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Article ; Online: Reply to G. Gui et al.

Craddock, Charles / Jackson, Aimee / Freeman, Sylvie D

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2021 Volume 39, Issue 21, Page(s) 2416–2417

Language	English
Publishing date	2021-05-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.21.00603
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Article ; Online: Youths and Violence: Changing the Narrative.

Metzler, Marilyn / Jackson, Trinidad / Trudeau, Aimée

American journal of public health

2021 Volume 111, Issue S1, Page(s) S35–S37

MeSH term(s)	Adolescent ; Adolescent Behavior ; Black or African American ; Humans ; Narration ; Racism ; United States ; Violence/ethnology ; Violence/prevention & control ; Young Adult
Language	English
Publishing date	2021-05-25
Publishing country	United States
Document type	Editorial ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2021.306309
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Article ; Online: Correction to: Opioid Use Disorder Among Ohio's Medicaid Population: Prevalence Estimates From 19 Counties Using a Multiplier Method.

Doogan, Nathan J / Mack, Aimee / Wang, Jianing / Crane, Dushka / Jackson, Rebecca / Applegate, Mary / Villani, Jennifer / Chandler, Redonna / Barocas, Joshua A

American journal of epidemiology

2023

Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2937-3
ISSN	1476-6256 ; 0002-9262
ISSN (online)	1476-6256
ISSN	0002-9262
DOI	10.1093/aje/kwad245
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Article ; Online: Letter to the editor regarding penicillin allergy de-labelling in Ireland.

McGreal-Bellone, Aimee / Fenton, Sarah / Barrett, Marita / Jackson, Arthur

Irish journal of medical science

2021 Volume 191, Issue 5, Page(s) 2221–2222

MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Drug Hypersensitivity/epidemiology ; Humans ; Ireland/epidemiology ; Penicillins/adverse effects
Chemical Substances	Anti-Bacterial Agents ; Penicillins
Language	English
Publishing date	2021-11-12
Publishing country	Ireland
Document type	Letter ; Comment
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-021-02844-4
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Article ; Online: Investigator choice of standard therapy versus sequential novel therapy arms in the treatment of relapsed follicular lymphoma (REFRACT): study protocol for a multi-centre, open-label, randomised, phase II platform trial.

McIlroy, Graham / Lax, Siân / Gaskell, Charlotte / Jackson, Aimee / Rhodes, Malcolm / Seale, Tania / Fox, Sonia / Hopkins, Lousie / Okosun, Jessica / Barrington, Sally F / Ringshausen, Ingo / Ramsay, Alan G / Calaminici, Maria / Linton, Kim / Bishton, Mark

BMC cancer

2024 Volume 24, Issue 1, Page(s) 370

Abstract: ... Research Institute, open-label, multi-centre, randomised phase II platform trial aimed at accelerating clinical ... Therefore, the aim of REFRACT is to provide an efficient platform to evaluate novel agents against standard therapies ...

Abstract	Background: Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies are in development, but few are licensed as their role in current treatment pathways is poorly defined. Methods: The REFRACT trial is an investigator-initiated, UK National Cancer Research Institute, open-label, multi-centre, randomised phase II platform trial aimed at accelerating clinical development of novel therapies by addressing evidence gaps. The first of the three sequential novel therapy arms is epcoritamab plus lenalidomide, to be compared with investigator choice standard therapy (ICT). Patients aged 18 years or older with biopsy proven relapsed or refractory CD20 positive, grade 1-3a follicular lymphoma and assessable disease by PET-CT are eligible. The primary outcome is complete metabolic response by PET-CT at 24 weeks using the Deauville 5-point scale and Lugano 2014 criteria. Secondary outcomes include overall metabolic response, progression-free survival, overall survival, duration of response, and quality of life assessed by EQ-5D-5 L and FACT-Lym. The trial employs an innovative Bayesian design with a target sample size of 284 patients: 95 in the ICT arm and 189 in the novel therapy arms. Discussion: Whilst there are many promising novel drugs in early clinical development for rrFL, understanding the relative efficacy and safety of these agents, and their place in modern treatment pathways, is limited by a lack of randomised trials and dearth of published outcomes for standard regimens to act as historic controls. Therefore, the aim of REFRACT is to provide an efficient platform to evaluate novel agents against standard therapies for rrFL. The adaptive Bayesian power prior methodology design will minimise patient numbers and accelerate trial delivery. Trial registration: ClinicalTrials.gov: NCT05848765; 08-May-2023. Eudract: 2022-000677-75; 10-Feb-2022.
MeSH term(s)	Humans ; Lymphoma, Follicular/drug therapy ; Positron Emission Tomography Computed Tomography ; Arm/pathology ; Bayes Theorem ; Quality of Life ; Treatment Outcome ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic ; Clinical Trials, Phase II as Topic
Language	English
Publishing date	2024-03-25
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-12112-0
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Book ; Online ; Conference proceedings ; E-Book: Bryozoan Studies 2022

Key, Marcus M. / Porter, Joanne S. / Wyse Jackson, Patrick N.

