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  1. Book ; Online: True accounting

    Baltussen, W.H.M. / Woltjer, G.B.

    Een instrument om duurzame productie en consumptie van voedsel te bevorderen

    2023  

    Keywords Life Science
    Language English
    Publisher Wageningen Economic Research
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: Factsheet True cost accounting

    Baltussen, W.H.M. / Woltjer, G.B.

    A tool to improve the sustainable production and consumption of food : Parlement en wetenschap

    2023  

    Keywords Life Science
    Language English
    Publisher Wageningen University & Research
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: White matter hyperintensities and the surrounding normal appearing white matter are associated with water channel disruption in the oldest old.

    Silbert, Lisa C / Roese, Natalie E / Krajbich, Victoria / Hurworth, Justin / Lahna, David / Schwartz, Daniel L / Dodge, Hiroko H / Woltjer, Randall L

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  

    Abstract: Introduction: Age-related magnetic resonance imaging (MRI) T2 white matter hyperintensities (WMHs) are common and associated with neurological decline. We investigated the histopathological underpinnings of MRI WMH and surrounding normal appearing white ...

    Abstract Introduction: Age-related magnetic resonance imaging (MRI) T2 white matter hyperintensities (WMHs) are common and associated with neurological decline. We investigated the histopathological underpinnings of MRI WMH and surrounding normal appearing white matter (NAWM), with a focus on astroglial phenotypes.
    Methods: Brain samples from 51 oldest old Oregon Alzheimer's Disease Research Center participants who came to autopsy underwent post mortem (PM) 7 tesla MRI with targeted histopathological sampling of WMHs and NAWM. Stained slides were digitized and quantified. Mixed-effects models determined differences in molecular characteristics between WMHs and the NAWM and across NAWM.
    Results: PM MRI-targeted WMHs are characterized by demyelination, microglial activation, and prominent astrocytic alterations, including disrupted aquaporin (AQP) expression. Similar changes occur within the surrounding NAWM in a pattern of decreasing severity with increased distance from WMHs.
    Discussion: Decreased AQP expression within WMH and proximal NAWM suggest an overwhelmed system wherein water homeostasis is no longer maintained, contributing to WM damage in older individuals.
    Highlights: Post mortem magnetic resonance imaging (MRI) was used to characterize the pathology of white matter hyperintensities (WMHs) and surrounding normal appearing white matter (NAWM). Stained immunohistochemical (IHC) slides from targeted WMH and NAWM samples were digitized and quantified. WMHs and NAWM were associated with inflammation, demyelination, and gliosis. WMHs and NAWM astrocytic changes included decreased AQP1 and AQP4 expression. Abnormal NAWM pathology diminished in severity with increasing distance from WMH.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online: Bedrijfsuitkomsten in de Nederlandse particuliere bosbouw over 2020

    Silvis, H.J. / Voskuilen, M.J. / Woltjer, P.J.

    2022  

    Abstract: Dit rapport biedt een overzicht van de bedrijfsresultaten van particuliere bosbedrijven in 2020. Hierbij gaat het om particuliere boseigenaren met meer dan 50 ha bos, met uitzondering van de particulieren natuurbeschermingsorganisaties. De Nederlandse ... ...

    Abstract Dit rapport biedt een overzicht van de bedrijfsresultaten van particuliere bosbedrijven in 2020. Hierbij gaat het om particuliere boseigenaren met meer dan 50 ha bos, met uitzondering van de particulieren natuurbeschermingsorganisaties. De Nederlandse particuliere bosbedrijven boekten in 2020 een bedrijfsresultaat van gemiddeld min 5 euro per ha, tegen min 10 euro per ha bos in 2019. De opbrengsten stegen iets meer dan de kosten (respectievelijk +9% en +7%), waardoor de opbrengsten-kostenverhouding met 98% in 2020 een procentpunt hoger uitkwam dan in 2019.
    Keywords Life Science
    Language Dutch
    Publisher Wageningen Economic Research
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: E.H. Kossmann, A.F. Mellink, Texts concerning the revolt of the Netherlands

    J.J. Woltjer

    BMGN : Low Countries Historical Review, Vol 92, Iss 1, Pp 100-

    1977  Volume 100

    Keywords History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 1977-01-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: E.H. Kossmann, A.F. Mellink, Texts concerning the revolt of the Netherlands

    J.J. Woltjer

    BMGN : Low Countries Historical Review, Vol 92, Iss 1, Pp 100-

    1977  Volume 100

    Keywords History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 1977-01-01T00:00:00Z
    Publisher Utrecht University Library Open Access Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Correlating continuously captured home-based digital biomarkers of daily function with postmortem neurodegenerative neuropathology.

    Hantke, Nathan C / Kaye, Jeffrey / Mattek, Nora / Wu, Chao-Yi / Dodge, Hiroko H / Beattie, Zachary / Woltjer, Randy

    PloS one

    2023  Volume 18, Issue 6, Page(s) e0286812

    Abstract: Background: Outcome measures available for use in Alzheimer's disease (AD) clinical trials are limited in ability to detect gradual changes. Measures of everyday function and cognition assessed unobtrusively at home using embedded sensing and computing ... ...

