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Article ; Online: Editorial commentary: Cystatin C and statins in HIV disease.

Kalayjian, Robert C

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2014 Volume 59, Issue 8, Page(s) 1157–1159

MeSH term(s)	Female ; Humans ; Male
Language	English
Publishing date	2014-10-15
Publishing country	United States
Document type	Comment ; Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciu527
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Article ; Online: Bisphosphonates in Perinatally Infected Children and Adolescents With Human Immunodeficiency Virus: Targeting Puberty.

Kalayjian, Robert C / McComsey, Grace A

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 71, Issue 5, Page(s) 1289–1291

MeSH term(s)	Adolescent ; Alendronate ; Bone Density ; Bone Diseases, Metabolic ; Child ; Diphosphonates/adverse effects ; HIV ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Puberty
Chemical Substances	Diphosphonates ; Alendronate (X1J18R4W8P)
Language	English
Publishing date	2020-09-01
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciz962
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Article ; Online: Kidney Disease in HIV-Infected Persons.

Kalayjian, Robert C

Current infectious disease reports

2011 Volume 14, Issue 1, Page(s) 83–90

Abstract: Kidney disease is more prevalent among persons living with HIV, and may arise from a combination of comorbidities, co-infections, and medication-associated toxicities. Additional effects of HIV-1 viral replication, immunodeficiency and genetic factors ... ...

Abstract	Kidney disease is more prevalent among persons living with HIV, and may arise from a combination of comorbidities, co-infections, and medication-associated toxicities. Additional effects of HIV-1 viral replication, immunodeficiency and genetic factors also contribute to kidney disease. As is true in the general population, persons of African descent exhibit a disproportionate risk for severe kidney disease. Antiretroviral therapy (ART) modifies the natural history of HIV-associated nephropathy (HIVAN), and renal benefits of ART may not be limited to persons with HIVAN. Robust associations between proteinuria and cardiovascular disease imply that common mechanisms of vascular endothelial dysfunction may contribute to both processes.
Language	English
Publishing date	2011-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2019948-X
ISSN	1534-3146 ; 1523-3847
ISSN (online)	1534-3146
ISSN	1523-3847
DOI	10.1007/s11908-011-0228-2
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Zs.A 5519: Show issues

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Article ; Online: Renal issues in HIV infection.

Kalayjian, Robert C

Current HIV/AIDS reports

2011 Volume 8, Issue 3, Page(s) 164–171

Abstract: Kidney disease remains a prominent complication of HIV disease, despite beneficial effects of antiretroviral therapy on the natural history of HIV-associated nephropathy, and on kidney function in general populations of HIV infected patients. Persons of ... ...

Abstract	Kidney disease remains a prominent complication of HIV disease, despite beneficial effects of antiretroviral therapy on the natural history of HIV-associated nephropathy, and on kidney function in general populations of HIV infected patients. Persons of African descent continue to bear a disproportionate burden of severe kidney disease, as is true for the general population. Recently identified genetic variants in the apolipoprotein L1 gene may contribute to this burden. As is also true for the general population, markers of kidney disease, including microalbuminuria, are sensitive predictors of cardiovascular disease and mortality among persons living with HIV. The emerging experience with kidney transplantation also suggests this to be a viable option in selected patients.
MeSH term(s)	Anti-HIV Agents/adverse effects ; Anti-HIV Agents/therapeutic use ; Antiretroviral Therapy, Highly Active/adverse effects ; HIV ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Kidney Diseases/chemically induced ; Kidney Diseases/virology
Chemical Substances	Anti-HIV Agents
Language	English
Publishing date	2011-06-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2151206-1
ISSN	1548-3576 ; 1548-3568
ISSN (online)	1548-3576
ISSN	1548-3568
DOI	10.1007/s11904-011-0080-x
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Zs.A 5920: Show issues

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Article ; Online: The treatment of HIV-associated nephropathy.

Kalayjian, Robert C

Advances in chronic kidney disease

2009 Volume 17, Issue 1, Page(s) 59–71

Abstract: Antiretroviral therapy (ART) preserves kidney function in patients with human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). Emerging data also document substantial renal benefits of ART in the general HIV-infected population, which is ... ...