Proceedings of the Nineteenth International Bryozoology Association Conference (dublin, Ireland, 22-26 August 2022)

2023

Abstract: ... to the present day. This volume includes papers that utilise tomographic techniques to their study, and is aimed ...

Author's details	edited by Marcus M. Key, Joanne S. Porter, and Patrick N. Wyse Jackson
Abstract	Bryozoans are colonial organisms found in marine and freshwater environments from the Cambrian to the present day. This volume includes papers that utilise tomographic techniques to their study, and is aimed at bryozoologists, palaeontologists, biologists, and natural scientists.
Keywords	Zoology
Subject code	025.063510941
Language	English
Size	1 online resource (204 pages)
Edition	First edition.
Publisher	CRC Press/Balkema
Publishing place	Abingdon, England
Document type	Book ; Online ; Conference proceedings ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-003-81165-5 ; 9781032594880 ; 978-1-003-81165-7 ; 1032594888
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Beta-hydroxy beta-methylbutyrate/arginine/glutamine (HMB/Arg/Gln) supplementation to improve the management of cachexia in patients with advanced lung cancer: an open-label, multicentre, randomised, controlled phase II trial (NOURISH).

Pascoe, Jennifer / Jackson, Aimee / Gaskell, Charlotte / Gaunt, Claire / Thompson, Joyce / Billingham, Lucinda / Steven, Neil

BMC cancer

2021 Volume 21, Issue 1, Page(s) 800

Abstract: Background: Cancer cachexia causes significant morbidity and mortality in advanced lung cancer patients. Clinical benefit of β-hydroxy-β-methylbutyrate, arginine, and glutamine (HMB/Arg/Gln) was assessed in newly diagnosed patients.: Methods: NOURISH, ...

Abstract	Background: Cancer cachexia causes significant morbidity and mortality in advanced lung cancer patients. Clinical benefit of β-hydroxy-β-methylbutyrate, arginine, and glutamine (HMB/Arg/Gln) was assessed in newly diagnosed patients. Methods: NOURISH, a prospective, two-arm, open-label, multi-centre, randomised controlled phase II trial compared cachexia in patients who received HMB/Arg/Gln with those who did not. All patients received structured nutritional, exercise and symptom control via a Macmillan Durham Cachexia Pack. Conducted in five UK centres, patients aged > 18 years, with newly diagnosed advanced small cell lung cancer (SCLC) or non-small cell lung cancer (NSCLC), who were able to take oral nutrition, with a performance status of 0-to-2 and a life expectancy > 4 months were eligible for trial entry. Patients suitable for treatment with curative intent were ineligible. The trial was designed as a signal-seeking pilot study with target recruitment of 96 patients. One-to-one randomisation was stratified by diagnosis (SCLC or NSCLC), stage of disease (locally advanced or metastatic) and performance status. The primary outcome measure was treatment success defined as a patient being alive without significant loss of lean body mass (not > 5%) by 12 weeks. Secondary outcome measures included quality of life. Results: Between February-2012 and February-2013, 38 patients were recruited, 19 to each arm. Baseline characteristics were balanced. The trial was halted due to slow accrual and partial adherence. Trial data demonstrated no evidence of treatment benefit. No serious adverse events were reported during the trial. Conclusions: Further evaluation of HMB/Arg/Gln in this setting could not be recommended on the basis of this trial. Clinical trial registration: ISRCTN registry: 39911673; 14-Apr-2011 https://doi.org/10.1186/ISRCTN39911673 .
MeSH term(s)	Arginine/pharmacology ; Arginine/therapeutic use ; Cachexia/drug therapy ; Female ; Glutamine/pharmacology ; Glutamine/therapeutic use ; Humans ; Lung Neoplasms/complications ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Prospective Studies ; Treatment Outcome
Chemical Substances	Glutamine (0RH81L854J) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2021-07-12
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-021-08519-8
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Article ; Online: Opioid Use Disorder Among Ohio's Medicaid Population: Prevalence Estimates From 19 Counties Using a Multiplier Method.

Doogan, Nathan J / Mack, Aimee / Wang, Jianing / Crane, Dushka / Jackson, Rebecca / Applegate, Mary / Villani, Jennifer / Chandler, Redonna / Barocas, Joshua A

American journal of epidemiology

2022 Volume 191, Issue 12, Page(s) 2098–2108

Abstract: The decades-long overdose epidemic in the United States is driven by opioid misuse. Overdoses commonly, although not exclusively, occur in individuals with opioid use disorder (OUD). To allocate adequate resources and develop appropriately scaled public ... ...

