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  1. Book: The heart and cardiovascular system / 1

    Fozzard, Harry A.

    scientific foundations

    1991  

    Author's details ed. Harry A. Fozzard
    Collection The heart and cardiovascular system
    Keywords Herz ; Physiologie ; Herzkrankheit ; Pathophysiologie ; Kardiologie ; Kardiovaskuläres System
    Subject Herz-Kreislauf-System ; Cardiovasculäres System ; Cardiologie ; Cardiology ; Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Herzerkrankung ; Herzkrankheiten ; Humanphysiologie ; Mensch ; Körperfunktion
    Language English
    Size XXI, 1169, I-71 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Raven Pr
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT003996666
    ISBN 0-88167-747-7 ; 978-0-88167-747-8
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 8603 order for loan Magazin
    1992 A 571 -1- order for loan Magazin

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  2. Book: The heart and cardiovascular system / 2

    Fozzard, Harry A.

    scientific foundations

    1991  

    Author's details ed. Harry A. Fozzard
    Collection The heart and cardiovascular system
    Keywords Herz ; Physiologie ; Herzkrankheit ; Pathophysiologie ; Kardiologie ; Kardiovaskuläres System
    Subject Herz-Kreislauf-System ; Cardiovasculäres System ; Cardiologie ; Cardiology ; Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie ; Herzerkrankung ; Herzkrankheiten ; Humanphysiologie ; Mensch ; Körperfunktion
    Language English
    Size XXI S., S. 1171 - 2193, I-71 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Raven Pr
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT003996692
    ISBN 0-88167-747-7 ; 978-0-88167-747-8
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 8604 order for loan Magazin
    1992 A 571 -2- order for loan Magazin

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  3. Book: Structure and function of ion channels in the heart and the vascular system

    Fozzard, Harry A.

    May 8 - 11, 1990, Chicago, IL

    (Journal of molecular and cellular cardiology ; 22, Suppl. 1)

    1990  

    Title variant Program and abstracts of the structure and function of the ion channels in the heart and vascular system
    Author's details organized by: Harry A. Fozzard
    Series title Journal of molecular and cellular cardiology ; 22, Suppl. 1
    Collection
    Keywords Ion Channels / physiology / congresses ; Cardiovascular System / physiology / congresses
    Language English
    Size S49 S. : graph. Darst.
    Publisher Acad. Pr
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003553129
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 426 -22,Suppl.1- verfügbar in Königswinter Königswinter

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  4. Book ; Collection: The heart and cardiovascular system

    Fozzard, Harry A.

    scientific foundations

    1986  

    Author's details ed. Harry A. Fozzard
    Keywords Cardiovascular System / physiology ; Heart / physiology ; Heart Diseases
    Language English
    Dates of publication 1986-9999
    Publisher Raven Pr
    Publishing place New York
    Publishing country United States
    Document type Book ; Collection (display volumes)
    Remark Neueste Aufl.: Handb. WG 202 H 1
    HBZ-ID HT002870619
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  5. Book: The heart and cardiovascular system / 1

    Fozzard, Harry A.

    scientific foundations

    1986  

    Author's details ed. Harry A. Fozzard
    Collection The heart and cardiovascular system
    Keywords Herz ; Physiologie ; Herzkrankheit ; Pathophysiologie ; Kardiologie ; Kardiovaskuläres System
    Subject Herzerkrankung ; Herzkrankheiten ; Humanphysiologie ; Mensch ; Körperfunktion ; Herz-Kreislauf-System ; Cardiovasculäres System ; Cardiologie ; Cardiology ; Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie
    Language English
    Size XIX, 778, I-45 S. : zahlr. Ill. u. graph. Darst.
    Edition 1. [Dr.]
    Publisher Raven Pr
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT002870635
    ISBN 0-88167-126-6 ; 978-0-88167-126-1
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1987 A 137 -1- order for loan Magazin

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  6. Book: The heart and cardiovascular system / 2

    Fozzard, Harry A.

    scientific foundations

    1986  

    Author's details ed. Harry A. Fozzard
    Collection The heart and cardiovascular system
    Keywords Herz ; Physiologie ; Herzkrankheit ; Pathophysiologie ; Kardiologie ; Kardiovaskuläres System
    Subject Herzerkrankung ; Herzkrankheiten ; Humanphysiologie ; Mensch ; Körperfunktion ; Herz-Kreislauf-System ; Cardiovasculäres System ; Cardiologie ; Cardiology ; Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie
    Language English
    Size XIX S., S. 779 - 1694, I-45 S. : Ill., zahlr. graph. Darst.
    Edition 1. [Dr.]
    Publisher Raven Pr
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT002870648
    ISBN 0-88167-126-6 ; 978-0-88167-126-1
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1987 A 137 -2- order for loan Magazin

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  7. Article ; Online: Increased sensitivity to local anesthetic drugs: bedside to bench.

    Fozzard, Harry A

    Circulation research

    2008  Volume 103, Issue 4, Page(s) 325–327

    MeSH term(s) Anesthetics, Local/adverse effects ; Brugada Syndrome/genetics ; Brugada Syndrome/physiopathology ; Electrocardiography ; Humans ; Lidocaine/adverse effects ; Mutation, Missense/genetics ; Sodium Channels/genetics
    Chemical Substances Anesthetics, Local ; Sodium Channels ; Lidocaine (98PI200987)
    Language English
    Publishing date 2008-08-13
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.108.182055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels.

