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  1. Article: Editorial: Endocrine disruptors: mechanism of action and implications for human health.

    Gaggi, Giulia / Barbagallo, Federica / De Toni, Luca / Bucci, Ines

    Frontiers in cell and developmental biology

    2024  Volume 12, Page(s) 1378345

    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1378345
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  2. Article: Does Sperm

    Leanza, Claudia / Cannarella, Rossella / Barbagallo, Federica / Gusmano, Carmelo / Calogero, Aldo E

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020445
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  3. Article ; Online: Once upon a Testis: The Tale of Cyclic Nucleotide Phosphodiesterase in Testicular Cancers.

    Campolo, Federica / Assenza, Maria Rita / Venneri, Mary Anna / Barbagallo, Federica

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: Phosphodiesterases are key regulators that fine tune the intracellular levels of cyclic nucleotides, given their ability to hydrolyze cAMP and cGMP. They are critical regulators of cAMP/cGMP-mediated signaling pathways, modulating their downstream ... ...

    Abstract Phosphodiesterases are key regulators that fine tune the intracellular levels of cyclic nucleotides, given their ability to hydrolyze cAMP and cGMP. They are critical regulators of cAMP/cGMP-mediated signaling pathways, modulating their downstream biological effects such as gene expression, cell proliferation, cell-cycle regulation but also inflammation and metabolic function. Recently, mutations in PDE genes have been identified and linked to human genetic diseases and PDEs have been demonstrated to play a potential role in predisposition to several tumors, especially in cAMP-sensitive tissues. This review summarizes the current knowledge and most relevant findings regarding the expression and regulation of PDE families in the testis focusing on PDEs role in testicular cancer development.
    MeSH term(s) Male ; Humans ; Testicular Neoplasms/genetics ; Cyclic AMP/metabolism ; Phosphoric Diester Hydrolases/metabolism ; Cyclic GMP/metabolism
    Chemical Substances diethylstilbestrol monophosphate (47341-71-9) ; Cyclic AMP (E0399OZS9N) ; Phosphoric Diester Hydrolases (EC 3.1.4.-) ; Cyclic GMP (H2D2X058MU)
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087617
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  4. Article ; Online: Age-related curves of AMH using the Gen II, the picoAMH and the Elecsys assays in women with polycystic ovary syndrome.

    Barbagallo, Federica / van der Ham, Kim / Willemsen, Sten P / Louwers, Yvonne V / Laven, Joop S

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Context: Several challenges still exist to adopt the anti-Müllerian hormone (AMH) as a marker of polycystic ovary morphology (PCOM), as included in the recently updated international guideline. Although different evaluations of age- and assay-specific ... ...

    Abstract Context: Several challenges still exist to adopt the anti-Müllerian hormone (AMH) as a marker of polycystic ovary morphology (PCOM), as included in the recently updated international guideline. Although different evaluations of age- and assay-specific reference ranges have been published in the last years, these studies have mainly been conducted in normo-ovulatory or infertile women.
    Objective: To develop an age-specific percentile distribution of AMH in patients with polycystic ovary syndrome (PCOS) measured by three different assays.
    Design: Retrospective cross-sectional study.
    Patients: 2,725 women aged 20 to 40 years with PCOS diagnosis were included.
    Intervention (s): Serum AMH measurement by the Gen II (Beckman Coulter), the picoAMH (Ansh Labs), and the Elecsys (Roche) assays.
    Main outcome meausre (s): Age-specific centile curves for all the assays and correlations between AMH, clinical, hormonal, and ultrasound characteristics.
    Results: Age-related nomograms for the 5th, 10th, 25th, 50th, 75th, 90th, and 95th percentiles of AMH were calculated using the LMS method for all the assays. AMH levels were significantly different between PCOS phenotypes. AMH levels were positive correlated to luteinizing hormone (LH), LH/follicular stimulating hormone (FSH) ratio, testosterone, androstenedione, free androgen index, mean follicular number, and mean ovarian volume.
    Conclusions: To our knowledge this is the first study reporting age specific percentile nomograms of serum AMH levels measured by the Gen II, the picoAMH and the Elecsys assays in a large population of PCOS women. These findings may help to interpret AMH levels in PCOS patients and facilitate the use of AMH as a diagnostic tool across age ranges.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae153
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
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  5. Article ; Online: Thyroid diseases and female sexual dysfunctions.

    Barbagallo, Federica / Cannarella, Rossella / Condorelli, Rosita A / Cucinella, Laura / La Vignera, Sandro / Nappi, Rossella E / Calogero, Aldo E

    Sexual medicine reviews

    2024  

    Abstract: Introduction: Female sexual dysfunctions (FSDs) have received little attention in the context of thyroid diseases, despite the high prevalence of both conditions.: Objectives: This review aims to update and summarize the state of knowledge on the ... ...

