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Artikel ; Online: Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish.

Drummond, Bridgette E / Ercanbrack, Wesley S / Wingert, Rebecca A

2023 Band 11, Heft 1

Abstract: Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to podocytes has dire consequences and initiates a cascade of pathological changes leading to renal ... ...

Abstract	Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to podocytes has dire consequences and initiates a cascade of pathological changes leading to renal disease states known as podocytopathies. In addition, animal models have been integral to discovering the molecular pathways that direct the development of podocytes. In this review, we explore how researchers have used the zebrafish to illuminate new insights about the processes of podocyte ontogeny, model podocytopathies, and create opportunities to discover future therapies.
Sprache	Englisch
Erscheinungsdatum	2023-02-20
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2720870-9
ISSN	2221-3759 ; 2221-3759
ISSN (online)	2221-3759
ISSN	2221-3759
DOI	10.3390/jdb11010009
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish

Bridgette E. Drummond / Wesley S. Ercanbrack / Rebecca A. Wingert

Journal of Developmental Biology, Vol 11, Iss 9, p

2023 Band 9

Abstract	Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to podocytes has dire consequences and initiates a cascade of pathological changes leading to renal disease states known as podocytopathies. In addition, animal models have been integral to discovering the molecular pathways that direct the development of podocytes. In this review, we explore how researchers have used the zebrafish to illuminate new insights about the processes of podocyte ontogeny, model podocytopathies, and create opportunities to discover future therapies.
Schlagwörter	podocyte ; nephron ; development ; zebrafish ; retinoic acid ; notch ; Biology (General) ; QH301-705.5
Sprache	Englisch
Erscheinungsdatum	2023-02-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish

Drummond, Bridgette E. / Ercanbrack, Wesley S. / Wingert, Rebecca A.

J Dev Biol. 2023 Feb. 20, v. 11, no. 1

2023

Abstract	Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to podocytes has dire consequences and initiates a cascade of pathological changes leading to renal disease states known as podocytopathies. In addition, animal models have been integral to discovering the molecular pathways that direct the development of podocytes. In this review, we explore how researchers have used the zebrafish to illuminate new insights about the processes of podocyte ontogeny, model podocytopathies, and create opportunities to discover future therapies.
Schlagwörter	Danio rerio ; blood ; congenital abnormalities ; filtration ; kidney diseases ; kidneys ; ontogeny
Sprache	Englisch
Erscheinungsverlauf	2023-0220
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel ; Online
ZDB-ID	2720870-9
ISSN	2221-3759
ISSN	2221-3759
DOI	10.3390/jdb11010009
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Scaling up to study

Drummond, Bridgette E / Wingert, Rebecca A

Cancer cell & microenvironment

2018 Band 5, Heft 1

Abstract: Specialized renal epithelial cells known as podocytes are essential components of the filtering structures within the kidney that coordinate the process of removing waste from the bloodstream. Podocyte loss initiates many human kidney diseases as it ... ...

Abstract	Specialized renal epithelial cells known as podocytes are essential components of the filtering structures within the kidney that coordinate the process of removing waste from the bloodstream. Podocyte loss initiates many human kidney diseases as it triggers subsequent damage to the kidney, leading to progressive loss of function that culminates with end stage renal failure. Podocyte morphology, function and gene expression profiles are well conserved between zebrafish and humans, making the former a relevant model to study podocyte development and model kidney diseases. Recently, we reported that whole genome sequencing of the
Sprache	Englisch
Erscheinungsdatum	2018-04-09
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2331-091X
ISSN	2331-091X
DOI	10.14800/ccm.1630
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Advances in Understanding the Genetic Mechanisms of Zebrafish Renal Multiciliated Cell Development.

Wesselman, Hannah M / Nguyen, Thanh Khoa / Chambers, Joseph M / Drummond, Bridgette E / Wingert, Rebecca A

Journal of developmental biology

2022 Band 11, Heft 1

Abstract: Cilia are microtubule-based organelles that project from the cell surface. In humans and other vertebrates, possession of a single cilium structure enables an assortment of cellular processes ranging from mechanosensation to fluid propulsion and ... ...

