Article ; Online: The HLA-G Genetic Contribution to Bipolar Disorder: A Trans-Ethnic Replication.
2018 Volume 47, Issue 6, Page(s) 593–604
Abstract: ... the genetic diversity of the immuno-modulatory human leukocyte antigen (HLA)-G locus in a French BD cohort ... The present study investigated the genetic and expression diversities of HLA-G in a geographically distinct ... Toxoplasma gondii pathogen. Three functionally relevant HLA-G polymorphisms, i.e. HLA-G 14 bp Ins/Del (rs66554220 ...
| Abstract | Bipolar disorder (BD) is frequently associated with immune dysfunctions. Studying the genetic diversity of the immuno-modulatory human leukocyte antigen (HLA)-G locus in a French BD cohort, we previously reported an association between a functionally relevant 14 bp Ins/Del polymorphism and BD risk. The present study investigated the genetic and expression diversities of HLA-G in a geographically distinct South Indian population-group BD patients, as well as the influence of exposure to the neurotropic Toxoplasma gondii pathogen. Three functionally relevant HLA-G polymorphisms, i.e. HLA-G 14 bp Ins/Del (rs66554220), +3142G>C (rs1063320) and +3187A>G (rs9380142) were genotyped by polymerase chain reaction (PCR) and real-time PCR. Sub-samples of BD patients and healthy controls (HC) were investigated for plasma levels of soluble HLA-G (sHLA-G) isoforms, as well as circulating stigma of T. gondii infection. Findings indicate: (i) the frequency of the HLA-G 14 bp Del/Del genotype was higher in BD cases, as compared to HC; (ii) the HLA-G + 3142 C allele and CC genotype were more prevalent in BD patients than in HC; (iii) sHLA-G levels were significantly higher in BD cases, especially in females and in the early onset sub-group; and (iv) the InsGA haplotype was more prevalent in HC. Our findings further support the genetic contribution of HLA-G to BD risk, as well as indicate relevant expression profiles. Such data may also indicate a potential developmental role in BD etiology, given that HLA-G is an important immune regulator from the intrauterine period and across development. |
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| MeSH term(s) | Adolescent ; Adult ; Bipolar Disorder/complications ; Bipolar Disorder/genetics ; Bipolar Disorder/immunology ; Case-Control Studies ; Ethnic Groups/genetics ; Female ; France ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; HLA-G Antigens/genetics ; HLA-G Antigens/immunology ; Humans ; INDEL Mutation/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Toxoplasma ; Toxoplasmosis/complications ; Young Adult |
| Chemical Substances | HLA-G Antigens |
| Language | English |
| Publishing date | 2018-05-08 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 632565-8 |
| ISSN | 1532-4311 ; 0882-0139 |
| ISSN (online) | 1532-4311 |
| ISSN | 0882-0139 |
| DOI | 10.1080/08820139.2018.1469649 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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