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  1. Book ; Thesis: Der Einfluss des Empfänger-Body-Mass-Index auf das Outcome nach Nierentransplantation

    Bottner, Nils Ole

    2020  

    Institution Goethe-Universität Frankfurt am Main
    Author's details vorgelegt von Nils Ole Bottner
    Language German
    Size 68 Seiten, Diagramme, 21 cm
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2021
    Note Zusammenfassung auf Deutsch und Englisch
    HBZ-ID HT021172851
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 D 652 order for loan Magazin

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  2. Article ; Online: Experimental validation of phase-only pre-compensation over 494  m free-space propagation.

    Brady, Aoife / Berlich, René / Leonhard, Nina / Kopf, Teresa / Böttner, Paul / Eberhardt, Ramona / Reinlein, Claudia

    Optics letters

    2017  Volume 42, Issue 14, Page(s) 2679–2682

    Abstract: It is anticipated that ground-to-geostationary orbit (GEO) laser communication will benefit from pre-compensation of atmospheric turbulence for laser beam propagation through the atmosphere. Theoretical simulations and laboratory experiments have ... ...

    Abstract It is anticipated that ground-to-geostationary orbit (GEO) laser communication will benefit from pre-compensation of atmospheric turbulence for laser beam propagation through the atmosphere. Theoretical simulations and laboratory experiments have determined its feasibility; extensive free-space experimental validation has, however, yet to be fulfilled. Therefore, we designed and implemented an adaptive optical (AO)-box which pre-compensates an outgoing laser beam (uplink) using the measurements of an incoming beam (downlink). The setup was designed to approximate the baseline scenario over a horizontal test range of 0.5 km and consisted of a ground terminal with the AO-box and a simplified approximation of a satellite terminal. Our results confirmed that we could focus the uplink beam on the satellite terminal using AO under a point-ahead angle of 28 μrad. Furthermore, we demonstrated a considerable increase in the intensity received at the satellite. These results are further testimony to AO pre-compensation being a viable technique to enhance Earth-to-GEO optical communication.
    Language English
    Publishing date 2017-07-15
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.42.002679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Induced responses contribute to rapid adaptation of Spirodela polyrhiza to herbivory by Lymnaea stagnalis.

    Malacrinò, Antonino / Böttner, Laura / Nouere, Sara / Huber, Meret / Schäfer, Martin / Xu, Shuqing

    Communications biology

    2024  Volume 7, Issue 1, Page(s) 81

    Abstract: Herbivory-induced responses in plants are typical examples of phenotypic plasticity, and their evolution is thought to be driven by herbivory. However, direct evidence of the role of induced responses in plant adaptive evolution to herbivores is scarce. ... ...

    Abstract Herbivory-induced responses in plants are typical examples of phenotypic plasticity, and their evolution is thought to be driven by herbivory. However, direct evidence of the role of induced responses in plant adaptive evolution to herbivores is scarce. Here, we experimentally evolve populations of an aquatic plant (Spirodela polyrhiza, giant duckweed) and its native herbivore (Lymnaea stagnalis, freshwater snail), testing whether herbivory drives rapid adaptive evolution in plant populations using a combination of bioassays, pool-sequencing, metabolite analyses, and amplicon metagenomics. We show that snail herbivory drove rapid phenotypic changes, increased herbivory resistance, and altered genotype frequencies in the plant populations. Additional bioassays suggest that evolutionary changes of induced responses contributed to the rapid increase of plant resistance to herbivory. This study provides direct evidence that herbivory-induced responses in plants can be subjected to selection and have an adaptive role by increasing resistance to herbivores.
    MeSH term(s) Animals ; Lymnaea ; Herbivory ; Araceae ; Adaptation, Physiological ; Biological Assay
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05706-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The chronic myelocytic cell line K 562 contains minor (m) as well as major (M) ber/abl fusion mRNAs.

    Seelig, R / Schranz, P / Bottner, C / Neubauer, A / Seelig, H P / Renz, M

    Leukemia

    1993  Volume 7, Issue 11, Page(s) 1886–1887

    Abstract: By searching for additional chimeric bcr/abl transcripts in K 562 cells characterized by major (M ... bcr/abl fusions, a new mRNA, a minor (m) bcr/abl transcript, was detected. A practical implication ...