    Abstract Background: Outcome measures available for use in Alzheimer's disease (AD) clinical trials are limited in ability to detect gradual changes. Measures of everyday function and cognition assessed unobtrusively at home using embedded sensing and computing generated "digital biomarkers" (DBs) have been shown to be ecologically valid and to improve efficiency of clinical trials. However, DBs have not been assessed for their relationship to AD neuropathology.
    Objectives: The goal of the current study is to perform an exploratory examination of possible associations between DBs and AD neuropathology in an initially cognitively intact community-based cohort.
    Methods: Participants included in this study were ≥65 years of age, living independently, of average health for age, and followed until death. Algorithms, run on the continuously-collected passive sensor data, generated daily metrics for each DB: cognitive function, mobility, socialization, and sleep. Fixed postmortem brains were evaluated for neurofibrillary tangles (NFTs) and neuritic plaque (NP) pathology and staged by Braak and CERAD systems in the context of the "ABC" assessment of AD-associated changes.
    Results: The analysis included a total of 41 participants (M±SD age at death = 92.2±5.1 years). The four DBs showed consistent patterns relative to both Braak stage and NP score severity. Greater NP severity was correlated with the DB composite and reduced walking speed. Braak stage was associated with reduced computer use time and increased total time in bed.
    Discussion: This study provides the first data showing correlations between DBs and neuropathological markers in an aging cohort. The findings suggest continuous, home-based DBs may hold potential to serve as behavioral proxies that index neurodegenerative processes.
    MeSH term(s) Humans ; Aged, 80 and over ; Alzheimer Disease/pathology ; Brain/pathology ; Neurofibrillary Tangles/pathology ; Cognition ; Aging/pathology ; Plaque, Amyloid/pathology
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0286812
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Identification of Factors Influencing the Adoption of Health Information Technology by Nurses Who Are Digitally Lagging: In-Depth Interview Study.

    De Leeuw, Jacqueline A / Woltjer, Hetty / Kool, Rudolf B

    Journal of medical Internet research

    2020  Volume 22, Issue 8, Page(s) e15630

    Abstract: Background: The introduction of health information technology (HIT) has drastically changed health care organizations and the way health care professionals work. Some health care professionals have trouble coping efficiently with the demands of HIT and ... ...

    Abstract Background: The introduction of health information technology (HIT) has drastically changed health care organizations and the way health care professionals work. Some health care professionals have trouble coping efficiently with the demands of HIT and the personal and professional changes it requires. Lagging in digital knowledge and skills hampers health care professionals from adhering to professional standards regarding the use of HIT and may cause professional performance problems, especially in the older professional population. It is important to gain more insight into the reasons and motivations behind the technology issues experienced by these professionals, as well as to explore what could be done to solve them.
    Objective: Our primary research objective was to identify factors that influence the adoption of HIT in a sample of nurses who describe themselves as digitally lagging behind the majority of their colleagues in their workplaces. Furthermore, we aimed to formulate recommendations for practice and leadership on how to help and guide these nurses through ongoing digital transformations in their health care work settings.
    Methods: In a Dutch university medical center, 10 face-to-face semi-structured interviews were performed with registered nurses (RN). Ammenwerth's FITT-framework (fit between the Individual, Task, and Technology) was used to guide the interview topic list and to formulate themes to explore. Thematic analysis was used to analyze the interview data. The FITT-framework was also used to further interpret and clarify the interview findings.
    Results: Analyses of the interview data uncovered 5 main categories and 12 subthemes. The main categories were: (1) experience with digital working, (2) perception and meaning, (3) barriers, (4) facilitators, and (5) future perspectives. All participants used electronic devices and digital systems, including the electronic health record. The latter was experienced by some as user-unfriendly, time-consuming, and not supportive in daily professional practice. Most of the interviewees described digital working as "no fun at all," "working in a fake world," "stressful," and "annoying." There was a lack of general digital knowledge and little or no formal basic digital training or education. A negative attitude toward computer use and a lack of digital skills contributed to feelings of increased incompetency and postponement or avoidance of the use of HIT, both privately and professionally. Learning conditions of digital training and education did not meet personal learning needs and learning styles. A positive impact was seen in the work environment when colleagues and nurse managers were aware and sensitive to the difficulties participants experienced in developing digital skills, and when there was continuous training on the job and peer support from digitally savvy colleagues. The availability of a digital play environment combined with learning on the job and support of knowledgeable peers was experienced as helpful and motivating by participants.
    Conclusions: Nurses who are digitally lagging often have had insufficient and ineffective digital education. This leads to stress, frustration, feelings of incompetency, and postponement or avoidance of HIT use. A digital training approach tailored to the learning needs and styles of these nurses is needed, as well as an on-the-job training structure and adequate peer support. Hospital management and nurse leadership should be informed about the importance of the fit between technology, task, and the individual for adequate adoption of HIT.
    MeSH term(s) Female ; Health Personnel/education ; Humans ; Interviews as Topic ; Medical Informatics/methods ; Middle Aged ; Qualitative Research
    Language English
    Publishing date 2020-08-14
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1438-8871
    ISSN (online) 1438-8871
    ISSN 1438-8871
    DOI 10.2196/15630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Achtergrondrapportage modelanalyses biodiversiteit en ecosysteemdiensten ten behoeve van de Ruimtelijke Verkenning

    Pouwels, R. / Woltjer, I. / de Knegt, B. / Roelofsen, H.D. / Biersteker, L.