Abstract	Antiretroviral therapy (ART) preserves kidney function in patients with human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). Emerging data also document substantial renal benefits of ART in the general HIV-infected population, which is associated in part with suppression of HIV-1 viral replication. The extent to which the response to ART differs in persons with HIVAN compared with those with other HIV-associated kidney disorders is unknown. Beneficial effects of corticosteroids and angiotensin-converting enzyme inhibitors on kidney function also are suggested by retrospective cohort studies and uncontrolled trials of patients with HIVAN. Underexposure to ART or inadequate ART dosing in HIV-infected patients with CKD may curtail the optimal benefits that may be derived from this therapy.
MeSH term(s)	AIDS-Associated Nephropathy/drug therapy ; Adrenal Cortex Hormones/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Anti-Retroviral Agents/therapeutic use ; Humans ; Kidney/drug effects
Chemical Substances	Adrenal Cortex Hormones ; Angiotensin-Converting Enzyme Inhibitors ; Anti-Retroviral Agents
Language	English
Publishing date	2009-12-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ISSN	1548-5609 ; 1548-5595
ISSN (online)	1548-5609
ISSN	1548-5595
DOI	10.1053/j.ackd.2009.08.013
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Zs.A 4627: Show issues

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Article ; Online: Human Immunodeficiency Virus and Aging in the Era of Effective Antiretroviral Therapy.

Van Epps, Puja / Kalayjian, Robert C

Infectious disease clinics of North America

2017 Volume 31, Issue 4, Page(s) 791–810

Abstract: Persons living with HIV (PLWH) have accentuated risks for age-associated comorbidities. Compared to the general population, PLWH have a 2-fold higher risk of cardiovascular disease, a 3-fold increased risk of fracture, and a risk of kidney disease that ... ...

Abstract	Persons living with HIV (PLWH) have accentuated risks for age-associated comorbidities. Compared to the general population, PLWH have a 2-fold higher risk of cardiovascular disease, a 3-fold increased risk of fracture, and a risk of kidney disease that is comparable to that in diabetes. Some comorbidities may present at younger ages than among the general population, suggesting the possibility of accelerated aging with HIV infection.
Language	English
Publishing date	2017-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1077676-x
ISSN	1557-9824 ; 0891-5520
ISSN (online)	1557-9824
ISSN	0891-5520
DOI	10.1016/j.idc.2017.07.007
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Article ; Online: A Systems-Based Analysis of Mono- and Combination Therapy for Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections.

Luterbach, Courtney L / Qiu, Hongqiang / Hanafin, Patrick O / Sharma, Rajnikant / Piscitelli, Joseph / Lin, Feng-Chang / Ilomaki, Jenni / Cober, Eric / Salata, Robert A / Kalayjian, Robert C / Watkins, Richard R / Doi, Yohei / Kaye, Keith S / Nation, Roger L / Bonomo, Robert A / Landersdorfer, Cornelia B / van Duin, David / Rao, Gauri G

Antimicrobial agents and chemotherapy

2022 Volume 66, Issue 10, Page(s) e0059122

Abstract: Antimicrobial resistance is a global threat. As "proof-of-concept," we employed a system-based approach to identify patient, bacterial, and drug variables contributing to mortality in patients with carbapenem-resistant Klebsiella pneumoniae ( ... ...