    Abstract Introduction: Female sexual dysfunctions (FSDs) have received little attention in the context of thyroid diseases, despite the high prevalence of both conditions.
    Objectives: This review aims to update and summarize the state of knowledge on the association between thyroid diseases and FSDs and to investigate the complex mechanisms through which thyroid hormone imbalance can impact female sexual health in the context of the biopsychosocial model.
    Methods: A comprehensive literature search was performed through the PubMed, MEDLINE, and Scopus databases, using the following keywords: "female sexual function," "sexual dysfunction," "hypoactive sexual desire disorder," "thyroid disease," "thyroiditis," "hypothyroidism," and "hyperthyroidism."
    Results: To date, well-designed studies that describe the relationship between FSDs and thyroid disorders are lacking. However, despite the limitations on available studies, current data indicate that sexual alterations are frequently associated with thyroid diseases in women. A complex interplay of direct and indirect hormonal and nonhormonal mechanisms has been hypothesized, including hormonal changes, neurotransmitter imbalance, reduced nitric oxide release, mood disorders, and other systemic consequences of both hypothyroidism and hyperthyroidism. Thyroid hormone receptors have also been identified in the genitourinary system.
    Conclusions: In a clinical setting, physicians should investigate the sexuality of patients consulting for thyroid disease. At the same time, an evaluation of thyroid function should be performed in patients presenting with FSD, especially after menopause, when the risk of thyroid diseases and FSDs increases strongly.
    Language English
    Publishing date 2024-04-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2722257-3
    ISSN 2050-0521 ; 2050-0513
    ISSN (online) 2050-0521
    ISSN 2050-0513
    DOI 10.1093/sxmrev/qeae021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6997: Show issues Location:
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  6. Article: In-Vitro Effects of Perfluorooctanoic Acid on Human Sperm Function: What Are the Clinical Consequences?

    Alamo, Angela / La Vignera, Sandro / Mogioì, Laura M / Crafa, Andrea / Barbagallo, Federica / Cannarella, Rossella / Aversa, Antonio / Calogero, Aldo E / Condorelli, Rosita A

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082201
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  7. Article: Assisted Reproductive Technology without Embryo Discarding or Freezing in Women ≥40 Years: A 5-Year Retrospective Study at a Single Center in Italy.

    Manna, Claudio / Barbagallo, Federica / Sagnella, Francesca / Farrag, Ashraf / Calogero, Aldo E

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: The protocols commonly used in assisted reproductive technology (ART) consist of long-term embryo culture up to the blastocyst stage after the insemination of all mature oocytes, the freezing of all the embryos produced, and their subsequent transfer one ...

    Abstract The protocols commonly used in assisted reproductive technology (ART) consist of long-term embryo culture up to the blastocyst stage after the insemination of all mature oocytes, the freezing of all the embryos produced, and their subsequent transfer one by one. These practices, along with preimplantation genetic testing, although developed to improve the live birth rate (LBR) and reduce the risk of multiple pregnancies, are drawing attention to the possible increase in obstetric and perinatal risks, and adverse epigenetic consequences in offspring. Furthermore, ethical-legal concerns are growing regarding the increase in cryopreservation and storage of frozen embryos. In an attempt to reduce the risk associated with prolonged embryo culture and avoid embryo storage, we have chosen to inseminate a limited number of oocytes not exceeding the number of embryos to be transferred, after two days or less of culture. We retrospectively analyzed 245 ICSI cycles performed in 184 infertile couples with a female partner aged ≥40 from January 2016 to July 2021. The results showed a fertilization rate of 95.7%, a miscarriage rate of 48.9%, and a LBR of 10% with twin pregnancies of 16.7%. The cumulative LBR in our group of couples was 13%. No embryos were frozen. In conclusion, these results suggest that oocyte selection and embryo transfer at the cleaving stage constitute a practice that has a LBR comparable to that of the more commonly used protocols in older women who have reduced ovarian reserve.
    Language English
    Publishing date 2023-01-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020504
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  8. Article: Effects of the ketogenic diet on bone health: A systematic review.

    Garofalo, Vincenzo / Barbagallo, Federica / Cannarella, Rossella / Calogero, Aldo Eugenio / La Vignera, Sandro / Condorelli, Rosita Angela

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1042744

    Abstract: Objective: To carry out a systematic review of published studies to evaluate the relationship between different type of ketogenic diet (KD) and bone health as supported by the scientific literature.: Methods: The study involved all articles that ... ...

