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Article ; Online: Ipsilateral immunization after a prior SARS-CoV-2 mRNA vaccination elicits superior B cell responses compared to contralateral immunization.

Jiang, Wenxia / Maldeney, Alexander R / Yuan, Xue / Richer, Martin J / Renshaw, Scott E / Luo, Wei

2024 Volume 43, Issue 1, Page(s) 113665

Abstract: mRNA vaccines have proven to be pivotal in the fight against COVID-19. A recommended booster, given 3 to 4 weeks post the initial vaccination, can substantially amplify protective antibody levels. Here, we show that, compared to contralateral boost, ... ...

Abstract	mRNA vaccines have proven to be pivotal in the fight against COVID-19. A recommended booster, given 3 to 4 weeks post the initial vaccination, can substantially amplify protective antibody levels. Here, we show that, compared to contralateral boost, ipsilateral boost of the SARS-CoV-2 mRNA vaccine induces more germinal center B cells (GCBCs) specific to the receptor binding domain (RBD) and generates more bone marrow plasma cells. Ipsilateral boost can more rapidly generate high-affinity RBD-specific antibodies with improved cross-reactivity to the Omicron variant. Mechanistically, the ipsilateral boost promotes the positive selection and plasma cell differentiation of pre-existing GCBCs from the prior vaccination, associated with the expansion of T follicular helper cells. Furthermore, we show that ipsilateral immunization with an unrelated antigen after a prior mRNA vaccination enhances the germinal center and antibody responses to the new antigen compared to contralateral immunization. These findings propose feasible approaches to optimize vaccine effectiveness.
MeSH term(s)	Humans ; COVID-19 Vaccines ; SARS-CoV-2 ; COVID-19/prevention & control ; Immunization ; Vaccination ; RNA, Messenger/genetics ; Antibodies, Viral ; Antibodies, Neutralizing
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger ; Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.113665
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Oxidase-like manganese oxide nanoparticles: a mechanism of organic acids/aldehydes as electron acceptors and potential application in cancer therapy.

Pan, Yang / Zhang, Zhuangzhuang / Cun, Ju-E / Fan, Xi / Pan, Qingqing / Gao, Wenxia / Luo, Kui / He, Bin / Pu, Yuji

Nanoscale

2024 Volume 16, Issue 6, Page(s) 2860–2867

Abstract: Identifying the underlying catalytic mechanisms of synthetic nanocatalysts or nanozymes is important in directing their design and applications. Herein, we revisited the oxidation process of 4,4'-diamino-3,3',5,5'-tetramethylbiphenyl (TMB) by ... ...

Abstract	Identifying the underlying catalytic mechanisms of synthetic nanocatalysts or nanozymes is important in directing their design and applications. Herein, we revisited the oxidation process of 4,4'-diamino-3,3',5,5'-tetramethylbiphenyl (TMB) by Mn
MeSH term(s)	Humans ; Oxides ; Manganese Compounds/pharmacology ; Oxidoreductases ; Manganese ; Aldehydes ; Electrons ; Hydrogen Peroxide ; Neoplasms/drug therapy ; Nanoparticles ; Peroxidases
Chemical Substances	manganese oxide (64J2OA7MH3) ; Oxides ; Manganese Compounds ; Oxidoreductases (EC 1.-) ; Manganese (42Z2K6ZL8P) ; Aldehydes ; Hydrogen Peroxide (BBX060AN9V) ; Peroxidases (EC 1.11.1.-)
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr05127g
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction to "Reversing Chemotherapy Resistance by a Synergy between Lysosomal pH-Activated Mitochondrial Drug Delivery and Erlotinib-Mediated Drug Efflux Inhibition".

Cheng, Furong / Pan, Qingqing / Gao, Wenxia / Pu, Yuji / Luo, Kui / He, Bin

ACS applied materials & interfaces

2022 Volume 14, Issue 16, Page(s) 19077

Language	English
Publishing date	2022-04-18
Publishing country	United States
Document type	Published Erratum
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c04966
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy.

