LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 246

Search options

  1. Book ; Online: Double-edged Swords: Genetic Factors That Influence the Pathogenesis of Both Metabolic Disease and Cancer

    Kung, Che-Pei / Murphy, Maureen E. / Lu, Hua

    2019  

    Keywords Medicine ; Endocrinology ; CER ; metabolic disease ; genetic factors ; diabetes ; Obesity ; cardiovascular disease ; ferroptosis ; RNA ; fatty acid ; Glycolysis
    Size 1 electronic resource (130 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230320
    ISBN 9782889630301 ; 2889630307
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Elucidating the chain of command: our current understanding of critical target genes for p53-mediated tumor suppression.

    Indeglia, Alexandra / Murphy, Maureen E

    Critical reviews in biochemistry and molecular biology

    2024  , Page(s) 1–11

    Abstract: ... ...

    Abstract TP53
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1000977-2
    ISSN 1549-7798 ; 1381-3455 ; 1040-9238
    ISSN (online) 1549-7798
    ISSN 1381-3455 ; 1040-9238
    DOI 10.1080/10409238.2024.2344465
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1024: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: p53 Oligomerization Domain Mutants: A New Class of Mutants That Retain "License to Kill".

    Stieg, David / Casey, Kaitlyn / Murphy, Maureen E

    Cancer discovery

    2023  Volume 13, Issue 5, Page(s) 1046–1048

    Abstract: Summary: In this issue of Cancer Discovery, companion articles from the Prives and Lozano groups describe functional analyses of a common dimeric mutant of p53 found in Li-Fraumeni disease and sporadic cancer: A347D (AD). The authors show that the AD ... ...

    Abstract Summary: In this issue of Cancer Discovery, companion articles from the Prives and Lozano groups describe functional analyses of a common dimeric mutant of p53 found in Li-Fraumeni disease and sporadic cancer: A347D (AD). The authors show that the AD mutant is completely defective for canonical p53 transcriptional function, but interestingly retains some tumor suppressor function, which they show is manifested as "neomorphic" activities in transcription and the control of mitochondrial metabolism. See related article by Gencel-Augusto et al., p. 1230 (7). See related article by Choe et al., p. 1250 (6).
    MeSH term(s) Humans ; Li-Fraumeni Syndrome/metabolism ; Tumor Suppressor Protein p53/metabolism ; Transcriptional Activation ; Cell Death
    Chemical Substances Tumor Suppressor Protein p53
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-23-0200
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6916: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Editorial: Double-edged swords: Important factors connecting metabolic disorders and cancer development - from basic research to translational applications.

    Kung, Che-Pei / Barnoud, Thibaut / Yao, Cong-Hui / Murphy, Maureen E

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1168700

    MeSH term(s) Humans ; Metabolic Syndrome ; Metabolic Diseases/etiology ; Neoplasms/etiology
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1168700
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: The Use of Albuterol/Budesonide as Reliever Therapy to Reduce Asthma Exacerbations.

    Panettieri, Reynold A / Chipps, Bradley E / Skolnik, Neil / George, Maureen / Murphy, Kevin / Lugogo, Njira

    The journal of allergy and clinical immunology. In practice

    2024  Volume 12, Issue 4, Page(s) 882–888

    Abstract: Prevention of asthma exacerbations and reduction of systemic corticosteroid burden remain unmet needs in asthma. US asthma guidelines recommend concomitant short-acting ... ...

    Abstract Prevention of asthma exacerbations and reduction of systemic corticosteroid burden remain unmet needs in asthma. US asthma guidelines recommend concomitant short-acting β
    MeSH term(s) Humans ; Adolescent ; Adult ; Budesonide/therapeutic use ; Albuterol/therapeutic use ; Anti-Asthmatic Agents ; Ethanolamines/adverse effects ; Asthma/drug therapy ; Asthma/chemically induced ; Adrenal Cortex Hormones ; Administration, Inhalation ; Inflammation/drug therapy ; Formoterol Fumarate/therapeutic use ; Bronchodilator Agents/therapeutic use
    Chemical Substances Budesonide (51333-22-3) ; Albuterol (QF8SVZ843E) ; Anti-Asthmatic Agents ; Ethanolamines ; Adrenal Cortex Hormones ; Formoterol Fumarate (W34SHF8J2K) ; Bronchodilator Agents
    Language English
    Publishing date 2024-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2024.01.043
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 7086: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: P53 regulates cellular redox state, ferroptosis and metabolism.

    Leu, Julia I-Ju / Murphy, Maureen E / George, Donna L

    Molecular & cellular oncology

    2021  Volume 8, Issue 2, Page(s) 1877076

    Abstract: The tumor ... ...

    Abstract The tumor protein
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2021.1877076
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Ironing out how p53 regulates ferroptosis.

