simpler walking tasks seem to require visual attention towards the surroundings.
MeSH term(s)	Humans ; Multiple Sclerosis/complications ; Disability Evaluation ; Walking ; Exercise Test ; Sense Organs ; Postural Balance
Language	English
Publishing date	2024-01-09
Publishing country	Netherlands
Document type	Observational Study ; Letter
ZDB-ID	2645330-7
ISSN	2211-0356 ; 2211-0348
ISSN (online)	2211-0356
ISSN	2211-0348
DOI	10.1016/j.msard.2024.105440
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Article ; Online: The suspected SARS-Cov-2 infection in a Charcot-Marie-Tooth patient undergoing postsurgical rehabilitation: the value of telerehabilitation for evaluation and continuing treatment.

Prada, Valeria / Bellone, Emilia / Schenone, Angelo / Grandis, Marina

International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation

2020 Volume 43, Issue 3, Page(s) 285–286

Abstract: We report, to the best of our knowledge, the first case of a probable COVID-19 infection in a 28-year-old man with Charcot-Marie-Tooth disease. The diagnosis was established through a remote interaction with the patient after early discharge from ... ...

Abstract	We report, to the best of our knowledge, the first case of a probable COVID-19 infection in a 28-year-old man with Charcot-Marie-Tooth disease. The diagnosis was established through a remote interaction with the patient after early discharge from outpatient therapy due to upcoming traveling restrictions. The COVID-19 disease appeared mild, without major respiratory problems, and no obvious neuromuscular deterioration was reported or observed. Telerehabilitation provided an opportunity to continue with hand rehabilitation after tendon transfer surgery, perform an ad-hoc online evaluation, and advise the patient how to prevent the spread of infection and cope with restrictions limiting outpatient visits. This experience seems valuable for further development of telerehabilitation in anticipation of future pandemics or adversarial events since it allows reaching out to patients unable to travel and overcomes the need for regular outpatient visits.
MeSH term(s)	Adult ; Betacoronavirus ; COVID-19 ; Charcot-Marie-Tooth Disease/complications ; Charcot-Marie-Tooth Disease/surgery ; Coronavirus Infections/complications ; Humans ; Male ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Telerehabilitation
Keywords	covid19
Language	English
Publishing date	2020-05-21
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	533323-4
ISSN	1473-5660 ; 0342-5282
ISSN (online)	1473-5660
ISSN	0342-5282
DOI	10.1097/MRR.0000000000000418
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Zs.A 1326: Show issues

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Article: Virtual Charcot-Marie-Tooth Examination Score: A Validated Virtual Evaluation for People With Charcot-Marie-Tooth Disease.

Prada, Valeria / Laurà, Matilde / Zuccarino, Riccardo / Reilly, Mary M / Shy, Michael E

Neurology. Clinical practice

2022 Volume 12, Issue 5, Page(s) e98–e104

Abstract: Background and objectives: The Charcot-Marie-Tooth Examination Score (CMTES) has been used since 2005 in clinics to measure impairment in patients with CMT and has provided natural history data for patients with CMT1A, CMT1B, CMTX1, CMT2A, and many ... ...

Abstract	Background and objectives: The Charcot-Marie-Tooth Examination Score (CMTES) has been used since 2005 in clinics to measure impairment in patients with CMT and has provided natural history data for patients with CMT1A, CMT1B, CMTX1, CMT2A, and many other subtypes. However, the CMTES requires an in-person visit, and many individuals are unable to travel to CMT centers because of the distance from the clinic or physical disability or more recently because of COVID-19 restrictions. We therefore developed the virtual CMTES (vCMTES) as outlined below. The aim of this study is to create a remote clinical outcome assessment to measure impairment in patients with CMT. Methods: We modified the CMTESv2 replacing the pinprick and vibration items with light touch and position sense, which can be performed remotely by the patient or the patient with an assistant while being observed by the clinic evaluator. Motor evaluations were performed similar to CMTESv2 by the assistant or the patient, while being observed remotely. We developed a standardized protocol to be used with Zoom or a similar format, a training and certification program, and enabled the vCMTES data to be housed in the Inherited Neuropathy Consortium databases. Patients were evaluated in person and remotely for interexaminer and intraexaminer studies. Results: Sixty-four patients with genetically confirmed CMT were evaluated by vCMTES and CMTESv2; 53 patients were evaluated virtually 3 weeks after their initial examination. Ten patients were evaluated with the vCMTES by different examiners 5 days apart. CMTESv2 correlates strongly with the vCMTES in person and virtually ( Discussion: Statistical analyses demonstrated that the vCMTES was reproducible and reliable as a clinical outcome assessment for CMT. Further studies are needed to test responsiveness to change and progression in different subtypes. The vCMTES also offers the potential to reach diverse populations that do not have access to CMT centers.
Language	English
Publishing date	2022-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2645818-4
ISSN	2163-0933 ; 2163-0402
ISSN (online)	2163-0933
ISSN	2163-0402
DOI	10.1212/CPJ.0000000000200070
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Article ; Online: Objective and subjective evaluation of walking ability with and without the use of a passive brace for hip flexor muscles in individuals with multiple sclerosis.