Abstract	Antimicrobial resistance is a global threat. As "proof-of-concept," we employed a system-based approach to identify patient, bacterial, and drug variables contributing to mortality in patients with carbapenem-resistant Klebsiella pneumoniae (CR
MeSH term(s)	Humans ; Klebsiella pneumoniae/genetics ; Colistin/pharmacology ; Colistin/therapeutic use ; Prospective Studies ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Ceftazidime/pharmacology ; Ceftazidime/therapeutic use ; Azabicyclo Compounds/pharmacology ; Azabicyclo Compounds/therapeutic use ; Carbapenem-Resistant Enterobacteriaceae/genetics ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Drug Combinations ; Sepsis/drug therapy ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology
Chemical Substances	Colistin (Z67X93HJG1) ; Anti-Bacterial Agents ; Ceftazidime (9M416Z9QNR) ; Azabicyclo Compounds ; Carbapenems ; Drug Combinations
Language	English
Publishing date	2022-09-20
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/aac.00591-22
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Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Naïve CD4+ T Cell Lymphopenia and Apoptosis in Chronic Hepatitis C Virus Infection Is Driven by the CD31+ Subset and Is Partially Normalized in Direct-Acting Antiviral Treated Persons.

Auma, Ann W N / Shive, Carey L / Lange, Alyssa / Damjanovska, Sofi / Kowal, Corinne / Zebrowski, Elizabeth / Pandiyan, Pushpa / Wilson, Brigid / Kalayjian, Robert C / Canaday, David H / Anthony, Donald D

Frontiers in immunology

2021 Volume 12, Page(s) 641230

Abstract: Background: The mechanisms underlying naïve CD4+ lymphopenia during chronic Hepatitis C Virus (HCV ...

Abstract	Background: The mechanisms underlying naïve CD4+ lymphopenia during chronic Hepatitis C Virus (HCV) infection are unclear. Whether direct-acting antiviral (DAA) therapy restores peripheral naïve CD4+ T cell numbers and function is unknown. Methods: We enumerated frequencies and counts of peripheral naïve CD4+, CD4+CD31+ and CD4+CD31- T cells by flow cytometry in a cross sectional analysis comparing chronic HCV infected (n=34), DAA-treated(n=29), and age-range matched controls (n=25), as well as in a longitudinal cohort of HCV DAA treated persons (n=16). The cross-sectional cohort was stratified by cirrhosis state. Cell apoptosis/survival (AnnexinV+7AAD+/BCL-2 labeling) and cell cycle entry (Ki67 expression) of CD31+ and CD31- naïve CD4+ T cells was analyzed directly Results: In the cross-sectional cohort, naïve CD4+ proportions were lower in chronic HCV infected persons compared to controls and DAA-treated persons, an effect in part attributed to cirrhosis. Age was associated with naïve cell counts and proportions in HCV infected and treated persons as well. Naïve CD4+ cell proportions negatively correlated with plasma levels of soluble CD14 following therapy in DAA-treated persons. Naïve CD4+ cells from HCV infected persons exhibited greater direct Conclusions: Activation and apoptosis of peripheral naïve CD4+CD31+ T cells appear to contribute to naïve CD4+ lymphopenia in chronic HCV infection, and this defect is partially reversible with HCV DAA therapy. Age and cirrhosis -associated naïve CD4+ lymphopenia is present both before and after HCV DAA therapy. These findings have implications for restoration of host immune function after DAA therapy.
MeSH term(s)	Antiviral Agents/therapeutic use ; Apoptosis/immunology ; CD4-Positive T-Lymphocytes/immunology ; Cohort Studies ; Cross-Sectional Studies ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/immunology ; Humans ; Lymphopenia/immunology ; Lymphopenia/virology ; Platelet Endothelial Cell Adhesion Molecule-1/immunology ; T-Lymphocyte Subsets/immunology
Chemical Substances	Antiviral Agents ; PECAM1 protein, human ; Platelet Endothelial Cell Adhesion Molecule-1
Language	English
Publishing date	2021-04-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.641230
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Article: T-cell Activation Is Correlated With Monocyte Activation in HCV/HIV Coinfection and Declines During HCV Direct-Acting Antiviral Therapy.

Auma, Ann W N / Shive, Carey / Damjanovska, Sofi / Kowal, Corinne / Cohen, Daniel E / Bhattacharya, Debika / Alston-Smith, Beverly / Osborne, Melissa / Kalayjian, Robert / Balagopal, Ashwin / Sulkowski, Mark / Wyles, David / Anthony, Donald D

Open forum infectious diseases

2021 Volume 8, Issue 4, Page(s) ofab079

Abstract: ... hepatitis C virus (HCV) infection. We investigated how T-cell and monocyte activation are related over the course ...

