LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 123

Search options

  1. Book: Endocannabinoids

    Pertwee, Roger G.

    (Handbook of experimental pharmacology ; 231)

    2015  

    Author's details Roger G. Pertwee ed
    Series title Handbook of experimental pharmacology ; 231
    Collection
    Keywords Endocannabinoids / physiology ; Cannabinoid Receptor Modulators / pharmacology ; Endocannabinoids / pharmacology ; Receptors, Cannabinoid / therapeutic use
    Language English
    Size XII, 475 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018817745
    ISBN 978-3-319-20824-4 ; 3-319-20824-1 ; 978-3-319-20825-1 ; 3-319-20825-X
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 4004 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book: Handbook of cannabis

    Pertwee, Roger G.

    (Handbooks in psychopharmacology)

    2014  

    Author's details ed. by Roger Pertwee
    Series title Handbooks in psychopharmacology
    Keywords Cannabis ; Cannabis/Therapeutic use
    Subject code 615.7827
    Language English
    Size XXIV, 747 S., [4] Bl. : Ill., graph. Darst., 25 cm
    Edition 1. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Note Formerly CIP. ; Hier auch später erschienene, unveränderte Nachdrucke ; Includes bibliographical references and index
    HBZ-ID HT018438442
    ISBN 978-0-19-966268-5 ; 978-0-19-879260-4 ; 0-19-966268-1 ; 0-19-879260-3
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 4076 available for loan (reading room) Lesesaal EG

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The 90th Birthday of Professor Raphael Mechoulam, a Top Cannabinoid Scientist and Pioneer.

    Pertwee, Roger G

    International journal of molecular sciences

    2020  Volume 21, Issue 20

    MeSH term(s) Cannabinoids/history ; Cannabinoids/pharmacology ; History, 20th Century ; History, 21st Century ; Israel ; Pharmacology/history
    Chemical Substances Cannabinoids
    Language English
    Publishing date 2020-10-16
    Publishing country Switzerland
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21207653
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: The 90th Birthday of Professor Raphael Mechoulam, a Top Cannabinoid Scientist and Pioneer

    Roger G. Pertwee

    International Journal of Molecular Sciences, Vol 21, Iss 7653, p

    2020  Volume 7653

    Abstract: ... n/ ... ...

    Abstract n/a
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Cyclic AMP Assay Using Human Cannabinoid CB

    Marini, Pietro / Cascio, Maria Grazia / Pertwee, Roger G

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2576, Page(s) 171–179

    Abstract: ... behavior (agonists, antagonists, and inverse agonists) of G-protein coupled receptor ligands. Here, we describe ...

    Abstract The cyclic AMP assay is a functional assay that is commonly used to determine the pharmacological behavior (agonists, antagonists, and inverse agonists) of G-protein coupled receptor ligands. Here, we describe the cyclic AMP assay that is carried out with commercially available nonradioligand ready-to-use kits and CHO (Chinese Hamster Ovarian) cells stably transfected with the human cannabinoid CB
    MeSH term(s) Animals ; CHO Cells ; Cannabinoids ; Cricetinae ; Cricetulus ; Cyclic AMP ; Humans ; Ligands ; Receptor, Cannabinoid, CB2/genetics ; Receptors, Cannabinoid
    Chemical Substances Cannabinoids ; Ligands ; Receptor, Cannabinoid, CB2 ; Receptors, Cannabinoid ; Cyclic AMP (E0399OZS9N)
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2728-0_13
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Displacement Binding Assay Using Human Cannabinoid CB

    Cascio, Maria Grazia / Marini, Pietro / Pertwee, Roger G

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2576, Page(s) 111–118

    Abstract: Displacement binding assays are nonfunctional assays mostly used with the aim of determining whether a certain compound (plant-derived or synthetic) can bind to a specific receptor with high affinity. Here, we describe the displacement binding assay that ...