    Abstract By searching for additional chimeric bcr/abl transcripts in K 562 cells characterized by major (M) bcr/abl fusions, a new mRNA, a minor (m) bcr/abl transcript, was detected. A practical implication of this finding is that the K 562 cell line can be used as positive control for the detection by the polymerase chain reaction of both types of transcripts for the diagnosis of Philadelphia chromosome associated leukemias.
    MeSH term(s) Base Sequence ; Fusion Proteins, bcr-abl/genetics ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism ; Molecular Sequence Data ; Polymerase Chain Reaction/methods ; RNA, Messenger/analysis ; RNA, Neoplasm/analysis ; Transcription, Genetic ; Tumor Cells, Cultured/chemistry
    Chemical Substances RNA, Messenger ; RNA, Neoplasm ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
    Language English
    Publishing date 1993-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 807030-1
    ISSN 1476-5551 ; 0887-6924
    ISSN (online) 1476-5551
    ISSN 0887-6924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2295: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Book ; Thesis: Frühergebnisse nach operativer und konservativer Kreuzbandbehandlung

    Böttner, Matthias

    eine prospektive vergleichende Studie

    1995  

    Author's details vorgelegt von Matthias Böttner
    Language German
    Size 88 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Göttingen, Univ., Diss., 1997
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT011099355
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1999 MB 1103 order for loan Magazin

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  6. Article ; Online: Deciphering integration loci of CHO manufacturing cell lines using long read nanopore sequencing.

    Clappier, Christian / Böttner, Dennis / Heinzelmann, Daniel / Stadermann, Anna / Schulz, Patrick / Schmidt, Moritz / Lindner, Benjamin

    New biotechnology

    2023  Volume 75, Page(s) 31–39

    Abstract: Despite advances in genetic characterization of Chinese hamster ovary (CHO) cell lines regarding identification of integration sites using next generation sequencing, e.g. targeted locus amplification sequencing (TLA-seq), the concatemer structure of the ...

    Abstract Despite advances in genetic characterization of Chinese hamster ovary (CHO) cell lines regarding identification of integration sites using next generation sequencing, e.g. targeted locus amplification sequencing (TLA-seq), the concatemer structure of the integrated vectors remains elusive. Here, the entire integration locus of two CHO manufacturing cell lines was reconstructed combining CRISPR/Cas9 target enrichment, nanopore sequencing and the Canu de novo assembly pipeline. An IgG producing CHO cell line integrated 3 vector copies, which were near full-length and contained all relevant vector elements such as transgenes and their promoters on each of the vector copies. In contrast, a second CHO cell line producing a bivalent bispecific antibody integrated 7 highly fragmented vector copies in different orientations leading to head-to-head and tail-to-tail fusions. The size of the vector fragments ranged from 3.0 to 11.4 kbp each carrying 1-3 transgenes. The breakpoints of the genome-vector and vector-vector junctions were validated using Sanger sequencing and Southern blotting. A comparison to TLA-seq data confirmed the genomic breakpoints, but most of the breakpoints of the vector-vector fusions were missed by TLA-seq. For the first time, the complete transgene locus of CHO manufacturing cell lines could be deciphered. Strikingly, the application of the nanopore long-read sequencing technology led to novel insights into the complexity of genomic transgene integrations of CHO manufacturing cell lines generated via random integration.
    MeSH term(s) Cricetinae ; Animals ; Cricetulus ; CHO Cells ; Nanopore Sequencing ; Transgenes ; Promoter Regions, Genetic
    Language English
    Publishing date 2023-03-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2400836-9
    ISSN 1876-4347 ; 1876-4347
    ISSN (online) 1876-4347
    ISSN 1876-4347
    DOI 10.1016/j.nbt.2023.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Decomposition of Standard Plant Material Along an Altitudinal Transect (65-3968 m) in the Tropical Andes

    Couteaux, M. M. / Sarmiento, L. / Bottner, P. / Acevedo, D. / Thiery, J. M.