Abstract	Cilia are microtubule-based organelles that project from the cell surface. In humans and other vertebrates, possession of a single cilium structure enables an assortment of cellular processes ranging from mechanosensation to fluid propulsion and locomotion. Interestingly, cells can possess a single cilium or many more, where so-called multiciliated cells (MCCs) possess apical membrane complexes with several dozen or even hundreds of motile cilia that beat in a coordinated fashion. Development of MCCs is, therefore, integral to control fluid flow and/or cellular movement in various physiological processes. As such, MCC dysfunction is associated with numerous pathological states. Understanding MCC ontogeny can be used to address congenital birth defects as well as acquired disease conditions. Today, researchers used both in vitro and in vivo experimental models to address our knowledge gaps about MCC specification and differentiation. In this review, we summarize recent discoveries from our lab and others that have illuminated new insights regarding the genetic pathways that direct MCC ontogeny in the embryonic kidney using the power of the zebrafish animal model.
Sprache	Englisch
Erscheinungsdatum	2022-12-21
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article ; Review
ZDB-ID	2720870-9
ISSN	2221-3759 ; 2221-3759
ISSN (online)	2221-3759
ISSN	2221-3759
DOI	10.3390/jdb11010001
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Insights into kidney stem cell development and regeneration using zebrafish.

Drummond, Bridgette E / Wingert, Rebecca A

World journal of stem cells

2016 Band 8, Heft 2, Seite(n) 22–31

Abstract: Kidney disease is an escalating global health problem, for which the formulation of therapeutic approaches using stem cells has received increasing research attention. The complexity of kidney anatomy and function, which includes the diversity of renal ... ...

Abstract	Kidney disease is an escalating global health problem, for which the formulation of therapeutic approaches using stem cells has received increasing research attention. The complexity of kidney anatomy and function, which includes the diversity of renal cell types, poses formidable challenges in the identification of methods to generate replacement structures. Recent work using the zebrafish has revealed their high capacity to regenerate the integral working units of the kidney, known as nephrons, following acute injury. Here, we discuss these findings and explore the ways that zebrafish can be further utilized to gain a deeper molecular appreciation of renal stem cell biology, which may uncover important clues for regenerative medicine.
Sprache	Englisch
Erscheinungsdatum	2016-03-15
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Review
ZDB-ID	2583482-4
ISSN	1948-0210
ISSN	1948-0210
DOI	10.4252/wjsc.v8.i2.22
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Advances in Understanding the Genetic Mechanisms of Zebrafish Renal Multiciliated Cell Development

Hannah M. Wesselman / Thanh Khoa Nguyen / Joseph M. Chambers / Bridgette E. Drummond / Rebecca A. Wingert

Journal of Developmental Biology, Vol 11, Iss 1, p

2022 Band 1

Abstract	Cilia are microtubule-based organelles that project from the cell surface. In humans and other vertebrates, possession of a single cilium structure enables an assortment of cellular processes ranging from mechanosensation to fluid propulsion and locomotion. Interestingly, cells can possess a single cilium or many more, where so-called multiciliated cells (MCCs) possess apical membrane complexes with several dozen or even hundreds of motile cilia that beat in a coordinated fashion. Development of MCCs is, therefore, integral to control fluid flow and/or cellular movement in various physiological processes. As such, MCC dysfunction is associated with numerous pathological states. Understanding MCC ontogeny can be used to address congenital birth defects as well as acquired disease conditions. Today, researchers used both in vitro and in vivo experimental models to address our knowledge gaps about MCC specification and differentiation. In this review, we summarize recent discoveries from our lab and others that have illuminated new insights regarding the genetic pathways that direct MCC ontogeny in the embryonic kidney using the power of the zebrafish animal model.
Schlagwörter	multiciliated cell ; development ; ciliogenesis ; Notch signaling ; mecom ; retinoic acid signaling ; Biology (General) ; QH301-705.5
Sprache	Englisch
Erscheinungsdatum	2022-12-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Advances in Understanding the Genetic Mechanisms of Zebrafish Renal Multiciliated Cell Development

Wesselman, Hannah M. / Nguyen, Thanh Khoa / Chambers, Joseph M. / Drummond, Bridgette E. / Wingert, Rebecca A.