    Abstract Displacement binding assays are nonfunctional assays mostly used with the aim of determining whether a certain compound (plant-derived or synthetic) can bind to a specific receptor with high affinity. Here, we describe the displacement binding assay that is carried out with a radioligand and CHO (Chinese Hamster Ovarian) cells stably transfected with the human cannabinoid CB
    MeSH term(s) Animals ; Biological Assay ; CHO Cells ; Cannabinoids/metabolism ; Cricetinae ; Cricetulus ; Humans ; Radioligand Assay ; Receptor, Cannabinoid, CB2/genetics ; Receptors, Cannabinoid
    Chemical Substances Cannabinoids ; Receptor, Cannabinoid, CB2 ; Receptors, Cannabinoid
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2728-0_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: The Plant Derived 3-3'-Diindolylmethane (DIM) Behaves as CB

    Tucci, Paolo / Brown, Iain / Bewick, Guy S / Pertwee, Roger G / Marini, Pietro

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: 3-3'-Diindolylmethane (DIM) is a biologically active dimer derived from the endogenous conversion of indole-3-carbinol (I3C), a naturally occurring glucosinolate found in many cruciferous vegetables (i.e., ...

    Abstract 3-3'-Diindolylmethane (DIM) is a biologically active dimer derived from the endogenous conversion of indole-3-carbinol (I3C), a naturally occurring glucosinolate found in many cruciferous vegetables (i.e.,
    MeSH term(s) Humans ; Male ; Androgens/metabolism ; Brassicaceae/chemistry ; Cell Line ; Prostatic Neoplasms/metabolism ; Receptors, Androgen/metabolism ; Receptor, Cannabinoid, CB2/agonists ; Receptor, Cannabinoid, CB2/chemistry
    Chemical Substances 3,3'-diindolylmethane (SSZ9HQT61Z) ; Androgens ; Receptors, Androgen ; Receptor, Cannabinoid, CB2
    Language English
    Publishing date 2023-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043620
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Endocannabinoids and Their Pharmacological Actions.

    Pertwee, Roger G

    Handbook of experimental pharmacology

    2015  Volume 231, Page(s) 1–37

    Abstract: The endocannabinoid system consists of G protein-coupled cannabinoid CB(1) and CB(2) receptors ...

    Abstract The endocannabinoid system consists of G protein-coupled cannabinoid CB(1) and CB(2) receptors, of endogenous compounds known as endocannabinoids that can target these receptors, of enzymes that catalyse endocannabinoid biosynthesis and metabolism, and of processes responsible for the cellular uptake of some endocannabinoids. This review presents in vitro evidence that most or all of the following 13 compounds are probably orthosteric endocannabinoids since they have all been detected in mammalian tissues in one or more investigation, and all been found to bind to cannabinoid receptors, probably to an orthosteric site: anandamide, 2-arachidonoylglycerol, noladin ether, dihomo-γ-linolenoylethanolamide, virodhamine, oleamide, docosahexaenoylethanolamide, eicosapentaenoylethanolamide, sphingosine, docosatetraenoylethanolamide, N-arachidonoyldopamine, N-oleoyldopamine and haemopressin. In addition, this review describes in vitro findings that suggest that the first eight of these compounds can activate CB(1) and sometimes also CB(2) receptors and that another two of these compounds are CB(1) receptor antagonists (sphingosine) or antagonists/inverse agonists (haemopressin). Evidence for the existence of at least three allosteric endocannabinoids is also presented. These endogenous compounds appear to target allosteric sites on cannabinoid receptors in vitro, either as negative allosteric modulators of the CB1 receptor (pepcan-12 and pregnenolone) or as positive allosteric modulators of this receptor (lipoxin A(4)) or of the CB(2) receptor (pepcan-12). Also discussed are current in vitro data that indicate the extent to which some established or putative orthosteric endocannabinoids seem to target non-cannabinoid receptors and ion channels, particularly at concentrations at which they have been found to interact with CB(1) or CB(2) receptors.
    MeSH term(s) Animals ; Binding Sites ; Cannabinoid Receptor Agonists/metabolism ; Cannabinoid Receptor Agonists/pharmacology ; Cannabinoid Receptor Antagonists/pharmacology ; Dose-Response Relationship, Drug ; Endocannabinoids/metabolism ; Endocannabinoids/pharmacology ; Humans ; Ligands ; Protein Binding ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/agonists ; Receptor, Cannabinoid, CB2/metabolism ; Signal Transduction/drug effects
    Chemical Substances Cannabinoid Receptor Agonists ; Cannabinoid Receptor Antagonists ; Endocannabinoids ; Ligands ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2
    Language English
    Publishing date 2015
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/978-3-319-20825-1_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues
     danach: Sign. bei den Einzelbänden: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book: Cannabinoid receptors

    Pertwee, Roger G.