    2002  , Page(s) S. 69–78

    Keywords Biologischer Abbau ; Topographische Hoehe ; Pflanze ; Organische Substanz ; Gebirge ; Terrestrisches Oekosystem ; Tropisches Oekosystem ; Alpines Oekosystem ; Reaktionskinetik ; Bodenchemie ; Gesamter organischer Kohlenstoff ; Kohlenstoffzyklus ; Klimawirkung ; Klimaabhaengigkeit ; Wirkungsanalyse ; Standortbewertung ; Kohlenstoffisotop ; Isotopenanwendung ; Vegetation ; Flaechennutzung ; Grasland ; Meteorologischer Parameter ; Niederschlagshoehe ; Bodenbeschaffenheit ; Bodenuntersuchung ; pH-Wert ; Gesamtstickstoff ; Sand ; Schluff ; Ton (Mineral) ; Stroh ; Temperaturabhaengigkeit ; Kausalzusammenhang ; Bedarfsanalyse
    Language English
    Document type Article
    Database OPAC and Environmental database (ULIDAT) of The Federal Environment Agency (UBA)

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  8. Article: Decomposition of standard plant material along an altitudinal transect (65-3968 m) in the tropical Andes

    Couteaux, M.M / Sarmiento, L / Bottner, P / Acevedo, D / Thiery, J.M

    Soil biology & biochemistry. Jan 2002. v. 34 (1)

    2002  

    Abstract: ... to 3968 m under tropical conditions. Six sites were studied, with a mean annual temperature ranging from 5 ...

    Abstract The dynamics of plant decomposition in the soil were analysed in an altitudinal transect from 65 to 3968 m under tropical conditions. Six sites were studied, with a mean annual temperature ranging from 5.5 to 27.4 degrees C, and an annual precipitation from 790 to 1992 mm. A 14C-labelled standard plant material was incubated in situ, at 5 cm depth, over a period of 1.5-3 years, depending on the altitude. The aim was to determine the contribution of climate (temperature and moisture) and of other factors, such as soil properties, to explaining the differences in mineralisation between the sites. Data analysis was performed using two-compartment models with first-order kinetics. To evaluate the effect of climate on decomposition, a response function to temperature (tau) and a response function to moisture (mu) were calculated. The kinetics of the remaining 14C were adjusted to the two-compartment first-order model considering successively time, tau(cum) (cumulated tau), and tau mu(cum) (cumulated tau mu) as independent variables. The assumption was that if the introduction of a climatic component into the explanatory variable reduces the distances between the decomposition curves of the sites, the differences are related to this factor. If the distance is not reduced, other factors in addition to climate must influence decomposition and/or the climatic response to altitude is not linear. The results show a clear decrease in decomposition with increasing altitude. Nevertheless, the altitudinal effect is not equal for the two fractions estimated using the two-compartment model. The size of the labile fraction decreased with altitude, whereas the recalcitrant fraction increased. The labile fraction decomposed very quickly, independently of the altitude, whereas the rate of decomposition of the recalcitrant fraction decreased with altitude. When tau(cum) is used as the independent variable, the distance between the curves diminishes, indicating the great effect of temperature on decomposition, but in the high mountain sites, additional factors act. Using tau mu(cum) the difference between sites was not reduced, showing that the moisture effect is low or that the moisture response function is not appropriate.
    Keywords soil microorganisms ; degradation ; soil organic matter ; tropical soils ; forest soils ; mountain soils ; altitude ; mountains ; air temperature ; ambient temperature ; soil water ; mineralization ; Venezuela
    Language English
    Dates of publication 2002-01
    Size p. 69-78.
    Document type Article
    ZDB-ID 280810-9
    ISSN 0038-0717
    ISSN 0038-0717
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2637: Show issues

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  9. Article ; Online: Natural rubber reduces herbivory and alters the microbiome below ground.

    Böttner, Laura / Malacrinò, Antonino / Schulze Gronover, Christian / van Deenen, Nicole / Müller, Boje / Xu, Shuqing / Gershenzon, Jonathan / Prüfer, Dirk / Huber, Meret

    The New phytologist

    2023  Volume 239, Issue 4, Page(s) 1475–1489

    Abstract: ... root microbiota (ecto- and endophytes) and that these changes depended on M. melolontha damage ...