    2023  

    Abstract: Background report on model analyses of biodiversity and ecosystem services for the Spatial Outlook. In early 2023 the Netherlands Environmental Assessment Agency (PBL) published its Spatial Outlook (Ruimtelijke Verkenning), which describes four possible ... ...

    Abstract Background report on model analyses of biodiversity and ecosystem services for the Spatial Outlook. In early 2023 the Netherlands Environmental Assessment Agency (PBL) published its Spatial Outlook (Ruimtelijke Verkenning), which describes four possible spatial development futures for the Netherlands in 2050. Scenario maps illustrate the consequences of the choices made in the scenarios. The present report describes the technical aspects of the development of these scenarios and the indicators for biodiversity calculated with the Model for Nature Policy and the indicators for the supply of ecosystem services calculated with the Natural Capital Model. It is a technical supplement to the background report published by the Netherlands Environmental Assessment Agency (PBL) and documents the model analyses carried out by Wageningen Environmental Research (WENR).

    Begin 2023 heeft PBL de Ruimtelijke Verkenning uitgebracht. Hierin zijn vier mogelijke ruimtelijke toekomsten voor Nederland in 2050 gepresenteerd. Met scenariokaarten is in beeld gebracht wat gevolgen zijn van de verschillende keuzes die zijn gemaakt in de scenario’s. Het voorliggende rapport beschrijft de technische achtergrond van de uitwerking van deze scenario’s en de berekende indicatoren voor biodiversiteit met het MNP model en de levering van ecosysteemdiensten met het NKM model. Het is een aanvulling op het achtergrondrapport dat door het PBL is uitgebracht en heeft tot doel de modelanalyses te borgen die door WENR zijn uitgevoerd.
    Keywords Life Science
    Language Dutch
    Publisher WOT Natuur & Milieu
    Publishing country nl
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Low-Intensity Ultrasound Reduces Brain Infarct Size by Upregulating Phosphorylated Endothelial Nitric Oxide in Mouse Model of Middle Cerebral Artery Occlusion.

    Davis, Catherine M / Ammi, Azzdine Y / Zhu, Wenbin / Methner, Carmen / Cao, Zhiping / Giraud, David / Alkayed, Nabil J / Woltjer, Randy L / Kaul, Sanjiv

    Ultrasound in medicine & biology

    2023  Volume 49, Issue 5, Page(s) 1091–1101

    Abstract: ... at each frequency in which infarct size (IS) was measured 24 h later. Group II included 11 mice undergoing treatment ... based on best US results from group I animals in which the IS/risk area (RA) ratio was measured 24 h ...

    Abstract Objective: There have been attempts to use therapeutic ultrasound (US) for the treatment of both experimental and clinical stroke. We hypothesized that low-intensity US has direct beneficial effects on the brain independent of cerebral blood flow (CBF) during middle cerebral artery occlusion (MCAO).
    Methods: Three groups of mice were studied. Group I included 84 mice with MCAO undergoing US treatment/no treatment at two US frequencies (0.25 and 1.05 MHz) with three different acoustic pressures at each frequency in which infarct size (IS) was measured 24 h later. Group II included 11 mice undergoing treatment based on best US results from group I animals in which the IS/risk area (RA) ratio was measured 24 h later. Group III included 38 normal mice undergoing US treatment/no treatment for assessment of CBF, tissue metabolite and protein expression and histopathology.
    Discussion: Ultrasound at both frequencies and most acoustic pressures resulted in reduction in IS in group I animals, with the best results obtained with 0.25 MHz at 2.0 MPa: IS was reduced 4-fold in the cerebral cortex, 1.5-fold in the caudate putamen and 3.5-fold in the cerebral hemisphere compared with control. US application in group III animals elicited only a marginal increase in CBF despite a 2.6-fold increase in phosphorylated endothelial nitric oxide synthase (p-eNOS)-S1177 and a corresponding decrease in p-eNOS-T494. Histopathology revealed no evidence of hemorrhage, inflammation or necrosis.
    Conclusion: Low-intensity US at specific frequencies and acoustic pressures results in marked neuroprotection in a mouse model of stroke by modulation of p-eNOS independent of its effect on CBF.
    MeSH term(s) Mice ; Animals ; Infarction, Middle Cerebral Artery/therapy ; Nitric Oxide/metabolism ; Stroke ; Brain/pathology ; Brain Ischemia ; Cerebrovascular Circulation ; Disease Models, Animal
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2022.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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