    Murphy, Maureen E

    Proceedings of the National Academy of Sciences of the United States of America

    2016  Volume 113, Issue 44, Page(s) 12350–12352

    Language English
    Publishing date 2016-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1615159113
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Targeting ErbB3 and Cellular NADPH/NADP

    Leu, Julia I. / Murphy, Maureen E / George, Donna L

    ACS chemical biology

    2022  Volume 17, Issue 5, Page(s) 1038–1044

    Abstract: Melanoma is a serious health challenge. Ferroptosis is a regulated form of oxidative cell death that shows varied efficacy in melanoma. We aimed to better understand the molecular basis for this differential ferroptosis sensitivity. We find that elevated ...

    Abstract Melanoma is a serious health challenge. Ferroptosis is a regulated form of oxidative cell death that shows varied efficacy in melanoma. We aimed to better understand the molecular basis for this differential ferroptosis sensitivity. We find that elevated expression of ErbB3 (V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homologue 3) associates with ferroptosis resistance and that ErbB3 knockdown sensitizes to ferroptosis inducers. ErbB3 depletion also promotes a marked reduction in the cellular ratio of GSH/GSSG (reduced/oxidized glutathione) and that of NADPH/NADP
    MeSH term(s) Ferroptosis ; Glutathione Disulfide/metabolism ; Humans ; Melanoma/drug therapy ; NADP/metabolism ; Receptor, ErbB-3 ; Skin Neoplasms ; Melanoma, Cutaneous Malignant
    Chemical Substances NADP (53-59-8) ; ERBB3 protein, human (EC 2.7.10.1) ; Receptor, ErbB-3 (EC 2.7.10.1) ; Glutathione Disulfide (ULW86O013H)
    Language English
    Publishing date 2022-04-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/acschembio.2c00113
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article: NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in Solitary Fibrous Tumors.

    Hill, Connor M / Indeglia, Alexandra / Picone, Francis / Murphy, Maureen E / Cipriano, Cara / Maki, Robert G / Gardini, Alessandro

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The pathogenesis of many rare tumor types is poorly understood, preventing the design of effective treatments. Solitary fibrous tumors (SFTs) are neoplasms of mesenchymal origin that affect 1/1,000,000 individuals every year and are clinically ... ...

    Abstract The pathogenesis of many rare tumor types is poorly understood, preventing the design of effective treatments. Solitary fibrous tumors (SFTs) are neoplasms of mesenchymal origin that affect 1/1,000,000 individuals every year and are clinically assimilated to soft tissue sarcomas. SFTs can arise throughout the body and are usually managed surgically. However, 30-40% of SFTs will relapse local-regionally or metastasize. There are no systemic therapies with durable activity for malignant SFTs to date. The molecular hallmark of SFTs is a gene fusion between the
    Language English
    Publishing date 2024-04-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.04.15.589533
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article ; Online: Shifting the paradigms for tumor suppression: lessons from the p53 field.

    Barnoud, Thibaut / Indeglia, Alexandra / Murphy, Maureen E

    Oncogene

    2021  Volume 40, Issue 25, Page(s) 4281–4290

    Abstract: The TP53 gene continues to hold distinction as the most frequently mutated gene in cancer. Since its discovery in 1979, hundreds of research groups have devoted their efforts toward understanding why this gene is so frequently selected against by tumors, ...

    Abstract The TP53 gene continues to hold distinction as the most frequently mutated gene in cancer. Since its discovery in 1979, hundreds of research groups have devoted their efforts toward understanding why this gene is so frequently selected against by tumors, with the hopes of harnessing this information toward the improved therapy of cancer. The result is that this protein has been meticulously analyzed in tumor and normal cells, resulting in over 100,000 publications, with an average of 5000 papers published on p53 every year for the past decade. The journey toward understanding p53 function has been anything but straightforward; in fact, the field is notable for the numerous times that established paradigms not only have been shifted, but in fact have been shattered or reversed. In this review, we will discuss the manuscripts, or series of manuscripts, that have most radically changed our thinking about how this tumor suppressor functions, and we will delve into the emerging challenges for the future in this important area of research. It is hoped that this review will serve as a useful historical reference for those interested in p53, and a useful lesson on the need to be flexible in the face of established paradigms.
    MeSH term(s) Animals ; Genes, p53/genetics ; Humans ; Mutation/genetics ; Neoplasms/genetics ; Tumor Suppressor Protein p53/genetics
    Chemical Substances Tumor Suppressor Protein p53
    Language English
    Publishing date 2021-06-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 639046-8
    ISSN 1476-5594 ; 0950-9232
    ISSN (online) 1476-5594
    ISSN 0950-9232
    DOI 10.1038/s41388-021-01852-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top