Abstract	The decades-long overdose epidemic in the United States is driven by opioid misuse. Overdoses commonly, although not exclusively, occur in individuals with opioid use disorder (OUD). To allocate adequate resources and develop appropriately scaled public health responses, accurate estimation of the prevalence of OUD is needed. Indirect methods (e.g., a multiplier method) of estimating prevalence of problematic substance-use behavior circumvent some limitations of household surveys and use of administrative data. We used a multiplier method to estimate OUD prevalence among the adult Medicaid population (ages 18-64 years) in 19 Ohio counties that are highly affected by overdose. We used Medicaid claims data and the US National Vital Statistics System overdose death data, which were linked at the person level. A statistical model leveraged opioid-related death rate information from a group with known OUD to estimate prevalence among a group with unknown OUD status given recorded opioid-related deaths in that group. We estimated that 13.6% of the total study population had OUD in 2019. Men (16.7%) had a higher prevalence of OUD than women (11.4%), and persons aged 35-54 had the highest prevalence (16.7%). Our approach to prevalence estimation has important implications for OUD surveillance and treatment in the United States.
MeSH term(s)	Adult ; Male ; Humans ; United States/epidemiology ; Female ; Analgesics, Opioid/adverse effects ; Medicaid ; Prevalence ; Ohio/epidemiology ; Opioid-Related Disorders/epidemiology ; Drug Overdose/epidemiology
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2022-08-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2937-3
ISSN	1476-6256 ; 0002-9262
ISSN (online)	1476-6256
ISSN	0002-9262
DOI	10.1093/aje/kwac154
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Article: Strategies to Achieve Breast Health Equity in the St. Louis Region and Beyond over 15+ Years.

Drake, Bettina / James, Aimee / Miller, Heidi / Anandarajah, Akila / Davis, Kia L / Jackson, Sheryll / Colditz, Graham A / Thompson, Vetta Sanders

Cancers

2022 Volume 14, Issue 10

Abstract: Community-based participatory strategies are a promising approach to addressing disparities in community health outcomes. This paper details the efforts of Siteman Cancer Center to achieve breast health equity over the past 15+ years. We begin by ... ...

Abstract	Community-based participatory strategies are a promising approach to addressing disparities in community health outcomes. This paper details the efforts of Siteman Cancer Center to achieve breast health equity over the past 15+ years. We begin by describing the activities and successes arising from our breast health community partnerships including identifying priorities, developing recommendations, and implementing patient navigation services to advance breast health. This system-wide coordinated navigation approach that includes primary and specialty care providers helped to increase potential impact on reducing breast health disparities by expediting care, increasing care efficiency, and standardizing referral procedures across systems for all women including those who are uninsured and underinsured. We also discuss a mobile mammography unit that has been deployed to serve women living in both urban and rural regions. The van reached a particularly vulnerable population that was mostly poor, uninsured, and with limited educational backgrounds regardless of their zip code of service. This work shows that collaborations between academic and community partners have resulted in decreased late stage at diagnosis and improved access to mammography. Furthermore, we offer lessons learned and recommendations that may be applicable to other communities.
Language	English
Publishing date	2022-05-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14102550
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Article ; Online: Heterogeneous genetic and non-genetic mechanisms contribute to response and resistance to azacitidine monotherapy.

Symeonidou, Vasiliki / Metzner, Marlen / Usukhbayar, Batchimeg / Jackson, Aimee E / Fox, Sonia / Craddock, Charles F / Vyas, Paresh

EJHaem

2022 Volume 3, Issue 3, Page(s) 794–803

Abstract: Acute myeloid leukaemia is prevalent in older patients that are often ineligible for intensive chemotherapy and treatment options remain limited with azacitidine being at the forefront. Azacitidine has been used in the clinic for decades, however, we ... ...

Abstract	Acute myeloid leukaemia is prevalent in older patients that are often ineligible for intensive chemotherapy and treatment options remain limited with azacitidine being at the forefront. Azacitidine has been used in the clinic for decades, however, we still lack a complete understanding of the mechanisms by which the drug exerts its anti-tumour effect. To gain insight into the mechanism of action, we defined the mutational profile of sequential samples of patients treated with azacitidine. We did not identify any mutations that could predict response and observed lack of a uniform pattern of clonal evolution. Focusing on responders, at remission, we observed three types of response: (1) an almost complete elimination of mutations (33%), (2) no change (17%), and (3) change with no discernible pattern (50%). Heterogeneous patterns were also observed at relapse, with no clonal evolution between remission and relapse in some patients. Lack of clonal evolution suggests that non-genetic mechanisms might be involved. Towards understanding such mechanisms, we investigated the immune microenvironment in a number of patients and we observed lack of a uniform response following therapy. We identified a higher frequency of cytotoxic T cells in responders and higher frequency of naïve helper T cells in non-responders.
Language	English
Publishing date	2022-07-08
Publishing country	United States
Document type	Journal Article
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.527
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