Prada, Valeria / Grange, Erica / Sgarito, Caterina / Pedrazzoli, Elisabetta / Konrad, Giovanna / Di Giovanni, Rachele / Brichetto, Giampaolo / Solaro, Claudio

Prosthetics and orthotics international

2023

Abstract: Background: Multiple sclerosis (MS) affects the cognitive and motor domains. Muscle weakness often leads to abnormal gait. Several solutions are rising, including the use of passive exoskeletons.: Objective: The purpose of this study is to evaluate ... ...

Abstract	Background: Multiple sclerosis (MS) affects the cognitive and motor domains. Muscle weakness often leads to abnormal gait. Several solutions are rising, including the use of passive exoskeletons. Objective: The purpose of this study is to evaluate the effect of a first-ever use of a passive exoskeleton on walking ability in people with MS. Methods: We recruited 50 persons with MS. All subjects were assessed using the 2-min walking test, the timed 25-foot walk test, and a two-stage rate of perceived exertion (RPE) without the exoskeleton (T0) and with the exoskeleton (T1). Results: The data showed a significant decrease in walking endurance while the exoskeleton is worn (2-min walking test: T0: 65.19 ± 23.37 m; T1: 59.40 ± 22.99; p < 0.0001) and a not significant difference in walking speed on a shortened distance (T0: 15.71 ± 10.30 s; T1: 15.73 ± 11.86 s; p = 0.25). No significant differences were also found for the effort perception scale (RPE: T0: 13.24 ± 3.01; T1: 13.60 ± 2.9; p = 0.3). Seventy-two percent of subjects reported a positive or neutral global perceived effect. Conclusions: The exoskeleton does not add any fatiguing or negative effects. Although the walking performance decreases, the overall perception of the subjects is positive. Further studies are needed to evaluate the effect of the exoskeleton on gait quality.
Language	English
Publishing date	2023-11-22
Publishing country	France
Document type	Journal Article
ZDB-ID	753382-2
ISSN	1746-1553 ; 0309-3646
ISSN (online)	1746-1553
ISSN	0309-3646
DOI	10.1097/PXR.0000000000000299
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Article ; Online: Techniques for the standard histological and ultrastructural assessment of nerve biopsies.

Weis, Joachim / Katona, Istvan / Nikolin, Stefan / Nobbio, Lucilla / Prada, Valeria / Grandis, Marina / Schenone, Angelo

Journal of the peripheral nervous system : JPNS

2021 Volume 26 Suppl 2, Page(s) S3–S10

Abstract: It is always a challenge to acquire a clear picture of the pathological processes and changes in any disease. For this purpose, it is advantageous to directly examine the affected organ. Nerve biopsy has been a method of choice for decades to classify ... ...

Abstract	It is always a challenge to acquire a clear picture of the pathological processes and changes in any disease. For this purpose, it is advantageous to directly examine the affected organ. Nerve biopsy has been a method of choice for decades to classify peripheral neuropathies and to find clues to uncover their etiology. The histologic examination of the peripheral nerve provides information on axonal or myelin pathology as well as on the surrounding connective tissue and vascularization of the nerve. Minimal requirements of the workup include paraffin histology as well as resin semithin section histology. Cryostat sections, teased fiber preparations and electron microscopy are potentially useful in a subset of cases. Here we describe our standard procedures for the workup of the tissue sample and provide examples of diagnostically relevant findings.
MeSH term(s)	Axons/pathology ; Biopsy/methods ; Humans ; Myelin Sheath/pathology ; Peripheral Nerves/pathology ; Peripheral Nervous System Diseases/diagnosis ; Peripheral Nervous System Diseases/pathology ; Sural Nerve/pathology
Language	English
Publishing date	2021-11-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1364009-4
ISSN	1529-8027 ; 1085-9489
ISSN (online)	1529-8027
ISSN	1085-9489
DOI	10.1111/jns.12468
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Article ; Online: Leukocytoclastic vasculitis in a patient with syphilis and HIV coinfection.