    Sheets, Michael F / Fozzard, Harry A / Hanck, Dorothy A

    Biophysical journal

    2015  Volume 109, Issue 11, Page(s) 2277–2286

    Abstract: Voltage-gated sodium (NaV) channels contain an α-subunit incorporating the channel's pore and gating machinery composed of four homologous domains (DI-DIV), with a pore domain formed by the S5 and S6 segments and a voltage-sensor domain formed by the S1- ... ...

    Abstract Voltage-gated sodium (NaV) channels contain an α-subunit incorporating the channel's pore and gating machinery composed of four homologous domains (DI-DIV), with a pore domain formed by the S5 and S6 segments and a voltage-sensor domain formed by the S1-S4 segments. During a membrane depolarization movement, the S4s in the voltage-sensor domains exert downstream effects on the S6 segments to control ionic conductance through the pore domain. We used lidocaine, a local anesthetic and antiarrhythmic drug, to probe the role of conserved Asn residues in the S6s of DIII and DIV in NaV1.5 and NaV1.4. Previous studies have shown that lidocaine binding to the pore domain causes a decrease in the maximum gating (Qmax) charge of ∼38%, and three-fourths of this decrease results from the complete stabilization of DIII-S4 (contributing a 30% reduction in Qmax) and one-fourth is due to partial stabilization of DIV-S4 (a reduction of 8-10%). Even though substitutions for the Asn in DIV-S6 in NaV1.5, N1764A and N1764C, produce little ionic current in transfected mammalian cells, they both express robust gating currents. Anthopleurin-A toxin, which inhibits movement of DIV-S4, still reduced Qmax by nearly 30%, a value similar to that observed in wild-type channels, in both N1764A and N1764C. By applying lidocaine and measuring the gating currents, we demonstrated that Asn residues in the S6s of DIII and DIV are important for coupling their pore domains to their voltage-sensor domains, and that Ala and Cys substitutions for Asn in both S6s result in uncoupling of the pore domains from their voltage-sensor domains. Similar observations were made for NaV1.4, although substitutions for Asn in DIII-S6 showed somewhat less uncoupling.
    MeSH term(s) Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Asparagine ; HEK293 Cells ; Humans ; Lidocaine/pharmacology ; Molecular Sequence Data ; Muscle Proteins/chemistry ; Muscle Proteins/genetics ; Muscle Proteins/metabolism ; NAV1.5 Voltage-Gated Sodium Channel/chemistry ; NAV1.5 Voltage-Gated Sodium Channel/metabolism ; Porosity ; Protein Structure, Tertiary ; Rats ; Sodium Channels/chemistry ; Sodium Channels/genetics ; Sodium Channels/metabolism
    Chemical Substances Muscle Proteins ; NAV1.5 Voltage-Gated Sodium Channel ; SCN5A protein, human ; Scn4a protein, rat ; Sodium Channels ; Asparagine (7006-34-0) ; Lidocaine (98PI200987)
    Language English
    Publishing date 2015-12-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2015.10.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 235: Show issues Location:
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  9. Article ; Online: Fifty years of cardiovascular science together.

    Fozzard, Harry A

    Circulation research

    2003  Volume 92, Issue 1, Page(s) 4–5

    MeSH term(s) Biomedical Research/history ; Cardiology/education ; Cardiology/history ; Cardiology/trends ; Electrophysiology/history ; Heart Diseases/history ; Heart Diseases/therapy ; History, 20th Century ; History, 21st Century ; Humans ; United States
    Language English
    Publishing date 2003-01-10
    Publishing country United States
    Document type Autobiography ; Biography ; Editorial ; Historical Article
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/01.res.0000052926.89426.d2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.70: Show issues Location:
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  10. Article ; Online: The tetrodotoxin binding site is within the outer vestibule of the sodium channel.

    Fozzard, Harry A / Lipkind, Gregory M

    Marine drugs

    2010  Volume 8, Issue 2, Page(s) 219–234

    Abstract: Tetrodotoxin and saxitoxin are small, compact asymmetrical marine toxins that block voltage-gated Na channels with high affinity and specificity. They enter the channel pore's outer vestibule and bind to multiple residues that control permeation. ... ...

    Abstract Tetrodotoxin and saxitoxin are small, compact asymmetrical marine toxins that block voltage-gated Na channels with high affinity and specificity. They enter the channel pore's outer vestibule and bind to multiple residues that control permeation. Radiolabeled toxins were key contributors to channel protein purification and subsequent cloning. They also helped identify critical structural elements called P loops. Spacial organization of their mutation-identified interaction sites in molecular models has generated a molecular image of the TTX binding site in the outer vestibule and the critical permeation and selectivity features of this region. One site in the channel's domain I P loop determines affinity differences in mammalian isoforms.
    MeSH term(s) Binding Sites ; Cloning, Molecular ; Ion Channel Gating ; Models, Molecular ; Mutation ; Sodium Channel Blockers/pharmacology ; Sodium Channels/chemistry ; Sodium Channels/genetics ; Sodium Channels/metabolism ; Tetrodotoxin/metabolism ; Tetrodotoxin/pharmacology
    Chemical Substances Sodium Channel Blockers ; Sodium Channels ; Tetrodotoxin (4368-28-9)
    Language English
    Publishing date 2010-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md8020219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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