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  1. Book: Endocrine immunology

    Savino, Wilson / Guaraldi, Federica

    (Frontiers of hormone research ; 48)

    2017  

    Author's details volume editors Wilson Savino, Federica Guaraldi
    Series title Frontiers of hormone research ; 48
    Collection
    Keywords Endocrine System / immunology ; Endocrine System / physiology ; Immunomodulation / immunology ; Hormones / immunology ; Autoimmunity / immunology
    Language English
    Size VII, 180 Seiten, Illustrationen, Diagramme
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019282787
    ISBN 978-3-31806013-3 ; 9783318060140 ; 3-31806013-5 ; 3318060143
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 A 606 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Uma experiência no ensino de Embriologia para pequenos grupos

    Wilson Savino

    Revista Brasileira de Educação Médica, Vol 6, Iss 1, Pp 25-

    2022  Volume 27

    Keywords Education (General) ; L7-991 ; Medicine (General) ; R5-920
    Language Portuguese
    Publishing date 2022-01-01T00:00:00Z
    Publisher Associção Brasileira de Educação Médica
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  3. Book ; Online: Hormones, Neurotransmitters, and T-Cell Development in Health and Disease

    Savino, Wilson / Areas Mendes-da-Cruz, Daniella / Rosa Pérez, Ana / Geenen, Vincent

    2019  

    Keywords Medicine ; Endocrinology ; Glucocorticoids ; Growth hormone ; Sympathetic innervation ; Galectins ; Thymus ; Norepinephrine ; Ephrins ; Diabetes ; Infectious diseases ; Cytokines
    Size 1 electronic resource (110 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231169
    ISBN 9782889630264 ; 2889630269
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Book ; Conference proceedings: Neuroimmunomodulation

    Savino, Wilson

    from fundamental biology to therapy ; [result of a conference entitled the VII congress of the International Society for Neuroimmunomodulation (ISNIM), held April 14 - 27, 2008 in Rio de Janeiro, Brazil

    (Annals of the New York Academy of Sciences ; 1153)

    2009  

    Institution International Society for Neuroimmunomodulation
    Author's details ed. by Wilson Savino
    Series title Annals of the New York Academy of Sciences ; 1153
    Collection
    Language English
    Size XI, 274 S. : Ill., graph. Darst.
    Publisher Blackwell
    Publishing place Boston, Mass
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT015862128
    ISBN 978-1-57331-746-7 ; 1-57331-746-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 110 -1153- verfügbar in Königswinter Königswinter

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  5. Book: Neuroendocrine immunology of the thymus

    Savino, Wilson / Dardenne, Mireille

    5 tables

    (Neuroimmunomodulation ; 18,5)

    2011  

    Author's details ed. Wilson Savino ; Mireille Dardenne
    Series title Neuroimmunomodulation ; 18,5
    Collection
    Language English
    Size S. 263 - 357 : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT016982681
    ISBN 978-3-8055-9831-6 ; 3-8055-9831-9 ; 9783805598323 ; 3805598327
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3975 -18- not available for loan Zeitschriften-Lesesaal

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  6. Article: Thymus-derived hormonal and cellular control of cancer.

    Savino, Wilson / Lepletier, Ailin

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1168186

    Abstract: The thymus gland is a central lymphoid organ in which developing T cell precursors, known as thymocytes, undergo differentiation into distinct type of mature T cells, ultimately migrating to the periphery where they exert specialized effector functions ... ...

    Abstract The thymus gland is a central lymphoid organ in which developing T cell precursors, known as thymocytes, undergo differentiation into distinct type of mature T cells, ultimately migrating to the periphery where they exert specialized effector functions and orchestrate the immune responses against tumor cells, pathogens and self-antigens. The mechanisms supporting intrathymic T cell differentiation are pleiotropically regulated by thymic peptide hormones and cytokines produced by stromal cells in the thymic microenvironment and developing thymocytes. Interestingly, in the same way as T cells, thymic hormones (herein exemplified by thymosin, thymulin and thymopoietin), can circulate to impact immune cells and other cellular components in the periphery. Evidence on how thymic function influences tumor cell biology and response of patients with cancer to therapies remains unsatisfactory, although there has been some improvement in the knowledge provided by recent studies. Herein, we summarize research progression in the field of thymus-mediated immunoendocrine control of cancer, providing insights into how manipulation of the thymic microenvironment can influence treatment outcomes, including clinical responses and adverse effects of therapies. We review data obtained from clinical and preclinical cancer research to evidence the complexity of immunoendocrine interactions underpinning anti-tumor immunity.
    MeSH term(s) Humans ; Thymus Gland ; T-Lymphocytes ; Cytokines/metabolism ; Neoplasms/metabolism ; Peptides/metabolism ; Tumor Microenvironment
    Chemical Substances Cytokines ; Peptides
    Language English
    Publishing date 2023-07-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1168186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Brain-Thymus Connections in Chagas Disease.