Ariza Ordoñez, Nicolás / Sepúlveda, Valeria Gómez / Marín, Antonia Pino / Nieto, Lina Patricia Vargas / León, Julián Moreno / Prada, Henry Augusto Millán

Revista do Instituto de Medicina Tropical de Sao Paulo

2022 Volume 64, Page(s) e65

Abstract: Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis characterized by an inflammatory infiltrate composed of neutrophils with fibrinoid necrosis and "leukocytoclasia", a term that refers to nuclei disintegration into fragments. LCV is related ... ...

Abstract	Leukocytoclastic vasculitis (LCV) is a small vessel vasculitis characterized by an inflammatory infiltrate composed of neutrophils with fibrinoid necrosis and "leukocytoclasia", a term that refers to nuclei disintegration into fragments. LCV is related to multiple conditions including ANCA-associated vasculitis, cryoglobulinemia, IgA vasculitis, infectious and systemic diseases such as rheumatoid arthritis and systemic erythematous lupus (SLE) as well as infections and malignancy. We describe the clinical case of severe systemic vasculitis in a young male patient with secondary syphilis and HIV coinfection manifested by cutaneous and neurological involvement, as well as peripheral necrosis that requires bilateral lower limb amputation. The skin biopsy revealed histopathological changes compatible with endarteritis obliterans and LCV related to treponemal infection. This case highlights the plethora of clinical manifestations of treponemal infection and the diagnostic challenge this poses in current clinical practice.
MeSH term(s)	HIV Infections/complications ; Humans ; Male ; Necrosis ; Syphilis/complications ; Syphilis/diagnosis ; Vasculitis, Leukocytoclastic, Cutaneous/complications ; Vasculitis, Leukocytoclastic, Cutaneous/diagnosis
Language	English
Publishing date	2022-09-30
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	128928-7
ISSN	1678-9946 ; 0036-4665
ISSN (online)	1678-9946
ISSN	0036-4665
DOI	10.1590/S1678-9946202264065
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Article ; Online: Manejo de las hemorragias en el enfermo oncológico avanzado

Valeria Quintero Carreño / Laura Juliana Gómez Márquez / Laura Jimena Prada Martínez / Carlos Hernán Rodríguez Martínez

Revista Chilena de Anestesia, Vol 51, Iss 4, Pp 360-

2022 Volume 367

Keywords	hemorragia ; oncológico ; cuidado paliativo ; terminal ; calidad de vida ; Medicine ; R ; Anesthesiology ; RD78.3-87.3
Language	Spanish
Publishing date	2022-07-01T00:00:00Z
Publisher	Editorial Iku
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The suspected SARS-Cov-2 infection in a Charcot-Marie-Tooth patient undergoing postsurgical rehabilitation: the value of telerehabilitation for evaluation and continuing treatment

Prada, Valeria / Bellone, Emilia / Schenone, Angelo / Grandis, Marina

Int. j. rehabil. res

Abstract	We report, to the best of our knowledge, the first case of a probable COVID-19 infection in a 28-year-old man with Charcot-Marie-Tooth disease. The diagnosis was established through a remote interaction with the patient after early discharge from outpatient therapy due to upcoming traveling restrictions. The COVID-19 disease appeared mild, without major respiratory problems, and no obvious neuromuscular deterioration was reported or observed. Telerehabilitation provided an opportunity to continue with hand rehabilitation after tendon transfer surgery, perform an ad-hoc online evaluation, and advise the patient how to prevent the spread of infection and cope with restrictions limiting outpatient visits. This experience seems valuable for further development of telerehabilitation in anticipation of future pandemics or adversarial events since it allows reaching out to patients unable to travel and overcomes the need for regular outpatient visits.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32317558
Database	COVID19

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