Ding, Yuanyuan / Pan, Qingqing / Gao, Wenxia / Pu, Yuji / Luo, Kui / He, Bin

Biomaterials science

2023 Volume 11, Issue 4, Page(s) 1182–1214

Abstract: Reactive oxygen species (ROS) play a crucial role in physiological and pathological processes, emerging as a therapeutic target in cancer. Owing to the high concentration of ROS in solid tumor tissues, ROS-based treatments, such as photodynamic therapy ... ...

Abstract	Reactive oxygen species (ROS) play a crucial role in physiological and pathological processes, emerging as a therapeutic target in cancer. Owing to the high concentration of ROS in solid tumor tissues, ROS-based treatments, such as photodynamic therapy and chemodynamic therapy, and ROS-responsive drug delivery systems have been widely explored to powerfully and specifically suppress tumors. However, their anticancer efficacy is still hampered by the heterogeneous ROS levels, and thus comprehensively upregulating the ROS levels in tumor tissues can ensure an enhanced therapeutic effect, which can further sensitize and/or synergize with other therapies to inhibit tumor growth and metastasis. Herein, we review the recently emerging drug delivery strategies and technologies for increasing the H
MeSH term(s)	Humans ; Reactive Oxygen Species ; Hydrogen Peroxide ; Nanomedicine ; Photochemotherapy ; Neoplasms/drug therapy ; Neoplasms/pathology ; Cell Line, Tumor
Chemical Substances	Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-02-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d2bm01833k
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Retraction Note: Circular RNA hsa_circ_0001829 promotes gastric cancer progression through miR155-5p/SMAD2 axis.

Niu, Qiuling / Dong, Zhijie / Liang, Min / Luo, Yuanwei / Lin, Hai / Lin, Mingzhen / Zhong, Xiu / Yao, Wenxia / Weng, Jinsheng / Zhou, Xinke

Journal of experimental & clinical cancer research : CR

2023 Volume 42, Issue 1, Page(s) 101

Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Retraction of Publication
ZDB-ID	803138-1
ISSN	1756-9966 ; 0392-9078
ISSN (online)	1756-9966
ISSN	0392-9078
DOI	10.1186/s13046-023-02673-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ipsilateral immunization after a prior SARS-CoV-2 mRNA vaccination elicits superior B cell responses compared to contralateral immunization

Wenxia Jiang / Alexander R. Maldeney / Xue Yuan / Martin J. Richer / Scott E. Renshaw / Wei Luo

Cell Reports, Vol 43, Iss 1, Pp 113665- (2024)

2024

Abstract: Summary: mRNA vaccines have proven to be pivotal in the fight against COVID-19. A recommended booster, given 3 to 4 weeks post the initial vaccination, can substantially amplify protective antibody levels. Here, we show that, compared to contralateral ... ...

Abstract	Summary: mRNA vaccines have proven to be pivotal in the fight against COVID-19. A recommended booster, given 3 to 4 weeks post the initial vaccination, can substantially amplify protective antibody levels. Here, we show that, compared to contralateral boost, ipsilateral boost of the SARS-CoV-2 mRNA vaccine induces more germinal center B cells (GCBCs) specific to the receptor binding domain (RBD) and generates more bone marrow plasma cells. Ipsilateral boost can more rapidly generate high-affinity RBD-specific antibodies with improved cross-reactivity to the Omicron variant. Mechanistically, the ipsilateral boost promotes the positive selection and plasma cell differentiation of pre-existing GCBCs from the prior vaccination, associated with the expansion of T follicular helper cells. Furthermore, we show that ipsilateral immunization with an unrelated antigen after a prior mRNA vaccination enhances the germinal center and antibody responses to the new antigen compared to contralateral immunization. These findings propose feasible approaches to optimize vaccine effectiveness.
Keywords	CP: Immunology ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An Engineered Butyrate-Derived Polymer Nanoplatform as a Mucosa-Healing Enhancer Potentiates the Therapeutic Effect of Magnolol in Inflammatory Bowel Disease.

Fan, Xi / Zhang, Zhuangzhuang / Gao, Wenxia / Pan, Qingqing / Luo, Kui / He, Bin / Pu, Yuji

ACS nano

2023 Volume 18, Issue 1, Page(s) 229–244

Abstract: Colonic epithelial damage and dysregulated immune response are crucial factors in the progression and exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted drug delivery to the inflamed intestinal mucosa has shown promise in inducing and ...