    González, Florencia Belén / Savino, Wilson / Pérez, Ana Rosa

    Neuroimmunomodulation

    2024  Volume 31, Issue 1, Page(s) 78–88

    Abstract: Background: The brain and the immune systems represent the two primary adaptive systems within the body. Both are involved in a dynamic process of communication, vital for the preservation of mammalian homeostasis. This interplay involves two major ... ...

    Abstract Background: The brain and the immune systems represent the two primary adaptive systems within the body. Both are involved in a dynamic process of communication, vital for the preservation of mammalian homeostasis. This interplay involves two major pathways: the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system.
    Summary: The establishment of infection can affect immunoneuroendocrine interactions, with functional consequences for immune organs, particularly the thymus. Interestingly, the physiology of this primary organ is not only under the control of the central nervous system (CNS) but also exhibits autocrine/paracrine regulatory circuitries mediated by hormones and neuropeptides that can be altered in situations of infectious stress or chronic inflammation. In particular, Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), impacts upon immunoneuroendocrine circuits disrupting thymus physiology. Here, we discuss the most relevant findings reported in relation to brain-thymic connections during T. cruzi infection, as well as their possible implications for the immunopathology of human Chagas disease.
    Key messages: During T. cruzi infection, the CNS influences thymus physiology through an intricate network involving hormones, neuropeptides, and pro-inflammatory cytokines. Despite some uncertainties in the mechanisms and the fact that the link between these abnormalities and chronic Chagasic cardiomyopathy is still unknown, it is evident that the precise control exerted by the brain over the thymus is markedly disrupted throughout the course of T. cruzi infection.
    MeSH term(s) Humans ; Chagas Disease/immunology ; Chagas Disease/physiopathology ; Animals ; Brain/immunology ; Thymus Gland/immunology ; Thymus Gland/physiology ; Trypanosoma cruzi/physiology ; Trypanosoma cruzi/immunology ; Hypothalamo-Hypophyseal System/immunology ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/physiopathology ; Neuroimmunomodulation/physiology ; Neuroimmunomodulation/immunology ; Pituitary-Adrenal System/immunology ; Pituitary-Adrenal System/physiopathology ; Pituitary-Adrenal System/metabolism
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1184368-8
    ISSN 1423-0216 ; 1021-7401
    ISSN (online) 1423-0216
    ISSN 1021-7401
    DOI 10.1159/000538220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3975: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Developing anti-helminth vaccines for people and cattle: (For)seeing the

    Tendler, Miriam / Savino, Wilson / Almeida, Marilia Sirianni Dos Santos

    One health (Amsterdam, Netherlands)

    2023  Volume 17, Page(s) 100616

    Language English
    Publishing date 2023-08-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2023.100616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Neuroendocrine control of the thymus

    Savino, Wilson

    18 tables

    1999  

    Author's details ed. W. Savino
    Language English
    Size 143 S. : Ill., graph. Darst.
    Edition Reprint.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    Note Aus: Neuroimmunomodulation ; 6.1999,1-2
    HBZ-ID HT010079055
    ISBN 3-8055-6769-3 ; 978-3-8055-6769-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 A 1797 order for loan Magazin

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  10. Article ; Online: Prolactin: An Immunomodulator in Health and Disease.

    Savino, Wilson

    Frontiers of hormone research

    2017  Volume 48, Page(s) 69–75

    Abstract: Various lines of evidence show that prolactin (PRL) is an immunomodulator in health and disease. Cells of the immune system express PRL receptors and respond to the cognate ligand. Also, PRL itself is produced by several immune cells, indicating that in ... ...

    Abstract Various lines of evidence show that prolactin (PRL) is an immunomodulator in health and disease. Cells of the immune system express PRL receptors and respond to the cognate ligand. Also, PRL itself is produced by several immune cells, indicating that in addition to its classic endocrine effects, it may also act via paracrine/autocrine pathways. PRL stimulates B and T lymphocyte proliferation, and its excess is associated with the appearance or recrudescence of various systemic and organ-specific autoimmune diseases, as demonstrated by experimental studies performed in mice, and by human case reports and case control studies. Very recently, dopamine agonists have been demonstrated to be efficacious in the treatment of some autoimmune disorders, placing PRL-mediated interactions as potential therapeutic targets for treating autoimmunity.
    MeSH term(s) Animals ; Autoimmune Diseases/metabolism ; Autoimmune Diseases/therapy ; Humans ; Immunomodulation/physiology ; Prolactin/metabolism
    Chemical Substances Prolactin (9002-62-4)
    Language English
    Publishing date 2017
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1662-3762 ; 0301-3073
    ISSN (online) 1662-3762
    ISSN 0301-3073
    DOI 10.1159/000452906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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