J Dev Biol. 2022 Dec. 21, v. 11, no. 1

2022

Abstract	Cilia are microtubule-based organelles that project from the cell surface. In humans and other vertebrates, possession of a single cilium structure enables an assortment of cellular processes ranging from mechanosensation to fluid propulsion and locomotion. Interestingly, cells can possess a single cilium or many more, where so-called multiciliated cells (MCCs) possess apical membrane complexes with several dozen or even hundreds of motile cilia that beat in a coordinated fashion. Development of MCCs is, therefore, integral to control fluid flow and/or cellular movement in various physiological processes. As such, MCC dysfunction is associated with numerous pathological states. Understanding MCC ontogeny can be used to address congenital birth defects as well as acquired disease conditions. Today, researchers used both in vitro and in vivo experimental models to address our knowledge gaps about MCC specification and differentiation. In this review, we summarize recent discoveries from our lab and others that have illuminated new insights regarding the genetic pathways that direct MCC ontogeny in the embryonic kidney using the power of the zebrafish animal model.
Schlagwörter	Danio rerio ; animal models ; cell movement ; kidneys ; locomotion ; ontogeny ; organelles
Sprache	Englisch
Erscheinungsverlauf	2022-1221
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel ; Online
ZDB-ID	2720870-9
ISSN	2221-3759
ISSN	2221-3759
DOI	10.3390/jdb11010001
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: osr1

Drummond, Bridgette E / Chambers, Brooke E / Wesselman, Hannah M / Gibson, Shannon / Arceri, Liana / Ulrich, Marisa N / Gerlach, Gary F / Kroeger, Paul T / Leshchiner, Ignaty / Goessling, Wolfram / Wingert, Rebecca A

Biomedicines

2022 Band 10, Heft 11

Abstract: Knowledge about the genetic pathways that control nephron development is essential for better understanding the basis of congenital malformations of the kidney. The transcription factors Osr1 and Hand2 are known to exert antagonistic influences to ... ...

Abstract	Knowledge about the genetic pathways that control nephron development is essential for better understanding the basis of congenital malformations of the kidney. The transcription factors Osr1 and Hand2 are known to exert antagonistic influences to balance kidney specification. Here, we performed a forward genetic screen to identify nephrogenesis regulators, where whole genome sequencing identified an
Sprache	Englisch
Erscheinungsdatum	2022-11-09
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10112868
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2

Bridgette E. Drummond / Brooke E. Chambers / Hannah M. Wesselman / Shannon Gibson / Liana Arceri / Marisa N. Ulrich / Gary F. Gerlach / Paul T. Kroeger / Ignaty Leshchiner / Wolfram Goessling / Rebecca A. Wingert

Biomedicines, Vol 10, Iss 2868, p

2022 Band 2868

Abstract	Knowledge about the genetic pathways that control nephron development is essential for better understanding the basis of congenital malformations of the kidney. The transcription factors Osr1 and Hand2 are known to exert antagonistic influences to balance kidney specification. Here, we performed a forward genetic screen to identify nephrogenesis regulators, where whole genome sequencing identified an osr1 lesion in the novel oceanside ( ocn ) mutant. The characterization of the mutant revealed that osr1 is needed to specify not renal progenitors but rather their maintenance. Additionally, osr1 promotes the expression of wnt2ba in the intermediate mesoderm (IM) and later the podocyte lineage. wnt2ba deficiency reduced podocytes, where overexpression of wnt2ba was sufficient to rescue podocytes and osr1 deficiency. Antagonism between osr1 and hand2 mediates podocyte development specifically by controlling wnt2ba expression. These studies reveal new insights about the roles of Osr1 in promoting renal progenitor survival and lineage choice.
Schlagwörter	kidney ; podocyte ; nephron ; development ; zebrafish ; osr1 ; Biology (General) ; QH301-705.5
Thema/Rubrik (Code)	616
Sprache	Englisch
Erscheinungsdatum	2022-11-01T00:00:00Z
Verlag	MDPI AG
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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