Abstract	Colonic epithelial damage and dysregulated immune response are crucial factors in the progression and exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted drug delivery to the inflamed intestinal mucosa has shown promise in inducing and maintaining colitis remission, while minimizing side effects. Inspired by the excellent antioxidative and anti-inflammatory efficacy of naturally derived magnolol (Mag) and gut homeostasis regulation of microbiota-derived butyrate, we developed a pH/redox dual-responsive butyrate-rich polymer nanoparticle (PSBA) as an oral Mag delivery system for combinational therapy of IBD. PSBA showed a high butyrate content of 22% and effectively encapsulated Mag. The Mag-loaded nanoparticles (PSBA@Mag) demonstrated colonic pH and reduction-responsive drug release, ensuring efficient retention and adhesion in the colon of colitis mice. PSBA@Mag not only normalized the level of reactive oxygen species and inflammatory effectors in inflamed colonic mucosa but also restored the epithelial barrier function in both ulcerative colitis and Crohn's disease mouse models. Importantly, PSBA promoted the migration and healing ability of intestinal epithelial cells
MeSH term(s)	Animals ; Mice ; Polymers/pharmacology ; Butyrates/metabolism ; Butyrates/pharmacology ; Inflammatory Bowel Diseases/drug therapy ; Intestinal Mucosa ; Colon/metabolism ; Colitis/metabolism ; Disease Models, Animal
Chemical Substances	magnolol (001E35HGVF) ; Polymers ; Butyrates
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c05732
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Study on the accelerated biodegradation of PAHs in subsurface soil via coupled low-temperature thermally treatment and electron acceptor stimulation based on metagenomic sequencing.

Gou, Yaling / Song, Yun / Li, Peizhong / Wei, Wenxia / Luo, Nan / Wang, Hongqi

Journal of hazardous materials

2023 Volume 465, Page(s) 133265

Abstract: In situ anoxic bioremediation is a sustainable technology to remediate PAHs contaminated soils. However, the limited degradation rate of PAHs under anoxic conditions has become the primary bottleneck hindering the application of this technology. In this ... ...

Abstract	In situ anoxic bioremediation is a sustainable technology to remediate PAHs contaminated soils. However, the limited degradation rate of PAHs under anoxic conditions has become the primary bottleneck hindering the application of this technology. In this study, coupled low-temperature thermally treatment (<50 °C) and EA biostimulation was used to enhance PAH removal. Anoxic biodegradation of PAHs in soil was explored in microcosms in the absence and presence of added EAs at 3 temperatures (15 °C, 30 °C, and 45 °C). The influence of temperature, EA, and their interaction on the removal of PAHs were identified. A PAH degradation model based on PLSR analysis identified the importance and the positive/negative role of parameters on PAH removal. Soil archaeal and bacterial communities showed similar succession patterns, the impact of temperature was greater than that of EA. Soil microbial community and function were more influenced by temperature than EAs. Close and frequent interactions were observed among soil bacteria, archaea, PAH-degrading genes and methanogenic genes. A total of 15 bacterial OTUs, 1 PAH-degrading gene and 2 methanogenic genes were identified as keystones in the network. Coupled low-temperature thermally treatment and EA stimulation resulted in higher PAH removal efficiencies than EA stimulation alone and low-temperature thermally treatment alone.
MeSH term(s)	Soil ; Temperature ; Biodegradation, Environmental ; Electrons ; Soil Pollutants/metabolism ; Polycyclic Aromatic Hydrocarbons/metabolism ; Archaea/metabolism ; Bacteria/metabolism ; Euryarchaeota/metabolism ; Soil Microbiology
Chemical Substances	Soil ; Soil Pollutants ; Polycyclic Aromatic Hydrocarbons
Language	English
Publishing date	2023-12-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.133265
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Level of knowledge on low-dose CT lung cancer screening in Sichuan province, China: a cross-sectional study.

Li, Ruicen / Luo, Li / Tao, Wenjuan / Huang, Wenxia / Bao, Ting

BMJ open

2022 Volume 12, Issue 9, Page(s) e061987

Abstract: Objectives: Low-dose CT (LDCT) can help determine the early stage of lung cancer and reduce mortality. However, knowledge of lung cancer and lung cancer screening among community residents and medical workers, and potential factors that may affect ... ...