Abstract	Background: Immune activation markers associate with morbidity and mortality in HIV and hepatitis C virus (HCV) infection. We investigated how T-cell and monocyte activation are related over the course of HCV direct-acting antiviral (DAA) therapy during HCV/HIV coinfection. Methods: Peripheral blood mononuclear cells from AIDS Clinical Trials Group (ACTG) A5329 participants and a single-site separate cohort treated with DAAs were analyzed for central memory (CM)/effector memory (EM) T-cell subsets, monocyte subsets, and cell activation (CD38 and HLA-DR expression) before, during, and after therapy. Results: Before therapy, classical and inflammatory monocyte subset HLA-DR expression positively correlated with absolute counts and frequencies of CD38 Conclusions: During HCV/HIV coinfection, memory T-cell activation is associated with monocyte subset activation, consistent with related underlying mechanisms. Following therapy initiation, memory T-cell, but not monocyte, activation decreased. Residual CD4
Language	English
Publishing date	2021-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofab079
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Article ; Online: Plasma Cystatin C Associates With HIV-Associated Neurocognitive Disorder but Is a Poor Diagnostic Marker in Antiretroviral Therapy-Treated Individuals.

Kalayjian, Robert C / Robertson, Kevin R / Albert, Jeffrey M / Fichtenbaum, Carl J / Brown, Todd T / Taiwo, Babafemi O

Journal of acquired immune deficiency syndromes (1999)

2019 Volume 81, Issue 2, Page(s) e49–e54

Abstract: Objective: To examine associations between plasma cystatin C and neurocognitive impairment (NCI ... Results: Cystatin C was associated with NCI before ART [odds ratio (OR) 3.4 (95% CI: 1.2 to 9.4 ... impairment vs. no impairment]. Cystatin C performed poorly as a diagnostic marker for NCI ...

Abstract	Objective: To examine associations between plasma cystatin C and neurocognitive impairment (NCI) and its performance as a diagnostic marker before and during initial antiretroviral therapy (ART). Methods: Multivariable logistic regression and generalized estimating equations examined associations with NCI, determined by neuropsychological measurements, in participants of a 48-week randomized clinical trial of initial ART. Receiver operator characteristic curves examined diagnostic models of NCI. Results: Cystatin C was associated with NCI before ART [odds ratio (OR) 3.4 (95% CI: 1.2 to 9.4) for each 2-fold increase in baseline levels] and during 48 weeks of ART, in models that excluded baseline measurements [OR 3.0 (1.2 to 7.8) for each 2-fold increase in time-updated levels]. The strength of association increased with more severe impairment using HIV-associated neurocognitive disorder criteria [OR 2.2 (0.8 to 6.0) with asymptomatic NCI and OR 4.0 (1.5 to 11.0) with mild neurocognitive disorder or HIV-associated dementia vs. no impairment, for each 2-fold increase in time-updated levels] or by global development score [OR 2.6 (1.1 to 6.3) with mild impairment and OR 4.6 (1.1 to 18.9) with moderate or severe impairment vs. no impairment]. Cystatin C performed poorly as a diagnostic marker for NCI, however, with an area under the receiver operator characteristic curve of 0.58 at baseline and 0.54 at week 48. Conclusions: Higher plasma cystatin C levels were significantly associated with NCI, but these levels did not seem to be useful as a diagnostic marker for this condition.
MeSH term(s)	AIDS Dementia Complex/drug therapy ; Adult ; Anti-Retroviral Agents/therapeutic use ; Cognitive Dysfunction/complications ; Cystatin C/blood ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Logistic Models ; Male ; Neurocognitive Disorders/complications ; Neurocognitive Disorders/diagnosis ; Neuropsychological Tests ; Odds Ratio ; Plasma ; Viral Load
Chemical Substances	Anti-Retroviral Agents ; CST3 protein, human ; Cystatin C
Language	English
Publishing date	2019-03-23
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000002016
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