    (Neuroscience perspectives)

    1995  

    Author's details ed. by R. G. Pertwee
    Series title Neuroscience perspectives
    Keywords Receptors, Drug / physiology ; Cannabinoids / pharmacology ; Fatty Acids, Unsaturated / pharmacology ; Amides / pharmacology ; Rezeptor ; Cannabinoide
    Language English
    Size XIV, 264 S. : Ill., graph. Darst.
    Publisher Acad. Press
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT006625587
    ISBN 0-12-551460-3 ; 978-0-12-551460-6
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1995 A 2433 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications.

    Pertwee, Roger G

    The Proceedings of the Nutrition Society

    2014  Volume 73, Issue 1, Page(s) 96–105

    Abstract: The endocannabinoid system consists of cannabinoid CB1 and CB2 receptors, of endogenous agonists for these receptors known as 'endocannabinoids', and of processes responsible for endocannabinoid biosynthesis, cellular uptake and metabolism. There is ... ...

    Abstract The endocannabinoid system consists of cannabinoid CB1 and CB2 receptors, of endogenous agonists for these receptors known as 'endocannabinoids', and of processes responsible for endocannabinoid biosynthesis, cellular uptake and metabolism. There is strong evidence first, that this system up-regulates in certain disorders as indicated by an increased release of endocannabinoids onto their receptors and/or by increases in the expression levels or coupling efficiency of these receptors, and second, that this up-regulation often appears to reduce or abolish unwanted effects of these disorders or to slow their progression. This discovery has raised the possibility of developing a medicine that enhances up-regulation of the endocannabinoid system associated with these disorders by inhibiting the cellular uptake or intracellular metabolism of an endocannabinoid following its 'autoprotective' endogenous release. For inhibition of endocannabinoid metabolism, research has focused particularly on two highly investigated endocannabinoids, anandamide and 2-arachidonoyl glycerol, and hence on inhibitors of the main anandamide-metabolising enzyme, fatty acid amide hydrolase (FAAH), and of the main 2-arachidonoyl glycerol-metabolising enzyme, monoacylglycerol (MAG) lipase. The resulting data have provided strong preclinical evidence that selective FAAH and MAG lipase inhibitors would ameliorate the unwanted effects of several disorders, when administered alone or with a cyclooxygenase inhibitor, and that the benefit-to-risk ratio of a FAAH inhibitor would exceed that of a MAG lipase inhibitor or dual inhibitor of FAAH and MAG lipase. Promising preclinical data have also been obtained with inhibitors of endocannabinoid cellular uptake. There is now an urgent need for clinical research with these enzyme and uptake inhibitors.
    MeSH term(s) Amidohydrolases/antagonists & inhibitors ; Arachidonic Acids/metabolism ; Endocannabinoids/metabolism ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Glycerides/metabolism ; Humans ; Metabolic Networks and Pathways ; Monoacylglycerol Lipases/antagonists & inhibitors ; Polyunsaturated Alkamides/metabolism
    Chemical Substances Arachidonic Acids ; Endocannabinoids ; Enzyme Inhibitors ; Glycerides ; Polyunsaturated Alkamides ; glyceryl 2-arachidonate (8D239QDW64) ; Monoacylglycerol Lipases (EC 3.1.1.23) ; Amidohydrolases (EC 3.5.-) ; fatty-acid amide hydrolase (EC 3.5.1.-) ; anandamide (UR5G69TJKH)
    Language English
    Publishing date 2014-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391142-1
    ISSN 1475-2719 ; 0029-6651
    ISSN (online) 1475-2719
    ISSN 0029-6651
    DOI 10.1017/S0029665113003649
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.179: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top