    Abstract Objective: To carry out a systematic review of published studies to evaluate the relationship between different type of ketogenic diet (KD) and bone health as supported by the scientific literature.
    Methods: The study involved all articles that assessed the relationship between the use of KD for the treatment of overweight or obesity and bone health. The quality assessment was evaluated with using the Cambridge Quality Checklists. The search strategy included the following combination of Medical Subjects Headings terms and keywords: "osteoporosis", "bone health, "bone function", "bone mineral density", and "ketogenic diet".
    Results: Seven trials were identified and reviewed. No significant changes in bone mass density (BMD) were observed after KD. The results showed no significant effect on bone resorption by measuring urinary N-telopeptide levels, on bone formation by measuring bone-specific alkaline phosphatase, or alterations in overall bone turnover in patients who followed KD. Only in female subject after a 10% weight loss, bone resorption increases while new bone synthesis decreases, but without increasing the risk of osteoporosis. Finally, patients on KD lost significantly more weight than controls, associated with an increase in serum vitamin D levels and a reduction in plasma parathyroid hormone (PTH) levels.
    Conclusion: No human studies have currently been conducted with adequate and powerful experimental designs to definitively understand the impact of KD therapy on bone health.
    MeSH term(s) Humans ; Female ; Bone Density ; Bone and Bones ; Osteoporosis ; Diet, Ketogenic/methods ; Parathyroid Hormone/pharmacology ; Bone Resorption
    Chemical Substances Parathyroid Hormone
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1042744
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  9. Article ; Online: Bisphenols and perfluoroalkyls alter human stem cells integrity: A possible link with infertility.

    Gaggi, Giulia / Di Credico, Andrea / Barbagallo, Federica / Ghinassi, Barbara / Di Baldassarre, Angela

    Environmental research

    2023  Volume 235, Page(s) 116487

    Abstract: Bisphenols and Perfluoroalkyls are chemical compounds widely used in industry known to be endocrine disruptors (EDs). Once ingested through contaminated aliments, they mimic the activity of endogenous hormones leading to a broad spectrum of diseases. Due ...

    Abstract Bisphenols and Perfluoroalkyls are chemical compounds widely used in industry known to be endocrine disruptors (EDs). Once ingested through contaminated aliments, they mimic the activity of endogenous hormones leading to a broad spectrum of diseases. Due to the extensive use of plastic in human life, particular attention should be paid to antenatal exposure to Bisphenols and Perfluoroalkyls since they cross the placental barrier and accumulates in developing embryo. Here we investigated the effects of Bisphenol-A (BPA), Bisphenol-S (BPS), perfluorooctane-sulfonate (PFOS) and perfluorooctanoic-acid (PFOA), alone or combined, on human-induced pluripotent stem cells (hiPSCs) that share several biological features with the stem cells of blastocysts. Our data show that these EDs affect hiPSC inducing a great mitotoxicity and dramatic changes in genes involved in the maintenance of pluripotency, germline specification, and epigenetic regulation. We also evidenced that these chemicals, when combined, may have additive, synergistic but also negative effects. All these data suggest that antenatal exposure to these EDs may affect the integrity of stem cells in the developing embryos, interfering with critical stages of early human development that might be determinant for fertility. The observation that the effects of exposure to a combination of these chemicals are not easily foreseeable further highlights the need for wider awareness of the complexity of the EDs effects on human health and of the social and economic burden attributable to these compounds.
    MeSH term(s) Humans ; Female ; Pregnancy ; Epigenesis, Genetic ; Placenta ; Infertility ; Fertility ; Benzhydryl Compounds/toxicity ; Benzhydryl Compounds/chemistry ; Fluorocarbons/toxicity ; Endocrine Disruptors/toxicity
    Chemical Substances bis(4-hydroxyphenyl)sulfone (80-09-1) ; bisphenol A (MLT3645I99) ; Benzhydryl Compounds ; Fluorocarbons ; Endocrine Disruptors
    Language English
    Publishing date 2023-07-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.116487
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 726: Show issues Location:
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  10. Article: Cell Shortening and Calcium Homeostasis Analysis in Adult Cardiomyocytes via a New Software Tool.

    Fassina, Lorenzo / Assenza, Maria Rita / Miragoli, Michele / Isidori, Andrea M / Naro, Fabio / Barbagallo, Federica

    Biomedicines

    2022  Volume 10, Issue 3

    Abstract: Intracellular calcium ( ... ...

    Abstract Intracellular calcium (Ca
    Language English
    Publishing date 2022-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines10030640
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