Abstract	Objectives: Low-dose CT (LDCT) can help determine the early stage of lung cancer and reduce mortality. However, knowledge of lung cancer and lung cancer screening among community residents and medical workers, and potential factors that may affect medical institutions to set up LDCT are limited. Design: A cross-sectional study was conducted in Sichuan province, China, in 2021. Community residents, medical workers and medical institutions were randomly selected, and participants responded to related questionnaires. Knowledge of lung cancer and LDCT lung cancer screening was evaluated. Data analyses were performed using SAS V.9.4. Results: A total of 35 692 residents, 6350 medical workers and 81 medical institutions were recruited; 4.05% of the residents were very familiar with lung cancer and 37.89% were (completely) unfamiliar. Characteristics, such as age and level of education, were significantly related to residents who were very familiar with lung cancer. Furthermore, 22.87% of the residents knew that LDCT can effectively screen for early-stage lung cancer, which was correlated with smoking (OR 1.1300; 95% CI 1.0540 to 1.2110; p=0.006) and family history of cancer (OR 1.2210; 95% CI 1.1400 to 1.3080; p<0.0001); 66.06% of medical workers believed that LDCT can detect early-stage lung cancer. Technicians and nurses were less knowledgeable than doctors about whether LDCT can effectively screen for early-stage lung cancer (OR 0.6976; 95% CI 0.5399 to 0.9015; p=0.0059 and OR 0.6970; 95% CI 0.5718 to 0.8496; p=0.0004, respectively). Setting up LDCT in medical institutions was related to grade, administrative rank, number of hospital beds that opened and total number of medical workers. Conclusions: The knowledge of lung cancer in residents is relatively low, and the knowledge of LDCT in screening (early-stage) lung cancer needs to be improved both in residents and medical workers. Possible factors that affect medical institutions to set up LDCT may need to be incorporated.
MeSH term(s)	China/epidemiology ; Cross-Sectional Studies ; Early Detection of Cancer ; Health Knowledge, Attitudes, Practice ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/prevention & control ; Mass Screening ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-09-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-061987
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Enhanced Feature Extraction Network Based on Acoustic Signal Feature Learning for Bearing Fault Diagnosis.

Luo, Yuanqing / Lu, Wenxia / Kang, Shuang / Tian, Xueyong / Kang, Xiaoqi / Sun, Feng

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 21

Abstract: The method of acoustic radiation signal detection not only enables contactless measurement but also provides comprehensive state information during equipment operation. This paper proposes an enhanced feature extraction network (EFEN) for fault diagnosis ...

Abstract	The method of acoustic radiation signal detection not only enables contactless measurement but also provides comprehensive state information during equipment operation. This paper proposes an enhanced feature extraction network (EFEN) for fault diagnosis of rolling bearings based on acoustic signal feature learning. The EFEN network comprises four main components: the data preprocessing module, the information feature selection module (IFSM), the channel attention mechanism module (CAMM), and the convolutional neural network module (CNNM). Firstly, the one-dimensional acoustic signal is transformed into a two-dimensional grayscale image. Then, IFSM utilizes three different-sized convolution filters to process input image data and fuse and assign weights to feature information that can attenuate noise while highlighting effective fault information. Next, a channel attention mechanism module is introduced to assign weights to each channel. Finally, the convolutional neural network (CNN) fault diagnosis module is employed for accurate classification of rolling bearing faults. Experimental results demonstrate that the EFEN network achieves high accuracy in fault diagnosis and effectively detects rolling bearing faults based on acoustic signals. The proposed method achieves an accuracy of 98.52%, surpassing other methods in terms of performance. In comparative analysis of antinoise experiments, the average accuracy remains remarkably high at 96.62%, accompanied by a significantly reduced average iteration time of only 0.25 s. Furthermore, comparative analysis confirms that the proposed algorithm exhibits excellent accuracy and resistance against noise.
Language	English
Publishing date	2023-10-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23218703
Database	MEDical Literature Analysis and Retrieval System OnLINE

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