    Abstract Laticifers are hypothesized to mediate both plant-herbivore and plant-microbe interactions. However, there is little evidence for this dual function. We investigated whether the major constituent of natural rubber, cis-1,4-polyisoprene, a phylogenetically widespread and economically important latex polymer, alters plant resistance and the root microbiome of the Russian dandelion (Taraxacum koksaghyz) under attack of a root herbivore, the larva of the May cockchafer (Melolontha melolontha). Rubber-depleted transgenic plants lost more shoot and root biomass upon herbivory than normal rubber content near-isogenic lines. Melolontha melolontha preferred to feed on artificial diet supplemented with rubber-depleted rather than normal rubber content latex. Likewise, adding purified cis-1,4-polyisoprene in ecologically relevant concentrations to diet deterred larval feeding and reduced larval weight gain. Metagenomics and metabarcoding revealed that abolishing biosynthesis of natural rubber alters the structure but not the diversity of the rhizosphere and root microbiota (ecto- and endophytes) and that these changes depended on M. melolontha damage. However, the assumption that rubber reduces microbial colonization or pathogen load is contradicted by four lines of evidence. Taken together, our data demonstrate that natural rubber biosynthesis reduces herbivory and alters the plant microbiota, which highlights the role of plant-specialized metabolites and secretory structures in shaping multitrophic interactions.
    MeSH term(s) Animals ; Rubber/chemistry ; Rubber/metabolism ; Latex/metabolism ; Herbivory ; Coleoptera ; Larva ; Plants, Genetically Modified/metabolism ; Taraxacum/genetics
    Chemical Substances Rubber (9006-04-6) ; 1,4-polyisoprene (9003-31-0) ; Latex
    Language English
    Publishing date 2023-01-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    DOI 10.1111/nph.18709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 868: Show issues

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  10. Article ; Online: Localization Pattern of Dispatched Homolog 2 (DISP2) in the Central and Enteric Nervous System.

    Heimke, Marvin / Richter, Florian / Heinze, Tillmann / Kunke, Madlen / Wedel, Thilo / Böttner, Martina / Egberts, Jan-Hendrik / Lucius, Ralph / Cossais, François

    Journal of molecular neuroscience : MN

    2023  Volume 73, Issue 7-8, Page(s) 539–548

    Abstract: Dispatched homolog (DISP) proteins have been implicated in the regulation of hedgehog signaling during embryologic development. Although DISP2 has recently been associated with neuronal development and control of cognitive functions, its localization ... ...

    Abstract Dispatched homolog (DISP) proteins have been implicated in the regulation of hedgehog signaling during embryologic development. Although DISP2 has recently been associated with neuronal development and control of cognitive functions, its localization pattern in the mammalian central and peripheral nervous system has not yet been investigated. In this study, the Disp2 expression profile was assessed in human tissues from publicly available transcriptomic datasets. The DISP2 localization pattern was further characterized in the human and rat central nervous system (CNS), as well as within the colonic enteric nervous system (ENS) using dual-label immunohistochemistry. Colocalization of DISP2 with neuronal and glial markers was additionally analyzed in murine primary ENS culture. At transcriptomic level, DISP2 expression was predominant in neuronal cell types of the CNS and ENS. DISP2 immunoreactivity was mainly located within PGP9.5-positive neurons rather than in S100-positive glial cells throughout the nervous system. Investigation of human and rat brain tissues, colonic specimens, and murine ENS primary cultures revealed that DISP2 was located in neuronal cell somata, as well as along neuronal processes both in the human and murine CNS and ENS. Our results indicate that DISP2 is prominently localized within neuronal cells of the CNS and ENS and support putative functions of DISP2 in these tissues.
    MeSH term(s) Rats ; Mice ; Animals ; Humans ; Hedgehog Proteins/metabolism ; Enteric Nervous System ; Neurons/metabolism ; Neuroglia ; Mammals
    Chemical Substances Hedgehog Proteins
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1043392-2
    ISSN 1559-1166 ; 0895-8696
    ISSN (online) 1559-1166
    ISSN 0895-8696
    DOI 10.1007/s12031-023-02129-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3006: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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